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Review Article

Structural biology of solute carrier (SLC) membrane transport proteins

, &
Pages 1-32 | Received 03 Dec 2017, Accepted 27 Feb 2018, Published online: 13 Apr 2018

References

  • Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. 2003. Structure and mechanism of the lactose permease of Escherichia coli. Science 301:610–615.
  • Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL, Cazenave-Gassiot A, et al. 2015. A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. Nat Genet 47:814–817.
  • Alper SL, Sharma AK. 2013. The SLC26 gene family of anion transporters and channels. Mol Aspects Med 34:494–515.
  • Anderson CM, Stahl A. 2013. SLC27 fatty acid transport proteins. Mol Aspects Med 34:516–528.
  • Anderson IM. 2000. Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability. J Affect Disord 58:19–36.
  • Ansermet C, Moor MB, Centeno G, Auberson M, Hu DZ, Baron R, et al. 2017. Renal fanconi syndrome and hypophosphatemic rickets in the absence of xenotropic and polytropic retroviral receptor in the nephron. J Am Soc Nephrol 28:1073–1078.
  • Appel M, Hizlan D, Vinothkumar KR, Ziegler C, Kuhlbrandt W. 2009. Conformations of NhaA, the Na/H exchanger from Escherichia coli, in the pH-activated and ion-translocating states. J Mol Biol 386:351–365.
  • Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, et al. 2015. Crystal structure of the anion exchanger domain of human erythrocyte band 3. Science 350:680–684.
  • Arroyo JP, Kahle KT, Gamba G. 2013. The SLC12 family of electroneutral cation-coupled chloride cotransporters. Mol Aspects Med 34:288–298.
  • Aukland K. 1961. Renal tubular permeability to urea with special reference to accumulation of urea in the renal medulla. Scand J Clin Lab Invest 13:646–660.
  • Axelrod J, Whitby LG, Hertting G. 1961. Effect of psychotropic drugs on the uptake of H3-norepinephrine by tissues. Science 133:383–384.
  • Bai X, Moraes TF, Reithmeier RA. 2016. Effect of SLC26 anion transporter disease-causing mutations on the stability of the homologous STAS domain of E. coli DauA (YchM). Biochem J 473:615–626.
  • Bakouh N, Benjelloun F, Hulin P, Brouillard F, Edelman A, Cherif-Zahar B, Planelles G. 2004. NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. J Biol Chem 279:15975–15983.
  • Ballatori N, Christian WV, Wheeler SG, Hammond CL. 2013. The heteromeric organic solute transporter, OSTalpha-OSTbeta/SLC51: a transporter for steroid-derived molecules. Mol Aspects Med 34:683–692.
  • Beach RS, Gershwin ME, Makishima RK, Hurley LS. 1980. Impaired immunologic ontogeny in postnatal zinc deprivation. J Nutr 110:805–815.
  • Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, Gu C. 2014. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature 509:507–511.
  • Berardi MJ, Shih WM, Harrison SC, Chou JJ. 2011. Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature 476:109–113.
  • Bergeron MJ, Clemencon B, Hediger MA, Markovich D. 2013. SLC13 family of Na+-coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med 34:299–312.
  • Berridge MJ, Bootman MD, Roderick HL. 2003. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4:517–529.
  • Blauw HM, van Rheenen W, Koppers M, Van Damme P, Waibel S, Lemmens R, et al. 2012. NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis. Hum Mol Genet 21:2497–2502.
  • Bodoy S, Fotiadis D, Stoeger C, Kanai Y, Palacin M. 2013. The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1. Mol Aspects Med 34:638–645.
  • Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E. 2007. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature 445:387–393.
  • Brandsch M. 2009. Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls. Expert Opin Drug Metab Toxicol 5:887–905.
  • Burzle M, Suzuki Y, Ackermann D, Miyazaki H, Maeda N, Clemencon B, et al. 2013. The sodium-dependent ascorbic acid transporter family SLC23. Mol Aspects Med 34:436–454.
  • Cano-Soldado P, Molina-Arcas M, Alguero B, Larrayoz I, Lostao MP, Grandas A, et al. 2008. Compensatory effects of the human nucleoside transporters on the response to nucleoside-derived drugs in breast cancer MCF7 cells. Biochem Pharmacol 75:639–648.
  • Carstea ED, Polymeropoulos MH, Parker CC, Detera-Wadleigh SD, O'Neill RR, Patterson MC, et al. 1993. Linkage of Niemann-Pick disease type C to human chromosome 18. Proc Natl Acad Sci USA 90:2002–2004.
  • Cesar-Razquin A, Snijder B, Frappier-Brinton T, Isserlin R, Gyimesi G, Bai X, et al. 2015. A call for systematic research on solute carriers. Cell 162:478–487.
  • Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J. 2011. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proc Natl Acad Sci USA 108:9361–9366.
  • Chen L, Yao X, Young A, McNulty J, Anderson D, Liu Y, et al. 2012. Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. Am J Physiol Endocrinol Metab 302:E68–E76.
  • Chen LY, Pan CJ, Shieh JJ, Chou JY. 2002. Structure-function analysis of the glucose-6-phosphate transporter deficient in glycogen storage disease type Ib. Hum Mol Genet 11:3199–3207.
  • Chou JY, Sik Jun H, Mansfield BC. 2013. The SLC37 family of phosphate-linked sugar phosphate antiporters. Mol Aspects Med 34:601–611.
  • Claro da Silva T, Polli JE, Swaan PW. 2013. The solute carrier family 10 (SLC10): beyond bile acid transport. Mol Aspects Med 34:252–269.
  • Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS. 2010. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol 17:822–829.
  • Coleman JA, Green EM, Gouaux E. 2016. X-ray structures and mechanism of the human serotonin transporter. Nature 532:334–339.
  • Dahlqvist J, Klar J, Hausser I, Anton-Lamprecht I, Pigg MH, Gedde-Dahl T Jr, et al. 2007. Congenital ichthyosis: mutations in ichthyin are associated with specific structural abnormalities in the granular layer of epidermis. J Med Genet 44:615–620.
  • Damaraju VL, Damaraju S, Young JD, Baldwin SA, Mackey J, Sawyer MB, Cass CE. 2003. Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 22:7524–7536.
  • Danbolt NC. 2001. Glutamate uptake. Prog Neurobiol 65:1–105.
  • Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, et al. 2010. Structure of a fucose transporter in an outward-open conformation. Nature 467:734–738.
  • Danks DM. 1988. Copper deficiency in humans. Annu Rev Nutr 8:235–257.
  • Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, et al. 2015. Molecular basis of ligand recognition and transport by glucose transporters. Nature 526:391–396.
  • Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, Yan N. 2014. Crystal structure of the human glucose transporter GLUT1. Nature 510:121–125.
  • Doki S, Kato HE, Solcan N, Iwaki M, Koyama M, Hattori M, et al. 2013. Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT. Proc Natl Acad Sci USA 110:11343–11348.
  • Donowitz M, Ming Tse C, Fuster D. 2013. SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Aspects Med 34:236–251.
  • Ehrnstorfer IA, Geertsma ER, Pardon E, Steyaert J, Dutzler R. 2014. Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport. Nat Struct Mol Biol 21:990–996.
  • Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A. 1999. LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients. Genomics 60:218–225.
  • Ermolova N, Madhvani RV, Kaback HR. 2006. Site-directed alkylation of cysteine replacements in the lactose permease of Escherichia coli: helices I, III, VI, and XI. Biochemistry 45:4182–4189.
  • Escary JL, Cecillon M, Maciazek J, Lathrop M, Tournier-Lasserve E, Joutel A. 2000. Mutational analysis of GLUT1 (SLC2A1) in glut-1 deficiency syndrome; dong wang; pamela kranz-eble; darryl C. De vivo; (Article was originally published in human mutation 16:224-231, 2000.). Hum Mutat 16:527.
  • Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, et al. 2008. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science 321:810–814.
  • Faria TN, Timoszyk JK, Stouch TR, Vig BS, Landowski CP, Amidon GL, et al. 2004. A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists. Mol Pharm 1:67–76.
  • Festa RA, Thiele DJ. 2011. Copper: an essential metal in biology. Curr Biol 21:R877–R883.
  • Fiore C, Arlot-Guilligay D, Trezeguet V, Lauquin GJ, Brandolin G. 2001. Fluorometric detection of ADP/ATP carrier deficiency in human muscle. Clin Chim Acta Int J Clin Chem 311:125–135.
  • Fleming MD, Campagna DR, Haslett JN, Trenor CC, III, Andrews NC. 2001. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev 15:652–657.
  • Fluman N, Ryan CM, Whitelegge JP, Bibi E. 2012. Dissection of mechanistic principles of a secondary multidrug efflux protein. Mol Cell 47:777–787.
  • Forrest LR, Kramer R, Ziegler C. 2011. The structural basis of secondary active transport mechanisms. Biochim Biophys Acta 1807:167–188.
  • Forrest LR, Zhang YW, Jacobs MT, Gesmonde J, Xie L, Honig BH, Rudnick G. 2008. Mechanism for alternating access in neurotransmitter transporters. Proc Natl Acad Sci USA 105:10338–10343.
  • Forster IC, Hernando N, Biber J, Murer H. 2013. Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med 34:386–395.
  • Fotiadis D, Kanai Y, Palacin M. 2013. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med 34:139–158.
