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Effectiveness of physical exercise at improving functional capacity in older adults living with Alzheimer's disease: a systematic review of randomized controlled trials

ORCID Icon, , , , &
Pages 391-402 | Received 18 May 2021, Accepted 30 Jan 2022, Published online: 16 Feb 2022

References

  • Prince M, Wimo A, Guerchet M, et al. World Alzheimer Report 2015: the global impact of dementia. An analysis of prevalence, incidence, costs & trends. London (UK): Alzheimer’s Disease International; 2015; [cited 2021 Jul 15].
  • World Health Organization. Definition of an older or elderly person. Geneva: World Health Organization; 2010.
  • Sheridan PL, Hausdorff JM. The role of higher-level cognitive function in gait: executive dysfunction contributes to fall risk in Alzheimer's disease. Dement Geriatr Cogn Disord. 2007;24(2):125–137.
  • Barbe C, Jolly D, Morrone I, et al. Factors associated with quality of life in patients with Alzheimer's disease. BMC Geriatr. 2018;18(1):159.
  • Alzheimer’s Association. 2021 Alzheimer’s disease facts and figures. Alzheimers Dement. 2021;17(3):327–406.
  • Cedervall Y, Kilander L, Aberg AC. Declining physical capacity but maintained aerobic activity in early Alzheimer's disease. Am J Alzheimers Dis Other Dement. 2012;27(3):180–187.
  • Marshall GA, Amariglio RE, Sperling RA, et al. Activities of daily living: where do they fit in the diagnosis of Alzheimer's disease? Neurodegener Dis Manag. 2012;2(5):483–491.
  • Gras LZ, Kanaan SF, McDowd JM, et al. Balance and gait of adults with very mild Alzheimer disease. J Geriatr Phys Ther. 2015;38(1):1–7.
  • Pedroso RV, Corazza DI, Andreatto CAA, et al. Cognitive, functional and physical activity impairment in elderly with Alzheimer's disease. Dement Neuropsychol. 2018;12(1):28–34.
  • Szeto JYY, Lewis SJG. Current treatment options for Alzheimer's disease and Parkinson's disease dementia. Curr Neuropharmacol. 2016;14(4):326–338.
  • Vigorito C, Giallauria F. Effects of exercise on cardiovascular performance in the elderly. Front Physiol. 2014;5:51.
  • Izquierdo M, Merchant RA, Morley JE, et al. International exercise recommendations in older adults (ICFSR): expert consensus guidelines. J Nutr Health Aging. 2021;25(7):824–853.
  • Leandri M, Campbell J, Molfetta L, et al. Relationship between balance and cognitive performance in older people. J Alzheimers Dis. 2015;45(3):705–707.
  • Demnitz N, Zsoldos E, Mahmood A, et al. Associations between mobility, cognition, and brain structure in healthy older adults. Front Aging Neurosci. 2017;9(155):155.
  • Valkanova V, Esser P, Demnitz N, et al. Association between gait and cognition in an elderly population based sample. Gait Posture. 2018;65:240–245.
  • Sui SX, Holloway-Kew KL, Hyde NK, et al. Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men. Sci Rep. 2020;10(1):10367.
  • Morris JK, Vidoni ED, Johnson DK, et al. Aerobic exercise for Alzheimer's disease: a randomized controlled pilot trial. PLOS One. 2017;12(2):e0170547.
  • Silva FO, Ferreira JV, Plácido J, et al. Three months of multimodal training contributes to mobility and executive function in elderly individuals with mild cognitive impairment, but not in those with Alzheimer's disease: a randomized controlled trial. Maturitas. 2019;126:28–33.
  • Vidoni ED, Perales J, Alshehri M, et al. Aerobic exercise sustains performance of instrumental activities of daily living in early-stage Alzheimer disease. J Geriatr Phys Ther. 2019;42(3):129–134.
  • Steinberg M, Leoutsakos J-MS, Podewils LJ, et al. Evaluation of a home-based exercise program in the treatment of Alzheimer's disease: the maximizing independence in dementia (MIND) study. Int J Geriatr Psychiatry. 2009;24(7):680–685.
  • Vreugdenhil A, Cannell J, Davies A, et al. A community-based exercise programme to improve functional ability in people with Alzheimer's disease: a randomized controlled trial. Scand J Caring Sci. 2012;26(1):12–19.
  • Rolland Y, Pillard F, Klapouszczak A, et al. Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. J Am Geriatr Soc. 2007;55(2):158–165.
  • Lowery D, Cerga-Pashoja A, Iliffe S, et al. The effect of exercise on behavioural and psychological symptoms of dementia: the EVIDEM-E randomised controlled clinical trial. Int J Geriatr Psychiatry. 2014;29(8):819–827.
