Advanced search
Publication Cover
Molecular Membrane Biology Volume 20, 2003 - Issue 2
Journal homepage
918
Views
121
CrossRef citations to date
0
Altmetric
Research Article

Membrane dynamics and the biogenesis of lysosomes (Review)

J. Paul Luzio Cambridge Institute for Medical Research and Department of Clinical Biochemistry University of Cambridge, Addenbrooke's Hospital Hills Road CB2 2XY Cambridge
,
Viviane Poupon Cambridge Institute for Medical Research and Department of Clinical Biochemistry University of Cambridge, Addenbrooke's Hospital Hills Road CB2 2XY Cambridge
,
Margaret R. Lindsay Cambridge Institute for Medical Research and Department of Clinical Biochemistry University of Cambridge, Addenbrooke's Hospital Hills Road CB2 2XY Cambridge
,
Barbara M. Mullock Cambridge Institute for Medical Research and Department of Clinical Biochemistry University of Cambridge, Addenbrooke's Hospital Hills Road CB2 2XY Cambridge
,
Robert C. Piper Department of Physiology and Biophysics University of Iowa 52242 Iowa City, IA
&
Paul R. Pryor Cambridge Institute for Medical Research and Department of Clinical Biochemistry University of Cambridge, Addenbrooke's Hospital Hills Road CB2 2XY Cambridge
Pages 141-154 | Published online: 09 Jul 2009

  • Advani, R. J., Yang, B., Prekeris, R., Lee, K. C., Klumperman, J. and Scheller, R. H., 1999, VAMP-7 mediates vesicular transport from endosomes to lysosomes. Journal of Cell Biology, 146, 765-776.
  • Aguilar R. C., Boehm M., Gorshkova I., Crouch R. J., Tomita K., Saito T., Ohno H., Bonifacino J. S. Signal-binding specificity of the μ4 subunit of the adaptor protein complex AP-4 Journal of Biological Chemistry 2001; 276: 13145-13152
  • Akasaki, K., Michihara, A., Fujiwara, Y., Mibuka, K. and Tsuji, H., 1996, Biosynthetic transport of a major lysosome-associated membrane glycoprotein 2, lamp-2: a significant fraction of newly synthesized lamp-2 is delivered to lysosomes by way of early endosomes. Journal of Biochemistry, 120, 1088-1094.
  • Akasaki K., Michihara A., Mibuka K., Fujiwara Y., Tsuji H. Biosynthetic transport of a major lysosomal membrane glycoprotein, lamp-1: convergence of biosynthetic and endocytic pathways occurs at three distinctive points Experimental Cell Research 1995; 220: 464-473
  • Andrews N. W. Regulated secretion of conventional lysosomes Trends in Cell Biology 2000; 10: 316-321
  • Andrews, N. W., 2002, Lysosomes and the plasma membrane: trypanosomes reveal a secret relationship. Journal of Cell Biology, 158, 389-394.
  • Andrejewski N., Punnonen E.-L., Guhde G., Tanaka Y., Lüllmann-Rauch R., Hartmann D., von Figura K., Saftig P. Normal lysosomal morphology and function in LAMP-1-deficient mice Journal of Biological Chemistry 1999; 274: 12692-12701
  • Aniento F., Emans N., Griffiths G., Gruenberg J. Cytoplasmic dyneindependent vesicular transport from early to late endosomes Journal of Cell Biology 1993; 123: 1373-1387
  • Antonin, W., Dulubova, I., Arac, D., Pabst, S., Plitzner, J., Rizo, J. and Jahn R., 2002b, The N-terminal domains of syntaxin 7 and vti 1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly. Journal of Biological Chemistry, in press.
  • Antonin, W., Fasshauer, D., Becker, S., Jahn, R. and Schneider, T. R., 2002, Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nature Structure Biology, 9, 107-111.
  • Antonin, W., Holroyd, C., Fasshauer, D., Pabst, S., Von Mollard, G. F. and Jahn, R., 2000, A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. EMBO Journal, 19, 6453-6464.
  • Arvan, P., Zhang, B.-Y., Feng, L., Liu, M. and Kuliawat, R., 2002, Lumenal protein multimerization in the distal secretory pathway/ secretory granules. Current Opinions in Cell Biology, 14, 448453.
