Molecular insights into ion channel function (Review)

References

• Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., van Der Oost, J., Smit, A. B. and Sixma, T. K., 2001, Crystal structure of the ACh-binding protein reveals the ligand binding domain of nicotinic receptors. Nature, 411, 269 -276.
   PubMed Web of Science ®Google Scholar
• Brelidze, T. I., Niu, X. and Magleby, K. L., 2003, A ring of eight conserved negatively charged amino acids doubles the conduc- tance of BKchannels and prevents inward rectification. Proc. Natl Acad. Sci. USA, 100, 9017 -9022.
   PubMedGoogle Scholar
• Chang, G., Spencer, R. H., Lee, A. T., Barclay, M. T. and Rees, D. C., 1998, Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science, 282, 2220–2226.
   PubMed Web of Science ®Google Scholar
• Corringer, P. J., Bertrand, S., Galzi, J. L., Devillers-Thiery, A., Changeux, J. P. and Bertrand, D., 1999, Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels. Novartis Found. Symp., 225, 215 - 224.
   PubMedGoogle Scholar
• Cruickshank, C. C., Minchin, R. F., Le Dain, A. C. and Martinac, B., 1997, Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli. Biophys. J., 73, 1925 -1931.
   Google Scholar
• Doyle, D. A., 2004, Structural themes in ion channels, Eur. Biophys. J., in press.
   Google Scholar
• Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T. and MacKinnon, R., 1998, The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280, 69 -77.
   PubMed Web of Science ®Google Scholar
• Froehner, S. C., Luetje, C. W., Scotland, P. B. and Patrick, J., 1990, The postsynaptic 43Kprotein clusters muscle nicotinic acetylcho- line receptors in Xenopus oocytes. Neuron, 5, 403 -410.
   PubMed Web of Science ®Google Scholar
• Galzi, J. L., Devillers-Thiery, A., Hussy, N., Bertrand, S., Changeux, J. P. and Bertrand, D., 1992, Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature, 359, 500 -505.
   PubMed Web of Science ®Google Scholar
• Gunthorpe, M. J. and Lummis, S. C., 2001, Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. J. Biol. Chem., 276, 10977–10983.
   Google Scholar
• Imoto, K., Busch, C., Sakmann, B., Mishina, M., Konno, T., Nakai, J., Bujo, H., Mori, Y., Fukuda, K. and Numa, S., 1988, Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature, 335, 645 -648.
   PubMed Web of Science ®Google Scholar
• Kubo, Y. and Murata, Y., 2001, Control of rectification and permea- tion by two distinct sites after the second transmembrane region in Kir2.1 K+ channel. J. Physiol., 531, 645 -660.
   PubMedGoogle Scholar
• Kuo, A., Gulbis, J. M., Antcliff, J. F., Rahman, T., Lowe, E. D., Zimmer, J., Cuthbertson, J., Ashcroft, F. M., Ezaki, T. and Doyle, D. A., 2003, Crystal structure of the potassium channel KirBac1.1 in the closed state. Science, 300, 1922 -1926.
   PubMed Web of Science ®Google Scholar
• Langloh, A. L., Berdiev, B., Ji, H. L., Keyser, K., Stanton, B. A. and Benos, D. J., 2000, Charged residues in the M2 region of alpha- hENaC play a role in channel conductance. Am. J. Physiol. Cell. Physiol., 278, C277–C291.
   Google Scholar
• Li, R. A., Velez, P., Chiamvimonvat, N., Tomaselli, G. F. and Marban, E., 2000, Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel. J. Gen. Physiol., 115, 81 -92.
   PubMedGoogle Scholar
• Miyazawa, A., Fujiyoshi, Y. and Unwin, N., 2003, Structure and gating mechanism of the acetylcholine receptor pore. Nature, 423, 949 -955.
   PubMed Web of Science ®Google Scholar
• Nimigean, C. M., Chappie, J. S. and Miller, C., 2003, Electrostatic tuning of ion conductance in potassium channels. Biochemistry, 42, 9263 -9268.
   PubMed Web of Science ®Google Scholar
• Oliver, D., Baukrowitz, T. and Fakler, B., 2000, Polyamines as gating molecules of inward-rectifier K+ channels. Eur. J. Biochem., 267, 5824–5829.
   PubMedGoogle Scholar
• Perozo, E., Cortes, D. M., Sompornpisut, P., Kloda, A. and Martinac, B., 2002, Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Nature, 418, 942 - 948.
   PubMed Web of Science ®Google Scholar
• Ruppersberg, J. P., 2000, Intracellular regulation of inward rectifier K+ channels. Pflugers Arch., 441, 1 -11.
   PubMed Web of Science ®Google Scholar
• Sheng, S., McNulty, K. A., Harvey, J. M. and Kleyman, T. R., 2001, Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity. J. Biol. Chem., 276, 44091- 44098.
   PubMed Web of Science ®Google Scholar
• Smart, O. S., Goodfellow, J. M. and Wallace, B. A., 1993, The pore dimensions of gramiciclin A. Biophys. J., 65, 2455 -2460.
   PubMed Web of Science ®Google Scholar
• Song, L., Hobaugh, M. R., Shustak, C., Cheley, S., Bayley, H. and Gouaux, J. E., 1996, Structure of staphylococcal alpha-hemoly- sin, a heptameric transmembrane pore. Science, 274, 1859 - 1866.
   PubMed Web of Science ®Google Scholar
• Sukharev, S. I., Blount, P., Martinac, B., Blattner, F. R. and Kung, C., 1994, A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature, 368, 265 -268.
   PubMed Web of Science ®Google Scholar
• Sukharev, S. I., Blount, P., Martinac, B. and Kung, C., 1997, Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities. Annu. Rev. Physiol., 59, 633 -657.
   PubMed Web of Science ®Google Scholar
• Sukharev, S., Betanzos, M., Chiang, C. S. and Guy, H. R., 2001, The gating mechanism of the large mechanosensitive channel MscL. Nature, 409, 720 -724.
   PubMed Web of Science ®Google Scholar
• Unwin, N., 2002, Structure of the acetylcholine-gated channel. Novartis Found Symp, 245, 5 -15.
   PubMedGoogle Scholar
• Van den Berg, B., Clemons, W. M., Jr, Collinson, I., Modis, Y., Hartmann, E., Harrison, S. C. and Rapoport, T. A., 2004, X-ray structure of a protein-conducting channel. Nature, 427, 36 -44.
   PubMed Web of Science ®Google Scholar
• Yang, J., Jan, Y. N. and Jan, L. Y., 1995, *Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel. Neuron, 14, 1047–1054.
   PubMedGoogle Scholar