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In vitro and animal studies

Chemopreventive effects of raw and roasted oat flakes after in vitro fermentation with human faecal microbiota

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Pages 57-69 | Received 20 Apr 2020, Accepted 18 May 2020, Published online: 01 Jun 2020

References

  • Aune D, Chan DSM, Lau R, Vieira R, Greenwood DC, Kampman E, Norat T. 2011. Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. Br Med J. 343:d6617.
  • Beeren SR, Christensen CE, Tanaka H, Jensen MG, Donaldson I, Hindsgaul O. 2015. Direct study of fluorescently-labelled barley β-glucan fate in an in vitro human colon digestion model. Carbohydr Polym. 115:88–92.
  • Boffetta P, Thies F, Kris-Etherton P. 2014. Epidemiological studies of oats consumption and risk of cancer and overall mortality. Br J Nutr. 112(S2):S14–S18.
  • Borowicki A, Stein K, Scharlau D, Scheu K, Brenner-Weiss G, Obst U, Hollmann J, Lindhauer M, Wachter N, Glei M. 2010. Fermented wheat aleurone inhibits growth and induces apoptosis in human ht29 colon adenocarcinoma cells. Br J Nutr. 103(3):360–369.
  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 2018. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394–424.
  • Cao Y, Gao X, Zhang W, Zhang G, Nguyen AK, Liu X, Jimenez F, Cox CS Jr, Townsend CM Jr, Ko TC. 2011. Dietary fiber enhances TGF-β signaling and growth inhibition in the gut. Am J Physiol Gastrointest Liver Physiol. 301(1):G156–G164.
  • Chaney AL, Marbach EP. 1962. Modified reagents for determination of urea and ammonia. Clin Chem. 8(2):130–132.
  • Charalampopoulos D, Wang R, Pandiella SS, Webb C. 2002. Application of cereals and cereal components in functional foods: a review. Int J Food Microbiol. 79(1–2):131–141.
  • Collins AR. 2004. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol. 26(3):249–261.
  • Connolly ML, Lovegrove JA, Tuohy KM. 2010. In vitro evaluation of the microbiota modulation abilities of different sized whole oat grain flakes. Anaerobe. 16(5):483–488.
  • EFSA. 2011. Scientific opinion on the substantiation of health claims related to beta-glucans from oats and barley and maintenance of normal blood LDL-cholesterol concentrations (ID 1236, 1299), increase in satiety leading to a reduction in energy intake (ID 851, 852), reduction of post-prandial glycaemic responses (ID 821, 824), and “digestive function” (ID 850) pursuant to article 13(1) of regulation (EC) no 1924/2006. EFSA J. 9(6):2207–2221.
  • Fu R, Yang P, Li ZW, Liu W, Amin S, Li ZY. 2019a. Avenanthramide a triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Cell Death Dis. 10(8):1–14.
  • Fu R, Yang P, Sajid A, Li ZY. 2019b. Avenanthramide a induces cellular senescence via mir-129-3p/pirh2/p53 signaling pathway to suppress colon cancer growth. J Agric Food Chem. 67(17):4808–4816.
  • Gangopadhyay N, Hossain MB, Rai DK, Brunton NP. 2015. A review of extraction and analysis of bioactives in oat and barley and scope for use of novel food processing technologies. Molecules. 20(6):10884–10909.
  • Glei M, Fischer S, Lamberty J, Ludwig D, Lorkowski S, Schlörmann W. 2018. Chemopreventive potential of in vitro fermented raw and roasted hazelnuts in lt97 colon adenoma cells. Anticancer Res. 38(1):83–93.
  • Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. 2008. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 27(2):104–119.
  • Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA. 2002. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr. 132(5):1012–1017.
