162
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Extracellularly truncated desmoglein 1 compromises desmosomes in MDCK cells

Pages 175-183 | Published online: 09 Jul 2009

References

  • Allen, E., Yu, Q.-C. and Fuchs, E., 1996, Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation and epidermal differentiation. Journal of Cell Biology, 133, 1367–1382.
  • Amagai, M., Fujimori, T., Masunaga, T., Shimizu, H., Nishikawa, T., Shimizu, N., Takeichi, M. and Hashimoto, T., 1995, Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant. Journal of Investiga tive Dermatology, 104, 27–32.
  • Armstrong, K. D. B., McKenna, K. E., Purkis, P. E., Green, K. J., Eady,-R.-A.-J.,-Leigh,-I.-M.-and Hughes,-A.-E.,-1999, Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma. Human Molecular Genetics, 8, 143 148.
  • Arnemann, J., Sullivan, K. H., Magee, A. I., King, I. A. and Buxton, R. S., 1993, Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis. Journal of Cell Science, 104, 741–750.
  • Bao, Q. and Hughes, R. C., 1995, Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitro. Journal of Cell Science, 108, 2791–2800.
  • Bierkamp, C., McLaughlin, J. K., Schwarz, H., Huber, O. and Kemler, R., 1996, Embyonic heart and skin defects in mice lacking plakoglobin. Developmental Biology, 180, 780–785.
  • Bornslaeger, E. A., Corcoran, C. M., Stappenbeck, T. S. and Green, K. J., 1996, Breaking the connection; displacement of the desmosomal plaque protein desmoplakin from cell cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. Journal of Cell Biology, 134, 985 1001.
  • Burdett, I. D. J., 1993, Internalization of desmosomes and their entry into the endocytic pathway via late endosomes in MDCK cells. Possible mechanisms for the modulation of cell adhesion by desmosomes during development. Journal of Cell Science, 4, 1115–1130.
  • Burdett, I. D. J., 1998, Aspects of the structure and assembly of desmosomes. Micron, 29, 309–328.
  • Chitaev, N. A., Averbakh, A. Z., Troyanovsky, R. B. and Troyanovs-ky, S. M., 1998, Molecular organization of the desmoglein-plakoglobin complex. Journal of Cell Science, 14, 1941-1949.
  • Chitaev, N. A., Leube, R. E., Troyanovsky, R. B., Eshkind, L. G., Franke, W. W. and Troyanovsky, S. M., 1996, The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential. Journal of Cell Biology, 133, 359–369.
  • Delmas, V., Pla, P., Feracci, H., Thiery, J. P., Kemler, R. and Larue, L., 1999, Expression of the cytoplasmic domain of E-cadherin induces precocious mammary epithelial alveolar formation and affects cell polarity and cell-matrix integrity. Developmental Biology, 216, 491–506.
  • Demlehner, M. P., Schafer, S., Grund, C. and Franke, W. W., 1995, Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated sisyphyus cycle. Journal of Cell Biology, 131, 745–760.
  • Fujimori, T. and Takeichi, M., 1993, Disruption of epithelial cell cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin. Molecular Biology of the Cell, 4, 37–47.
  • Gallicano, G. I., Kouklis, P., Bauer, C., Yin, M., Vasioukhin, V., Degenstein, L. and Fuchs, E., 1998, Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. Journal of Cell Biology, 143, 2009–2022.
  • Green, K. J. and Jones, J. C. R., 1996, Desmosomes and hemidesmosomes: structure and function of molecular components. FASEB Journal, 10, 871–881.
  • Hanakawa, Y., Amagai, M., Shirakata, Y., Sayama, Y. and Hashimoto, K., 2000, Different effects of dominant negative mutants of desmocollin and desmoglein on the cell cell adhesion of keratinocytes. Journal of Cell Science, 113, 1803-1811.
  • Hatzfeld, M., Haffner, C., Schulze, K. and Vinzens, U., 2000, The function of plakophilin 1 in desmosome assembly and actin filament organisation. Journal of Cell Biology, 149, 209–222.
  • Hermiston, M. L. and Gordon, J. I., 1995, Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science, 270, 1203–1207.
