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Education and Training

The effect of rehabilitation interventions on freezing of gait in people with Parkinson’s disease is unclear: a systematic review and meta-analyses

, , , &
Pages 3199-3218 | Received 19 Dec 2021, Accepted 29 Aug 2022, Published online: 15 Sep 2022

References

  • Nutt JG, Bloem BR, Giladi N, et al. Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol. 2011;10(8):734–744.
  • Macht M, Kaussner Y, Moller JC, et al. Predictors of freezing in Parkinson’s disease: a survey of 6,620 patients. Mov Disord. 2007;22(7):953–956.
  • Perez-Lloret S, Negre-Pages L, Damier P, et al. Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease. JAMA Neurol. 2014;71(7):884–890.
  • Lichter DG, Benedict RHB, Hershey LA. Freezing of gait in Parkinson’s disease: risk factors, their interactions, and associated nonmotor symptoms. Parkinsons Dis. 2021;2021:1–12.
  • Allen NE, Schwarzel AK, Canning CG. Recurrent falls in Parkinson’s disease: a systematic review. Parkinsons Dis. 2013;2013:906274.
  • Bloem BR, Hausdorff JM, Visser JE, et al. Falls and freezing of gait in Parkinson’s disease: a review of two interconnected, episodic phenomena. Mov Disord. 2004;19(8):871–884.
  • Moore O, Peretz C, Giladi N. Freezing of gait affects quality of life of peoples with Parkinson’s disease beyond its relationships with mobility and gait. Mov Disord. 2007;22(15):2192–2195.
  • Paul SS, Canning CG, Sherrington C, et al. Three simple clinical tests to accurately predict falls in people with Parkinson’s disease. Mov Disord. 2013;28(5):655–662.
  • Gilat M, Ligia Silva de Lima A, Bloem BR, et al. Freezing of gait: promising avenues for future treatment. Parkinsonism Relat Disord. 2018;52:7–16.
  • Nonnekes J, Snijders AH, Nutt JG, et al. Freezing of gait: a practical approach to management. Lancet Neurol. 2015;14(7):768–778.
  • World Health Organisation. Rehabilitation; 2021 [cited 2022 Jun 22]. Available from: https://www.who.int/news-room/fact-sheets/detail/rehabilitation
  • Nieuwboer A, Giladi N. Characterizing freezing of gait in Parkinson’s disease: models of an episodic phenomenon. Mov Disord. 2013;28(11):1509–1519.
  • Ginis P, Nackaerts E, Nieuwboer A, et al. Cueing for people with Parkinson’s disease with freezing of gait: a narrative review of the state-of-the-art and novel perspectives. Ann Phys Rehabil Med. 2018;61(6):407–413.
  • Feng YS, Yang SD, Tan ZX, et al. The benefits and mechanisms of exercise training for Parkinson’s disease. Life Sci. 2020;245:117345.
  • Johansson H, Hagstromer M, Grooten WJA, et al. Exercise-Induced neuroplasticity in Parkinson’s disease: a metasynthesis of the literature. Neural Plast. 2020;2020:8961493.
  • Cosentino C, Baccini M, Putzolu M, et al. Effectiveness of physiotherapy on freezing of gait in Parkinson’s disease: a systematic review and meta-analyses. Mov Disord. 2020;35(4):523–536.
  • Gilat M, Ginis P, Zoetewei D, et al. A systematic review on exercise and training-based interventions for freezing of gait in Parkinson’s disease. NPJ Parkinsons Dis. 2021;7(1):81.
  • Delgado-Alvarado M, Marano M, Santurtun A, et al. Nonpharmacological, nonsurgical treatments for freezing of gait in Parkinson’s disease: a systematic review. Mov Disord. 2020;35(2):204–214.
  • Rutz DG, Benninger DH. Physical therapy for freezing of gait and gait impairments in Parkinson disease: a systematic review. PM R. 2020;12(11):1140–1156.
  • Miller KJ, Suarez-Iglesias D, Seijo-Martinez M, et al. Physiotherapy for freezing of gait in Parkinson’s disease: a systematic review and meta-analysis. Rev Neurol. 2020;70(5):161–170.
