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British Journal of Biomedical Science Volume 76, 2019 - Issue 3
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Biomedical Science in Brief

Pushing the boundaries of in situ hybridisation for mRNA demonstration: demonstration of kappa and lambda light chain restriction in follicular lymphoma

A WarfordLife sciences, University of Westminster, London, UKCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3979-4963View further author information
ORCID Icon,
M RahmanLife sciences, University of Westminster, London, UKView further author information
,
JA HughesAdvanced Diagnostics, University College London, London, UKView further author information
,
G GerrardSarah Cannon Molecular Diagnostics, HCA Healthcare, London, UKORCID Iconhttp://orcid.org/0000-0002-4614-227XView further author information
ORCID Icon &
DA RibeiroLife sciences, University of Westminster, London, UKView further author information
Pages 143-146 | Received 16 Feb 2019, Accepted 18 Mar 2019, Published online: 26 Apr 2019

References

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  • Guo L, Wang Z, Anderson CM, et al. Ultrasensitive automated RNA in situ hybridization for kappa and lambda light chain mRNA detects B-cell clonality in tissue biopsies with performance comparable or superior to flow cytometry. Mod Pathol. 2018;31:385–394.
  • Arora K, Chebib I, Zukerberg L, et al. Branched-chain in situ hybridization for κ and λ light chains: A powerful ancillary technique for determining B-cell clonality in cytology samples. Cancer Cytopathol. 2016;124:203–212.
  • Klopfleisch R, Weiss ATA, Gruber AD. Excavation of a buried treasure – DNA, mRNA, miRNA and protein analysis in formalin fixed, paraffin embedded tissues. Histol Histopathol. 2011;26:797–810.

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