Intracellular signalling mechanisms regulating glucose transport in insulin-sensitive tissues

References

• Aguirre, V., Uchida, T., Yenush, L., Davis, R. and White, M. F., 2000, The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphor- ylation of Ser(307). Journal of Biologica l Chemistry, 275, 9047 ± 9054.
   PubMed Web of Science ®Google Scholar
• Ahmed, Z., Smith, B. J. and Pillay, T. S., 2000, The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitate s ligand-stimulated ubiquitination of the insulin receptor. FEBS Letters, 475, 31 ± 34.
   PubMed Web of Science ®Google Scholar
• Balon, T. W. and Nadler, J. L., 1997, Evidence that nitric oxide increases glucose transport in skeletal muscle. Journal of Applied Physiology, 82, 359 ± 363.
   PubMed Web of Science ®Google Scholar
• Baumann, C. A. and Saltiel, A. R., 2001, Spatial compartmentaliza- tion of signal transduction in insulin action. Bioessays, 23, 215 ± 222.
   Google Scholar
• Baumann, C. A., Ribon, V., Kanzaki, M., Thurmond, D. C., Mora, S., Shigematsu, S., Bickel, P. E., Pessin, J. E. and Saltiel, A. R., 2000, CAP defines a s econd signalling pathway required for insulin-stimulated glucos e transport. Nature, 407, 202 ± 207.
   PubMed Web of Science ®Google Scholar
• Bergeron, R., Russ ell, R. R., Young, L. H., Ren, J. M., Marcucci, M., Lee, A. and Shulman, G. I., 1999, Effect of AMPK activation on muscle glucose metabolism in conscious rats. American Journal of Physiology, 276, E938 ± E944.
   Google Scholar
• Blair, A. S., Hajduch, E., Litherland, G. J. and Hundal, H. S., 1999, Regulation of glucos e transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activate d protein kinas e signaling pathways. Journal of Biologica l Chemistry, 274, 36293 ± 36299.
   PubMed Web of Science ®Google Scholar
• Bradley, S. J., Kingwell, B. A. and McConell, G. K., 1999, Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercis e in humans. Diabetes, 48, 1815 ± 1821.
   PubMed Web of Science ®Google Scholar
• Buhl, E. S., Jessen, N., Schmitz, O., Pedersen, S. B., Pedersen, O., Holman, G. D. and Lund, S., 2001, Chronic treatment with 5- aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner. Diabetes, 50, 12 ± 17. Cantrell, D. A., 2001, Phosphoinositide 3-kinas e signalling pathways. Journal of Cell Science, 114, 1439 ± 1445.
   Google Scholar
• Chen, D., Elmendorf, J. S., Olson, A. L., Li, X., Earp, H. S. and Pessin, J. E., 1997, Osmotic shock stimulates GLUT4 transloca- tion in 3T3L1 adipocytes by a novel tyrosine kinase pathway. Journal of Biological Chemistry, 272, 27401 ± 27410.
   PubMedGoogle Scholar
• Chen, D., Fucini, R. V., Olson, A. L., Hemmings, B. A. and Pessin, J. E., 1999a, Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinas e B in an inactive dephosphorylated state. Molecula r Cell Biology, 19, 4684 ± 4694.
   PubMedGoogle Scholar
• Chen, Z. P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodriguez-
   Google Scholar
• Crespo, I., Witters, L. A., Power, D. A., Ortiz, D. M. P. and Kemp,B. E., 1999b, AMP-activate d protein kinas e phosphorylation of endothelia l NO synthas e. FEBS Letters, 443, 285 ± 289.
   Google Scholar
• Chiang, S. H., Baumann, C. A., Kanzaki, M., Thurmond, D. C., Watson, R. T., Neudauer, C. L., Macara, I. G., Pessin, J. E. and Saltiel, A. R., 2001, Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature, 410, 944 ± 948.
   PubMed Web of Science ®Google Scholar
• Chibalin, A. V., Yu, M., Ryder, J. W., Song, X. M., Galuska, D., Krook, A., Wallberg-Henriksson, H. and Zierath, J. R., 2000, Exercis e-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differentia l effects on insulin-receptor substrates 1 and 2. Proceedings of the National Academy of Sciences (USA), 97, 38 ± 43.