  • Foulquier F, Amyere M, Jaeken J, Zeevaert R, Schollen E, Race V, et al. 2012. TMEM165 deficiency causes a congenital disorder of glycosylation. Am J Hum Genet 91:15–26.
  • Fowler PW, Orwick-Rydmark M, Radestock S, Solcan N, Dijkman PM, Lyons JA, et al. 2015. Gating topology of the proton-coupled oligopeptide symporters. Structure 23:290–301.
  • Fredriksson R, Nordstrom KJ, Stephansson O, Hagglund MG, Schioth HB. 2008. The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett 582:3811–3816.
  • Gallucci E, Micelli S, Lippe C. 1971. Non-electrolyte permeability across thin lipid membranes. Arch Int Physiol Biochim 79:881–887.
  • Ganapathy ME, Huang W, Wang H, Ganapathy V, Leibach FH. 1998. Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun 246:470–475.
  • Geertsma ER, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R. 2015. Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family. Nat Struct Mol Biol 22:803–808.
  • Grewer C, Rauen T. 2005. Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling. J Membr Biol 203:1–20.
  • Groeneveld M, Slotboom DJ. 2010. Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph). Biochemistry 49:3511–3513.
  • Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, et al. 2010. Function of human Rh based on structure of RhCG at 2.1 A. Proc Natl Acad Sci USA 107:9638–9643.
  • Guan L, Kaback HR. 2006. Lessons from lactose permease. Annu Rev Biophys Biomol Struct 35:67–91.
  • Guan L, Mirza O, Verner G, Iwata S, Kaback HR. 2007. Structural determination of wild-type lactose permease. Proc Natl Acad Sci USA 104:15294–15298.
  • Guettou F, Quistgaard EM, Raba M, Moberg P, Low C, Nordlund P. 2014. Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2. Nat Struct Mol Biol 21:728–731.
  • Guettou F, Quistgaard EM, Tresaugues L, Moberg P, Jegerschold C, Zhu L, et al. 2013. Structural insights into substrate recognition in proton-dependent oligopeptide transporters. EMBO Rep 14:804–810.
  • Hagenbuch B, Stieger B. 2013. The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med 34:396–412.
  • Halestrap AP. 2013. The SLC16 gene family – structure, role and regulation in health and disease. Mol Aspects Med 34:337–349.
  • Harborne SP, Ruprecht JJ, Kunji ER. 2015. Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier. Biochim Biophys Acta 1847:1245–1253.
  • Heddi A, Lestienne P, Wallace DC, Stepien G. 1993. Mitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP production. J Biol Chem 268:12156–12163.
  • Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA. 2004. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch Eur J Physiol 447:465–468.
  • Henderson PJ, Maiden MC. 1990. Homologous sugar transport proteins in Escherichia coli and their relatives in both prokaryotes and eukaryotes. Phil Trans R Soc Lond Ser B Biol Sci 326:391–410.
  • Hirabayashi Y, Nomura KH, Nomura K. 2013. The acetyl-CoA transporter family SLC33. Mol Aspects Med 34:586–589.
  • Holton KL, Loder MK, Melikian HE. 2005. Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Nat Neurosci 8:881–888.
  • Hu NJ, Iwata S, Cameron AD, Drew D. 2011. Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. Nature 478:408–411.
  • Huang L, Tepaamorndech S. 2013. The SLC30 family of zinc transporters – a review of current understanding of their biological and pathophysiological roles. Mol Aspects Med 34:548–560.
  • Huang Y, Lemieux MJ, Song J, Auer M, Wang DN. 2003. Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301:616–620.
  • Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H. 2005. Structure of a Na+/H + antiporter and insights into mechanism of action and regulation by pH. Nature 435:1197–1202.
  • Iancu CV, Zamoon J, Woo SB, Aleshin A, Choe JY. 2013. Crystal structure of a glucose/H + symporter and its mechanism of action. Proc Natl Acad Sci USA 110:17862–17867.
  • Jardetzky O. 1966. Simple allosteric model for membrane pumps. Nature 211:969–970.
  • Jensen S, Guskov A, Rempel S, Hanelt I, Slotboom DJ. 2013. Crystal structure of a substrate-free aspartate transporter. Nat Struct Mol Biol 20:1224–1226.
  • Jeong J, Eide DJ. 2013. The SLC39 family of zinc transporters. Mol Aspects Med 34:612–619.
  • Jiang D, Zhao Y, Wang X, Fan J, Heng J, Liu X, et al. 2013. Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A. Proc Natl Acad Sci USA 110:14664–14669.
  • Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, et al. 2016. Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. Proc Natl Acad Sci USA 113:12420–12425.
  • Johnson ZL, Cheong CG, Lee SY. 2012. Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å. Nature 483:489–493.
