Advanced search
Publication Cover
Molecular Membrane Biology Volume 19, 2002 - Issue 3
Journal homepage
254
Views
32
CrossRef citations to date
0
Altmetric
Research Article

Peroxisome biogenesis and protein import in plants, animals and yeasts: enigma and variations? (Review)

Imogen A. Sparkes Centre for Plant Sciences, University of Leeds, Leeds LS2 9JT, UK
&
Alison Baker Centre for Plant Sciences, University of Leeds, Leeds LS2 9JT, UK
Pages 171-185 | Published online: 09 Jul 2009

  • Albertini, M., Rehling, P., Erdmann, R., Girzalsky, W., Kiel, J., Veenhuis, M. and Kunau, W. H., 1997, Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell, 89, 83-92.
  • Baerends, R. J. S., Faber, K. N., Kram, A. M., Kiel, J., van der Kiel, I. J. and Veenhuis, M., 2000, A stretch of positively charged amino acids at the N terminus of Hansenula polymorphe Pex3p is involved in incorporation of the protein into the peroxisomal membrane. Journal of Biological Chemistry, 275, 9986-9995.
  • Baerends, R. J. S., Rasmussen, S. W., Hilbrands, R. E., van der Heide, M., Faber, K. N., Reuvekamp, P. T. W., Kiel, J., Cregg, J. M., van der Klei, I. J. and Veenhuis, M., 1996, The Hansenula polymorphe PER9 gene encodes a peroxisomal membrane protein essential for peroxisome assembly and integrity. Journal of Biological Chemistry, 271, 8887-8894.
  • Baker, A., 1996, Biogenesis of plant peroxisomes. In Membranes, specialised functions in plants, M. Smallwood, J. P. Knox and D. J. Bowles, eds (Oxford: BIOS Scientific Publishers), 421-440.
  • Beevers, H., 1979, Microbodies in higher plants. Annual Review of Plant Physiology, 30, 159-193.
  • Behari, R. and Baker, A., 1993, The carboxyl terminus of isocitrate lyase is not essential for import into glyoxysomes in an in vitro system. Journal of Biological Chemistry, 268, 7315-7322.
  • Berks, B. C., 1996, A common export pathway for proteins binding complex redox cofactors? Molecular Microbiology, 22, 393-404.
  • Braverman, N., Dodt, G., Gould, S. J. and Valle, D., 1998, An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Human Molecular Genetics, 7, 1195-1205.
  • Brosius, U., Dehmel, T. and Gartner, J., 2002, Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes. Journal of Biological Chemistry, 277, 774-784.
  • Chang, C. C., Lee, W. H., Moser, H., Valle, D. and Gould, S. J., 1997, Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Nature Genetics, 15, 385-388.
  • Chang, C. C., Warren, D. S., Sacksteder, K. A. and Gould, S. J., 1999, PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. Journal of Cell Biology, 147, 761-773.
  • Charlton, W. and Lopez-Huertas, E., 2002, PEX genes in plants and other organisms. In Plant peroxisomes. Biochemistry, Cell biology and Biotechnological applications, A. Bakerand I. A. Graham, eds (Dordrecht: Kluwer Academic Publishers), 385-426.
  • Collins, C. S., Kalish, J. E., Morrell, J. C., McCaffery, J. M. and Gould, S. J., 2000, The peroxisome biogenesis factors Pex4p, Pex22p, Pexlp, and Pex6p act in the terminal steps of peroxisomal matrix protein import. Molecular and Cellular Biology, 20, 7516-7526.
  • Crookes, W. J. and Olsen, L. J., 1999, Peroxin puzzles and folded freight: peroxisomal protein import in review. Naturwissenschaften, 96, 51-61.
  • Dammai, V. and Subramani, S., 2001, The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell, 105, 187-196.
  • Danpure, C. J., 1995, How can the products of a single-gene be localized to more than one intracellular compartment Trends in Cell Biology, 5, 230-238.
  • de Duve, C., 1965, Functions of microbodies (peroxisomes). Journal of Cell Biology, 27, 25A.
  • Dodt, G. and Gould, S. J., 1996, Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor Evidence that PTS1 protein import is mediated by a cycling receptor. Journal of Cell Biology, 135, 1763-1774.