   PubMed Web of Science ®Google Scholar
• Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I. and Birnbaum, M. J., 2001, Insulin resistance and a diabetes mellitus- like syndrome in mice lacking the protein kinas e Akt2 (PKB beta). Science, 292, 1728 ± 1731.
   PubMed Web of Science ®Google Scholar
• Clement, S., Kraus e, U., Desmedt, F., Tanti, J. F., Behrends, J., Pesess e, X., Sasaki, T., Penninger, J., Doherty, M., Malaiss e, W., Dumont, J. E ., Le Marchand-Brustel, Y., Erneux, C., Hue, L. and Schurmans, S., 2001, The lipid phosphatas e SHIP2 controls insulin s ensitivity. Nature, 409, 92 ± 97.
   Google Scholar
• Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M. and Hemmings, B. A., 1995, Inhibition of glycogen synthas e kinas e-3 by insulin mediated by protein kinas e B. Nature, 378, 785 ± 789.
   PubMed Web of Science ®Google Scholar
• Czech, M. P., 2000, Lipid rafts and insulin action. Nature, 407, 147 ± 148.
   PubMedGoogle Scholar
• Derave, W., Ai, H., Ihlemann, J., Witters, L. A., Kristiansen, S., Richter, E. A. and Ploug, T., 2000, Dissociation of AMP-activated protein kinas e activation and glucos e transport in contracting slow-twitch muscle. Diabetes, 49, 1281 ± 1287.
   PubMed Web of Science ®Google Scholar
• Dombrowski, L., Faure, R. and Marette, A., 2000, Sustained activation of insulin receptors internaliz ed in GLUT4 vesicles of insulin-stimulated skeleta l muscle. Diabetes, 49, 1772 ± 1782.
   Google Scholar
• Doornbos, R. P., Theelen, M., van der Hoeven, P. C., van
   Google Scholar
• Blitterswijk, W. J., Verkleij, A. J. and van Bergen en Henegouwen, P. M., 1999, Protein kinase Czeta is a negative regulator of protein kinase B activity. Journal of Biological Chemistry, 274, 8589 ± 8596.
   Google Scholar
• Egawa, K., Sharma, P. M., Nakashima, N., Huang, Y., Huver, E ., Boss, G. R. and Olefsky, J. M., 1999, Membrane-targeted phosphatidylinos itol 3-kinas e mimics insulin actions and induces a state of cellular insulin resistance. Journal of Biological Chemistry, 274, 14306 ± 14314.
   PubMedGoogle Scholar
• Eldar-Finkelman, H. and Krebs, E. G., 1997, Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinas e 3 impairs insulin action. Proceedings of the National Academy of Sciences (USA), 94, 9660 ± 9664.
   PubMed Web of Science ®Google Scholar
• Etgen, G. J., Fryburg, D. A. and Gibbs, E. M., 1997, Nitric oxidestimulates skeletal muscle glucose transport through a calcium/ contraction- and phosphatidylinos itol-3-kinas e-independent path- way. Diabetes, 46, 1915 ± 1919.
   PubMed Web of Science ®Google Scholar
• Fryer, L. G., Hajduch, E., Rencurel, F., Salt, I. P., Hundal, H. S., Hardie, D. G. and Carling, D., 2000, Activation of glucose transport by AMP-activate d protein kinase via stimulation of nitric oxide synthase. Diabetes, 49, 1978 ± 1985.
   PubMed Web of Science ®Google Scholar
• Fujishiro, M., Gotoh, Y., Katagiri, H., Sakoda, H., Ogihara, T., Anai, M., Onishi, Y., Ono, H., Funaki, M., Inukai, K., Fukushima, Y., Kikuchi, M., Oka, Y. and Asano, T., 2001, MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake, but regulates glucos e transporter expression. Journal of Biological Chemistry, 276, 19800 ± 19806.
   PubMed Web of Science ®Google Scholar
• Goodyear, L. J. and Kahn, B. B., 1998, Exercis e, glucose transport, and insulin s ensitivity. Annual Reviews in Medicine, 49, 235 ± 261. Gustavsson, J., Parpal, S. and Stralfors, P., 1996, Insulin-stimulated glucos e uptake involves the transition of glucos e transporters to a caveola e-rich fraction within the plasma membrane: implications for type II diabetes. Molecular Medicine, 2, 367 ± 372.