  • Hogervorst JG, de Bruijn-Geraets D, Schouten LJ, van Engeland M, de Kok TM, Goldbohm RA, van den Brandt PA, Weijenberg MP. 2014. Dietary acrylamide intake and the risk of colorectal cancer with specific mutations in KRAS and APC. Carcinogenesis. 35(5):1032–1038.
  • Hughes R, Magee EA, Bingham S. 2000. Protein degradation in the large intestine: relevance to colorectal cancer. Curr Issues Intest Microbiol. 1(2):51–58.
  • Hussain PR, Rather SA, Suradkar PP. 2018. Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) beta-glucan. Radiat Phys Chem. 144:218–230.
  • Karppinen S, Liukkonen K, Aura AM, Forssell P, Poutanen K. 2000. In vitro fermentation of polysaccharides of rye, wheat and oat brans and inulin by human faecal bacteria. J Sci Food Agric. 80(10):1469–1476.
  • Kim HJ, White PJ. 2009. In vitro fermentation of oat flours from typical and high beta-glucan oat lines. J Agric Food Chem. 57(16):7529–7536.
  • Kim YH, Park JW, Lee JY, Kwon TK. 2004. Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. Carcinogenesis. 25(10):1813–1820.
  • Lazarova D, Lee A, Wong T, Marian B, Chiaro C, Rainey C, Bordonaro M. 2014. Modulation of Wnt activity and cell physiology by butyrate in LT97 microadenoma cells. J Cancer. 5(3):203–213.
  • Malcomson FC. 2018. Mechanisms underlying the effects of nutrition, adiposity and physical activity on colorectal cancer risk. Nutr Bull. 43(4):400–415.
  • Mosele JI, Motilva MJ, Ludwig IA. 2018. Beta-glucan and phenolic compounds: their concentration and behavior during in vitro gastrointestinal digestion and colonic fermentation of different barley-based food products. J Agric Food Chem. 66(34):8966–8975.
  • Naumann S, Schweiggert-Weisz U, Eglmeier J, Haller D, Eisner P. 2019. In vitro interactions of dietary fibre enriched food ingredients with primary and secondary bile acids. Nutrients. 11(6):1424.
  • Nordlund E, Aura AM, Mattila I, Kosso T, Rouau X, Poutanen K. 2012. Formation of phenolic microbial metabolites and short-chain fatty acids from rye, wheat, and oat bran and their fractions in the metabolical in vitro colon model. J Agric Food Chem. 60(33):8134–8145.
  • Pfaffl MW, Horgan GW, Dempfle L. 2002. Relative expression software tool (rest) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30(9):36.
  • Pool-Zobel BL, Selvaraju V, Sauer J, Kautenburger T, Kiefer J, Richter KK, Soom M, Wolfl S. 2005. Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics. Carcinogenesis. 26(6):1064–1076.
  • Richter M, Jurek D, Wrba F, Kaserer K, Wurzer G, Karner-Hanusch J, Marian B. 2002. Cells obtained from colorectal microadenomas mirror early premalignant growth patterns in vitro. Eur J Cancer. 38(14):1937–1945.
  • Scarpa ES, Mari M, Antonini E, Palma F, Ninfali P. 2018. Natural and synthetic avenanthramides activate caspases 2, 8, 3 and downregulate hTERT, MDR1 and Cox-2 genes in CaCo-2 and Hep3B cancer cells. Food Funct. 9(5):2913–2921.
  • Scharlau D, Borowicki A, Habermann N, Hofmann T, Klenow S, Miene C, Munjal U, Stein K, Glei M. 2009. Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. Mutat Res. 682(1):39–53.
  • Schlörmann W, Atanasov J, Lorkowski S, Dawczynski C, Glei M. 2020a. Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model. Food Funct. 11(3):2626–2638.
  • Schlörmann W, Birringer M, Lochner A, Lorkowski S, Richter I, Rohrer C, Glei M. 2016. In vitro fermentation of nuts results in the formation of butyrate and c9,t11 conjugated linoleic acid as chemopreventive metabolites. Eur J Nutr. 55(6):2063–2073.