  • Dodt, G., Braverman, N., Wong, C., Moser, A., Moser, H. W., Watkins, P., VaIIe, D. and Gould, S. J., 1995, Mutations in the PTS1 receptor gene, Pxr1, define complementation group-2 of the peroxisome biogenesis disorders. Nature Genetics, 9, 115-125.
  • Dodt, G., Warren, D., Becker, E., Rehling, P. and Gould, S. J., 2001, Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p. Journal of Biological Chemistry, 276, 41769-41781.
  • Dyer, J. M., McNew, J. A. and Goodman, J. M., 1996, The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop. Journal of Cell Biology, 133, 269-280.
  • Eastmond, P. J., Germain, V., Lange, P. R., Bryce, J. H., Smith, S. M. and Graham, I. A., 2000, Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle. Proceedings of the National Academy of Sciences (USA), 97, 5669-5674.
  • Einwachter, H., Sowinski, S., Kunau, W. H. and Schliebs, W., 2001, Yarrowia lipolydca Pex20p, Saccharomyces cerevisiae Pex18p/ Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway. Embo Reports, 2, 1035-1039.
  • Elgersma, Y., Elgersma-Hooisma, M., Wenzel, T., McCaffery, J. M., Farquhar, M. G. and Subramani, S., 1998, A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris. Journal Of Cell Biology, 140, 807-820.
  • Elgersma, Y., Kwast, L., van den Berg, M., Snyder, W. B., Distel, B., Subramani, S. and Tabak, H. F., 1997, Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S- cerevisiae, causes proliferation of the endoplasmic reticulum membrane. Embo Journal, 16, 7326-7341.
  • Elgersma, Y., Vanroermund, C. W. T., Wanders, R. J. A. and Tabak, H. F., 1995, Peroxisomal and mitochondria! camitine acetyltransferases of saccharomyces-cerevisiae are encoded by a singlegene. Embo Journal, 14, 3472-3479.
  • Faber, K. N., Haan, G. J., Baerends, R. J. S., Kram, A. M. and Veenhuis, M., 2002, Normal peroxisome development from vesicles induced by truncated Hansenula polymorphe Pex3p. Journal of Biological Chemistry. 277, 11026-11033.
  • Faber, K. N., Heyman, J. A. and Subramani, S., 1998, Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes. Molecular and Cellular Biology, 18, 936-943.
  • Fransen, M., Wylin, T., Brees, C., Mannaerts, G. P. and Van Veldhoven, P. P., 2001, Human Pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. Molecular and Cellular Biology, 21, 4413-4424.
  • Fujiki, Y., 2000, Peroxisome biogenesis and peroxisome biogenesis disorders. Febs Letters. 476, 42-46.
  • Gao, X., Marrison, J. L., Pool, M. R., Leech, R. M. and Baker, A., 1996, Castor bean isocitrate lyase lacking the putative peroxisomal targeting signal 1 ARM is imported into plant peroxisomes both in vitro and in vivo. Plant Physiology, 112, 1457-1464.
  • Gatto, G. J., Geisbrecht, B. V., Gould, S. J. and Berg, J. M., 2000a, Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5. Nature Structural Biology, 7, 1091-1095.
  • Gatto, G. J., Geisbrecht, B. V., Gould, S. J. and Berg, J. M., 2000b, A proposed model for the PEX5-peroxisomal targeting signal-1 recognition complex. Proteins-Structure Function and Genetics, 38, 241-246.
  • Germain, V., Rylott, E. L., Larson, T. R., Sherson, S. M., Bechtold, N., Carde, J. P., Bryce, J. H., Graham, I. A. and Smith, S. M., 2001, Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings. Plant Journal, 28, 1-12.
  • Girzalsky, W., Rehling, P., Stein, K., Kipper, J., Blank, L., Kunau, W. H. and Erdmann, R., 1999, Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes. Journal of Cell Biology, 144, 1151-1162.
  • Glover, J. R., Andrews, D. W. and Rachubinski, R. A., 1994, Saccharomyces-cerevisiae peroxisomal thiolase is imported as a dimer. Proceedings of the National Academy of Sciences (USA), 91, 10541-10545.