  • Kaback HR, Sahin-Toth M, Weinglass AB. 2001. The kamikaze approach to membrane transport. Nat Rev Mol Cell Biol 2:610–620.
  • Kaback HR, Smirnova I, Kasho V, Nie Y, Zhou Y. 2011. The alternating access transport mechanism in LacY. J Membr Biol 239:85–93.
  • Kahn BB. 1992. Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest 89:1367–1374.
  • Kanai Y, Clemencon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. 2013. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med 34:108–120.
  • Kanda M, Shimizu D, Tanaka H, Shibata M, Iwata N, Hayashi M, et al. 2016. Metastatic pathway-specific transcriptome analysis identifies MFSD4 as a putative tumor suppressor and biomarker for hepatic metastasis in patients with gastric cancer. Oncotarget 7:13667–13679.
  • Kantcheva AK, Quick M, Shi L, Winther AM, Stolzenberg S, Weinstein H, et al. 2013. Chloride binding site of neurotransmitter sodium symporters. Proc Natl Acad Sci USA 110:8489–8494.
  • Kaplan A, Lieman-Hurwitz J, Tchernov D. 2004. Resolving the biological role of the Rhesus (Rh) proteins of red blood cells with the aid of a green alga. Proc Natl Acad Sci USA 101:7497–7498.
  • Kaukonen J, Juselius JK, Tiranti V, Kyttala A, Zeviani M, Comi GP, et al. 2000. Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 289:782–785.
  • Khademi S, O'Connell J, III, Remis J, Robles-Colmenares Y, Miercke LJ, Stroud RM. 2004. Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Science 305:1587–1594.
  • Khan AA, Quigley JG. 2013. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med 34:669–682.
  • Khananshvili D. 2013. The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease. Mol Aspects Med 34:220–235.
  • Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. 2013. The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site. J Am Chem Soc 135:14266–14275.
  • Kim H, Wu X, Lee J. 2013. SLC31 (CTR) family of copper transporters in health and disease. Mol Aspects Med 34:561–570.
  • Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U. 2008. An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem 283:17691–17701.
  • Ko J, Lee YH, Hwang SY, Lee YS, Shin SM, Hwang JH, et al. 2003. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene 22:4679–4689.
  • Koepsell H. 2013. The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med 34:413–435.
  • Krishnamurthy H, Gouaux E. 2012. X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature 481:469–474.
  • Kristensen AS, Andersen J, Jorgensen TN, Sorensen L, Eriksen J, Loland CJ, et al. 2011. SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol Rev 63:585–640.
  • Kroncke BM, Horanyi PS, Columbus L. 2010. Structural origins of nitroxide side chain dynamics on membrane protein α-helical sites. Biochemistry 49:10045–10060.
  • Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM. 2014. Structure of sugar-bound LacY. Proc Natl Acad Sci USA 111:1784–1788.
  • Kurian MA, Zhen J, Cheng SY, Li Y, Mordekar SR, Jardine P, et al. 2009. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. J Clin Invest 119:1595–1603.
  • Law CJ, Maloney PC, Wang DN. 2008. Ins and outs of major facilitator superfamily antiporters. Annu Rev Microbiol 62:289–305.
  • Lefevre C, Bouadjar B, Karaduman A, Jobard F, Saker S, Ozguc M, et al. 2004. Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis. Hum Mol Genet 13:2473–2482.
  • Legati A, Giovannini D, Nicolas G, Lopez-Sanchez U, Quintans B, Oliveira JR, et al. 2015. Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nat Genet 47:579–581.
  • Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M. 2012. Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci USA 109:11194–11199.
  • Levin EJ, Quick M, Zhou M. 2009. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature 462:757–761.
  • Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, et al. 2011. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature 475:471–476.
  • Liao J, Li H, Zeng W, Sauer DB, Belmares R, Jiang Y. 2012. Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science 335:686–690.
  • Liu KH, Tsay YF. 2003. Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation. EMBO J 22:1005–1013.
  • Lu F, Li S, Jiang Y, Jiang J, Fan H, Lu G, et al. 2011. Structure and mechanism of the uracil transporter UraA. Nature 472:243–246.
  • Lu M, Chai J, Fu D. 2009. Structural basis for autoregulation of the zinc transporter YiiP. Nat Struct Mol Biol 16:1063–1067.
  • Lu M, Fu D. 2007. Structure of the zinc transporter YiiP. Science 317:1746–1748.
  • Ludewig U. 2004. Electroneutral ammonium transport by basolateral rhesus B glycoprotein. J Physiol 559:751–759.
  • Lutsenko S, Barnes NL, Bartee MY, Dmitriev OY. 2007. Function and regulation of human copper-transporting ATPases. Physiol Rev 87:1011–1046.
  • Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, et al. 2014. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep 15:886–893.
  • Macey RI. 1984. Transport of water and urea in red blood cells. Am J Physiol 246:C195–C203.