   Google Scholar
• Hajduch, E., Litherland, G. J. and Hundal, H. S., 2001, Protein kinase B (PKB/Akt)± a key regulator of glucos e transport? FE BS Letters, 492, 199 ± 203.
   PubMed Web of Science ®Google Scholar
• Han, D. H., Hansen, P. A., Nolte, L. A. and Holloszy, J. O., 1998, Removal of adenosine decreas es the responsivenes s of muscle glucos e transport to insulin and contractions. Diabetes, 47, 1671 ± 1675.
   PubMed Web of Science ®Google Scholar
• Hansen, L. L., Ikeda, Y., Olsen, G. S., Busch, A. K. and Mosthaf, L., 1999, Insulin signaling is inhibited by micromolar concentrations of H2O2. Evidence for a role of H2O2 in tumor necrosis factor alpha- mediated insulin resistance. Journal of Biological Chemistry, 274, 25078 ± 25084.
   PubMed Web of Science ®Google Scholar
• Hausdorff, S. F., Fingar, D. C., Morioka, K., Garza, L. A., Whiteman, E. L., Summers, S. A. and Birnbaum, M. J., 1999, Identifica tion of wortmannin-sensitiv e targets in 3T3-L1 adipocytes. Dissociation of insulin-stimulated glucose uptake and GLUT4 translocation. Journal of Biologica l Chemistry, 274, 24677 ± 24684.
   PubMedGoogle Scholar
• Hayashi, T., Hirshman, M. F., Fujii, N., Habinowski, S. A., Witters, L.A. and Goodyear, L. J., 2000, Metabolic stress and altered glucos e transport: activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes, 49, 527 ± 531.
   PubMed Web of Science ®Google Scholar
• Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W. and Goodyear, L. J., 1998, Evidence for 5’ AMP-activated protein kinase mediation of the effect of muscle contraction on glucos e transport. Diabetes, 47, 1369 ± 1373.
   PubMed Web of Science ®Google Scholar
• Hespel, P. and Richter, E. A., 1998, Role of adenosine in regulation of carbohydrate metabolis m in contracting muscle. Advances in Experimenta l Medical Biology, 441, 97 ± 106.
   Google Scholar
• Higaki, Y., Hirshman, M. F., Fujii, N. and Goodyear, L. J., 2001, Nitric oxide increas es glucos e uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. Diabetes, 50, 241 ± 247.
   PubMed Web of Science ®Google Scholar
• Hill, K. M., Huang, Y., Yip, S. C., Yu, J., Segall, J. E. and Backer, J. M., 2001, N-terminal domains of the clas s IA PI 3-kinas e regulatory subunit play a role in cytoskeleta l but not mitogenic signaling. Journal of Biologica l Chemistry, 276, 16374 ± 16378.
   PubMedGoogle Scholar
• Hill, M. M., Clark, S. F., Tucker, D. F., Birnbaum, M. J., James, D. E. and Macaulay, S. L., 1999, A role for protein kinas e Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Molecular Cell Biology, 19, 7771 ± 7781.
   PubMedGoogle Scholar
• Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F. and Spiegelman, B. M., 1996, IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity- induced insulin resistance. Science, 271, 665 ± 668.
   PubMed Web of Science ®Google Scholar
• Ihlemann, J., Ploug, T., Hellsten, Y. and Galbo, H., 1999, E ffect of tension on contraction-induced glucos e transport in rat skeletal muscle. American Journal of Physiology, 277, E208 ± E214.
   Google Scholar
• Ihlemann, J., Ploug, T., Hellsten, Y. and Galbo, H., 2000, E ffect of stimulation frequency on contraction-induced glucose transport in rat skeleta l muscle. American Journal of Physiology, 279, E862 ± E867.
   Google Scholar
• Ijuin, T., Mochizuki, Y., Fukami, K., Funaki, M., Asano, T. and Takenawa, T., 2000, Identifica tion and characterizatio n of a novel inositol polyphosphate 5-phosphatase. Journal of Biological Chemistry, 275, 10870 ± 10875.