  • Borenstein M. Research note: in a meta-analysis, the I(2) index does not tell us how much the effect size varies across studies. J Physiother. 2020;66(2):135–139.
  • Giladi N, Shabtai H, Simon ES, et al. Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat Disord. 2000;6(3):165–170.
  • Nieuwboer A, Rochester L, Herman T, et al. Reliability of the new freezing of gait questionnaire: agreement between patients with Parkinson’s disease and their carers. Gait Posture. 2009;30(4):459–463.
  • Gilat M. How to annotate freezing of gait from video: a standardized method using open-source software. J Parkinsons Dis. 2019;9(4):821–824.
  • Mancini M, Smulders K, Cohen RG, et al. The clinical significance of freezing while turning in Parkinson’s disease. Neuroscience. 2017;343:222–228.
  • Ziegler K, Schroeteler F, Ceballos-Baumann AO, et al. A new rating instrument to assess festination and freezing gait in Parkinsonian patients. Mov Disord. 2010;25(8):1012–1018.
  • Snijders AH, Haaxma CA, Hagen YJ, et al. Freezer or non-freezer: clinical assessment of freezing of gait. Parkinsonism Relat Disord. 2012;18(2):149–154.
  • Podsiadlo D, Richardson S. The timed "up and go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–148.
  • Flynn A, Allen NE, Dennis S, et al. Home-based prescribed exercise improves balance-related activities in people with Parkinson’s disease and has benefits similar to centre-based exercise: a systematic review. J Physiother. 2019;65(4):189–199.
  • Leddy AL, Crowner BE, Earhart GM. Utility of the Mini-BESTest, BESTest, and BESTest sections for balance assessments in individuals with Parkinson disease. J Neurol Phys Ther. 2011;35(2):90–97.
  • Marchetti GF, Whitney SL. Construction and validation of the 4-item dynamic gait index. Phys Ther. 2006;86(12):1651–1660.
  • Wrisley DM, Marchetti GF, Kuharsky DK, et al. Reliability, internal consistency, and validity of data obtained with the functional gait assessment. Phys Ther. 2004;84(10):906–918.
  • Steffen T, Seney M. Test–retest reliability and minimal detectable change on balance and ambulation tests, the 36-item short form health survey, and the Unified Parkinson Disease Rating Scale in people with Parkinsonism. Phys Ther. 2008;88(6):733–746.
  • Rose DJ, Lucchese N, Wiersma LD. Development of a multidimensional balance scale for use with functionally independent older adults. Arch Phys Med Rehabil. 2006;87(11):1478–1485.
  • Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85–M94.
  • Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc. 1986;34(2):119–126.
  • Powell LE, Myers AM. The Activities-Specific Balance Confidence (ABC) Scale. J Gerontol A Biol Sci Med Sci. 1995;50A(1):M28–M34.
  • Movement Disorder Society URTF. The Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations. Mov Disord. 2003;18(7):738–750.
  • Goetz CG, Tilley BC, Shaftman SR, et al. Movement disorder society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129–2170.
  • Nouri FM, Lincoln NB. An extended activities of daily living scale for stroke patients. Clin Rehabil. 1987;1(4):301–305.
  • McRae C, Diem G, Vo A, et al. Reliability of measurements of patient health status: a comparison of physician, patient, and caregiver ratings. Parkinsonism Relat Disord. 2002;8(3):187–192.
  • Peto V, Jenkinson C, Fitzpatrick R. PDQ-39: a review of the development, validation and application of a Parkinson’s Disease Quality of Life Questionnaire and its associated measures. J Neurol. 1998;245(S1):S10–S14.
  • Jenkinson C, Fitzpatrick R, Peto V, et al. The PDQ-8: development and validation of a short-form Parkinson’s Disease Questionnaire. Psychol Health. 1997;12(6):805–814.
  • Tinetti ME, Richman D, Powell L. Falls efficacy as a measure of fear of falling. J Gerontol. 1990;45(6):P239–P243.
  • Hill KD, Schwarz JA, Kalogeropoulos AJ, et al. Fear of falling revisited. Arch Phys Med Rehabil. 1996;77(10):1025–1029.
  • Yardley L, Beyer N, Hauer K, et al. Development and initial validation of the Falls Efficacy Scale-International (FES-I). Age Ageing. 2005;34(6):614–619.