  • Mackenzie B, Ujwal ML, Chang MH, Romero MF, Hediger MA. 2006. Divalent metal-ion transporter DMT1 mediates both H+-coupled Fe2+ transport and uncoupled fluxes. Pflugers Arch Eur J Physiol 451:544–558.
  • Maiden MC, Davis EO, Baldwin SA, Moore DC, Henderson PJ. 1987. Mammalian and bacterial sugar transport proteins are homologous. Nature 325:641–643.
  • Mak DO, Dang B, Weiner ID, Foskett JK, Westhoff CM. 2006. Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG. Am J Physiol Renal Physiol 290:F297–F305.
  • Malinauskaite L, Quick M, Reinhard L, Lyons JA, Yano H, Javitch JA, Nissen P. 2014. A mechanism for intracellular release of Na + by neurotransmitter/sodium symporters. Nat Struct Mol Biol 21:1006–1012.
  • Malinauskaite L, Said S, Sahin C, Grouleff J, Shahsavar A, Bjerregaard H, et al. 2016. A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nature Commun 7:11673.
  • Masson J, Sagne C, Hamon M, El Mestikawy S. 1999. Neurotransmitter transporters in the central nervous system. Pharmacol Rev 51:439–464.
  • Mayrand RR, Levitt DG. 1983. Urea and ethylene glycol-facilitated transport systems in the human red cell membrane. Saturation, competition, and asymmetry. J Gen Physiol 81:221–237.
  • Meinild AK, Hirayama BA, Wright EM, Loo DD. 2002. Fluorescence studies of ligand-induced conformational changes of the Na(+)/glucose cotransporter. Biochemistry 41:1250–1258.
  • Mirza O, Guan L, Verner G, Iwata S, Kaback HR. 2006. Structural evidence for induced fit and a mechanism for sugar/H + symport in LacY. EMBO J 25:1177–1183.
  • Montalbetti N, Simonin A, Kovacs G, Hediger MA. 2013. Mammalian iron transporters: families SLC11 and SLC40. Mol Aspects Med 34:270–287.
  • Motohashi H, Inui K. 2013. Multidrug and toxin extrusion family SLC47: physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K. Mol Aspects Med 34:661–668.
  • Moura DA, Oliveira JR. 2015. XPR1: a gene linked to primary familial brain calcification might help explain a spectrum of neuropsychiatric disorders. J Mol Neurosci 57:519–521.
  • Mouro-Chanteloup I, Cochet S, Chami M, Genetet S, Zidi-Yahiaoui N, Engel A, et al. 2010. Functional reconstitution into liposomes of purified human RhCG ammonia channel. PLoS One 5:e8921.
  • Mueckler M, Thorens B. 2013. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med 34:121–138.
  • Nakhoul NL, Abdulnour-Nakhoul SM, Boulpaep EL, Rabon E, Schmidt E, Hamm LL. 2010a. Substrate specificity of Rhbg: ammonium and methyl ammonium transport. Am J Physiol Cell Physiol 299:C695–C705.
  • Nakhoul NL, Abdulnour-Nakhoul SM, Schmidt E, Doetjes R, Rabon E, Hamm LL. 2010b. pH sensitivity of ammonium transport by Rhbg. Am J Physiol Cell Physiol 299:C1386–C1397.
  • Nakhoul NL, Dejong H, Abdulnour-Nakhoul SM, Boulpaep EL, Hering-Smith K, Hamm LL. 2005. Characteristics of renal Rhbg as an NH4(+) transporter. Am J Physiol Renal Physiol 288:F170–F181.
  • Nakhoul NL, Lee Hamm L. 2013. Characteristics of mammalian Rh glycoproteins (SLC42 transporters) and their role in acid-base transport. Mol Aspects Med 34:629–637.
  • Nakhoul NL, Schmidt E, Abdulnour-Nakhoul SM, Hamm LL. 2006. Electrogenic ammonium transport by renal Rhbg. Transfus Clin Biol 13:147–153.
  • Napoli L, Bordoni A, Zeviani M, Hadjigeorgiou GM, Sciacco M, Tiranti V, et al. 2001. A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family. Neurology 57:2295–2298.
  • Newstead S, Drew D, Cameron AD, Postis VL, Xia X, Fowler PW, et al. 2011. Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. EMBO J 30:417–426.
  • Nicolas V, Mouro-Chanteloup I, Lopez C, Gane P, Gimm A, Mohandas N, et al. 2006. Functional interaction between Rh proteins and the spectrin-based skeleton in erythroid and epithelial cells. Transfus Clin Biol 13:23–28.
  • Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, et al. 2015. Structure and mechanism of the mammalian fructose transporter GLUT5. Nature 526:397–401.