  • Babst M., Katzmann D. J., Estepa-Sabal E. J., Meerloo T., Emr S. D. ESCRT-III: an endosome-associated heterooligomeric protein complex required for MVB sorting Developmental Cell 2002; 3: 271-282
  • Babst M., Katzmann D. J., Snyder W. B., Wendland B., Emr S. D. Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body Developmental Cell 2002; 3: 283-289
  • Babst M., Odorizzi G., Estepa E. J., Emr S. D. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking Traffic 2000; 1: 248-258
  • Bainton D. F. The discovery of lysosomes Journal of Cell Biology 1981; 91: 66s-76s
  • Bargal, R., Avidan, N., Ben-Asher, E., Olender, Z., Zeigler, M., Frumkin, A., Raas-Rothschild, A., Glusman, G., Lancet, D. and Bach, G., 2000, Identification of the gene causing mucolipidosis type IV. Nature Genetics, 26, 120-123.
  • Barois N., de Saint-Vis B., Lebecque S., Geuze H. J., Kleijmeer M. J. MHC class II compartments in human dendritic cells undergo profound structural changes upon activation Traffic 2002; 3: 894-905
  • Barriocanal, J. G., Bonifacino, J. S., Yuan, L. and Sandoval, I. V., 1986, Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrateindependent mechanism of three lysosomal integral membrane proteins. Journal of Biological Chemistry, 261, 16755-16763.
  • Bassi, M. T., Manzoni, M., Monti, E., Pizzo, M. T., Ballabio, A. and Borsani, G., 2000, Cloning of the gene encoding a novel integral membrane protein, mucolipidin- and identification of the two major founder mutations causing mucolipidosis type PV. American Journal of Human Genetics, 67, 1110-1120.
  • Bauerfeind, R. and Huttner, W. B., 1993, Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles. Current Opinion in Cell Biology, 5, 628-635.
  • Bilodeau, P. S., Urbanowski, J. L., Winistorfer, S. C. and Piper, R. C., 2002, The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nature Cell Biology, 4, 534-539.
  • Blott, E. J. and Griffiths, G. M., 2002, Secretory lysosomes. Nature Reviews in Molecular Cell Biology, 3, 122-131.
  • Bock, J. B., Matem, H. T., Peden, A. A. and Scheller, R. H., 2001, A genomic perspective on membrane compartment organization. Nature, 409, 839-841.
  • Bogdanovic A., Bennett N., Kieffer S., Louwagie M., Morio T., Garin J., Satre M., Bruckert F. Syntaxin 7, Syntaxin 8, Vti1 and VAMP7 form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum Biochemical Journal 2002; 368: 29-39
  • Bonangelino, C. J., Chavez, E. M. and Bonifacino, J. S., 2002, Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Molecular Biology of the Cell, 13, 24862501.
  • Bonifacino J. S., Dell'Angelica E. C. Molecular bases for the recognition of tyrosine-based sorting signals Journal of Cell Biology 1999; 145: 923-926
  • Braun, M., Waheed, A. and von Figura, K., 1989, Lysosomal acid phosphatase is transported to lysosomes via the cell surface. EMBO Journal, 8, 3633-3640.
  • Bright, N. A., Reaves, B. J., Mullock, B. M. and Luzio, J. P., 1997, Dense core lysosomes can fuse with late endosomes and are reformed from the resultant hybrid organelles. Journal of Cell Science, 110, 2027-2040.
  • Bucci, C., Thomson, P., Nicoziani, P., McCarthy, J. and van Deurs, B., 2000, Rab7: a key to lysosome biogenesis. Molecular Biology of the Cell, 11, 467-480.
  • Caplan, S., Hartnell, L. M., Aguilar, R. C., Naslavsky, N. and Bonifacino, J. S., 2001, Human Vam6p promotes lysosome clustering and fusion in vivo. Journal of Cell Biology, 154, 109122.
  • Carisson, S. R. and Fukuda, M., 1992, The lysosomal membrane glycoprotein lamp-1 is transported to lysosomes by two alternative pathways. Archives of Biochemistry and Biophysics, 296, 630-639.
  • Casciola-Rosen, L. A. and Hubbard, A. L., 1991, Hydrolases in intracellular compartments of rat liver cells. Evidence for selective activation and/or delivery. Journal of Biological Chemistry, 266, 4341-4347.
  • Chen, C.-S., Bach, G. and Pagano, R. E., 1998, Abnormal transport along the lysosomal pathway in Mucolipidosis type IV disease. Proceeding of the National Academy of Sciences (USA), 95, 6373-6378.
