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Research Article

GLUT2 in pancreatic and extra-pancreatic gluco-detection

Pages 265-273 | Published online: 09 Jul 2009

  • Adachi, A., 1981, Electrophysiological study of hepatic vagal projection to the medulla. Neurscience Letters. 24, 19-23.
  • Ahlgren, U., Jonsson. J., Jonsson, L. Srnu, K. and Edlund, H., 1998, ß-cell-specific ractivation of the mouse Ipf1/Pdx1 gene results r loss of the ß-cell phenolype and maturity onset diabetes. Genes Development. 12, 1763-1768.
  • Burcelin, R. and Thorens, B., 2001, Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion. Diabetes. 50, 1282-1289.
  • Burcelin, R., DaCoste, A., Drucker, D. and Thorens, B., 2001, Glucose competence of the hepatoporal vein sensor requires the presence of an activated GLP-1 receptor. Diabetes, 50, 1720-1728.
  • Burcelin, R., Dolci, W. and Thorens, B., 2000a, Portal glucose illusion ri the mouse induces hypoglycemia. Evidence that the hepatopcrtal glucose sensor stimulates glucose utilization. Diabetes. 49, 1635-1642.
  • Burcelin, R., Dolci, W. and Thorens, B., 2000b, Glucose sensing by the hepatopcrtal sensor is GLUT2-dependent In vim analysis n GLUT2-null mice. Diabetes. 49, 1643-1648.
  • Burcelin, R. Muñoz, M C., Guilam, M.-T. and Thorens, B., 2000c, Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression ri GLUT2null hepattocytes. Further evidence for the existence of a membrane-based glucose release pathway. Journal of Biological Chemistry. 275, 10930-10936.
  • Cardin. S., Jackson. P. A., Edgerton, D. S., Meal, D. W., Coffey, C. S. and Chentigton, A. D., 2001, Effect of vagal cooing on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog. Diabetes, 50, 558-564.
  • Dallaporta, M. Himmi, T., Perrin, J. and Orsni, J.-C., 1999, A solitary tract nucleus sensitivity to moderate changes ri glucose level. NeuroReport 10, 1-4.
  • De Vos, A., Hernberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeteers, D. and Schuit, F., 1995, Human and rat beta cells differ ri glucose transporter but not ri glucokrinase gene expression. Journal of Clinical Investigations. 96, 2489-2495.
  • Donovan, C. M, Hamilton-Wessler, M, Halter, J. B. and Bergnan, R. N., 1994, Primary of liver glucosenscrs in the sympathetic response to progressive hypoglycemia. Proceedings of the National Academy of Sciences (USA), 91, 2863-2867.
  • Gannon, M, Ray, M. K., Van Zee, K., Rausa, F., Costa, R. H. and Wright, C. V. E., 2000, Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development 127, 2883-2895.
  • Gardemann, A. and Jungermann, K., 1986, Control of glucose balance ri the perfused rat iver by the parasympathetic innervation. Biological Chemistry Hoppes-Seyler. 367, 559-566.
  • Guillam, M-T., Burcein, R. and Thorens, B., 1998, Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes. Proceedings of the National Academy of Sciences (USA), 95, 12317-12321.
  • Guillam, M-T., Dupraz, P. and Thorens, B., 2000, Glucose uptake, utilization, and signaling in Glut2-Null islets. Diabetes. 49, 1485-1491.
  • Guillam, M-T., Hümmler, E., Schaerer, E., Yeh, J.-Y, Bimbaum, M J., Beermann, F., Schmidt A., Dériaz, M. and Thorens, B., 1997, Early diabetes and abnormal postnatal pancreatic islet development in mice lacking GLUT2. Nature Genetics, 17, 327-330.
  • Hamilton-Wessler, M, Bergnan, R. N., Halter, J. B., Watanabe, R. M and Donovan, C. M, 1994, The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs. Diabetes, 43, 1052-1060.