  • Blankevoort CG, van Heuvelen MJG, Boersma F, et al. Review of effects of physical activity on strength, balance, mobility and ADL performance in elderly subjects with dementia. Dement Geriatr Cogn Disord. 2010;30(5):392–402.
  • Potter R, Ellard D, Rees K, et al. A systematic review of the effects of physical activity on physical functioning, quality of life and depression in older people with dementia. Int J Geriatr Psychiatry. 2011;26(10):1000–1011.
  • Pitkälä K, Savikko N, Poysti M, et al. Efficacy of physical exercise intervention on mobility and physical functioning in older people with dementia: a systematic review. Exp Gerontol. 2013;48(1):85–93.
  • Lam FM, Huang M-Z, Liao L-R, et al. Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review. J Physiother. 2018;64(1):4–15.
  • Gill DP, Hubbard RA, Koepsell TD, et al. Differences in rate of functional decline across three dementia types. Alzheimers Dement. 2013;9(0):63–71.
  • Hong YJ, Yoon B, Shim YS, et al. Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently? Arch Gerontol Geriatr. 2014;58(3):415–419.
  • Tolea MI, Morris JC, Galvin JE. Trajectory of mobility decline by type of dementia. Alzheimer Dis Assoc Disord. 2016;30(1):60–66.
  • Allan L, McKeith I, Ballard C, et al. The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life. Dement Geriatr Cogn Disord. 2006;22(3):230–237.
  • Sicras A, Rejas J, Arco S, et al. Prevalence, resource utilization and costs of vascular dementia compared to Alzheimer's dementia in a population setting. Dement Geriatr Cogn Disord. 2005;19(5–6):305–315.
  • Giovannetti T, Seligman SC, Britnell P, et al. Differential effects of goal cues on everyday action errors in Alzheimer's disease versus Parkinson's disease dementia. Neuropsychology. 2015;29(4):592–602.
  • Hernández SSS, Sandreschi PF, Silva FC, et al. What are the benefits of exercise for Alzheimer's disease? A systematic review of the past 10 years. J Aging Phys Act. 2015;23(4):659–668.
  • Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med. 2021;18(3):e1003583.
  • Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions version 6.1. Chichester (UK): The Cochrane Collaboration; 2020.
  • Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924–926.
  • World Health Organization. International Classification of Functioning, Disabilities, and Health: ICF. Geneva: World Health Organization; 2001.
  • World Health Organization. How to use the ICF: a practical manual for using the International Classification of Functioning, Disability and Health (ICF). Exposure draft for comment. Geneva: World Health Organization; 2013.
  • World Health Organization and Alzheimer’s Disease International. Dementia: a public health priority. Geneva: World Health Organization; 2012.
  • Hernandes E, Zamboni A, Fabbri S. Using GQM and TAM to evaluate StArt – a tool that supports systematic review. CLEI Electr J. 2012;15:13–25.
  • Hedges L, Olkin I. Statistical methods for meta-analysis. 1st ed. Orlando: Academic Press; 1985.
  • Cohen J. The concepts of power analysis. In: Cohen J, editor. Statistical power analysis for the behavioral sciences. 2nd ed. New Jersey: Academic Press; 1988. p. 1–17.
  • Oliveira MPB, Reis LM, Pereira ND. Effect of resistance exercise on body structure & function, activity and participation in individuals with Parkinson’s disease: a systematic review. Arch Phys Med Rehabil. 2021;9993(21):151–159.
  • Oliveira MPB, Lobato DFM, Smaili SM, et al. Effect of aerobic exercise on functional capacity and quality of life in individuals with Parkinson's disease: a systematic review of randomized controlled trials. Arch Gerontol Geriatr. 2021;95:104422.
  • Maher CG, Sherrington C, Herbert RD, et al. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713–721.
  • Tappen RM, Roach KE, Applegate EB, et al. Effect of a combined walking and conversation intervention on functional mobility of nursing home residents with Alzheimer disease. Alzheimer Dis Assoc Disord. 2000;14(4):196–201.
  • Santana-Sosa E, Barriopedro MI, López-Mojares LM, et al. Exercise training is beneficial for Alzheimer's patients. Int J Sports Med. 2008;29(10):845–850.
  • Roach EK, Tappen RM, Kirk-Sanchez N, et al. A randomized controlled trial of an activity specific exercise program for individuals with Alzheimer disease in long-term care settings. J Geriatr Phys Ther. 2011;34(2):50–56.
  • Venturelli M, Scarsini R, Schena F. Six-month walking program changes cognitive and ADL performance in patients with Alzheimer. Am J Alzheimers Dis Other Dement. 2011;26(5):381–388.
  • Suttanon P, Hill KD, Said CM, et al. Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer's disease: a pilot randomized controlled trial. Clin Rehabil. 2013;27(5):427–438.
  • Holthoff VA, Marschner K, Scharf M, et al. Effects of physical activity training in patients with Alzheimer's dementia: results of a pilot RCT study. PLOS One. 2015;10(4):e0121478.