  • Hertig, C. M., Eppenberger-Eberhardt, M., Koch, S. and Eppenber-ger, H. M., 1996, N-cadherin and impairment of cell cell contact by a truncated N-cadherin mutant. Journal of Cell Science, 109, 1–10.
  • Hunt, D. M., Sahota, V. K., Taylor, K., Simrak, D., Hornigold, N., Arnemann, J., Wolfe, J. and Buxton, R. S., 1999, Clustered cadherin genes: a sequence-ready contig for the desmosomal cadherinlocus onhumanchromosome 18. Genomics, 3, 445–455.
  • King, I. A., Angst, B. D., Hunt, D. M., Kruger, M., Arnemann, J. and Buxton, R. S., 1997, Hierarchical expression of desmosomal cadherins during stratifield epithelial morphogenesis in the mouse. Differentiation, 2, 83–96.
  • Koch, P. J. and Franke, W. W., 1994, Desmosomal cadherins: another growing multigene family of adhesion molecules. Current Biology, 6, 682–687.
  • Koch, P. J., Mahoney, M. G., Ishikawa, H., Pulkkinen, L., Uitto, J., Shultz, L., Murphy, G. F., Whitaker-Menezes, D. and Stanley, J. R., 1997, Targeted disruption of the pemphigus vulgaris antigen (Desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. Journal of Cell Biology, 137, 1091–1102.
  • Kowalczyk, A. P., Borgwardt, J. E. and Green, K. J., 1996, Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes. Journal of Investigative Dermatology, 107, 293–300.
  • Kowalczyk, A. P., Bornslaeger, E. A., Borgwardt, J. E., Palka, H. L., Dhaliwal, A. S., Corcoran, C. M., Denning, M. F. and Green, K. J., 1997, The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. Journal of Cell Biology, 139, 773–784.
  • Kowalczyk, A. P., Hatzfeld, M., Bornslaeger, E. A., Kopp, D. S., Borwardt, J. E., Corcoran, C. M., Settler, A. and Green, K. J., 1999, The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes: implications for cutaneous disease. Journal of Biological Chemisry, 274, 18145–18148.
  • Laemmli, U. K., 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680 685.
  • Magee, A. I. and Buxton, R. S., 1991, Transmembrane molecular assemblies regulated by the greater cadherin family. Current Opinion in Cell Biology, 5, 854–861.
  • Marcozzi, C., Burdett, I. D. J., Buxton, R. S. and Magee, A. I., 1998, Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion. Journal of Cell Science, 11, 495–509.
  • Mathur, M., Goodwin, L. and Cowin, P., 1994, Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. Journal of Biological Chemistry, 19, 14075–14080.
  • McGrath, J. A., McMillan, J. R., Shemanko, C. S., Runswick, S. K., Leigh, I. M., Lane, E. B., Garrod, D. R. and Eady, R. A. J., 1997, Mutations in the plakophilin 1 gene result in ectodermal dysplasia/ skin fragility syndrome. Nature Genetics, 17, 240–244.
  • Nagar, B., Overduin, M., Ikura, M. and Rini, J. M., 1996, Structural basis of calcium-induced E-cadherin rigidification and dimeriza-tion. Nature, 380, 360–364.
  • Nieman, M. T., Kim, J., Johnson, K. R. and Wheelock, M. J., 1999, Mechanism of extracellular domain-deleted dominant negative cadherins. Journal of Cell Science, 112, 1621–1632.
  • North, A. J., Bardsley, W. G., Hyam, J., Bornslaeger, E. A., Cordingley, H. C., Trinnaman, B., Hatzfeld, M., Green, K. J., Magee, A. I. and Garrod, D. R., 1999, Molecular map of the desmosomal plaque. Journal of Cell Science, 112, 4325–4336.
  • Norvell, S. M. and Green, K. J., 1998, Contributions of extracellula r and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells. Journal of Cell Science, 9, 1305–1318.
  • Palka, H. L. and Green, K. J., 1997, Roles of plakoglobin ends domains in desmosome assembly. Journal of Cell Science, 110, 2359–2371.
  • Parker, A. E., Wheeler, G. N., Arnemann, J., Pidsley, S. C., Ataliotis, P., Thomas, C. L., Rees, D. A., Magee, A. I. and Buxton, R. S., 1991, Desmosomal glycoproteins II and III: cadherin-like junc-tional molecules generated by alternative splicing. Journal of Biological Chemis try, 266, 10438–10445.