   PubMedGoogle Scholar
• Isakoff, S. J., Taha, C., Ros e, E., Marcusohn, J., Klip, A. and Skolnik, E. Y., 1995, The inability of phosphatidylinositol 3-kinas e activa- tion to stimulate GLUT4 translocation indicates additional signal- ing pathways are required for insulin-stimulated glucos e uptake. Proceedings of the National Academy of Sciences (USA), 92, 10247 ± 10251.
   Google Scholar
• Jiang, T., Sweeney, G., Rudolf, M. T., Klip, A., Traynor-Kaplan, A. and Tsien, R. Y., 1998, Membrane-permeant esters of phospha- tidylinositol 3,4,5-trisphosphate. Journal of Biologica l Chemistry, 273, 11017 ± 11024.
   PubMed Web of Science ®Google Scholar
• Kanety, H., Feinstein, R., Papa, M. Z., Hemi, R. and Karasik, A., 1995, Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-Journal of Biological Chemistry, 270, 23780 ± 23784.
   Google Scholar
• Kayali, A. G., Austin, D. A. and Webster, N. J., 2000, Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinas e in glucos e transport in 3T3-L1 adipocytes. Diabetes, 49, 1783 ± 1793.
   PubMed Web of Science ®Google Scholar
• Kessler, A., Uphues, I., Ouwens, D. M., Till, M. and Eckel, J., 2001, Diversification of cardia c insulin signaling involves the p85 alpha/ beta subunits of phosphatidylinos itol 3-kinas e. American Journal of Physiology, 280, E65 ± E74.
   Google Scholar
• Kotani, K., Ogawa, W., Hashiramoto, M., Onishi, T., Ohno, S. and Kasuga, M., 2000, Inhibition of insulin-induced glucose uptake by atypica l protein kinas e C isotype-specific interacting protein in 3T3-L1 adipocytes. Journal of Biologica l Chemistry, 275, 26390 ± 26395.
   PubMedGoogle Scholar
• Krook, A., Widegren, U., Jiang, X. J., Henriksson, J., Wallberg- Henriksson, H., Alessi, D. and Zierath, J. R., 2000, E ffects of exercis e on mitogen- and stress-activate d kinase signal transduc- tion in human skeleta l muscle. American Journal of Physiology, 279, R1716 ± R1721.
   Google Scholar
• Levkowitz, G., Waterman, H., Ettenberg, S. A., Katz, M., Tsygankov,Y., Alroy, I., Lavi, S., Iwai, K., Reiss, Y., Ciechanover, A., Lipkowitz, S. and Yarden, Y., 1999, Ubiquitin ligas e activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Molecular Cell, 4, 1029 ± 1040.
   PubMed Web of Science ®Google Scholar
• Liu, Y. F., Paz, K., Herschkovitz, A., Alt, A., Tennenbaum, T., Sampson, S. R., Ohba, M., Kuroki, T., LeRoith, D. and Zick, Y., 2001, Insulin stimulates PKCzeta-mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. Journal of Biologica l Chemistry, 276, 14459 ± 14465.
   PubMed Web of Science ®Google Scholar
• MacDougald, O. A. and Lane, M. D., 1995, Transcriptiona l regulation of gene expression during adipocyte differentiatio n. Annual Review of Biochemistry, 64, 345 ± 373.
   PubMed Web of Science ®Google Scholar
• Maddux, B. A., See, W., Lawrence, J. C., Goldfine, A. L., Goldfine, I.D. and Evans, J. L., 2001, Protection against oxidative stress- induced insulin resistance in rat L6 muscle cells by micromolar concentrations of alpha-lipoic acid. Diabetes, 50, 404 ± 410.
   PubMed Web of Science ®Google Scholar
• Mu, J., Brozinick, J. T., Valladares, O., Bucan, M. and Birnbaum, M. J., 2001, A role for amp-activated protein kinas e in contraction- and hypoxia-regulated glucose transport in skeleta l muscle. Molecular Cell, 7, 1085 ± 1094.
   PubMed Web of Science ®Google Scholar
• Musi, N., Hayashi, T., Fujii, N., Hirshman, M. F., Witters, L. A. and Goodyear, L. J., 2001, AMP-activated protein kinas e activity and glucose uptake in rat skeletal muscle. American Journal of Physiology, 280, E677 ± E684.