  • Cherqui, S., Kalatzis, V., Trugnan, G. and Antignac, C., 2001, The targeting of cystinosin to the lysosomal membrane requires atyrosine-based signal and a novel sorting motif. Journal of Biological Chemistry, 276, 13314-13321.
  • Chow A., Toomre D., Garrett W., Mellman I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane Nature 2002; 418: 988-994
  • Christensen, K. A., Myers, J. T. and Swanson, J. A., 2001, pHdependent regulation of lysosomal calcium in macrophages. Journal of Cell Science, 115, 599-607.
  • Collins B. M., McCoy A. J., Kent H. M., Evans P. R., Owen D. J. Molecular architecture and functional model of the endocytic AP2 complex Cell 2002; 109: 523-535
  • Conibear E. An ESCRT into the endosome Molecular Cell 2002; 10: 215
  • Cowles C. R., Odorizzi G., Payne G. S., Emr S. D. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole Cell 1997; 91: 109-118
  • Darsow, T., Rieder, S. E. and Emr, S. D., 1997, A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. Journal of Cell Biology, 138, 517-529.
  • de Duve, C., 1983, Lysosomes revisited. European Journal of Biochemistry, 137, 391-397.
  • Dell'Angelica E. C., Payne G. S. Intracellular cycling of lysosomal enzyme receptors: cytoplasmic tails' tales Cell 2001; 106: 395-398
  • Dell'Angelica E. C., Klumperman J., Stoorvogel W., Bonifacino J. S. Association of the AP-3 adaptor complex with clathrin Science 1998; 280: 431-434
  • Dell'Angelica E. C., Shotelersuk V., Aguilar R. C., Gahl W. A., Bonifacino J. S. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the β3A subunit of the AP-3 adaptor Molecular Cell 1999; 3: 11-21
  • Diaz E., Pfeffer S. R. TIP47: a cargo selection device for mannose 6 phosphate receptor trafficking Cell 1998; 93: 433-443
  • Doray, B., Ghosh, P., Griffith, J., Geuze, H. J. and Kornfeld, S., 2002, Cooperation of GGAs and AP-1 in packaging MPRs at the transGolgi network. Science, 297, 1700-1703.
  • D'Souza M. P., August J. T. A kinetic analysis of biosynthesis and localization of a lysosome-associated membrane glycoprotein Archives of Biochemistry and Biophysics 1986; 249: 522-532
  • Fares H., Grant B. Deciphering endocytosis in Caenorhabditis elegans Traffic 2002; 3: 11-19
  • Fasshauer, D., Sutton, R. B., Brunger, A. T. and Jahn, R., 1998, Conserved structural features of the synaptic fusion complex: SNARE proteins reclassifled as Q- and R-SNAREs. Proceedings of the National Academy of Sciences (USA), 95, 15781-15786.
  • Filippini F., Rossi V., Galli T., Budillon A., D'Urso M., D'Esposito M. Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain Trends in Biochemical Science 2001; 26: 407-409
  • Fukuda, R., McNew, J. A., Weber, T., Parlati, F., Engel, T., Nickel, W., Rothman, J. E. and Sollner, T. H., 2000, Functional architecture of an intracellular membrane t-SNARE. Nature, 407, 198-202.
  • Futter C. E., Pearse A., Hewlett L. J., Hopkins C. R. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes Journal of Cell Biology 1996; 132: 1011-1023
  • Gagnon E., Duclos S., Rondeau C., Chevet E., Cameron P. H., Steele-Mortimer O., Paiement J., Bergeron J. J. M., Desjardins M. Endoplasmic reticulum mediated phagocytosis is a mechanism of entry into macrophages Cell 2002; 110: 119-131
  • Gillooly, D. J., Morrow, I. C., Lindsay, M., Gould, R., Bryant, N. J., Gaultier, J. M., Parton, R. G. and Stenmark, H., 2000, Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO Journal, 19, 4577-4588.
  • Green S. A., Zimmer K. P., Griffiths G., Mellman I. Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins Journal of Cell Biology 1987; 105: 1227-1240
  • Griffiths, G., 1996, On vesicles and membrane compartments. Protoplasma, 195, 37-58.
