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PAPERS

Insight into factors directing high production of eukaryotic membrane proteins; production of 13 human AQPs in Pichia pastoris

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Pages 215-227 | Received 16 Oct 2008, Published online: 09 Jul 2009

References

  • von Heijne G. The membrane protein universe: What's out there and why bother?. J Intern Med 2007; 261: 543–557
  • Russell RB, Eggleston DS. New roles for structure in biology and drug discovery. Nat Struct Biol 2000; 7(Suppl.)928–930
  • White SH. The progress of membrane protein structure determination. Protein Sci 2004; 13: 1948–1949
  • Barth P, Schonbrun J, Baker D. Toward high-resolution prediction and design of transmembrane helical protein structures. Proc Natl Acad Sci USA 2007; 104: 15682–15687
  • White, LS. 2008. Database of Membrane Proteins of Known Structure. Accessed from the website: http://blanco.biomol.uci.edu/.
  • Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 2007; 448: 609–612
  • Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW. Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science 2007; 317: 510–512
  • Hiller S, Garces RG, Malia TJ, Orekhov VY, Colombini M, Wagner G. Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 2008; 321: 1206–1210
  • Horsefield, R, Norden, K, Fellert, M, Backmark, A, Tornroth-Horsefield, S, Terwisscha van Scheltinga AC, Kvassman, J, Kjellbom, P, Johanson, U, Neutze, R. 2008. High-resolution x-ray structure of human aquaporin 5. Proc Natl Acad Sci USA, 105:13327–13332.
  • Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P. Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. Nature 2007; 448: 613–616
  • Teriete P, Franzin CM, Choi J, Marassi FM. Structure of the Na,K-ATPase regulatory protein FXYD1 in micelles. Biochemistry 2007; 46: 6774–6783
  • Hebert H, Jegerschold C. The structure of membrane associated proteins in eicosanoid and glutathione metabolism as determined by electron crystallography. Curr Opin Struct Biol 2007; 17: 396–404
  • Tate CG. Overexpression of mammalian integral membrane proteins for structural studies. FEBS Lett 2001; 504: 94–98
  • Rosenfeld SA. Use of Pichia pastoris for expression of recombinant proteins. Methods Enzymol 1999; 306: 154–169
  • Cereghino JL, Cregg JM. Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiol Rev 2000; 24: 45–66
  • Bill RM. Yeast – a panacea for the structure-function analysis of membrane proteins?. Curr Genet 2001; 40: 157–171
  • Joseph-Liauzun E, Farges R, Le Fur G, Ferrara P, Loison G. High-level production of a human membrane protein in yeast: The peripheral-type benzodiazepine receptor. Gene 1995; 155: 195–199
  • Bonander N, Hedfalk K, Larsson C, Mostad P, Chang C, Gustafsson L, Bill RM. Design of improved membrane protein production experiments: Quantitation of the host response. Protein Sci 2005; 14: 1729–1740
  • Tate CG, Haase J, Baker C, Boorsma M, Magnani F, Vallis Y, Williams DC. Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter. Biochim Biophys Acta 2003; 1610: 141–153
  • Tornroth-Horsefield S, Wang Y, Hedfalk K, Johanson U, Karlsson M, Tajkhorshid E, Neutze R, Kjellbom P. Structural mechanism of plant aquaporin gating. Nature 2006; 439: 688–694
  • Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature 2007; 450: 376–382
  • Jidenko M, Nielsen R C, Sorensen TL, Moller JV, le Maire M, Nissen P, Jaxel C. Crystallization of a mammalian membrane protein overexpressed in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2005; 102: 11687–11691
  • Nyblom M, Oberg F, Lindkvist-Petersson K, Hallgren K, Findlay H, Wikstrom J, Karlsson A, Hansson O, Booth PJ, Bill RM, Neutze R, Hedfalk K. Exceptional overproduction of a functional human membrane protein. Protein Expr Purif 2007; 56: 110–120
  • Grisshammer R. Understanding recombinant expression of membrane proteins. Curr Opin Biotechnol 2006; 17: 337–340
  • Agre P, Saboori AM, Asimos A, Smith BL. Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen. J Biol Chem 1987; 262: 17497–17503
  • Preston GM, Carroll TP, Guggino WB, Agre P. Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 1992; 256: 385–387
  • Nejsum LN. The renal plumbing system: Aquaporin water channels. Cell Mol Life Sci 2005; 62: 1692–1706
  • King LS, Kozono D, Agre P. From structure to disease: The evolving tale of aquaporin biology. Nat Rev Mol Cell Biol 2004; 5: 687–698
  • Takata K, Matsuzaki T, Tajika Y. Aquaporins: Water channel proteins of the cell membrane. Prog Histochem Cytochem 2004; 39: 1–83