  • Nurnberg P, Thiele H, Chandler D, Hohne W, Cunningham ML, Ritter H, et al. 2001. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nat Genet 28:37–41.
  • Nury H, Dahout-Gonzalez C, Trezeguet V, Lauquin G, Brandolin G, Pebay-Peyroula E. 2005. Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomers. FEBS Lett 579:6031–6036.
  • Oka Y, Asano T, Shibasaki Y, Lin JL, Tsukuda K, Katagiri H, et al. 1990. C-terminal truncated glucose transporter is locked into an inward-facing form without transport activity. Nature 345:550–553.
  • Palmieri F. 2013. The mitochondrial transporter family SLC25: identification, properties and physiopathology. Mol Aspects Med 34:465–484.
  • Panayotova-Heiermann M, Loo DD, Lam JT, Wright EM. 1998. Neutralization of conservative charged transmembrane residues in the Na+/glucose cotransporter SGLT1. Biochemistry 37:10522–10528.
  • Pao SS, Paulsen IT, Saier MH, Jr. 1998. Major facilitator superfamily. Microbiol Mol Biol Rev MMBR 62:1–34.
  • Parker JL, Newstead S. 2014. Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1. Nature 507:68–72.
  • Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G. 2003. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature 426:39–44.
  • Pedersen BP, Kumar H, Waight AB, Risenmay AJ, Roe-Zurz Z, Chau BH, et al. 2013. Crystal structure of a eukaryotic phosphate transporter. Nature 496:533–536.
  • Pena MM, Lee J, Thiele DJ. 1999. A delicate balance: homeostatic control of copper uptake and distribution. J Nutr 129:1251–1260.
  • Penmatsa A, Wang KH, Gouaux E. 2013. X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature 503:85–90.
  • Piscitelli CL, Gouaux E. 2012. Insights into transport mechanism from LeuT engineered to transport tryptophan. EMBO J 31:228–235.
  • Pittman JK, Hirschi KD. 2001. Regulation of CAX1, an arabidopsis Ca(2+)/H + antiporter. Identification of an N-terminal autoinhibitory domain. Plant Physiol 127:1020–1029.
  • Pittman JK, Sreevidya CS, Shigaki T, Ueoka-Nakanishi H, Hirschi KD. 2002. Distinct N-terminal regulatory domains of Ca(2+)/H(+) antiporters. Plant Physiol 130:1054–1062.
  • Pramod AB, Foster J, Carvelli L, Henry LK. 2013. SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med 34:197–219.
  • Prasad AS, Halsted JA, Nadimi M. 1961. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 31:532–546.
  • Quick M, Shi L, Zehnpfennig B, Weinstein H, Javitch JA. 2012. Experimental conditions can obscure the second high-affinity site in LeuT. Nat Struct Mol Biol 19:207–211.
  • Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA. 2009. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci USA 106:5563–5568.
  • Quistgaard EM, Low C, Moberg P, Tresaugues L, Nordlund P. 2013. Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters. Nat Struct Mol Biol 20:766–768.
  • Rainier S, Chai JH, Tokarz D, Nicholls RD, Fink JK. 2003. NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6). Am J Hum Genet 73:967–971.
  • Rask-Andersen M, Masuram S, Fredriksson R, Schioth HB. 2013. Solute carriers as drug targets: current use, clinical trials and prospective. Mol Aspects Med 34:702–710.
  • Reichenberger E, Tiziani V, Watanabe S, Park L, Ueki Y, Santanna C, et al. 2001. Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK. Am J Hum Genet 68:1321–1326.
  • Reimer RJ. 2013. SLC17: a functionally diverse family of organic anion transporters. Mol Aspects Med 34:350–359.
  • Reithmeier RA, Casey JR, Kalli AC, Sansom MS, Alguel Y, Iwata S. 2016. Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context. Biochim Biophys Acta 1858:1507–1532.
  • Reithmeier RA, Moraes TF. 2015. Solute carriers keep on rockin'. Nat Struct Mol Biol 22:752–754.
  • Reyes N, Ginter C, Boudker O. 2009. Transport mechanism of a bacterial homologue of glutamate transporters. Nature 462:880–885.
  • Reyes N, Oh S, Boudker O. 2013. Binding thermodynamics of a glutamate transporter homolog. Nat Struct Mol Biol 20:634–640.
  • Ripoche P, Bertrand O, Gane P, Birkenmeier C, Colin Y, Cartron JP. 2004. Human Rhesus-associated glycoprotein mediates facilitated transport of NH(3) into red blood cells. Proc Natl Acad Sci USA 101:17222–17227.
  • Romero MF, Chen AP, Parker MD, Boron WF. 2013. The SLC4 family of bicarbonate (HCO3-) transporters. Mol Aspects Med 34:159–182.