  • Gruenberg J., Maxfield F. R. Membrane transport in the endocytic pathway Current Opinion in Cell Biology 1995; 7: 552-563
  • Gu F., Gruenberg J. Biogenesis of transport intermediates in the endocytic pathway FEBS Letters 1999; 452: 61-66
  • Haft, C. R., de Ia Luz Sierra, M., Bafford, R., Lesniak, M. A., Barr, V. A. and Taylor, S. I., 2000, Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Molecular Biology of the Cell, 11, 4105-4116.
  • Hanna, J., Carroll, K. and Pfeffer, S. R., 2002, Identification of residues in TIP47 essential for Rab9 binding. Proceedings of the National Academy of Sciences (USA), 99, 7450-7454.
  • Harding C. V., Collins D. S., Slot J. W., Geuze H. J., Unanue E. R. Liposome-encapsulated antigens are processed in lysosomes, recycled and presented to T-cells Cell 1991; 64: 393-401
  • Harris, E. and Cardelli, J., 2002, RabD, a dictyostelium Rab14related GTPase, regulates phagocytosis and homotypic phagosome and lysosome fusion. Journal of Cell Science, 115, 37033713.
  • Hilden, S. A. and Madias, N. E., 1989, H+/Ca2+ exchange in rabbit renal cortical endosomes. Journal of Membrane Biology, 112, 131-138.
  • Hirst, J. and Robinson, M. S., 1998, Clathrin and adaptors. Biochimica et Biophysics Acta, 1404, 173-193.
  • Hirst, J., Futter, C. E. and Hopkins, C. R., 1998, The kinetics of mannose 6-phosphate receptor trafficking in the endocytic pathway in HEp-2 cells: the receptor enters and rapidly leaves multivesicular endosomes without accumulating in a prelysosomal compartment. Molecular Biology of the Cell, 9, 809-816.
  • Holroyd, C., Kistner, U., Annaert, W. and Jahn, R., 1999, Fusion of endosomes involved in synaptic vesicle recycling. Molecular Biology of the Cell, 10, 3035-3044.
  • Holtzmann, E., 1989, Lysosomes (New York, London: Plenum Press).
  • Honing, S., Griffith, J., Geuze, H. J. and Hunziker, W., 1996, The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles. EMBO Journal, 15, 5230-5239.
  • Huizing, M., Sarangarajan, R., Strovel, E., Zhao, Y., Gahl, Y. and Boissy, R. E., 2001a, AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes. Molecular Biology of the Cell, 12, 2075-2085.
  • Huizing M., Didier A., Walenta J., Anikster Y., Gahl W. A., Kramer H. Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33 Gene 2001b; 264: 241-247
  • Hunziker, W. and Geuze, H. J., 1996, lntracellular trafficking of lysosomal membrane proteins. Bioessays, 18, 379-389.
  • Ihrke G., Gray S. R., Luzio J. P. Endolyn is a mucin-like type I membrane protein targeted to lysosomes by its cytoplasmic tail Biochemical Journal 2000; 345: 287-296
  • Jahraus, A., Egeberg, M., Hinner, B., Habermann, A., Sackman, E., Pralle, A., Faulstich, H., Rybin, V., Defacque, H. and Griffiths, G., 2001, ATP-dependent membrane assembly of F-actin facilitates membrane fusion. Molecular Biology of the Cell, 12, 155-170.
  • Jahraus, A., Tjelle, T. E., Berg, T., Habermann, A., Storrie, B., Ullrich, O. and Griffiths, G., 1998, In vitro fusion of phagosomes with different endocytic organelles from J774 macrophages. Journal of Biological chemistry, 273, 30379-30390.
  • Jones, E. W., 1977, Proteinase mutants of Saccharomyces cerevisiae. Genetics, 85, 23-33.
  • Katzmann D. J., Babst M., Emr S. D. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I Cell 2001; 106: 145-155
  • Kim, B. Y., Kramer, H., Yamamoto, A., Kominami, E., Kohsaka, S. and Akazawa, C., 2001, Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. Journal of Biological Chemistry, 276, 29393-29402.
  • Kleijmeer, M., Ramm, G., Schuurhuis, D., Griffith, J., Rescigno, M., Ricciardi-Castagnoli, P., Rudensky, A. Y., Ossendorp, F., Melief, C. J., Stoorvogel, W. and Geuze, H. J., 2001, Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. Journal of Cell Biology, 155, 53-63.