   Google Scholar
• Nave, B. T., Haigh, R. J., Hayward, A. C., Siddle, K. and Shepherd, P. R., 1996, Compartment-specific regulation of phosphoinositide 3-kinas e by platelet-derived growth factor and insulin in 3T3-L1 adipocytes. Biochemical Journal, 318, 55 ± 60.
   PubMed Web of Science ®Google Scholar
• Nave, B. T., Ouwens, M., Withers, D. J., Alessi, D. R. and Shepherd,P. R., 1999, Mammalian target of rapamycin is a direct target for protein kinas e B: identifica tion of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochemical Journal, 344, 427 ± 431.
   PubMed Web of Science ®Google Scholar
• Ozes, O. N., Akca, H., Mayo, L. D., Gustin, J. A., Maehama, T., Dixon, J. E. and Donner, D. B., 2001, A phosphatidylinositol 3- kinas e/Akt/mTOR pathway mediates and PTEN antagoniz es tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proceedings of the National Academy of Sciences (USA), 98, 4640 ± 4645.
   PubMed Web of Science ®Google Scholar
• Paz, K., Liu, Y. F., Shorer, H., Hemi, R., LeRoith, D., Quan, M., Kanety, H., Seger, R. and Zick, Y., 1999, Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinas e B positively regulates IRS-1 function. Journal of Biological Chemistry, 274, 28816 ± 28822.
   PubMed Web of Science ®Google Scholar
• Pessin, J. E. and Saltiel, A. R., 2000, Signaling pathways in insulin action: molecular targets of insulin resistance. Journal of Clinica l Investigation, 106, 165 ± 169.
   PubMed Web of Science ®Google Scholar
• Peyrollier, K., Hajduch, E., Gray, A., Litherland, G. J., Prescott, A. R., Leslie, N. R. and Hundal, H. S., 2000, A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activa- tion of protein kinas e B. Biochemical Journal, 352, 617 ± 622.
   Google Scholar
• Ravichandran, L. V., Esposito, D. L., Chen, J. and Quon, M. J., 2000, PKC-{z eta} phosphorylates IRS-1 and impairs its ability to activate PI 3-kinas e in respons e to insulin. Journal of Biological Chemistry, 276, 3543 ± 3549.
   Google Scholar
• Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K. and Saltiel, A. R., 1998, A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Molecular Cell Biology, 18, 872 ± 879.
   PubMed Web of Science ®Google Scholar
• Roberts, C. K., Barnard, R. J., Scheck, S. H. and Balon, T. W., 1997, Exercis e-stimulated glucose transport in skeletal muscle is nitric oxide dependent. American Journal of Physiology, 273, E220 ± E225.
   Google Scholar
• Rudich, A., Tirosh, A., Potashnik, R., Hemi, R., Kanety, H. and Bashan, N., 1998, Prolonged oxidative stres s impairs insulin- induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes, 47, 1562 ± 1569.
   PubMed Web of Science ®Google Scholar
• Rudich, A., Tirosh, A., Potashnik, R., Khamaisi, M. and Bashan, N., 1999, Lipoic acid protects against oxidative stres s induced impairment in insulin stimulation of protein kinase B and glucos e transport in 3T3-L1 adipocytes. Diabetologia, 42, 949 ± 957.
   Google Scholar
• Salt, I. P., Connell, J. M. and Gould, G. W., 2000, 5-aminoimidazole- 4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes, 49, 1649 ± 1656.
   PubMedGoogle Scholar
• Saltiel, A. R., 2001, New perspectives into the molecular pathogen- esis and treatment of type 2 diabetes. Cell, 104, 517 ± 529.
   PubMed Web of Science ®Google Scholar
• Simpson, F., Whitehead, J. P. and James, D. E., 2001, GLUT4-at the cross roads between membrane trafficking and signal transduc- tion. Traffic, 2, 2 ± 11.
   Google Scholar
• Stamler, J. S. and Meissner, G., 2001, Physiology of nitric oxide in skeleta l muscle. Physiological Reviews, 81, 209 ± 237.
   PubMed Web of Science ®Google Scholar
• Takayama, S., White, M. F. and Kahn, C. R., 1988, Phorbol ester- induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. Journal of Biological Chemistry, 263, 3440 ± 3447.