  • Ruprecht JJ, Hellawell AM, Harding M, Crichton PG, McCoy AJ, Kunji ER. 2014. Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism. Proc Natl Acad Sci USA 111:E426–E434.
  • Ryan RM, Compton EL, Mindell JA. 2009. Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii. J Biol Chem 284:17540–17548.
  • Sahni J, Scharenberg AM. 2013. The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med 34:620–628.
  • Sanders D, Brownlee C, Harper JF. 1999. Communicating with calcium. Plant Cell 11:691–706.
  • Sands JM, Knepper MA. 1987. Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium. J Clin Invest 79:138–147.
  • Schafer JA, Troutman SL, Andreoli TE. 1974. Osmosis in cortical collecting tubules. ADH-independent osmotic flow rectification. J Gen Physiol 64:228–240.
  • Schioth HB, Roshanbin S, Hagglund MG, Fredriksson R. 2013. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med 34:571–585.
  • Schnetkamp PP. 2013. The SLC24 gene family of Na(+)/Ca(2)(+)-K(+) exchangers: from sight and smell to memory consolidation and skin pigmentation. Mol Aspects Med 34:455–464.
  • Shaffer PL, Goehring A, Shankaranarayanan A, Gouaux E. 2009. Structure and mechanism of a Na+-independent amino acid transporter. Science 325:1010–1014.
  • Shaikh SA, Tajkhorshid E. 2010. Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologue. PLoS Comput Biol 6:e1000905.
  • Shan J, Javitch JA, Shi L, Weinstein H. 2011. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS One 6:e16350.
  • Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, et al. 2000. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 342:541–549.
  • Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA. 2008. The mechanism of a neurotransmitter:sodium symporter–inward release of Na + and substrate is triggered by substrate in a second binding site. Mol Cell 30:667–677.
  • Shigaki T, Rees I, Nakhleh L, Hirschi KD. 2006. Identification of three distinct phylogenetic groups of CAX cation/proton antiporters. J Mol Evol 63:815–825.
  • Singh SK, Piscitelli CL, Yamashita A, Gouaux E. 2008. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 322:1655–1661.
  • Singh SK, Yamashita A, Gouaux E. 2007. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 448:952–956.
  • Smirnova I, Kasho V, Kaback HR. 2011. Lactose permease and the alternating access mechanism. Biochemistry 50:9684–9693.
  • Smith DE, Clemencon B, Hediger MA. 2013. Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications. Mol Aspects Med 34:323–336.
  • Solcan N, Kwok J, Fowler PW, Cameron AD, Drew D, Iwata S, Newstead S. 2012. Alternating access mechanism in the POT family of oligopeptide transporters. EMBO J 31:3411–3421.
  • Song Z. 2013. Roles of the nucleotide sugar transporters (SLC35 family) in health and disease. Mol Aspects Med 34:590–600.
  • Soupene E, Inwood W, Kustu S. 2004. Lack of the Rhesus protein Rh1 impairs growth of the green alga Chlamydomonas reinhardtii at high CO2. Proc Natl Acad Sci USA 101:7787–7792.
  • Sujatha MS, Balaji PV. 2004. Identification of common structural features of binding sites in galactose-specific proteins. Proteins 55:44–65.
  • Sun J, Bankston JR, Payandeh J, Hinds TR, Zagotta WN, Zheng N. 2014. Crystal structure of the plant dual-affinity nitrate transporter NRT1.1. Nature 507:73–77.
  • Sun L, Zeng X, Yan C, Sun X, Gong X, Rao Y, Yan N. 2012. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature 490:361–366.
  • Suzuki T, Ishihara K, Migaki H, Ishihara K, Nagao M, Yamaguchi-Iwai Y, Kambe T. 2005. Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells. J Biol Chem 280:30956–30962.
  • Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, et al. 1997. The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J Pharm Pharmacol 49:796–801.
  • Thangaratnarajah C, Ruprecht JJ, Kunji ER. 2014. Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers. Nat Commun 5:5491.
  • Torroni A, Stepien G, Hodge JA, Wallace DC. 1990. Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes. J Biol Chem 265:20589–20593.
  • Toufaily C, Vargas A, Lemire M, Lafond J, Rassart E, Barbeau B. 2013. MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion. Placenta 34:85–88.
  • Traiffort E, O'Regan S, Ruat M. 2013. The choline transporter-like family SLC44: properties and roles in human diseases. Mol Aspects Med 34:646–654.
  • Tsui HW, Inman RD, Paterson AD, Reveille JD, Tsui FW. 2005. ANKH variants associated with ankylosing spondylitis: gender differences. Arthritis Res Ther 7:R513–R525.
  • Vallee BL, Falchuk KH. 1993. The biochemical basis of zinc physiology. Physiol Rev 73:79–118.
