Hepatitis C virus core antigen as a possible alternative for evaluation of treatment effectiveness after treatment with direct-acting antivirals

References

• GBD. Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–171.
   PubMed Web of Science ®Google Scholar
• Perz JF, Armstrong GL, Farrington LA, et al. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006;45:529–538.
   PubMed Web of Science ®Google Scholar
• Polaris Observatory HCV Collaborators. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. Lancet Gastroenterol Hepatol. 2017;2:161–176.
   PubMed Web of Science ®Google Scholar
• WHO. Global hepatitis report. 2017 [cited Jul 2016]. https://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/.
   Google Scholar
• Falade-Nwulia O, Suarez-Cuervo C, Nelson DR, et al. Oral direct-acting agent therapy for hepatitis C virus infection: a systematic review. Ann Intern Med. 2017;166:637–648.
   PubMed Web of Science ®Google Scholar
• European Union HCV Collaborators. Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling study. Lancet Gastroenterol Hepatol. 2017;2:325–336.
   PubMed Web of Science ®Google Scholar
• European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C 2018. J Hepatol. 2018;69:461–511.
   PubMed Web of Science ®Google Scholar
• Chevaliez S, Feld J, Cheng K, et al. Clinical utility of HCV core antigen detection and quantification in the diagnosis and management of patients with chronic hepatitis C receiving an all-oral, interferon-free regimen. Antivir Ther. 2018;23:211–217.
   PubMed Web of Science ®Google Scholar
• Kamal SM, Kassim S, El Gohary E, et al. The accuracy and cost-effectiveness of hepatitis C core antigen assay in the monitoring of anti-viral therapy in patients with chronic hepatitis C genotype 4. Aliment Pharmacol Ther. 2015;42:307–318.
   PubMed Web of Science ®Google Scholar
• Mederacke I, Wedemeyer H, Ciesek S, et al. Performance and clinical utility of a novel fully automated quantitative HCV core antigen assay. J Clin Virol. 2009;46:210–215.
   PubMed Web of Science ®Google Scholar
• Garbuglia AR, Lionetti R, Lapa D, et al. The clinical significance of HCV core antigen detection during telaprevir/peg-interferon/ribavirin therapy in patients with HCV 1 genotype infection. J Clin Virol. 2015;69:68–73.
   PubMed Web of Science ®Google Scholar
• Aghemo A, Degasperi E, De Nicola S, et al. Quantification of core antigen monitors efficacy of direct-acting antiviral agents in patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2016;14:1331–1336.
   PubMed Web of Science ®Google Scholar
• Łucejko M, Flisiak R. Quantitative measurement of HCV core antigen for management of interferon-free therapy in HCV infected patients. Antivir Ther. 2018;23:149–156.
   PubMed Web of Science ®Google Scholar
• Rockstroh JK, Feld JJ, Chevaliez S, et al. HCV core antigen as an alternate test to HCV RNA for assessment of virologic responses to all-oral, interferonfree treatment in HCV genotype 1 infected patients. J Virol Methods. 2017;245:14–18.
   PubMed Web of Science ®Google Scholar
• Lamoury FMJ, Soker A, Martinez D, et al. Hepatitis C virus core antigen: a simplified treatment monitoring tool, including for post-treatment relapse. J Clin Virol. 2017;92:32–38.
   PubMed Web of Science ®Google Scholar
• Cresswell FV, Fisher M, Hughes DJ, et al. Hepatitis C core antigen testing: a reliable, quick, and potentially cost-effective alternative to hepatitis C polymerase chain reaction in diagnosing acute hepatitis C virus infection. Clin Infect Dis. 2015;60:263–266.
   PubMed Web of Science ®Google Scholar
• Halota W, Flisiak R, Juszczyk J, et al. Polish Group of experts for HCV. Recommendations for the treatment of hepatitis C in 2017. Clin Exp Hepatol. 2017;3:47–55.
   PubMed Web of Science ®Google Scholar
• Aoyagi K, Ohue C, Lida K, et al. Development of a simple and highly sensitive enzyme immunoassay for hepatitis C virus core antigen. J Clin Microbiol. 1999;37:1802–1808.