   PubMedGoogle Scholar
• Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., Nakajima, H., Hanafusa, T., Matsuzawa, Y., Sekihara, H., Yin, Y., Barrett, J. C., Oda, H., Ishika wa, T., Akanuma, Y., Komuro, I., Suzuki, M., Yamamura, K., Kodama, T., Suzuki, H. and Kadowaki, T., 1999, Increas ed insulin s ensitivity and hypoglyca emia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinas e. Nature Genetics, 21, 230 ± 235.
   Google Scholar
• Tirosh, A., Rudich, A., Potashnik, R. and Bashan, N., 2001, Oxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytes. Biochemical Journal, 355, 757 ± 763.
   PubMed Web of Science ®Google Scholar
• Tsakiridis, T., Tong, P., Matthews, B., Tsiani, E., Bilan, P. J., Klip, A. and Downey, G. P., 1999, Role of the actin cytoskeleton in insulin action. Microscopy Res earch Techniques, 47, 79 ± 92.
   PubMed Web of Science ®Google Scholar
• Tsujikawa, K., Kawakami, N., Uchino, Y., Ichijo, T., Furukawa, T., Saito, H. and Yamamoto, H., 2001, Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor. Molecula r Endocrinology, 15, 271 ± 280.
   Google Scholar
• Vainshtein, I., Kovacina, K. S. and Roth, R. A., 2001, The insulin receptor substrate (IRS)-1 pleckstrin homology domain functions in downstream signaling. Journal of Biological Chemistry, 276, 8073 ± 8078.
   PubMedGoogle Scholar
• Vanhaesebroeck, B. and Waterfield, M. D., 1999, Signaling by distinct classes of phosphoinositide 3-kinas es. Experimental Cell Res earch, 253, 239 ± 254.
   PubMed Web of Science ®Google Scholar
• Vanhaesebroeck, B., Leevers, S. J., Panayotou, G. and Waterfield, M. D., 1997, Phosphoinositide 3-kinas es: a cons erved family of signal transducers. Trends in Biochemical Sciences, 22, 267 ± 272.
   PubMed Web of Science ®Google Scholar
• Wada, T., Sasaoka, T., Funaki, M., Hori, H., Murakami, S., Ishiki, M., Haruta, T., Asano, T., Ogawa, W., Ishihara, H. and Kobayashi, M., 2001, Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5’-phosphatase catalytic activity. Molecula r Cell Biology, 21, 1633 ± 1646.
   PubMed Web of Science ®Google Scholar
• White, M. F., 1998, The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Progress in Hormone Res earch, 53, 119 ± 138.
   PubMedGoogle Scholar
• Wiese, R. J., Mastick, C. C., Lazar, D. F. and Saltiel, A. R., 1995, Activation of mitogen-activated protein kinas e and phosphatidyli- nositol 3’-kinas e is not sufficient for the hormonal stimulation of glucos e uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes. Journal of Biologica l Chemistry, 270, 3442 ± 3446.
   PubMed Web of Science ®Google Scholar
• Wiley, H. S. and Burke, P. M., 2001, Regulation of receptor tyrosine kinase signaling by endocytic trafficking. Traffic, 2, 12 ± 18.
   PubMed Web of Science ®Google Scholar
• Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V. Cohen, P. and Alessi, D. R., 2000, The role of 3-phosphoinositide- dependent protein kinas e 1 in activating AGC kinases defined in embryonic stem cells. Current Biology, 10, 439 ± 448.
   Google Scholar
• Wojtaszewski, J. F., Niels en, P., Hans en, B. F., Richter, E. A. and Kiens, B., 2000, Isoform-specific and exercis e intensity-dependent activation of 5’-AMP-activated protein kinas e in human skeletal muscle. Journal of Physiology, 528, 221 ± 226.
   PubMed Web of Science ®Google Scholar
• Zabolotny, J. M., Kim, Y. B., Peroni, O. D., Kim, J. K., Pani, M. A.,
   Google Scholar
• Boss, O., Klaman, L. D., Kamatkar, S., Shulman, G. I., Kahn, B. B. and Neel, B. G., 2001, Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatas e in muscle causes insulin resistance. Proceedings of the National Academy of Sciences (USA), 98, 5187 ± 5192.
   Google Scholar