  • Gotte, K., Girzalsky, W., Linken, M., Baumgart, E., Kammerer, S., Kunau, W. H. and Erdmann, R., 1998, Pex19p, a famesylated protein essential for peroxisome biogenesis. Molecular and Cellular Biology, 18, 616-628.
  • Gould, S. J., Keller, G. A., Hosken, N., Wilkinson, J. and Subramani, S., 1989, A conserved tripeptide sorts proteins to peroxisomes. Journal of Cell Biology, 108, 1657-1664.
  • Gouveia, A. M. M., Reguenga, C., Oliveira, M. E. M., Sa-Miranda, C. and Azevedo, J. E., 2000, Characterization of peroxisomal Pex5p from rat liver-Pex5p in the Pex5p-Pex14p membrane complex is a transmembrane protein. Journal of Biological Chemistry, 275, 32444-32451
  • Harano, T., Nose, S., Uezu, R., Shimizu, N. and Fujiki, Y., 2001, Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTSI)-receptor Pex5p and PTS1. Biochemical Journal, 357, 157-165.
  • Hayashi, M., Toriyama, K., Kondo, M. and Nishimura, M., 1998, 2, 4-Dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid beta-oxidation. Plant Cell, 10, 183-195.
  • Hettema, E. H., Girzalsky, W., van den Berg, M., Erdmann, R. and Distel, B., 2000, Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins. Embo Journal, 19, 223-233.
  • Hettema, E. H., Ruigrok, C. C. M., Koerkamp, M. G., van den Berg, M., Tabak, H. F., Distel, B. and Braakman, L, 1998, The cytosolic DnaJ-like protein Djp1p is involved specifically in peroxisomal protein import. Journal of Cell Biology, 142, 421-434.
  • Honsho, M. and Fujiki, Y., 2001, Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments--study using human membrane protein PMP34. Journal of Biological Chemistry. 276, 9375-9382.
  • Huhse, B., Rehling, P., Albertini, M., Blank, L., Meiler, K. and Kunau, W. H., 1998, Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. Journal of Cell Biology, 140, 49-60.
  • lmanaka, T., Small, G. M. and Lazarow, P. B., 1987, Translocation of acyl-coa oxidase into peroxisomes requires ATP hydrolysis but not a membrane-potential Journal of Cell Biology, 105, 2915-2922.
  • James, G. L., Goldstein, J. L., Pathak, R. K., Andersen, R. G. W. and Brown, M. S., 1994, Pxf, a prenylated protein of peroxisomes. Journal of Biological Chemistry, 269, 14182-14190.
  • Jones, J. M., Morrell, J. C. and Gould, S. J., 2001, Multiple distinct targeting signals in integral peroxisomal membrane proteins. Journal of Cell Biology, 153, 1141-1149.
  • Kalish, J. E., Theda, C., Morrell, J., Berg, J. M. and Gould, S. J., 1995, Formation of peroxisome lumen is abolished by loss of Pichia pastoris Pas7p, a zinc-binding integral membrane protein of the peroxisome. Molecular and Cellular Biology, 15, 6406-6419.
  • Kammerer, S., Holzinger, A., Welsch, U. and Roscher, A. A., 1998, Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p. Febs Letters, 429, 53-60.
  • Keller, G. A., Gould, S., Deluca, M. and Subramani, S., 1987, Firefly luciferase is targeted to peroxisomes in mammalian-cells. Proceedings of the National Academy of Sciences (USA), 84, 3264-3268.
  • Klein, A. T. J., Bamett, P., Bottger, G., Konings, D., Tabak, H. F. and Distel, B., 2001, Recognition of peroxisomal targeting signal type 1 by the import receptor Pex5p. Journal of Biological Chemistry, 276, 15034-15041.
  • Klein, A. T. J., van den Berg, M., Bottger, G., Tabak, H. and Distel, B., 2002, Saccharomyces cerevisiae acyl-CoA oxidase follows a novel, non-PTS1, import pathway into peroxisomes that is dependent on Pex5p. Journal of Biological Chemistry, 277, 25011-25019.