  • Schlörmann W, Lamberty J, Lorkowski S, Ludwig D, Mothes H, Saupe C, Glei M. 2017a. Chemopreventive potential of in vitro fermented nuts in LT97 colon adenoma and primary epithelial colon cells. Mol Carcinog. 56(5):1461–1471.
  • Schlörmann W, Lamberty J, Ludwig D, Lorkowski S, Glei M. 2017b. In vitro-fermented raw and roasted walnuts induce expression of CAT and GSTT2 genes, growth inhibition, and apoptosis in LT97 colon adenoma cells. Nutr Res. 47:72–80.
  • Schlörmann W, Naumann S, Renner C, Glei M. 2015. Influence of miRNA-106b and mIRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells. Genes Nutr. 10(6):50.
  • Schlörmann W, Zetzmann S, Wiege B, Haase NU, Greiling A, Lorkowski S, Dawczynski C, Glei M. 2019. Impact of different roasting conditions on chemical composition, sensory quality and physicochemical properties of waxy-barley products. Food Funct. 10(9):5436–5445.
  • Schlörmann W, Zetzmann S, Wiege B, Haase NU, Greiling A, Lorkowski S, Dawczynski C, Glei M. 2020b. Impact of different roasting conditions on sensory properties and health-related compounds of oat products. Food Chem. 307:125548.
  • Shen RL, Wang Z, Dong JL, Xiang QS, Liu YQ. 2016. Effects of oat soluble and insoluble -glucan on 1,2-dimethylhydrazine-induced early colon carcinogenesis in mice. Food Agric Immunol. 27(5):657–666.
  • Su ZY, Shu L, Khor TO, Lee JH, Fuentes F, Kong AN. 2013. A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics. Top Curr Chem. 329:133–162.
  • Syberg K, Binderup ML, Cedergreen N, Rank J. 2015. Mixture genotoxicity of 2,4-dichlorophenoxyacetic acid, acrylamide, and maleic hydrazide on human caco-2 cells assessed with comet assay. J Toxicol Environ Health A. 78(6):369–380.
  • Thies F, Masson LF, Boffetta P, Kris-Etherton P. 2014. Oats and bowel disease: a systematic literature review. Br J Nutr. 112(S2):S31–S43.
  • Topping DL, Clifton PM. 2001. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 81(3):1031–1064.
  • Tosh SM. 2013. Review of human studies investigating the post-prandial blood-glucose lowering ability of oat and barley food products. Eur J Clin Nutr. 67(4):310–317.
  • Van den Abbeele P, Kamil A, Fleige L, Chung Y, De Chavez P, Marzorati M. 2018. Different oat ingredients stimulate specific microbial metabolites in the gut microbiome of three human individuals in vitro. ACS Omega. 3(10):12446–12456.
  • Wang HC, Hung CH, Hsu JD, Yang MY, Wang SJ, Wang CJ. 2011. Inhibitory effect of whole oat on aberrant crypt foci formation and colon tumor growth in ICR and BALB/c mice. J Cereal Sci. 53(1):73–77.
  • Wang L, Luo HS, Xia H. 2009. Sodium butyrate induces human colon carcinoma HT-29 cell apoptosis through a mitochondrial pathway. J Int Med Res. 37(3):803–811.
  • Wang P, Chen H, Zhu Y, McBride J, Fu J, Sang S. 2015. Oat avenanthramide-C (2c) is biotransformed by mice and the human microbiota into bioactive metabolites. J Nutr. 145(2):239–245.
  • Whitehead A, Beck EJ, Tosh S, Wolever TM. 2014. Cholesterol-lowering effects of oat beta-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 100(6):1413–1421.
  • Yaku K, Enami Y, Kurajyo C, Matsui-Yuasa I, Konishi Y, Kojima-Yuasa A. 2012. The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53. Mol Cell Biochem. 370(1–2):7–14.
  • Zeng H, Claycombe KJ, Reindl KM. 2015. Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation. J Nutr Biochem. 26(10):1022–1028.
  • Zhang Y, Zhou L, Bao YL, Wu Y, Yu CL, Huang YX, Sun Y, Zheng LH, Li YX. 2010. Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. Chem Biol Interact. 185(3):174–181.

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