  • Hoehn MM, Yahr MD. Parkinsonism: onset, progression, and mortality. Neurology. 1967;17(5):427–442.
  • Molley DW, Alemayehu E, Roberts R. Reliability of a standardized Mini-Mental State Examination compared with the traditional Mini-Mental State Examination. Am J Psychiatry. 1991;148:102–105.
  • Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699.
  • Tomlinson CL, Stowe R, Patel S, et al. Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Mov Disord. 2010;25(15):2649–2653.
  • Wan X, Wang W, Liu J, et al. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135.
  • Higgins JPT, Thomas J, Chandler J et al., (editors). Cochrane handbook for systematic reviews of interventions version 6.3 [updated Feb 2022]. Cochrane, 2022. Available from www.training.cochrane.org/handbook.
  • Rohatgi A. WebPlotDigitizer (version 4.5). Retrieved from https://automeris.io/WebPlotDigitizer; 20th September 2021.
  • Maher CG, Sherrington C, Herbert RD, et al. Reliability of the PEDro scale for rating quality of randomised controlled trials. Phys Ther. 2003;83(8):713–721.
  • Zhang Y, Akl EA, Schunemann HJ. Using systematic reviews in guideline development: the GRADE approach. Res Synth Methods. 2018.
  • Agosta F, Gatti R, Sarasso E, et al. Brain plasticity in Parkinson’s disease with freezing of gait induced by action observation training. J Neurol. 2017;264(1):88–101.
  • Akre M, Dave J, Deo M. The effect of rhythmic auditory cueing on functional gait performance in Parkinson’s disease patients. Indian J Physiother Occup Ther. 2019;13(2):75.
  • Allen NE, Canning CG, Sherrington C, et al. The effects of an exercise program on fall risk factors in people with Parkinson’s disease: a randomized controlled trial. Mov Disord. 2010;25(9):1217–1225.
  • Bega D, Stein J. Yoga versus resistance training in mild to moderate severity Parkinson’s disease: a 12-week pilot study. J Yoga Phys Ther. 2016;6(1).
  • Bekkers EMJ, Mirelman A, Alcock L, et al. Do patients with Parkinson’s disease with freezing of gait respond differently than those without to treadmill training augmented by virtual reality? Neurorehabil Neural Repair. 2020;34(5):440–449.
  • Mirelman A, Rochester L, Maidan I, et al. Addition of a non-immersive virtual reality component to treadmill training to reduce fall risk in older adults (V-TIME): a randomized controlled trial. Lancet. 2016;388(10050):1170–1182.
  • Byl N, Zhang W, Coo S, et al. Clinical impact of gait training enhanced with visual kinematic biofeedback: patients with Parkinson’s disease and patients stable post stroke. Neuropsychologia. 2015;79(Pt B):332–343.
  • Canning CG, Sherrington C, Lord S, et al. Exercise for falls prevention in Parkinson disease. Neurology. 2015;84(3):304–312.
  • Capato TTC, de Vries NM, IntHout J, et al. Multimodal balance training supported by rhythmical auditory stimuli in Parkinson’s disease: a randomized clinical trial. J Parkinsons Dis. 2020;10(1):333–346.
  • Capato TTC, de Vries NM, Bloem BR, et al. Multimodal balance training supported by rhythmic auditory stimuli in Parkinson disease: effects in freezers and nonfreezers. Phys Ther. 2020;100(11):2023–2034.
  • Capato TTC, Nonnekes J, de Vries NM, et al. Effects of multimodal balance training supported by rhythmical auditory stimuli in people with advanced stages of Parkinson’s disease: a pilot randomized clinical trial. J Neurol Sci. 2020;418:117086.
  • Capecci M, Pournajaf S, Galafate D, et al. Clinical effects of robot-assisted gait training and treadmill training for Parkinson’s disease. A randomized controlled trial. Ann Phys Rehabil Med. 2019;62(5):303–312.
  • Carpinella I, Cattaneo D, Bonora G, et al. Wearable sensor-based biofeedback training for balance and gait in Parkinson disease: a pilot randomized controlled trial. Arch Phys Med Rehabil. 2017;98(4):622–630.e3.