  • Knott, T. G., Birdsey, G. M., Sinclair, K. E., Gallagher, I. M., Purdue, P. E. and Danpure, C. J., 2000, The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine:glyoxylate aminotransferase. Biochemical Journal, 352, 409-418.
  • Koller, A., Snyder, W. B., Faber, K. N., Wenzel, T. J., Rangell, L., Keller, G. A. and Subramani, S., 1999, Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane. Journal of Cell Biology, 146, 99-112.
  • Kragler, F., Langeder, A., Raupachova, J., Binder, M. and Hartig, A., 1993, Two independent peroxisomal targeting signals in Ccatalase-a of saccharomyces-cerevisiae. Journal of Cell Biology, 120, 665-673.
  • Kunau, W. H., 2001, Peroxisomes: The extended shuttle to the peroxisome matrix. Current Biology, 11, R659-R662.
  • Lametschwandtner, G., Brocard, C., Fransen, M., Van Veldhoven, P., Berger, J. and Hartig, A., 1998, The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor PexSp to the cognate signal and to residues adjacent to it. Journal of Biological Chemistry. 273, 33635-33643.
  • Lazarow, P. B. and Fujiki, Y., 1985, Biogenesis of peroxisomes. Annual Review of Cell Biology, 1, 489-530.
  • Lin, Y., Sun, L., Nguyen, L. V., Rachubinski, R. A. and Goodman, H. M., 1999, The pex16p homolog SSE1 and storage organelte formation in Arabidopsis seeds. Science, 284, 328-330.
  • Marzioch, M., Erdmann, R., Veenhuis, M. and Kunau, W. H., 1994, Pas7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-coa thiolase, a Pts2-containing protein, into peroxisomes. Embo Journal, 13, 4908-4918.
  • Matsumura, T., Otera, H. and Fujiki, Y., 2000, Disruption of the interaction of the longer isoform of PexSp, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2-study with a novel PEX5-impaired Chinese hamster ovary cell mutant Journal of Biological Chemistry, 275, 21715-21721.
  • Matsuzono, Y., Kinoshita, N., Tamura, S., Shimozawa, N., Hamasaki, M. Ghaed, K., Wanders, R. J. A., Suzuki, Y., Kondo, N. and Fujiki, Y., 1999, Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Proceedings of the National Academy of Sciences (USA), 96, 2116-2121.
  • Motley, A. M., Hettema, E. H., Ketting, R., Plasterk, R. and Tabak, H. F., 2000, Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes. Embo Reports, 1, 40-46.
  • Mullen, R. T., 2002, Targeting and import of matrix proteins into peroxisomes. In Plant peroxisomes. Biochemistry, Cell biology and Biotechnological applications, A. Baker and I. A. Graham, eds (Dordrecht: Kluwer Academic Publishers), 339-384.
  • Mullen, R. T. and Trelease, R. N., 1996, Biogenesis and membrane properties of peroxisomes: does the boundary membrane serve and protect? Trends in Plant Science, 1, 389-394.
  • Mullen, R. T. and Trelease, R. N., 2000, The sorting signals for peroxisomal membrane-bound ascorbate peroxidase are within its C-terminal tail. Journal of Biological Chemistry, 275, 16337-16344.
  • Mullen, R. T., Flynn, C. R. and !release, R. N., 2001, How are peroxisomes formed? The role of the endoplasmic reticulum and peroxins. Trends in Plant Science, 6, 256-261.
  • Mullen, R. T., Lee, M. S., Flynn, C. R. and !release, R. N., 1997a, Diverse amino acid residues function within the type 1 peroxisomal targeting signal. Implications for the role of accessory residues upstream of the type 1 peroxisomal targeting signal. Plant Physiology, 115, 881-889.
  • Mullen, R. T., Lee, M. S. and !release, R. N., 1997b, Identification of the peroxisomal targeting signal for cottonseed catalase. Plant Journal, 12, 313-322.
  • Mullen, R. T., Lisenbee, C. S., Miemyk, J. A. and Trelease, R. N., 1999, Peroxisomal membrane ascorbate peroxidase is sorted to a membranous network that resembles a subdomain of the endoplasmic reticulum. Plant Cell, 11, 2167-2185.