  • Klionsky D. J. Protein transport from the cytoplasm to the vacuole Journal of Membrane Biology 1997; 157: 105-115
  • Klionsky, D. J., Herman, P. K. and Emr, S. D., 1990, The fungal vacuole: composition, function and biogenesis. Microbiology Reviews, 54, 266-292.
  • Ko, D. C., Gordon, M. D., Jin, J. Y. and Scott, M. P., 2001, Dynamic movements of organelles containing Niemann-Pick Cl protein: NPC1 involvement in late endocytic events. Molecular Biology of the Cell, 12, 601-614.
  • Kornfeld, S. and Mellman, I., 1989, The biogenesis of lysosomes. Annual Review of Cell Biology, 5, 483-525.
  • LaPlante, J. M., Falardeau, J., Sun, M., Kanazirska, M., Brown, E. M., Slaugenhaupt, S. A. and Vassilev, P. M., 2002, Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. FEBS Letters, 532, 183-187.
  • Lawrence, B. P. and Brown, W. J., 1992, Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes. Journal of Cell Science, 102, 515-526.
  • Le Borgne, R., Alconada, A., Bauer, U. and Hoflack, B., 1998, The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins. Journal of Biological Chemistry, 273, 29451-29461.
  • Lemons, R. M. and Thoene, J. G., 1991, Mediated calcium transport by isolated human flbroblast lysosomes. Journal of Biological Chemistry, 266, 14378-14382.
  • Liscum L. Niemann-Pick type C mutations cause lipid traffic jam Traffic 2000; 1: 218-225
  • Luzio, J. P., Rous, B. A., Bright, N. A., Pryor, P. R., Mullock, B. M. and Piper, R. C., 2000, Lysosome-endosome fusion and lysosome biogenesis. Journal of Cell Science, 113, 1515-1524.
  • Marsh, M., 2001, Endocytosis (Oxford University Press: Oxford).
  • Martinez, I., Chakrabart, S., Hellevik, T., Morehead, J., Fowler, K. and Andrews, N. W., 2000, Synaptotagmin VII regulates Ca2+-dependent exocytosis of lysosomes in flbroblasts. Journal of Cell Biology, 148, 1141-1149.
  • Martinez-Arca S., Alberts P., Galli T. Clostridial neurotoxin-insensitive vesicular SNAREs in exocytosis and endocytosis Biology of the Cell 2000; 92: 449-453
  • Matteoni R., Kreis T. E. Translocation and clustering of endosomes and lysosomes depends on microtubules Journal of Cell Biology 1987; 105: 1253-1265
  • McNell, P. L., 2002, Repairing a torn cell surface: make way, lysosomes to the rescue. Journal of Cell Science, 115, 873-879.
  • McNell, P. L. and Terasaki, M., 2001, Coping with the inevitable: how cells repair a torn surface membrane. Nature Cell Biology, 3, E124-E129.
  • Mellman, I., 1996, Endocytosis and molecular sorting. Annual Review of Cell Development Biology, 12, 575-625.
  • Mellman I., Warren G. The road taken: past and future foundations of membrane traffic Cell 2000; 100: 99-112
  • Meyer, C., Eskelinen, E. L., Guruprasad, M. R., von Figura, K. and Schu, P., 2001, Mu 1A deficiency induces a profound increase inMPR300/IGF-II receptor intemalization rate. Journal of Cell Science, 114, 4469-4476.
  • Meyer C., Zizioli D., Lausmann S., Eskelinen E.-L., Hamann J., Saftig P., von Figura K., Schu P. μ1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors EMBO Journal 2000; 19: 2193-2203
  • Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y. and Yoshimori, T., 2001, Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. Journal of Cell Biology, 152, 657-667.
  • Mukherjee, S., Ghosh, R. N. and Maxfield, F. R., 1997, Endocytosis. Physiological Reviews, 77, 759-803.
  • Müller O., Bayer M. J., Peters C., Andersen J. S., Mann M., Mayer A. The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation EMBO Journal 2002; 21: 259-269
  • Mullins C., Bonifacino J. S. The molecular machinery for lysosome biogenesis Bioessays 2001; 23: 333-343
  • Mullock, B. M., Bright, N. A., Fearon, C. W., Gray, S. R. and Luzio, J. P., 1998, Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent. Journal of Cell Biology, 140, 591-601.