  • Havel, P. J. and Taborsky, G. J., 1989, The contribution of the autonomie nervous system to changes of glucagon and insulin secretion during hypoglycemic stress. Endocrine Review, 10, 332-350.
  • Havel, P. J. and Valverde, C., 1996, Autonomie mediation of glucagon secretion during insuin-induced hypoglycennia in rhesus monkeys. Diabetes, 45, 960-966.
  • Havel, P. J., Akpan, J. O., Curry, D. L, Stem, J. S., Gingerich, R. L and Ahren, B., 1993, Autonomie control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycennia in mice. American Journal of Physiology, 265, R246-R254.
  • Hernberg, H., De Vos, A., Moens, K., Quartier, E., Bouwens, L., Pipeleers, D., Van Schaftingen, E., Madsen, O. and Schurt, F., 1996, The glucose sensor protein glucokriase is expressed in glucagon-producing a cells. Proceedings of the National Academy of Sciences (USA). 93, 7036-7041.
  • Herriberg, K, De Vos, A., Pipeleers, D., Thorens, B. and Schurt, F., 1995, Differences in glucose transporters gene expression between rat pancreatic a- and ß-cells are correlated to differences in glucose transport but not in glucose utilization. Journal of Biological Chemistry, 270, 9871-9875.
  • Hernberg, K, De Vos, A., Vandercarrmen, A., Van Schaftingen, E., Pipeleers, D. and Schurt, F., 1993, Heterogeneity in glucose sensitivity among pancreatic ß-cells is correlated to differences in glucose phosphorylation rather than glucose transport. EIVBO Journal, 12, 2873-2879.
  • Henquin, J. C., 2000, Triggering and amplifying pathways of regulation of insuin secretion by glucose. Diabetes, 49, 1751-1760.
  • Hevener, A. L, Bergman, R. N. and Donovan, C. M, 1997, Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes. 46, 1521-1525.
  • Jackson, P. A., Cardin, S., Coffey, C. S., Meal, D. W., Alien, E. J., Penaloza, A. R., Snead, W. L and Cherrington, A. D., 2000, Effect of hepatic denervation on the counterregulatory response to insuin-induced hypoglycemia in the dog. American Journal of Physiology, Endocrinology and Metaboism, 279, 1249-1257.
  • Jetton, T. L, Liang, Y., Pettepher, C. C., Zimmerman, E. C., Cox, F. G., Horvath, K., Matschinsky, F. M and Magnuson, M A., 1994, Analysis of upstream glucokriase promoter activity in transgenic mice and identification of glucokriase in rare neuroendocrine cells in the brain and gut. Journal of Biological Chemistry, 269 3641-3654
  • Leloup, C., ArluBon, M, Lepetit, N., Cartier, N, Marfaing-Jallat, P., Ferré, P. and Pénicaud, L, 1994, Glucose transporter 2 (GLUT2):expression in specific brain nuclei. Brain Research, 638, 221-226.
  • Leloup, C., Orosco, M, Serradas, P., Nicolaïdis, S. and Pénicaud, L., 1998, Specific inhibition of GLUT2 in arcuate nucleus by antisense oligonucleotides suppresses nervous control of insuin secretion. Molecular Brain Research. 57, 275-280.
  • Levin, B. E., Dunn-Meynell, A. A. and Routh, V. H., 1999, Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. American Journal of Physiology. 276, R1223R1231.
  • Maekawa, F., Toyoda, Y., Torii, N, Miwa, I., Thompson R. C., Foster, D. L., Tsukahara, S., Tsukamura, H. and Maeda, K.-l., 2000, Localization of gkjcokriase-ike immunoreactivity in the rat lower brain stem: far possble location of brain glucosesensrig mechanisms. Endocrinology. 141, 375-384.
  • Magnan, C., Philippe, J., Kassis, N, Laury, M C., Pénicaud, L, Gibert, M. and Ktorza, A., 1995, In vivo effects of glucose and risuin on secretion and gene expression of glucagon in rats. Endocrinology, 136, 5370-5376.