  • Hoffmann K, Sobol NA, Frederiksen KS, et al. Moderate-to-high intensity physical exercise in patients with Alzheimer's disease: a randomized controlled trial. J Alzheimers Dis. 2016;50(2):443–453.
  • McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939–944.
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed. Washington: American Psychiatric Association; 1994.
  • Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43(11):2412–2414.
  • Folstein MF, Folstein SE, McHugh PR. Mini-Mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198.
  • Lindquist R, Wyman JF, Talley KM, et al. Design of control-group conditions in clinical trials of behavioral interventions. J Nurs Scholarsh. 2007;39(3):214–221.
  • Mustafa RA, Santesso N, Brozek J, et al. The GRADE approach is reproducible in assessing the quality of evidence of quantitative evidence syntheses. J Clin Epidemiol. 2013;66(7):736–742.
  • James BD, Boyle PA, Bennett DA, et al. Total daily activity measured with actigraphy and motor function in community-dwelling older persons with and without dementia. Alzheimer Dis Assoc Disord. 2012;26(3):238–245.
  • van Alphen HJM, Volkers KM, Blankevoort CG, et al. Older adults with dementia are sedentary for most of the day. PLOS One. 2016;11(3):e0152457.
  • Andersen CK, Wittrup-Jensen KU, Lolk A, et al. Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia. Health Qual Life Outcomes. 2004;2:52.
  • Prigerson HG. Costs to society of family caregiving for patients with end-stage Alzheimer's disease. N Engl J Med. 2003;349(20):1891–1892.
  • Gélinas I, Gauthier L, McIntyre M, et al. Development of a functional measure for persons with Alzheimer's disease: the Disability Assessment for Dementia. Am J Occup Ther. 1999;53(5):471–481.
  • Johnson N, Barion A, Rademaker A, et al. The Activities of Daily Living Questionnaire: a validation study in patients with dementia. Alzheimer Dis Assoc Disord. 2004;18(4):223–230.
  • Stubbs B, Eggermont L, Soundy A, et al. What are the factors associated with physical activity (PA) participation in community dwelling adults with dementia? A systematic review of PA correlates. Arch Gerontol Geriatr. 2014;59(2):195–203.
  • Ries JD, Echternach JL, Nof L, et al. Test–retest reliability and minimal detectable change scores for the timed "up & go" test, the Six-Minute Walk test, and gait speed in people with Alzheimer disease. Phys Ther. 2009;89(6):569–579.
  • Campbell AJ, Robertson MC, Gardner MM, et al. Randomised controlled trial of a general practice programme of home based exercise to prevent falls in elderly women. BMJ. 1997;315(7115):1065–1069.
  • Johnson CSJ, Myers AM, Scholey LM, et al. Outcome evaluation of the Canadian Centre for activity and aging’s home support exercise program for frail older adults. J Aging Phys Act. 2003;11(3):408–424.
  • Blankevoort CG, van Heuvelen MJG, Scherder EJA. Reliability of six physical performance tests in older people with dementia. Phys Ther. 2013;93(1):69–78.
  • Olsen CF, Bergland A. Reliability of the Norwegian version of the short physical performance battery in older people with and without dementia. BMC Geriatr. 2017;17(1):124–134.
  • American College of Sports Medicine. ACSM's guidelines for exercise testing and prescription. 10th ed. London: Wolters Kluwer; 2018.
  • Suttanon P, Hill KD, Dodd KJ, et al. Retest reliability of balance and mobility measurements in people with mild to moderate Alzheimer's disease. Int Psychogeriatr. 2011;23(7):1152–1159.
  • Muir-Hunter SW, Graham L, Odasso MM. Reliability of the Berg Balance Scale as a clinical measure of balance in community-dwelling older adults with mild to moderate Alzheimer disease: a pilot study. Physiother Can. 2015;67(3):255–262.
  • Stephen R, Hongisto K, Solomon A, et al. Physical activity and Alzheimer's disease: a systematic review. J Gerontol A Biol Sci Med Sci. 2017;72(6):733–739.
  • Campbell KH, Stocking CB, Hougham GW, et al. Dementia, diagnostic disclosure, and self-reported health status. J Am Geriatr Soc. 2008;56(2):296–300.
  • Kunz R, Vist G, Oxman AD. Randomisation to protect against selection bias in healthcare trials. Cochrane Database Syst Rev. 2007;2007(2):MR000012.
  • Capurro D, Gabrielli D, Letelier LM. Intention to treat and follow up are important in assessing validity of a randomized clinical trial. Rev Med Chil. 2004;132(12):1557–1560.].
  • Herman A, Botser IB, Tenenbaum S, et al. Intention-to-treat analysis and accounting for missing data in orthopaedic randomized clinical trials. J Bone Joint Surg Am. 2009;91(9):2137–2143.

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