  • Penn, E. J., Hobson, C., Rees, D. A. and Magee, A. I., 1989, The assembly of the major desmosome glycoproteins of Madin-Darby canine kidney cells. FEBS Letters, 247, 13–16.
  • Pertz, O., Bozic, D., Koch, A. W., Fauser, C., Brancaccio, A. and Engel, J., 1999, A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homo-association. E MBO Journal, 7, 1738–1747.
  • Rickman, L., Simrak, D., Stevens, H. P., Hunt, D. M., King, I. A., Byant, S. P., Eady, R. A. J., Leigh, I. M., Arnemann, J., Magee, A. I., Kelsell, D. P. and Buxton, R. S., 1999, N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma. Human Molecular Genetics, 8, 971–976.
  • Roberts, G. A., Burdett, I. D. J., Pidsley, S. C., King, I. A., Magee, A. I. and Buxton, R. S., 1998, Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression. European Journal of Cell Biology, 76, 192–203.
  • Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Gunthert, U., Franke, W. W. and Birchmeier, W., 1996, Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. Journal of Cell Biology, 135, 1–11.
  • Sanson, B., White, P. and Vincent, J. P., 1996, Uncoupling cadherin-based adhesion from wingless signalling in Drosophila. Nature, 383, 627–630.
  • Schwarz, M. A., Owaribe, K., Kartenbeck, J. and Franke, W. W., 1990, Desmosomes and hemidesmosomes: constitutive molecular components. Annual Review of Cell Biology, 6, 461–491.
  • Shapiro, L., Fannon, A. M., Kwong, P. D., Thompson, A., Lehmann, M. S., Grubel, G., Legrand, J. F., Als-Nielsen, J., Colman, D. R. and Hendrickson, W. A., 1995, Structural basis of cell adhesion by cadherins. Nature, 374, 327–337.
  • Smith, E. A. and Fuchs, E., 1998, Defining the interactions between intermediate filaments and desmosomes. Journal of Cell Biology, 5, 1229–1241.
  • Steinberg, M. S. and McNutt, P. M., 1999, Cadherins and their connections: adhesion junctions have broader functions. Current Opinion in Cell Biology, 11, 554–560.
  • Troyanovsky, S. M., 1999, Mechanism of cell cell adhesion complex assembly. Current Opinion in Cell Biology, 11, 561–566.
  • Troyanovsky, S. M., Eshkind, L. G., Troyanovsky, R. B., Leube, R. E. and Franke, W. W., 1993, Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage. Cell, 72, 561–574.
  • Troyanovsky, S. M., Troyanovsky, R. B., Eshkind, L. G., Krutovskikh, V. A., Leube, R. E. and Franke, W. W., 1994, Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage. Journal of Cell Biology, 127, 151–160.
  • Tselepis, C., Chidgey, M., North, A. and Garrod, D., 1998, Desmosomal adhesion inhibits invasive behaviour. Proceedings of the National Academy of Science (USA), 95, 8064–8069.
  • Vilela, M. J., Hashimoto, T., Nishikawa, T., North, A. J. and Garrod, D., 1995, A simple epithelial cell line (MDCK)shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen. Journal of Cell Science, 108, 1743–1750.
  • Warren, S. L. and Nelson, W. J., 1987, Nonmitogenic morphoregu-latory action of pp 60v-src on multicellular epithelial structures. Molecular Cell Biology, 7, 1326–1337.
  • Wheeler, G. N., Parker, A. E., Thomas, C. L., Ataliotis, P, Poynter, D., Arnemann, J., Rutman, A. J., Pidsley, S. C., Watt, F. M., Rees, D. A. and Magee, A. I., 1991, Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules. Proceedings of the National Academy of Science (USA), 88, 4796–4800.
  • Witcher, L. L., Collins, R., Puttagunta, S., Mechanic, S. E., Munson, M., Gumbiner, B. and Cowin, P., 1996, Desmosomal cadherin binding domains of plakoglobin. Journal of Biological Chemis try, 271, 10904–10909.
  • Zhu, A. J. and Watt, F., 1996, Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. Journal of Cell Science, 109, 3013 3023.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.