  • Nilsson, I., Ohvo-Rekila, H., Slotte, J. P., Johnson, A. E. and von Heijne, G., 2001, Inhibition of protein translocation across the endoplasmic reticulum membrane by sterols. Journal of Biological Chemistry, 276, 41748-41754.
  • Nito, K., Hayashi, M. and Nishimura, M., 2002, Direct interaction and determination of binding domains among peroxisomal import factors in Arabidopsis thaliana. Plant and Cell Physiology, 43, 355-366.
  • Okumoto, K., Itoh, R., Shimozawa, N., Suzuki, Y., Tamura, S., Kondo, N. and Fujiki, Y., 1998a, Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B. Human Molecular Genetics, 7, 1399-1405.
  • Okumoto, K., Shimozawa, N., Kawai, A., Tamura, S., Tsukamoto, T., Osumi, T., Moser, H., Wanders, R. J. A., Suzuki, Y., Kondo, N. and Fujiki, Y., 1998b, PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation of a CHO cell mutant patient analysis, and characterization of Pex12p. Molecular and Cellular Biology, 18, 4324-4336.
  • Otera, H., Okumoto, K., Tateishi, K., Ikoma, Y., Matsuda, E., Nishimura, M., Tsukamoto, T., Osumi, T., Ohashi, K., Higuchi, O. and Fujiki, Y., 1998, Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants. Molecular and Cellular Biology, 18, 388-399.
  • Otera, H., Setoguchi, K., Hamasaki, M., Kumashiro, T., Shimizu, N. and Fujiki, Y., 2002, Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner conserved Pex5p WXXYF/Y motifs are critical for matrix protein import Molecular and Cellular Biology, 22, 1639-1655.
  • Pause, B., Saffrich, R., Hunziker, A., Ansorge, W. and Just, W. W., 2000, Targeting of the 22kDa integral peroxisomal membrane protein. Febs Letters. 471, 23-28.
  • Phoenix, D. A. and Harris, F., 1998, Amphiphilb alpha-helices and lipid interactions. In Protein targeting and translocation, D. A. Phoenix, ed. (London: Portland Press research monograph), 19-36.
  • Pool, M. R., Lopez-Huertas, E. and Baker, A., 1998, Characterization of intermediates in the process of plant peroxisomal protein import. Embo Journal. 17, 6854-6862.
  • Purdue, P. E. and Lazarow, P. B., 1996, Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence. Journal of Cell Biology, 134, 849-862.
  • Purdue, P. E. and Lazarow, P. B., 2001a, Peroxisome biogenesis. Annual Review of Cell and Developmental Biology, 17, 701-752.
  • Purdue, P. E. and Lazarow, P. B., 2001 b, Pex18p is constitutively degraded during peroxisome biogenesis. Journal of Biological Chemistry, 276, 47684-47689.
  • Reguenga, C., Oliveira, M. E. M., Gouveia, A. M. M., Sa-Miranda, C. and Azevedo, J. E., 2001, Characterization of the mammalian peroxisomal import machinery. Journal of Biological Chemistry, 276, 29935-29942.
  • Rehling, P., Skaletz-Rorowski, A., Girzalsky, W., Voorn-Brouwer, T., Franse, M. M., Distel, B., Veenhuis, M., Kunau, W. H. and Erdmann, R., 2000, Pex5p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor Pex5p. Journal of Biological Chemistry. 275, 3593-3602.
  • Rhodin, J., 1958, Anatomy of kidney tubules. International Review of Cytology, 7, 485-534.
  • Sacksteder, K. A. and Gould, S. J., 2000, The genetics of peroxisome biogenesis. Annual Review of Genetics, 34, 623-652.
  • Sacksteder, K. A., Jones, J. M. South, S. T., Li, X. L., Liu, Y. F. and Gould, S. J., 2000, PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. Journal of Cell Biology, 148, 931-944.
  • Saidowsky, J., Dodt, G., Kirchberg, K., Wegner, A., Nastainczyk, W., Kunau, W. H. and Schliebs, W., 2001, The di-aromatb pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14. Journal of Biological Chemistry. 276, 34524-34529.
