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Research Article

P-glycoprotein misfolds in Escherichia coli : evidence against alternating-topology models of the transport cycle

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Pages 51-58 | Published online: 09 Jul 2009

  • Andersson, H. and von Heijne, G., 1994, Membrane protein topology: effects of delta mu H+ on the translocation of charged residues explain the 'positive inside' rule. EMBO J. 13, 2267-2272.
  • Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I. and Gottesman, M. M., 1999, Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annual Review of Pharmacology and Toxicology, 39, 361-398.
  • Azzaria, M., Schurr, E. and Gros, P., 1989, Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance. Molecular Cellular Biology, 9, 5289-5297.
  • Beja, O. and Bibi, E., 1995, Multidrug resistance protein (Mdr)akaline phosphatase hybrids r E. coi suggest a major revision in the topology of the C-terminal half of Mdr. Journal of Biological Chemistry, 270,12351-12354.
  • Bibi, E. and Beja, O., 1994, Membrane topology of multidrug resistance protein expressed in Escherichia coli, the N-terminal domain. Journal of Biological Chemistry, 269,19910-19915.
  • Bibi, E., Gros, P. and Kaback, R. H., 1993, Functional expression of mouse mdr1 in Escherichia coli. Proceedings of the National Academy of Science (USA), 90, 9209-9213.
  • Canfield, V. A. and Levenson, R., 1993, Transmembrane organisation of the Na, K-ATPase determined by epitope addition. Biochemistry, 32,13782-13786.
  • Chen, C. J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M M and Roninson, I. B., 1986, Internal duplication and homology with bacterial transport praters r the Mdr1 (Pglycoprotein) gene from multidrug-resistant human cells. Cell, 47, 381-389.
  • Dong, M, Ladaviere, L., Penin, F., Deleage, G. and Baggetto L G., 1998, Secondary structure of P-glycoprotein investigated by circular dichroism and amino acid sequence analysis. Biochimica et Biophysica Acta, 1371, 317-334.
  • Ehrmann, M, Boyd, D. and Beckwith, J., 1990, Genetic analysis of membrane protein topology by a sandwich gene fusion approach. Proceedings of the National Academy of Sciences (USA). 87, 7574-7578.
  • Gill, D. R., Hyde, S. C., Higgins, C. F., Valverde, M. A., Mintenig, G. M. and Sepulveda, F. V., 1992, Separation of drug transport and chloride channel functions of the human multidrug resistance Pglycoprotein. Cell, 71, 1-20.
  • Goodfellow, H. R., Sardini, A., Reutz, S., Callaghan, R., Gros, P., McNaughton, P. A. and Higgins, C. F., 1996, Protein kinase Cmediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. Journal of Biological Chemistry, 271,13668-13674.
  • Hennesey, E. S. and Broome-Smith, J. K., 1993, Gene-fusion techniques for determining membrane-protein topology. Current Opinion in Structural Biology, 3, 524-531.
  • Hubbell, W. L, Cafiso, D. S. and Altenbach, C., 2000, Identifying conformational changes with site-drected spin labeling. Nature Structural Biology, 7, 735-739.
  • Kast, C., Canfield, V., Levenson, R. and Gros, P., 1995, Membrane topology of P-glycoprotein as determried by epitope insertion: transmembrane organization of the N-terminal domain of mdr3. Biochemisty, 34, 4402-4411.
  • Kast C., Canfield, V., Levenson, R. and Gros, P., 1996, Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence. Journal of Biological Chemistry, 271, 9240-9246.
  • Loo, T. W. and Clarke, D. M., 1995, Membrane topology of a cysteine-less mutant of human P-glycoprotein. Journal of Biological Chemistry, 270, 843-848.
  • Loo, T. W. and Clarke, D. M, 1997 Drug stimulated ATPase activity of human P-glycoprotein requires movement between transmembrane segments 6 and 12. Journal of Biological Chemistry, 272, 20985-20989.
  • Perozo, E., Cortes, D. M and Cuello, L G., 1999, Structural rearrangements underlying K+-channel activation gating. Science, 285, 73-78.
  • Rosenberg, M. F., Velarde, G., Ford, R. C., Martin, C., Berridge, G., Kerr, I. D., Callaghan, R., Schmidin, A., Wooding, C., Linton, K. J. and Higgins, C. F., 2001, Repacking of the transmembrane domains of an ABC transporter, the multidrug resistance Pglycoprotein, during the ATP catalytic cycle. EMBO Journal, 20, 5615-5625.
  • Skach, W. R. and Lingappa, V. R., 1993, Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences. Journal of Biological Chemistry, 268, 23552-23561.
  • Skach, W. R. and Lingappa, V. R., 1994, Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR 1). Cancer Research, 54, 3202-3209.
  • Skach, W. R., Calayag, M. C. and Lingappa, V. R., 1993, Evidence for an alternate model of human P-glycoprotein structure and biogenesis. Journal of Biological Chemistry, 268, 6903-6908.
  • Strauch, K. L. and Beckwith, J. 1988, An Escherichia cdi mutation preventing degradation of abnormal periplasmic proteins. Proceedings of the National Academy of Sciences (USA), 85,1576-1580.
  • Toyoshima, C., Nakasako, M., Nomura, H. and Ogawa, H., 2000, CrystaI structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Nature, 405, 647-655.
  • von Heijne, G., 1992, Membrane protein structure prediction. Hydrophobicity analysis and the positive-nside rule. Journal of Molecular Biology, 225, 487-494.
  • Zhang, J. T., 2001, Multidrug resistance gene product P-glycoprotein, a polytopic membrane protein with multiple features in structure and function. Molecular Membrane Biology, 18, 145-152.
  • Zhang, Y. and Broome-Smith, J. K., 1990, Correct insertion of a simple eukaryotic plasma-membrane protein into the cytoplasmic membrane of Escherichia coli. Gene, 96, 51-57.
  • Zhang, J. T. and Lina V., 1991, Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation. Journal of Biological Chemistry, 266, 18224-18232.
  • Zhang, J. T. and Ling, V., 1995, Involvement of cytoplasmic factors regulating the membrane orientation of P-glycoprotein sequences. Biochemistry, 34, 9159-9165.
  • Zhang, J. T., Duthie, M. and Ling, V., 1993, Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule. Journal of Biological Chemistry, 268, 15101-15110.

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