Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women

References

• Aguilar CM, Sant’Ana CT, Costa AGV, Silva PI, Costa NMB. 2017. Comparative effects of brown and golden flaxseeds on body composition, inflammation and bone remodelling biomarkers in perimenopausal overweight women. J Funct Foods. 33:166–175.
   Web of Science ®Google Scholar
• Al-Anazi AF, Qureshi VF, Javaid K, Qureshi S. 2011. Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: an overview. J Nat Sci Biol Med. 2(2):154–163.
   PubMedGoogle Scholar
• Arango CM, Molina CF, Gaviria BL. 2011. Efecto del consumo de linaza en el perfil lipídico, el control del cáncer y como terapia de reemplazo hormonal en la menopausia: una revisión sistemática de ensayos clínicos aleatorizados. Persp Nutric Hum. 13:73–91.
   Google Scholar
• Association of Official Analytical Chemists 1998. Official methods of analysis of the association of official analytical chemists (16th ed.). Washington (DC): A.O.A.C. International.
   Google Scholar
• Bhat M, Zinjarde SS, Bhargava SY, Kumar AR, Joshi BN. 2011. Antidiabetic Indian plants: a good source of potent amylase inhibitors. Evid Based Complement Alternat Med. 2011:810207.
   PubMed Web of Science ®Google Scholar
• Cherem ADAR, Bramosrki A. 2008. Excreção de gordura fecal em ratos (Rattus norvegicus Wistar) submetidos a dietas hiperlipídicas e hipercolesterolêmicas suplementadas com quitosana. Rev Bras Cienc Farm. 44(4):701–706.
   Google Scholar
• da Costa CAS, da Silva PCA, Ribeiro DC, Pereira AD, dos Santos A. d S, de Abreu MDC, Pessoa LR, Boueri B. F d C, Pessanha CR, do Nascimento-Saba CCA, et al. 2016. Effects of diet containing flaxseed flour (Linum usitatissimum) on body adiposity and bone health in young male rats. Food Funct. 7(2):698–703.
   PubMed Web of Science ®Google Scholar
• Dali S, Krouf D, Mellouk Z, Taleb-Dida N. 2019. Beneficial effects of linum usitatissimum L. on dyslipidemia, oxidative stress and inflammatory cytokines in hypercholesterolemic rats. NFS. 49(4):777–790.
   Web of Science ®Google Scholar
• Dehghan P, Gargari BP, Jafar-Abadi MA. 2014. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutr. 30(4):418–423.
   PubMed Web of Science ®Google Scholar
• Deng Q, Yu X, Ma F, Xu J, Huang F, Huang Q, Sheng F. 2017. Comparative analysis of the in-vitro antioxidant activity and bioactive compounds of flaxseed in China according to variety and geographical origin. Int J Food Proper. 20:2708–2722.
   Web of Science ®Google Scholar
• Dodin S, Lemay A, Jacques H, Légaré F, Forest J-C, Mâsse B. 2005. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab. 90(3):1390–1397.
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge. Clin Chem. 18(6):499–502.
   PubMed Web of Science ®Google Scholar
• Fuller S, Beck E, Salman H, Tapsell L. 2016. New horizons for the study of dietary fiber and health: a review. Plant Foods Hum Nutr. 71(1):1–12.
   PubMed Web of Science ®Google Scholar
• Garrido TS, Arantes MS, Marçal VM. 2015. Anthropometric profile, cardiometabolic and quality of life of menopausal diabetic women. Colloquiun Vita. 1:94–101.
   Google Scholar
• Gianluca GC. 2013. Treatment with n–3 polyunsaturated fatty acids reverses endothelial dysfunction and oxidative stress in experimental menopause. J Nutr Biochem. 24:371–379.
   PubMed Web of Science ®Google Scholar
• Gök M, Ulusu NN, Tarhan N, Tufan C, Ozansoy G, Arı N, Karasu Ç. 2016. Flaxseed protects against diabetes-induced glucotoxicity by modulating pentose phosphate pathway and glutathione dependent enzyme activities in rats. J Diet Suppl. 13(3):339–351.
   PubMedGoogle Scholar
• Kobiyama K, Ley K. 2018. Atherosclerosis. Circ Res. 123(10):1118–1120.
   PubMed Web of Science ®Google Scholar
• Lepage G, Roy C. 1986. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res. 27(1):114–120.
   PubMed Web of Science ®Google Scholar
• Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma S, Daggy BP, Stoecker BJ, Arjmandi BH. 2002. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab. 87(4):1527–1532.