  • Carroll LM, Volpe D, Morris ME, et al. Aquatic exercise therapy for people with Parkinson disease: a randomized controlled trial. Arch Phys Med Rehabil. 2017;98(4):631–638.
  • Cheng FY, Yang YR, Wu YR, et al. Effects of curved-walking training on curved-walking performance and freezing of gait in individuals with Parkinson’s disease: a randomized controlled trial. Parkinsonism Relat Disord. 2017;43:20–26.
  • Chivers Seymour K, Pickering R, Rochester L, et al. Multicentre, randomised controlled trial of PDSAFE, a physiotherapist-delivered fall prevention programme for people with Parkinson’s. J Neurol Neurosurg Psychiatry. 2019;90(7):774–782.
  • Ashburn A, Hulbert S, Kunkel D, et al. Exercise- and strategy-based physiotherapy-delivered intervention for preventing repeat falls in people with Parkinson’s: the PDSAFE RCT. Health Technol Assess. 2019;23(36):1–150.
  • Xin Y, Ashburn A, Pickering RM, et al. Cost-effectiveness of the PDSAFE personalized physiotherapy intervention for fall prevention in Parkinson’s: an economic evaluation alongside a randomized controlled trial. BMC Neurol. 2020;20(1):295.
  • Clerici I, Maestri R, Bonetti F, et al. Land plus aquatic therapy versus land-based rehabilitation alone for the treatment of freezing of gait in Parkinson disease: a randomized controlled trial. Phys Ther. 2019;99(5):591–600.
  • Cui LL, Yang Y, Zhu ZZ, et al. Rehabilitation effect of cueing strategies on balance function and gait in patients with Parkinson’s disease. Chin J Contemp Neurol Neurosurg. 2017;17(6):428–433.
  • Duncan RP, Earhart GM. Randomised controlled trial of community-based dancing to modify disease progression in Parkinson disease. Neurorehabil Neural Repair. 2012;26(2):132–143.
  • Duncan RP, Earhart GM. Are the effects of community-based dance on Parkinson disease severity, balance, and functional mobility reduced with time? A 2-year prospective pilot study. J Altern Complement Med. 2014;20(10):757–763.
  • Flynn A, Preston E, Dennis S, et al. Home-based exercise monitored with telehealth is feasible and acceptable compared to centre-based exercise in Parkinson’s disease: a randomised pilot study. Clin Rehabil. 2021;35(5):728–739.
  • Frazzitta G, Maestri R, Uccellini D, et al. Rehabilitation treatment of gait in patients with Parkinson’s disease with freezing: a comparison between two physical therapy protocols using visual and auditory cues with or without treadmill training. Mov Disord. 2009;24(8):1139–1143.
  • Frisaldi E, Bottino P, Fabbri M, et al. Effectiveness of a dance-physiotherapy combined intervention in Parkinson’s disease: a randomized controlled pilot trial. Neurol Sci. 2021;42(12):5045–5053.
  • Ghielen I, van Wegen EEH, Rutten S, et al. Body awareness training in the treatment of wearing-off related anxiety in patients with Parkinson’s disease: results from a pilot randomized controlled trial. J Psychosom Res. 2017;103:1–8.
  • Ginis P, Nieuwboer A, Dorfman M, et al. Feasibility and effects of home-based smartphone-delivered automated feedback training for gait in people with Parkinson’s disease: a pilot randomized controlled trial. Parkinsonism Relat Disord. 2016;22:28–34.
  • Hackney ME, Kantorovich S, Levin R, et al. Effects of tango on functional mobility in Parkinson’s disease: a preliminary study. J Neurol Phys Ther. 2007;31(4):173–179.
  • Hackney ME, Earhart GM. Effects of dance on movement control in Parkinson’s disease: a comparison of argentine tango and American ballroom. J Rehabil Med. 2009;41(6):475–481.
  • Hubble RP, Naughton G, Silburn PA, et al. Trunk exercises improve gait symmetry in Parkinson disease: a blind phase II randomized controlled trial. Am J Phys Med Rehabil. 2018;97(3):151–159.
  • Hubble RP, Silburn PA, Naughton GA, et al. Trunk exercises improve balance in Parkinson disease: a phase II randomized controlled trial. J Neurol Phys Ther. 2019;43(2):96–105.