  • Manz, F., Bickel, H., Brodehl, J., Feist D., Gelissen, K., GeschöllBauer, B., GiIIi, G., Hehftig, H., Nützenadel, W. and Waldherr, R., 1987, Fanconi-Bickel syndrome. Pedialric Nephrobgy. 1. 509-518.
  • Martin, J. R., Novin, D. and VanderWeele, D. A., 1978, Loss of glucagon suppressbn of feeding after vagotomy ri rats. American Journal of Physiology. 234. 314-318.
  • Matschinsky, F. M., 1996, A lesson ri metabolic regulation inspired by the glucokinase sensor paradigm. Diabetes, 45, 223-241.
  • Miki, T., Liss, B., Mnami, K., Shiuchi, T., Saraya, A., Kashrna, Y., Horiuchi, M. Ashcroft, F., Mnokoshi, Y., Roeper, J. and Serio, S., 2001, ATP-sensitive K+ channels of the hypothalamus are essential for the maintenance of glucose homeostasis. National Neumlogy. 4, 507-512.
  • Miki, T., Nagashrna, K., Tashro, F., Kotake, K., Yoshitami, H., Tamamoto, A., Gonoi, T., Iwanaga, T., Myazaki, J.-l. and Seino, S., 1998, Defective insulin secretion and enhanced insulin action ri KATP channel-defective mice. Proceedings of the National Academy of Sciences (USA), 95. 10402-10406.
  • Minami, T., Oomura, Y. and Sugrnori, M, 1986, Eledrophysiological properties and glucose responsiveness of guinea-pig ventromedial hypothalamic neurones ri vitro. Journal of Physiology, 380, 127-143.
  • Mzuno, Y. and Oomura, Y., 1984, Glucose responding neurons in the nucleus tractus soutenus of the rat ri vitro studies. Brain Research, 307, 109-116.
  • Nakabayashi, H., Kobayashi, K., Nakabayashi, I. O. and Kurata, Y., 1995, Somatostatin receptor on the afferent nerve terminals in the rat hepatoportal area. Neuroscience Letters, 183, 46-49.
  • Navarro, M, Rodriguez de Fonseca, F., Alvarez, E., Chowen, J. A., Zueco, J. A., Gomez, R., Eng, J. and Blazquez, E., 1996, Colocaization of glucagon-ike peptide-1 (GLP-1) receptors, glucose transporter GLUT2, and glucokriase mRNAs ri rat hypothalamic cells: evidence far a role of GLP-1 receptor agonist as an inhibitory signal for food and water intake. Journal of Neurochemistry. 67, 1982-1991.
  • Ngarmukos, C., Baur, E. L and Kimagai, A. K., 2001, Colocalization of GLUT1 and GLUT4 ri the blood--brain barrier of the rat ventromedial hypothalamus. Brain Research. 900, 18.
  • Nijima, A., 1969, Afferent impulse discharges from gluccreceptars in the iver of the guinea pig. Annals of the New York Academy of Science. 157, 690-700.
  • Nijima, A., 1984, The effect of D-gucose on the firing rate of glucose-sensitive vagal afferents ri the liver in comparison with the effect of 2-deoxy-D-gucose. Journal of Autonomie Nervous Systems. 10. 279-285.
  • Oomura, Y. and Yoshrnatsu, H., 1984, Neural network of glucose monharig system. Journal of Autonomie Nervous Systems. 10, 359-372.
  • Oomura, Y., Ooyama, H., Sugrnori, M, Nakamura, T. and Yamada, Y., 1974, Glucose inhbition of the glucose-sensitive neurone in the rat lateral hypothalamus. Mature, 247. 284-286.
  • Orci, L, Thorens, B., Ravazzola, M and Lodish, H. F., 1989, Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science, 245, 295-297.