   PubMed Web of Science ®Google Scholar
• Machado A, De Paula H, Cardoso L, Costa N. 2015. Effects of brown and golden flaxseed on the lipid profile, glycemia, inflammatory biomarkers, blood pressure and body composition in overweight adolescents. Nutrition. 31(1):90–96.
   PubMed Web of Science ®Google Scholar
• Mani V, Hollis JH, Gabler NK. 2013. Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia. Nutr Metab (Lond). 10(1):6.
   PubMedGoogle Scholar
• Mansfield DR, Gollogly NC, Kaye DM, Richardson M, Bergin P, Naughton MT. 2004. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med. 169(3):361–366.
   PubMed Web of Science ®Google Scholar
• Matusiewicz M, Kosieradzka I, Zuk M, Szopa J. 2015. Effect of dose and administration period of seed cake of genetically modified and non-modified flax on selected antioxidative activities in rats. Int J Mol Sci. 16(6):14259–14275.
   PubMed Web of Science ®Google Scholar
• Mehta NN, McGillicuddy FC, Anderson PD, Hinkle CC, Shah R, Pruscino L, Tabita-Martinez J, Sellers KF, Rickels MR, Reilly MP. 2010. Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes. 59(1):172–181.
   PubMed Web of Science ®Google Scholar
• Mendoza N, Sánchez-Borrego R, Cancelo MJ, Calvo A, Checa MA, Cortés J, Elorriaga MA, Díaz T, González JV, Lete I, et al. 2013. Position of the Spanish Menopause Society regarding the management of perimenopause. Maturitas. 74(3):283–290.
   PubMed Web of Science ®Google Scholar
• Mittal PC, Kant R. 2009. Correlation of increased oxidative stress to body weight in disease-free post menopausal women. Clin Biochem. 42(10–11):1007–1011.
   PubMed Web of Science ®Google Scholar
• Moetazza MA, Kassem SS, Abdelkader MM. 2015. Flaxseed as functional food. Res J Pharm Biol Chem Sci. 6:1944–1951.
   Google Scholar
• Moreira APB, Texeira TFS, Ferreira AB, Peluzio MDCG, Alfenas RDCG. 2012. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nutr. 108(5):801–809.
   PubMed Web of Science ®Google Scholar
• NEPA-UNICAMP. 2011. Tabela Brasileira de Composição de Alimentos – TACO. 4th ed. Campinas (São Paulo): NEPA-UNICAMP.
   Google Scholar
• Novak TE, Babcock TA, Jho DH, et al. 2003. NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am J Physiol: Lung Cell Molec Physiol. 284:84–89.
   PubMed Web of Science ®Google Scholar
• Nuernberg K, Fischer K, Nuernberg G, Kuechenmeister U, Klosowska D, Eliminowska-Wenda G, Fiedler I, Ender K. 2005. Effects of dietary olive and linseed oil on lipid composition, meat quality, sensory characteristics and muscle structure in pigs. Meat Sci. 70(1):63–74.
   PubMed Web of Science ®Google Scholar
• Pilar CB. Avaliação dos efeitos da semente de Linum usitatissimum L. em pacientes com síndrome metabólica [Dissertação (Mestrado Bioquímica)]. Uruguaiana: Universidade Federal Do Pampa; 2014.
   Google Scholar
• Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 26(9–10):1231–1237.
   PubMed Web of Science ®Google Scholar
• Rhee Y, Brunt A. 2011. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutr J. 10:44.
   PubMed Web of Science ®Google Scholar
• Rohrig B, Prel L, Wachtlin D, Kwiecien R, Blettner M. 2010. Sample size calculation in clinical trials. Deuts Arzteblatt Inter. 107:31–32.
   Web of Science ®Google Scholar
• Rufino M. d S M, Alves RE, de Brito ES, Pérez-Jiménez J, Saura-Calixto F, Mancini-Filho J. 2010. Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil. Food Chem. 121(4):996–1002.
   Web of Science ®Google Scholar
• Shahidi F, Alasalvar C, Liyana-Pathirana CM. 2007. Antioxidant phytochemicals in hazelnut kernel (Corylus avellana L.) and hazelnut byproducts. J Agric Food Chem. 55(4):1212–1220.
   PubMed Web of Science ®Google Scholar
• Shieh A, Epeldegui M, Karlamangla AS, Greendale GA. 2020. Gut permeability, inflammation, and beone density across the menopause transition. JCI Insight. 5(2):e134092.