  • Mullock, B. M., Smith, C. W., lhrke, G., Bright, N. A., Lindsay, M., Parkinson, E. J., Brooks, D. A., Parton, R. G., James, D. E., Luzio, J. P. and Piper, R. C., 2000, Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and is required for late endosome-lysosome fusion. Molecular Biology of the Cell, 11, 3137-3153.
  • Murphy R. F. Maturation models for endosome and lysosome biogenesis Trends in Cell Biology 1991; 1: 77-82
  • Nakamura, N., Yamamoto, A., Wada, Y. and Futai, M., 2000, Syntaxin 7 mediates endocytic trafficking to late endosomes. Journal of Biological Chemistry, 275, 6523-6529.
  • Nara, A., Mizushima, N., Yamamoto, A., Kabeya, Y., Ohsumi, Y. and Yoshimori, T., 2002, SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Structure and Function, 27, 29-37.
  • Nichols B. J., Lippincott-Scwartz J. Endocytosis without clathrin coats Trends in Cell Biology 2001; 11: 406-412
  • Noda, T., Suzuki, K. and Ohsumi, Y., 2002, Yeast autophagosomes: de now formation of a membrane structure. Trends in Cell Biology, 12, 231-235.
  • Obermuller, S., Kiecke, C., von Figura, K. and Honing, S., 2002, The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes. Journal of Cell Science, 115, 185-194.
  • Owen, D. J. and Evans, P. R., 1998, A structural explanation for the recognition of tyrosine-based endocytotic signals. Science, 282, 1327-1332.
  • Peden, A. A., Rudge, R. E., Lui, W. W. and Robinson, M. S., 2002, Assembly and function of AP-3 complexes in cells expressing mutant subunits. Journal of Cell Biology, 156, 327-336.
  • Peters, C. and Mayer, A., 1998, Ca++/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Nature, 396, 575-579.
  • Peters, C., Andrews, P. D., Stark, M. J. R., Cesaro-Tadic, S., Glatz, A., Podtelejnikov, A., Mann, M. and Mayer, A., 1999, Control of the terminal step of intracellular membrane fusion by protein phosphatase 1. Science, 285, 1084-1087.
  • Peters, C., Bayer, M. J., Buhler, S., Andersen, J. S., Mann, M. and Mayer, A., 2001, Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion. Nature, 409, 581-588.
  • Peyron, P., Maridonneau-Parini, I. and Stegmann, T., 2001, Fusion of human neutrophil phagosomes with lysosomes in vitro: involvement of tyrosine kinases of the Src family and inhibition by mycobacteria. Journal of Biological Chemistry, 276, 3551235517.
  • Pfeffer, S. R., 1999, Transport-vesicle targeting: tethers before SNAREs. Nature Cell Biology, 1, E17-E22.
  • Pfeffer S. R. Membrane transport: retromer to the rescue Current Biology 2001; 11: R109-R111
  • Pillay C. S., Elliott E., Dennison C. Endolysosomal proteolysis and its regulation Biochemical Journal 2002; 363: 417-429
  • Piper R. C., Luzio J. P. Late endosomes: sorting and partitioning in multivesicular bodies Traffic 2001; 2: 612-621
  • Piper, R. C., Bryant, N. J. and Stevens, T. H., 1997, The membrane protein alkaline phosphatase is delivered to the vacuole by a route that is distinct from the VPS-dependent pathway. Journal of Cell Biology, 138, 531-545.
  • Porat, A. and Elazar, Z., 2000, Regulation of intra-Golgi membrane transport by calcium. Journal of Biological Chemistry, 275, 29233-29237.
  • Preston, R. A., Manolson, M. F., Becherer, K., Weidenhammer, E., Kirkpatrick, D., Wright, R. and Jones, E. W., 1991, Isolation and characterization of PEP3, a gene required for vacuolar biogenesis. Molecular Cell Biology, 11, 5801-5812.
  • Pryor, P. R., Buss, F. and Luzio, J. P., 2000b, Calcium, calmodulin and the endocytic pathway, ELSO Gazette 2. http://www.the-elsogazette.org/magazines/issues2/reviews/reviews1 pr.asp
  • Pryor, P. R., Mullock, B. M., Bright, N. A., Gray, S. R. and Luzio, J. P., 2000, The role of intra-organellar Ca2+ in late endosomelysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. Journal of Cell Biology, 149, 1053-1062.