  • Kadivar Z, Corcos DM, Foto J, et al. Effect of step training and rhythmic auditory stimulation on functional performance in Parkinson patients. Neurorehabil Neural Repair. 2011;25(7):626–635.
  • Kalbe E, Folkerts AK, Ophey A, et al. Enhancement of executive functions but not memory by multidomain group cognitive training in patients with Parkinson’s disease and mild cognitive impairment: a multicenter randomized controlled trial. Parkinsons Dis. 2020;2020:4068706.
  • King LA, Wilhelm J, Chen Y, et al. Effects of group, individual, and home exercise in persons with Parkinson disease: a randomized clinical trial. J Neurol Phys Ther. 2015;39(4):204–212.
  • Martin T, Weatherall M, Anderson TJ, et al. A randomized controlled feasibility trial of a specific cueing program for falls management in persons with Parkinson disease and freezing of gait. J Neurol Phys Ther. 2015;39(3):179–184.
  • Medijainen K, Paasuke M, Lukmann A, et al. Versatile guideline-based physiotherapy intervention in groups to improve gait speed in Parkinson’s disease patients. NeuroRehabilitation. 2019;44(4):579–586.
  • Mezzarobba S, Grassi M, Pellegrini L, et al. Action observation plus sonification. A novel therapeutic protocol for Parkinson’s patient with freezing of gait. Front Neurol. 2017;8(723):723.
  • Mezzarobba S, Grassi M, Pellegrini L, et al. Action observation improves sit-to-walk in patients with Parkinson’s disease and freezing of gait. Biomechanical analysis of performance. Parkinsonism Relat Disord. 2020;80:133–137.
  • Mitsui T, Arii Y, Tsukamoto A, et al. Sociability-based fitness approach in Parkinson’s disease: comparison with conventional rehabilitation. Eur J Neurol. 2021;28(6):1893–1900.
  • Munneke M, Nijkrake MJ, Keus SHJ, et al. Efficacy of community-based physiotherapy networks for patients with Parkinson’s disease: a cluster-randomised trial. Lancet Neurol. 2010;9(1):46–54.
  • Murgia M, Pili R, Corona F, et al. The use of footstep sounds as rhythmic auditory stimulation for gait rehabilitation in Parkinson’s disease: a randomized controlled trial. Front Neurol. 2018;9:348.
  • Ophey A, Giehl K, Rehberg S, et al. Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: a randomized controlled trial. Parkinsonism Relat Disord. 2020;72:13–22.
  • Pacchetti C, Mancini F, Aglieri R, et al. Active music therapy in Parkinson’s disease: an integrative method for motor and emotional rehabilitation. Psychosom Med. 2000;62:386–393.
  • Paul SS, Canning CG, Song J, et al. Leg muscle power is enhanced by training in people with Parkinson’s disease: a randomized controlled trial. Clin Rehabil. 2014;28(3):275–288.
  • Pelosin E, Avanzino L, Bove M, et al. Action observation improves freezing of gait in patients with Parkinson’s disease. Neurorehabil Neural Repair. 2010;24(8):746–752.
  • Pelosin E, Avanzino L, Barella R, et al. Treadmill training frequency influences walking improvement in subjects with Parkinson’s disease: a randomized pilot study. Eur J Phys Rehabil Med. 2017;53(2):201–208.
  • Pelosin E, Barella R, Bet C, et al. Effect of group-based rehabilitation combining action observation with physiotherapy on freezing of gait in Parkinson’s disease. Neural Plast. 2018;2018:4897276.
  • Pohl P, Wressle E, Lundin F, et al. Group-based music intervention in Parkinson’s disease – findings from a mixed-methods study. Clin Rehabil. 2020;34(4):533–544.
  • Protas EJ, Mitchell K, Williams A, et al. Gait and step training to reduce falls in Parkinson’s disease. NeuroRehabilitation. 2005;20(3):183–190.
  • Reuter I, Mehnert S, Leone P, et al. Effects of a flexibility and relaxation programme, walking, and Nordic walking on Parkinson’s disease. J Aging Res. 2011;2011:232473.