   PubMed Web of Science ®Google Scholar
• Cetinera S, Duranb AC, Kibarb F, et al. Performance comparison of new generation HCV core antigen test versus HCV RNA test in management of hepatitis C virus infection. Transfus Apher Sci. 2017;56:362‐6.
   Google Scholar
• Thong VD, Akkarathamrongsin S, Avihingsanon A, et al. The correlation between hepatitis C core antigen and hepatitis C virus RNA levels with respect to human immunodeficiency virus status, hepatitis C virus genotype and interferon-lambda-4 polymorphism. Intervirology. 2015;58:73–79.
   PubMed Web of Science ®Google Scholar
• Hosseini-Moghaddam SM, Iran-Pour E, Rotstein C, et al. Hepatitis C core Ag and its clinical applicability: potential advantages and disadvantages for diagnosis and follow-up. Rev Med Virol. 2012;22:156‐65.
   PubMed Web of Science ®Google Scholar
• Mederacke I, Potthoff A, Meyer-Olson D, et al. HCV core antigen testing in HIV- and HBV-coinfected patients, and in HCV-infected patients on hemodialysis. J Clin Virol. 2012;53:110–115.
   PubMed Web of Science ®Google Scholar
• Łucejko M, Grzeszczuk A, Jaroszewicz J, et al. Serum HCV core antigen concentration in HCV monoinfection and HCV/HIV coinfection. Pol Merkur Lekarski. 2013;35:72–76.
   PubMedGoogle Scholar
• Wasitthankasem R, Vichaiwattana P, Auphimai C, et al. HCV core antigen is an alternative marker to HCV RNA for evaluating active HCV infection: implications for improved diagnostic option in an era of affordable DAAs. Peer J. 2017;5:e4008.
   PubMed Web of Science ®Google Scholar
• Ottiger C, Gygli N, Huber AR. Detection limit of architect hepatitis C core antigen assay in correlation with HCV RNA, and renewed confirmation algorithm for reactive anti-HCV samples. J Clin Virol. 2013;58:535–540.
   PubMed Web of Science ®Google Scholar
• Ross RS, Viazov S, Salloum S, et al. Analytical performance characteristics and clinical utility of a novel assay for total hepatitis C virus core antigen quantification. J Clin Microbiol. 2010;48:1161‐8.
   Web of Science ®Google Scholar
• Tanaka Y, Takagi K, Fujihara T, et al. High stability of enzyme immunoassay for hepatitis C virus core antigen evaluation before and after incubation at room temperature. Hepatol Res. 2003;26:261–267.
   PubMed Web of Science ®Google Scholar
• Tillmann HL. Hepatitis C virus core antigen testing: role in diagnosis, disease monitoring and treatment. World J Gastroenterol. 2014;20:6701‐6.
   PubMed Web of Science ®Google Scholar
• Ticehurst JR, Hamzeh FM, Thomas DL. Factors affecting serum concentrations of hepatitis C virus (HCV) RNA in HCV genotype 1-infected patients with chronic hepatitis. J Clin Microbiol. 2007;45:2426–2433.
   PubMed Web of Science ®Google Scholar
• Flisiak R, Łucejko M, Mazur W, et al. Effectiveness and safety of ledipasvir/sofosbuvir±ribavirin in the treatment of HCV infection: the real-world HARVEST study. Adv Med Sci. 2017;62:387–392.
   PubMed Web of Science ®Google Scholar
• Flisiak R, Janczewska E, Wawrzynowicz-Syczewska M, et al. Real-world effectiveness and safety of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin in hepatitis C: AMBER study. Aliment Pharmacol Ther. 2016;44:946–956.
   PubMed Web of Science ®Google Scholar
• Maasoumy B, Vermehren J, Welker MW, et al. Clinical value of on-treatment HCV RNA levels during different sofosbuvir-based antiviral regimens. J Hepatol. 2016;65:473–482.
   PubMed Web of Science ®Google Scholar
• van Tilborg M, Al Marzooqi SH, Wong WWL, et al. HCV core antigen as an alternative to HCV RNA testing in the era of direct-acting antivirals: retrospective screening and diagnostic cohort studies. Lancet Gastroenterol Hepatol. 2018;3:856–864.
   PubMed Web of Science ®Google Scholar