  • Puertollano, R., Aguilar, R. C., Gorshkova, I., Crouch, R. J. and Bonifacino, J. S., 2001, Sorting of mannose 6-phosphate receptors mediated by the GGAs. Science, 292, 1712-1716.
  • Raiborg, C., Bache, K. G., Gillooly, D. J., Madshus, I. H., Slang, E. and Stenmark, H., 2002, Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nature Cell Biology, 4, 394-398.
  • Reaves, B. J., Banting, G. and Luzio, J. P., 1998, Lumenal and transmembrane domains play a role in sorting type I membrane proteins on endocytic pathways. Molecular Biology of the Cell, 9, 1107-1122.
  • Reddy A., Caler E. V., Andrews N. W. Plasma membrane repair is mediated by Ca 2+ -regulated exocytosis of lysosomes Cell 2001; 106: 157-169
  • Reddy, J. V. and Seaman, M. N. J., 2001, Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval. Molecular Biology of the Cell, 12, 3242-3256.
  • Reggiori, F. and Pelham, H. R., 2001, Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO Journal, 20, 5176-5186.
  • Rieder, S. E. and Emr, S. D., 1997, A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Molecular Biology of the Cell, 8, 2307-2327.
  • Robinson, J. S., Klionsky, D. J., Banta, L. M. and Emr, S. D., 1988, Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Molecular Cell Biology, 8, 4936-4948.
  • Robinson, M. S. and Bonifacino, J. S., 2001, Adaptor-related proteins. Current Opinions in Cell Biology, 13, 444-453.
  • Rodriguez, A., Webster, P., Ortego, J. and Andrews, N. W., 1997, Lysosomes behave Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells. Journal of Cell Biology, 137, 93-104.
  • Rothman, J. E., 1994, Mechanisms of intracellular protein transport. Nature, 372, 55-63.
  • Rothman J. H., Stevens T. H. Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway Cell 1986; 47: 1041-1051
  • Rous, B. A., Reaves, B. T., lhrke, G., Briggs, J. A. G., Gray, S. R., Stephens, D. J., Banting, G. and Luzio, J. P., 2002, The role of the adaptor complex AP-3 in targeting wild type and mutated CD63 to lysosomes. Molecular Biology of the Cell, 13, 1071-1082.
  • Sachse, M., Urbe, S., Oorschot, V., Strous, G. J. and Klumperman, J., 2002, Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes. Molecular Biology of the Cell, 13, 1313-1328.
  • Sato T. K., Rehling P., Peterson M. R., Emr S. D. Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion Molecular Cell 2000; 6: 661-671
  • Scheenen, W. J. J. M., Wollheim, C. B., Pozzan, T. and Fasolato, C., 1998, Ca2+ depletion from granules inhibits exocytosis. Journal of Biological Chemistry, 273, 19002-19008.
  • Seals, D. F., Eitzen, G., Margolis, N., Wickner, W. T. and Price, A., 2000, A Ypt/Rab effector complex containing the Sec I homolog Vps33p is required for homotypic vacuole fusion. Proceedings of the National Academy of Sciences (USA), 97, 9402-9407.
  • Seaman, M. N. J. and Luzio, J. P., 2001, Lysosomes and other late compartments of the endocytic pathway. In Endocytosis, M. Marsh, ed. (Oxford University Press, Oxford), pp. 111-148.
  • Seaman, M. N. J., McCaffery, J. M. and Emr, S. D., 1998, A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. Journal of Cell Biology, 142, 665-681.
  • Seeley, E. S., Kalo, M., Margolis, N., Wickner, W. and Eitzen, G., 2002, Genomic analysis of homotypic vacuole fusion. Molecular Biology of the Cell, 13, 782-794.
  • Sevrioukov E. A., He J.-P., Moghrabi N., Sunio A., Kramer H. A role for deep orange and carnation eye-color genes in lysosomal delivery in Drosophila Molecular Cell 1999; 4: 479-486
  • Simonsen, A., Lippe, R., Christoforidis, S., Gaultier, J. M., Brach, A., Callaghan, J., Toh, B. H., Murphy, C., Zerial, M. and Stenmark, H., 1998, EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature, 394, 494-498.
  • Simpson F., Bright N. A., West M. A., Newman L. S., Darnell R. B., Robinson M. S. A novel adaptor-related protein complex Journal of Cell Biology 1996; 133: 749-760
  • Srivastava, A., Woolford, C. A. and Jones, E. W., 2000, Pep3p/ Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae. Genetics,156, 105-122.