  • Ricciardi L, Ricciardi D, Lena F, et al. Working on asymmetry in Parkinson’s disease: randomized, controlled pilot study. Neurol Sci. 2015;36(8):1337–1343.
  • Rios Romenets S, Anang J, Fereshtehnejad SM, et al. Tango for treatment of motor and non-motor manifestations in Parkinson’s disease: a randomized control study. Complement Ther Med. 2015;23(2):175–184.
  • Rocha P, Aguiar L, McClelland JA, et al. Dance therapy for Parkinson’s disease: a randomised feasibility trial. Int J Ther Rehabil. 2018;25(2):64–72.
  • Santos L, Fernandez-Rio J, Winge K, et al. Effects of progressive resistance exercise in akinetic-rigid Parkinson’s disease patients: a randomized controlled trial. Eur J Phys Rehabil Med. 2017;53(5):651–663.
  • Santos L, Fernandez-Rio J, Winge K, et al. Effects of supervised slackline training on postural instability, freezing of gait, and falls efficacy in people with Parkinson’s disease. Disabil Rehabil. 2017;39(16):1573–1580.
  • Schlenstedt C, Paschen S, Seuthe J, et al. Moderate frequency resistance and balance training do not improve freezing of gait in Parkinson’s disease: a pilot study. Front Neurol. 2018;9:1084.
  • Schlenstedt C, Paschen S, Kruse A, et al. Resistance versus balance training to improve postural control in Parkinson’s disease: a randomized rater blinded controlled study. PLOS One. 2015;10(10):e0140584.
  • Schlick C, Ernst A, Botzel K, et al. Visual cues combined with treadmill training to improve gait performance in Parkinson’s disease: a pilot randomized controlled trial. Clin Rehabil. 2016;30(5):463–471.
  • Sedaghati P, Goudarzian M, Daneshmandi H, et al. Effects of Alexander-based corrective techniques on forward flexed posture, risk of fall, and fear of falling in idiopathic Parkinson’s disease. Arch Neurosci. 2018;5(2).
  • Sharma NK, Robbins K, Wagner K, et al. A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson’s disease. Int J Yoga. 2015;8(1):74–79.
  • Colgrove YS, Sharma N. Effect of yoga on motor function in people with Parkinson’s disease: a randomized, controlled pilot study. J Yoga Phys Ther. 2012;2(2):1–11.
  • Silva-Batista C, de Lima-Pardini AC, Nucci MP, et al. A randomized, controlled trial of exercise for Parkinsonian individuals with freezing of gait. Mov Disord. 2020;35(9):1607–1617.
  • Song J, Paul SS, Caetano MJD, et al. Home-based step training using videogame technology in people with Parkinson’s disease: a single-blinded randomised controlled trial. Clin Rehabil. 2018;32(3):299–311.
  • Van Puymbroeck M, Walter A, Hawkins B, et al. Functional improvements in Parkinson’s disease following a randomized trial of yoga. Evid Based Complement Alternat Med. 2018;2018:4523743.
  • Volpe D, Signorini M, Marchetto A, et al. A comparison of Irish set dancing and exercises for people with Parkinson’s disease: a phase II feasibility study. BMC Geriatr. 2013;13:54–59.
  • Walton CC, Mowszowski L, Gilat M, et al. Cognitive training for freezing of gait in Parkinson’s disease: a randomized controlled trial. NPJ Parkinsons Dis. 2018;4(15):15.
  • Wróblewska A, Gajos A, Smyczyńska U, et al. The therapeutic effect of Nordic walking on freezing of gait in Parkinson’s disease: a pilot study. Parkinsons Dis. 2019;2019:3846279.
  • Xiao CM, Zhuang YC. Effect of health Baduanjin Qigong for mild to moderate Parkinson’s disease. Geriatr Gerontol Int. 2016;16(8):911–919.
  • Yang YR, Cheng SJ, Lee YJ, et al. Cognitive and motor dual task gait training exerted specific training effects on dual task gait performance in individuals with Parkinson’s disease: a randomized controlled pilot study. PLOS One. 2019;14(6):e0218180.
  • Zhu Z, Yin M, Cui L, et al. Aquatic obstacle training improves freezing of gait in Parkinson’s disease patients: a randomized controlled trial. Clin Rehabil. 2018;32(1):29–36.