  • Parrizas, M., Maestro, M. A., BoJ, S. F., Paniagua, A., Casamftjana, R., Garnis, R., Rivera, F. and Ferrer, J., 2001, Hepatic nuclear factor 1-alpha drects nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Molecular and Cellular Biology, 21, 3234-3243.
  • Pipeleers, D. G., Schuft F. C., Van Schravendijc, C. F. H. and Van De Wrikel, M., 1985, Interplay of nutrients and hormones in trie regulation of glucagon release. Endocrinology, 117, 817- 823.
  • Russek, M, 1963, Particbation of hepatic glucorecepters in the control of intake of food. Nature, 197, 79-80.
  • Russek, M., 1970, Demonstratian of the influence of an hepatic glucosensitive mechanism on food-ritake. Physiology & Behavior, 5, 1207-1209.
  • Santer, R., Schneppenhern, R., Dornbrcwski, A., Götze, H., Stermann, B. and Schaub, J., 1997, Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome. Nature Genetics, 17, 324-326.
  • Schmitt. M, 1973, Influences of hepatic portal receptors on hypothalamic feedrig and satiety centers. American Journal of Physiology. 225, 1089-1095.
  • Shimzu, N., Ocmura, Y., Novin, D., Grijalva, C. V. and Cooper, P. H., 1983, Functional correlations between lateral hypothalarnic glucose-sensitive neurons and hepatic portal glucose-sensitive units in rat Brain Research, 265, 49-54.
  • Silver, I. A. and Erecinska, M, 1998, Glucose-rduced intracellular bn changes in sugar-sensitive hypothalamic neurons. Journal of Neumphysiology. 79, 1733-1745.
  • Stümpel, F. and Jungermann, K., 1997, Sensing by intrahepatic muscarriic nerves of a portal-arterial glucose concentration gradient as a signal for insuin-dependent glucose uptake in the perfused rat liver. FEBS Letters, 406, 119-122.
  • Sundler, F. and Böttcher, G., 1991, Islet innervation, with special reference to neuropeptides. In The Endocrine Pancreas. E. Samols, ed. (New York: Raven Press), pp. 29-52.
  • Suzuki, M, Fujikura, K., Kotake, K., lnagaki, N., Seino, S. and Takata, K., 1999, Immuno-localization of sulphonylurea receptor 1 in rat pancreas. Diabetologia 42, 1204-1211.
  • Thorens, B., Guillam, M-T., Beermann, F., Burcein, R. and Jaquet, M, 2000, Transgenic reexpressbn of Glut1 or Glut2 in pancreatic ß cells rescues Glut2-null mice from early death and restores normal glucose-stimulated insuin secretion. Journal of Biological Chemistry, 275, 23751-23758.
  • Thorens, B., Wu, Y.-J., Leahy, J. L. and Wer, G. C., 1992, The loss of GLUT2 expression by glucose-unresponsive ß cells of db/db mice is reversble and is induced by the diabetic envronment Journal of Clinical Investigations, 90, 77-85.
  • Unger, R. K, 1991, Diabetic hyperglycerria: finktornpared glucose transport in pancreatic ß cells. Science, 251, 1200-1205.
  • Wan, H. Z., Hulsey, M G. and Martin, R. J., 1998, Intracerebroventricubr admriislration of antisense oligodeoxynucleotide against GLUT2 glucose transporter mRNA reduces food intake, body weight change and glucopnvic feeding response in rats. Journal of Nutrition, 128, 287-291.
  • Weir, G. C., Knowltan, S. D. and Martin, D. B., 1974, Glucagon secretion from the perfused rat pancreas. Studies with glucose and catecholarrines. Journal of Clinical Investigations, 54, 1403-1412.
  • Yettefti, K., Orsini, J.-C. and Perrin, J., 1997, Characteristics of glycemia-sensitive neurons in the nucleus tractus solitarii: possible involvement in nutritional regulation. Physiology & Behavior, 61, 93-100.

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