  • Santos, M. J., lmanaka, T., Shio, H., Small, G. M. and Lazarow, P. B., 1988, Peroxisomal membrane ghosts in Zellweger syndrome-aberrant organelte assembly. Science, 239, 1536-1538.
  • Shimozawa, N., Tsukamoto, T., Suzuki, Y., Orii, T., Shirayoshi, Y., Mori, T. and Fujiki, Y., 1992, A human gene responsible for Zellweger syndrome that affects peroxisome assembly. Science, 255, 1132-1134.
  • Smith, J. J. and Rachubinski, R. A., 2001, A role for the peroxin PexSp in Pex20p-dependent thiolase import into peroxisomes of the yeast Yarrowia lipolytica. Journal of Biological Chemistry, 276, 1618-1625.
  • Smith, M. D. and Schnell, D. J., 2001, Peroxisomal protein import the paradigm shifts. Cell, 105, 293-296.
  • Snyder, W. B., Faber, K. N., Wenzel, T. J., Koller, A., Luers, G. H., Rangell, L., Keller, G. A. and Subramani, S., 1999, Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris. Molecular Biology of the Cell, 10, 1745-1761.
  • Snyder, W. B., Koller, A., Choy, A. J. and Subramani, S., 2000, The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane. Journal of Cell Biology, 149, 1171-1177.
  • Soukupova, M., Sprenger, C., Gorgas, K., Kunau, W. H. and Dodt, G., 1999, Identification and characterization of the human peroxin PEX3. European Journal of Cell Biology. 78, 357-374.
  • South, S. T. and Gould, S. J., 1999, Peroxisome synthesis in the absence of preexisting peroxisomes. Journal of Cell Biology, 144, 255-266.
  • South, S. T., Baumgart, E. and Gould, S. J., 2001, Inactivation of the endoplasmic reticulum protein translocation factor, Sec61p, or its homolog, Ssh1p, does not affect peroxisome biogenesis. Proceedings of the National Academy of Sciences (USA), 98, 12027-12031.
  • South, S. T., Sacksteder, K. A., Li, X. L., Liu, Y. F. and Gould, S. J.,2000. Inhibitors of COPI and COPII do not block PEX3-mediatedperoxisome synthesis. Journal of Cell Biology, 149, 1345-1359.
  • Stewart, M. Q., Esposito, R. D., Gowani, J. and Goodman, J. M.,2001. Alcohol oxidase and dihydroxyacetone synthase, the abundant peroxisomal proteins of methylotrophic yeasts, assemble in different cellular compartments. Journal of Cell Science, 114, 2863-2868.
  • Swinkels, B. W., Gould, S. J., Bodnar, A. G., Rachubinski, R. A. and Subramani, S., 1991, A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. Embo Journal, 10, 3255-3262.
  • Teriecky, S. R., Legakis, J. E., Hueni, S. E. and Subramani, S., 2001, Quantitative analysis of peroxisomal protein import in vitro. Experimental Cell Research, 263, 98-106.
  • Teriecky, S. R., Nuttley, W. M., McCollum, D., Sock, E. and Subramani, S., 1995, The pichia-pastoris peroxisomal protein PasSp is the receptor for the C-terminal tripeptide peroxisomal targeting signal. Embo Journal, 14, 3627-3634.
  • Titorenko, V. I. and Rachubinski, R. A., 1998, Mutants of the yeast Yarrowia lipolytica defective in protein exit from the endoplasmic reticulum are also defective in peroxisome biogenesis. Molecular and Cellular Biology, 18, 2789-2803.
  • Titorenko, V. I. and Rachubinski, R. A., 2000, Peroxisomal membrane fusion requires two AAA family ATPases, Pex1p and Pex6p. Journal of Cell Biology, 150, 881-886.
  • Titorenko, V. I. and Rachubinski, R. A., 2001, Dynamics of peroxisome assembly and function. Trends in Cell Biology, 11, 22-29
  • Titorenko, V. I., Chan, H. and Rachubinski, R. A., 2000, Fusion of small peroxisomal vesicles In vitro reconstructs an early step in the in vivo multistep peroxisome assembly pathway of Yarrowia lipolytica. Journal of Cell Biology. 148, 29-43.