  • Verdon G, Boudker O. 2012. Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog. Nat Struct Mol Biol 19:355–357.
  • Verdon G, Oh S, Serio RN, Boudker O. 2014. Coupled ion binding and structural transitions along the transport cycle of glutamate transporters. eLife 3:e02283.
  • Vidaver GA. 1966. Inhibition of parallel flux and augmentation of counter flux shown by transport models not involving a mobile carrier. J Theoret Biol 10:301–306.
  • Vitavska O, Wieczorek H. 2013. The SLC45 gene family of putative sugar transporters. Mol. Aspects Med 34:655–660.
  • Vulpe CD, Packman S. 1995. Cellular copper transport. Annu Rev Nutr 15:293–322.
  • Waight AB, Pedersen BP, Schlessinger A, Bonomi M, Chau BH, Roe-Zurz Z, et al. 2013. Structural basis for alternating access of a eukaryotic calcium/proton exchanger. Nature 499:107–110.
  • Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, et al. 1998. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63:1767–1776.
  • Wang H, Elferich J, Gouaux E. 2012. Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol 19:212–219.
  • Wang H, Goehring A, Wang KH, Penmatsa A, Ressler R, Gouaux E. 2013. Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature 503:141–145.
  • Wang H, Gouaux E. 2012. Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep 13:861–866.
  • Wang JZ, Xiao N, Zhang YZ, Zhao CX, Guo XH, Lu LM. 2016. Mfsd2a-based pharmacological strategies for drug delivery across the blood-brain barrier. Pharmacol Res 104:124–131.
  • Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. 2010. The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature 468:988–991.
  • Wenzel U, Thwaites DT, Daniel H. 1995. Stereoselective uptake of beta-lactam antibiotics by the intestinal peptide transporter. Br J Pharmacol 116:3021–3027.
  • White PJ, Broadley MR. 2003. Calcium in plants. Ann Bot 92:487–511.
  • Widdas WF. 1952. Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transfer. J Physiol 118:23–39.
  • Williams CJ, Zhang Y, Timms A, Bonavita G, Caeiro F, Broxholme J, et al. 2002. Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH. Am J Hum Genet 71:985–991.
  • Wisedchaisri G, Park MS, Iadanza MG, Zheng H, Gonen T. 2014. Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE. Nat Commun 5:4521
  • Wright EM. 2013. Glucose transport families SLC5 and SLC50. Mol Aspects Med 34:183–196.
  • Wright EM, Hirayama BA, Loo DF. 2007. Active sugar transport in health and disease. J Intern Med 261:32–43.
  • Wu M, Tong S, Waltersperger S, Diederichs K, Wang M, Zheng L. 2013. Crystal structure of Ca2+/H + antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation. Proc Natl Acad Sci USA 110:11367–11372.
  • Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. 2004. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol 2:E50.
  • Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E. 2005. Crystal structure of a bacterial homologue of Na+/Cl–dependent neurotransmitter transporters. Nature 437:215–223.
  • Yan N. 2015. Structural biology of the major facilitator superfamily transporters. Annu Rev Biophys 44:257–283.
  • Yernool D, Boudker O, Jin Y, Gouaux E. 2004. Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature 431:811–818.
  • Yin Y, He X, Szewczyk P, Nguyen T, Chang G. 2006. Structure of the multidrug transporter EmrD from Escherichia coli. Science 312:741–744.
  • Yonezawa A, Inui K. 2013. Novel riboflavin transporter family RFVT/SLC52: identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52. Mol Aspects Med 34:693–701.
  • Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. 2013. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med 34:529–547.
  • Zeevaert R, de Zegher F, Sturiale L, Garozzo D, Smet M, Moens M, et al. 2013. Bone dysplasia as a key feature in three patients with a novel congenital disorder of glycosylation (CDG) type II due to a deep intronic splice mutation in TMEM165. JIMD Rep 8:145–152.
  • Zhao R, Goldman ID. 2013. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med 34:373–385.
  • Zhao Y, Mao G, Liu M, Zhang L, Wang X, Zhang XC. 2014. Crystal structure of the E. coli peptide transporter YbgH. Structure 22:1152–1160.
  • Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. 2010. Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature 465:188–193.
  • Zhao Y, Terry DS, Shi L, Quick M, Weinstein H, Blanchard SC, Javitch JA. 2011. Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature 474:109–113.
  • Zhou X, Levin EJ, Pan Y, McCoy JG, Sharma R, Kloss B, et al. 2014. Structural basis of the alternating-access mechanism in a bile acid transporter. Nature 505:569–573.
  • Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN. 2007. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science 317:1390–1393.
  • Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN. 2009. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol 16:652–657.
  • Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, Lopez C, Gane P, L, van Kim C, Cartron JP, et al. 2005. Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. Biochem J 391:33–40.

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