  • Verkman AS. More than just water channels: Unexpected cellular roles of aquaporins. J Cell Sci 2005; 118: 3225–3232
  • Chen YC, Cadnapaphornchai MA, Schrier RW. Clinical update on renal aquaporins. Biol Cell 2005; 97: 357–371
  • Amiry-Moghaddam M, Ottersen OP. The molecular basis of water transport in the brain. Nat Rev Neurosci 2003; 4: 991–1001
  • Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 2005; 434: 786–792
  • Jung JS, Preston GM, Smith BL, Guggino WB, Agre P. Molecular structure of the water channel through aquaporin CHIP. J Biological Chem 1994; 269: 14648–14654
  • Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y. Structural determinants of water permeation through aquaporin-1. Nature 2000; 407: 599–605
  • Walz T, Hirai T, Murata K, Heymann JB, Mitsuoka K, Fujiyoshi Y, Smith BL, Agre P, Engel A. The three-dimensional structure of aquaporin-1. Nature 1997; 387: 624–627
  • Sui H, Han BG, Lee JK, Walian P, Jap BK. Structural basis of water-specific transport through the AQP1 water channel. Nature 2001; 414: 872–878
  • Invitrogen, C. 2005. EasySelect Pichia Expression Kit, version G. Accessed from the website: http://www.invitrogen.com/content/sfs/manuals/easyselect_man.pdf.
  • Fantoni A, Bill RM, Gustafsson L, Hedfalk K. Improved yields of full-length functional human FGF1 can be achieved using the methylotrophic yeast Pichia pastoris. Protein Expr Purif 2007; 52: 31–39
  • Castle NA. Aquaporins as targets for drug discovery. Drug Discov Today 2005; 10: 485–493
  • Hessa T, Kim H, Bihlmaier K, Lundin C, Boekel J, Andersson H, Nilsson I, White S H, von Heijne G. Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature 2005; 433: 377–381
  • Lu Y, Turnbull IR, Bragin A, Carveth K, Verkman AS, Skach WR. Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum. Mol Biol Cell 2000; 11: 2973–2985
  • Sadlish H, Pitonzo D, Johnson AE, Skach WR. Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein. Nat Struct Mol Biol 2005; 12: 870–878
  • Foster W, Helm A, Turnbull I, Gulati H, Yang B, Verkman AS, Skach WR. Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4. J Biol Chem 2000; 275: 34157–34165
  • Buck TM, Wagner J, Grund S, Skach WR. A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization. Nat Struct Mol Biol 2007; 14: 762–769
  • Fu D, Libson A, Miercke LJ, Weitzman C, Nollert P, Krucinski J, Stroud RM. Structure of a glycerol-conducting channel and the basis for its selectivity. Science 2000; 290: 481–486
  • Newby, ZE, O'Connell, J, 3rd, Robles-Colmenares, Y, Khademi, S, Miercke, LJ, Stroud, RM. 2008. Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Nat Struct Mol Biol, 15:619–625.
  • Wang Y, Schulten K, Tajkhorshid E. What makes an aquaporin a glycerol channel? A comparative study of AqpZ and GlpF. Structure 2005; 13: 1107–1118
  • Duchesne L, Pellerin I, Delamarche C, Deschamps S, Lagree V, Froger A, Bonnec G, Thomas D, Hubert J F. Role of C-terminal domain and transmembrane helices 5 and 6 in function and quaternary structure of major intrinsic proteins: Analysis of aquaporin/glycerol facilitator chimeric proteins. J Biol Chem 2002; 277: 20598–20604
  • Lagree V, Pellerin I, Hubert JF, Tacnet F, Le Caherec F, Roudier N, Thomas D, Gouranton J, Deschamps S. A yeast recombinant aquaporin mutant that is not expressed or mistargeted in Xenopus oocyte can be functionally analyzed in reconstituted proteoliposomes. J Biol Chem 1998; 273: 12422–12426
  • Kozak M. Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo. Nature 1984; 308: 241–246
  • Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 1987; 15: 8125–8148
  • Xia, X. 2007. The +4G site in Kozak consensus is not related to the efficiency of translation initiation. PLoS ONE, 2:e188.
  • Cigan AM, Donahue TF. Sequence and structural features associated with translational initiator regions in yeast – a review. Gene 1987; 59: 1–18
  • Mohanty AK, Wiener MC. Membrane protein expression and production: Effects of polyhistidine tag length and position. Protein Expr Purif 2004; 33: 311–325
  • Hedfalk K, Pettersson N, Oberg F, Hohmann S, Gordon E. Production, characterization and crystallization of the Plasmodium falciparum aquaporin. Protein Expr Purif 2008; 59: 69–78
  • Beitz E. T(E)Xtopo: Shaded membrane protein topology plots in LAT(E)X2epsilon. Bioinformatics 2000; 16: 1050–1051
  • Beitz E. TEXshade: Shading and labeling of multiple sequence alignments using LATEX2 epsilon. Bioinformatics 2000; 16: 135–139

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