147
Views
35
CrossRef citations to date
0
Altmetric
Original Articles

Downregulation of miR-124 predicts poor prognosis in pancreatic ductal adenocarcinoma patients

, , , &
Pages 152-157 | Received 05 May 2016, Accepted 09 Jun 2016, Published online: 06 Dec 2016

References

  • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J. Clin. 2013;63:11–30.10.3322/caac.v63.1
  • Birk D, Fortnagel G, Formentini A, et al. Small carcinoma of the pancreas. Factors of prognostic relevance. J. Hepatobiliary Pancreat. Surg. 1998;5:450–454.10.1007/s005340050071
  • Tsuchiya R, Tsunoda T. Tumor size as a predictive factor. Int. J. Pancreatol. 1990;7:117–123.
  • Goonetilleke KS, Siriwardena AK. Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer. Eur. J. Surg. Oncol. 2007;33:266–270.10.1016/j.ejso.2006.10.004
  • Yasue M, Sakamoto J, Teramukai S, et al. Prognostic values of preoperative and postoperative CEA and CA19.9 levels in pancreatic cancer. Pancreas. 1994;9:735–740.10.1097/00006676-199411000-00011
  • Ćwik G, Wallner G, Skoczylas T, et al. Cancer Antigens 19-9 and 125 in the differential diagnosis of pancreatic mass lesions. Arch. Surg. 2006;141:968–973.10.1001/archsurg.141.10.968
  • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843–854.10.1016/0092-8674(93)90529-Y
  • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat. Rev. Cancer. 2006;6:857–866.10.1038/nrc1997
  • Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008;18:997–1006.10.1038/cr.2008.282
  • Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. USA. 2008;105:10513–10518.10.1073/pnas.0804549105
  • Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007;9:654–659.10.1038/ncb1596
  • Bloomston M, Frankel WL, Petrocca F. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA.2007;297:1901–1908. 10.1001/jama.297.17.1901
  • Lee EJ, Gusev Y, Jiang J. Expression profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer. 2007;120:1046–1054.
  • Szafranska AE, Davison TS, John J. MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene. 2007;26:4442–4452.10.1038/sj.onc.1210228
  • Zhang Y, Li M, Wang H. Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J. Surg. 2009;33:698–709.10.1007/s00268-008-9833-0
  • Lee MR, Kim JS, Kim KS. miR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells. Stem Cells. 2010;28:1550–1559.
  • Rajewsky N. microRNA target predictions in animals. Nat. Genet. 2006;38(6s):S8–S13.10.1038/ng1798
  • Wang P, Chen L, Zhang J, et al. Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. Oncogene. 2014;33:514–524.10.1038/onc.2012.598
  • Weber JA, Baxter DH, Zhang S, et al. The MicroRNA spectrum in 12 body fluids. Clin. Chem. 2010;56:1733–1741.10.1373/clinchem.2010.147405
  • Hidalgo M. Pancreatic cancer. New Engl. J. Med. 2008;362:1605–1617.
  • Wang J, Chen J, Chang P, et al. MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev. Res. (Phila). 2009;2:807–81310.1158/1940-6207.CAPR-09-0094
  • Kong X, Du Y, Wang G, et al. Detection of differentially expressed microRNAs in serum of pancreatic ductal adenocarcinoma patients: miR-196a could be a potential marker for poor prognosis. Dig. Dis. Sci. 2011;56:602–609.10.1007/s10620-010-1285-3
  • Alemar B, Izetti P, Gregório C, et al. miRNA-21 and miRNA-34a are potential minimally invasive biomarkers for the diagnosis of pancreatic ductal adenocarcinoma. Pancreas. 2016;45:84–92.10.1097/MPA.0000000000000383

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.