  • Titorenko, V. I., Ogrydziak, D. M. and Rachubinski, R. A., 1997, Four distinct secretory pathways serve protein secretion, cell surface growth, and peroxisome biogenesis in the yeast Yarrowia lipolytica. Molecular and Cellular Biology. 17, 5210-5226.
  • Titorenko, V. I., Smith, J. J., Szilard, R. K. and Rachubinski, R. A., 1998, Pex20p of the yeast Yarrowia lipolytica is required for the oligomerization of thiolase in the cytosol and for its targeting to the peroxisome. Journal of Cell Biology, 142, 403-420.
  • !release, R. N., 2002, Peroxisomal biogenesis and acquistion of membrane proteins. In Plant peroxisomes. Biochemistry,Cell biology and Biotechnological applications, A. Baker and I. A. Graham, eds (Dordrecht: Kluwer Academic Publishers), 305-338.
  • Urquhart, A. J., Kennedy, D., Gould, S. J. and Crane, D. I., 2000, Interaction of Pex5p, the type 1 peroxisome targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p. Journal of Biological Chemistry. 275, 4127-4136.
  • van der Klei, I. J., Hilbrands, R. E., Kiel, J., Rasmussen, S. W., Cregg, J. M. and Veenhuis, M., 1998, The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorphe is required for efficient functioning of the PTS1 import machinery. Embo Journal, 17, 3608-3618.
  • Voorn-Brouwer, T., Kragt, A., Rank, H. F. and Distel, B., 2001, Peroxisomal membrane proteins are property targeted to peroxisomes in the absence of COPI- and COPII-mediated vesicular transport Journal of Cell Science. 114, 2199-2204.
  • Wallon, P. A., Hill, P. E. and Subramani, S., 1995, Import of stably folded proteins into peroxisomes. Molecular Biology of the Cell, 6, 675-683.
  • Wallon, P. A., Wendland, M., Subramani, S., Rachubinski, R. A. and Welch, W. J., 1994, Involvement of 70-Kd heat-shock proteins in peroxisomal import Journal of Cell Biology, 125, 1037-1046.
  • Wang, X. D., Ballard, J. L., Shelton, S. N. and Goodman, J. M., 2001, Different fragments of Pmp47 target preferentially to subclasses of peroxisomes. Molecular Biology of the Cell, 12, 2764.
  • Warren, D. S., Morrell, J. C., Moser, H. W., VaIIe, D. and Gould, S. J., 1998, Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. American Journal of Human Genetics, 63, 347-359.
  • Watts, A. and Pinheiro, T. J. T., 1998, Biophysics of the membrane interface and its involvement in protein targeting and translocation. In Protein targeting and translocation, D. A. Phoenix, ed. (London: Portland press research monograph), 1-17.
  • Wendland, M. and Subramani, S., 1993, Cytosol-dependent peroxisomal protein import in a permeabilized cell system. Journal of Cell Biology, 120, 675-685.
  • Wiebel, F. F. and Kunau, W. H., 1992, The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature, 359, 73-76.
  • Wiener, E. A. C., Luers, G. H., Faber, K. N., Wenzel, T., Veenhuis, M. and Subramani, S., 1996, Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris. Journal of Biological Chemistry, 271, 18973-18980.
  • Wimmer, C., Schmid, M., Veenhuis, M. and Gietl, C., 1998, The plant PTS1 receptor similarities and differences to its human and yeast counterparts. Plant Journal, 16, 453-464.
  • Yang, X. D., Purdue, P. E. and Lazarow, P. B., 2001, EcI14p uses a PTS1 to enter peroxisomes: either its own or that of a partner, DcHp. European Journal of Cell Biology. 80, 126-138.
  • Zhang, J. W. and Lazarow, P. B., 1996, Peblp (Pas7p) is an intraperoxisomal receptor for the NH2- terminal, type 2, peroxisomal targeting sequence of thiolase: Peb1 p itself is targeted to peroxisomes by an NH2-terminal peptide. Journal of Cell Biology, 132, 325-334.
  • Zolman, B. K., Yoder, A. and Bartel, B., 2000, Genetic analysis of indole-3-butyrb acid responses in Arabidopsis thaliana reveals four mutant classes. Genetics, 156, 1323-1337.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.