  • Stepp, J. D., Huang, K. and Lemmon, S. K., 1997, The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. Journal of Cell Biology, 39, 1761-1774.
  • Stoorvogel W., Kleijmeer M. J., Geuze H. J., Raposo G. The biogenesis and functions of exosomes Traffic 2002; 3: 321-330
  • Stoorvogel W., Strous G. J., Geuze H. J., Oorschot V., Schwartz A. L. Late endosomes derive from early endosomes by maturation Cell 1991; 65: 417-427
  • Storrie, B. and Desjardins, M., 1996, The biogenesis of lysosomes: is it a kiss and run continuous fusion and fission process? BioEssays, 18, 895-903.
  • Sullivan K. M. C., Busa W. B., Wilson K. L. Calcium mobilization is required for nuclear vesicle fusion in vitro : implications for membrane traffic and IP 3 receptor function Cell 1993; 73: 1411-1422
  • Sun M., Goldin E., Stahl S., Falardeau J. L., Kennedy J. C., Acierno Jr. J. S., Bove C., Kaneski C. R., Nagle J., Bromley M. C., Colman M., Schiffmann R., Slaugenhaupt S. A. Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel Human Molecular Genetics 2000; 9: 2471-2478
  • Sutton, R. B., Fasshauer, D., Jahn, R. and Brunger, A. T., 1998, Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 angstrom resolution. Nature, 395, 347-353.
  • Thery, C., Zitvogel, L. and Amigorena, S., 2002, Exosomes: composition, biogenesis and function. Nature Reviews in Immunology, 2, 569-579.
  • Tooze, S. A., 1998, Biogenesis of secretory granule in the transGolgi network of neuroendocrine and endocrine cells. Biochimica et Biophysics Acta, 1404, 231-244.
  • Traub L. M., Bannykh S. I., Rodel J. E., Aridor M., Balch W. E., Komfeld S. AP-2-containing clathrin coats assemble on mature lysosomes Journal of Cell Biology 1996; 135: 1801-1814
  • van Deurs, B., Holm, P. K., Kayser, L. and Sandvig, K., 1995, Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes. European Journal of Cell Biology, 66, 309-323.
  • Wade, N., Bryant, N. J., Connolly, L. M., Simpson, R. J., Luzio, J. P., Piper, R. C. and James, D. E., 2001, Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. Journal of Biological Chemistry, 276, 19820-19827.
  • Wang L., Seeley E. S., Wickner W., Merz A. J. Vacuole fusion at a ring of vertex docking sites leaves membrane fragments within the organelle Cell 2002; 108: 357-369
  • Ward, D. M., Leslie, J. D. and Kaplan, J., 1997, Homotypic lysosome fusion in macrophages: analysis using an in vitro assay. Journal of Cell Biology, 139, 665-673.
  • Ward, D. M., Pevsner, J., Scullion, M. A., Vaughn, M. and Kaplan, J., 2000, Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimidesensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages. Molecular Biology of the Cell, 11, 2327-2333.
  • Wettey, F. R., Hawkins, S., Stewart, A., Luzio, J. P., Howard, J. C. and Jackson, A. P., 2002, Controlled elimination of clathrin heavychain expression in DT40 lymphocytes. Science, 297, 15211525.
  • Wickner, W., 2002, Yeast vacuoles and membrane fusion pathways. EMBO Journal, 21, 1241-1247.
  • Woolley K., Martin P. Conserved mechanisms of repair: from damaged single cells to wounds in multicellular tissues Bioessays 2000; 22: 911-919
  • Wurmser, A. E., Sato, T. K. and Emr, S. D., 2000, New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE dependent docking and fusion. Journal of Cell Biology, 151, 551-562.
  • Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R. and Tashiro, Y., 1998, Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E. Cell Structure and Function, 23, 33-42.
  • Ybe, J. A., Brodsky, F. M., Hofmann, K., Lin, K., Liu, S. H., Chen, L., Earnest, T. N., Fletterick, R. J. and Hwang, P. K., 1999, Clathrin self-assembly is mediated by a randomly repeated superhelix. Nature, 399, 371-375.
  • Zhu, Y., Doray, B., Poussu, A., Lehto, V. P. and Kornfeld, S., 2001, Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor. Science, 292, 1716-1718.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.