  • Chow R, Tripp BP, Rzondzinski D, et al. Investigating therapies for freezing of gait targeting the cognitive, limbic, and sensorimotor domains. Neurorehabil Neural Repair. 2021;35(3):290–299.
  • Fietzek UM, Schroeteler FE, Ziegler K, et al. Randomized cross-over trial to investigate the efficacy of a two-week physiotherapy programme with repetitive exercises of cueing to reduce the severity of freezing of gait in patients with Parkinson’s disease. Clin Rehabil. 2014;28(9):902–911.
  • King LA, Mancini M, Smulders K, et al. Cognitively challenging agility boot camp program for freezing of gait in Parkinson disease. Neurorehabil Neural Repair. 2020;34(5):417–427.
  • Nieuwboer A, Kwakkel G, Rochester L, et al. Cueing training in the home improves gait-related mobility in Parkinson’s disease: the RESCUE trial. J Neurol Neurosurg Psychiatry. 2007;78(2):134–140.
  • Hulzinga F, Nieuwboer A, Dijkstra BW, et al. The new freezing of gait questionnaire: unsuitable as an outcome in clinical trials? Mov Disord Clin Pract. 2020;7(2):199–205.
  • Abbruzzese G, Avanzino L, Marchese R, et al. Action observation and motor imagery: innovative cognitive tools in the rehabilitation of Parkinson’s disease. Parkinsons Dis. 2015;2015:124214.
  • Lotzke D, Ostermann T, Bussing A. Argentine tango in Parkinson’s disease – a systematic review and meta-analysis. BMC Neurol. 2015;15:226.
  • Tomlinson CL, Herd CP, Clarke CE, et al. Physiotherapy for Parkinson’s disease: a comparison of techniques. Cochrane Database Syst Rev. 2014;2014(6):CD002815.
  • Carapellotti AM, Stevenson R, Doumas M. The efficacy of dance for improving motor impairments, non-motor symptoms, and quality of life in Parkinson’s disease: a systematic review and meta-analysis. PLOS One. 2020;15(8):e0236820.
  • Ehgoetz Martens KA, Peterson DS, Almeida QJ, et al. Behavioural manifestations and associated non-motor features of freezing of gait: a narrative review and theoretical framework. Neurosci Biobehav Rev. 2020;116:350–364.
  • Heremans E, Nieuwboer A, Spildooren J, et al. Cognitive aspects of freezing of gait in Parkinson’s disease: a challenge for rehabilitation. J Neural Transm. 2013;120(4):543–557.
  • Mancini M, Bloem BR, Horak FB, et al. Clinical and methodological challenges for assessing freezing of gait: future perspectives. Mov Disord. 2019;34(6):783–790.
  • Sarasso E, Agosta F, Piramide N, et al. Brain activity of the emotional circuit in Parkinson’s disease patients with freezing of gait. Neuroimage Clin. 2021;30:102649.
  • Pang MY. Physiotherapy management of Parkinson’s disease. J Physiother. 2021;67(3):163–176.
  • Shen X, Wong-Yu IS, Mak MK. Effects of exercise on falls, balance, and gait ability in Parkinson’s disease: a meta-analysis. Neurorehabil Neural Repair. 2016;30(6):512–527.
  • Ehgoetz Martens KA, Hall JM, Georgiades MJ, et al. The functional network signature of heterogeneity in freezing of gait. Brain. 2018;141(4):1145–1160.
  • Ehgoetz Martens KA, Shine JM, Walton CC, et al. Evidence for subtypes of freezing of gait in Parkinson’s disease. Mov Disord. 2018;33(7):1174–1178.
  • Nonnekes J, Nieuwboer A. Towards personalized rehabilitation for gait impairments in Parkinson’s disease. J Parkinsons Dis. 2018;8(s1):S101–S106.
  • Ryden LE, Lewis SJG. Parkinson’s disease in the era of personalised medicine: one size does not fit all. Drugs Aging. 2019;36(2):103–113.
  • Shine JM, Moore ST, Bolitho SJ, et al. Assessing the utility of freezing of gait questionnaires in Parkinson’s disease. Parkinsonism Relat Disord. 2012;18(1):25–29.

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