   PubMed Web of Science ®Google Scholar
• Singleton VL, Rossi JA. 1965. Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents. Am J Enol Viticult. 16:144–158.
   Google Scholar
• Siobán DH, Margery MDG, Janet EH. 2012. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J North Am Menop Society. 19:387–395.
   PubMed Web of Science ®Google Scholar
• Siriwardhana N, Kalupahana NS, Moustaid-Moussa N. 2012. Health benefits of n–3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid. Adv Food Nutr Res. 65:211–222.
   PubMedGoogle Scholar
• SBD (Sociedade Brasileira de Diabetes). 2015. Diretrizes Sociedade Brasileira de Diabetes; São Paulo, Brazil. p. 374.
   Google Scholar
• Sposito A, Caramelli B, Fonseca F, Bertolami M. 2007. IV diretriz brasileira sobre dislipidemias e prevenção da aterosclerose. Arqu Brasil Cardiol. 88:1–22.
   Google Scholar
• Sudha P, Zinjarde SS, Bhargava SY, Kumar AR. 2011. Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants. BMC Complement Altern Med. 11(1):5.
   PubMedGoogle Scholar
• Tavarini S, Castagna A, Conte G, Foschi L, Sanmartin C, Incrocci L, Ranieri A, Serra A, Angelini LG. 2019. Evaluation of chemical composition of two Linseed varieties as sources of health-beneficial substances. Molecules. 24(20):3715–3729.
   Web of Science ®Google Scholar
• Tremollieres FA, Pouilles JM, Ribot CA. 1996. Relative influence of age and menopause on total and regional body composition changes in postmenopausal women. Am J Obstetreticy Gynecol. 6:594–600.
   Google Scholar
• de Sá LRV, de Oliveira MAL, Cammarota MC, Matos A, Ferreira-Leitão VS. 2011. Simultaneous analysis of carbohydrates and volatile fatty acids by HPLC for monitoring fermentative biohydroge production. Int J Hydrogen Energy. 36(23):15177–15186.
   Web of Science ®Google Scholar
• Verediano TA, Viana ML, Das Graças Vaz Tostes M, De Oliveira DS, Nunes LC, Costa NMB. 2020. Yacón (Smallanthus sonchifolius) prevented inflammation, oxidative stress, and intestinal alterations in an animal model of colorectal carcinogenesis. J Sci Food Agric. 100(15):5442–5449.
   PubMed Web of Science ®Google Scholar
• Vilela EG, Torres HOG, Ferrari MLA, Lima AS, Cunha AS. 2008. Gut permeability to lactulose and mannitol differs in treated Crohn’s disease and celiac disease patients and healthy subjects. Braz J Med Biol Res. 41(12):1105–1109.
   PubMed Web of Science ®Google Scholar
• Wang H, Wang J, Qiu C, Ye Y, Guo X, Chen G, Li T, Wang Y, Fu X, Liu RH. 2017. Comparison of phytochemical profiles and health benefits in fiber and oil flaxseeds (Linum usitatissimum L.). Food Chem. 214:227–233.
   PubMed Web of Science ®Google Scholar
• World Health Organization Obesity. 2000. Preventing and managing the global epidemic: report of a WHO consultation. World Health Organ Tech Rep Ser. 894:1–253.
   Web of Science ®Google Scholar
• Yang W, Fu J, Yu M, Huang Q, Wang D, Xu J, Deng Q, Yao P, Huang F, Liu L. 2012. Effects of flaxseed oil on anti-oxidative system and membrane deformation of human peripheral blood erythrocytes in high glucose level. Lipids Health Dis. 11:88–92.
   PubMed Web of Science ®Google Scholar
• Yuan YV, Rickard SE, Thompson LU. 1999. Short-term feeding of flaxseed or its lignan has minor influence on in vivo hepatic antioxidant status in young rats. Nutr Res. 19(8):1233–1243.
   Web of Science ®Google Scholar
• Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW, Sun SZ. 2008. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. Br J Nutr. 99(6):1301–1309.
   PubMed Web of Science ®Google Scholar
• Zhao G, Etherton TD, Martin KR, Gillies PJ, West SG, Kris-Etherton PM. 2007. Dietary α-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. Am J Clin Nutr. 85(2):385–391.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Joshi-Barve S, Barve S, Chen LH. 2004. Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J Am Coll Nutr. 23(1):71–78.
   PubMed Web of Science ®Google Scholar