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Research Article

Structural intermediates in influenza haemagglutinin-mediated fusion

Pages 33-42 | Published online: 09 Jul 2009

References

  • Alford, D., Ellens, H. and Bentz, J. 1994, Fusion of influenza virus with sialic acid-bearing target membranes. Biochemistry, 33, 1977-1987.
  • Basanez, G., Goni, F. M. and Alonso, A. 1998, Effect of single chain lipids on phospholipase C-promoted vesicle fusion. A test for the stalk hypothesis of membrane fusion. Biochemistry, 37, 3901–3908.
  • Besterman, J. M. and Domanico, P. L. 1992, Association and metabolism of exogenously-derived lysophosphatidylcholine by cultured mammalian cells: kinetics and mechanisms. Biochem-istry, 31, 2046–2056.
  • Blumenthal, R., Sarkar, D. P., Durell, S., Howard, D. E. and Morris, S. J. 1996, Dilation of the influenza hemagglutinin fusion pore revealed by the kinetics of individual cell-cell fusion events. Journal of Cell Biology, 135, 63–71.
  • Bullough, P. A., Hughson, F. M., Skehel, J. J. and Wiley, D. C. 1994, Structure of influenza haemagglutinin at the pH of membrane fusion. Nature, 371, 37–43.
  • Carr, C. M. and Kim, P. S. 1993, A spring-loaded mechanism for the conformational change of influenza hemagglutinin. Cell, 73, 823–832.
  • Chanturiya, A., Chernomordik, L. V. and Zimmerberg, J. 1997, Flickering fusion pores comparable to initial exocytotic pores occur in protein-free phospholipid bilayers. Proceedings of the National Academy of Sciences of U S A, 94, 14423–14428.
  • Chernomordik, L., Chanturiya, A., Green, J. and Zimmerberg, J. 1995b, The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition. Biophysi-cal Journal, 69, 922–929.
  • Chernomordik, L. V., Frolov, V. A., Leikina, E., Bronk, P. and Zimmerberg, J. 1998, The pathway of membrane fusion catalyzed by influenza hemagglutinin: restriction of lipids, hemifusion, and lipidic fusion pore formation. Journal of Cell Biology, 140, 1369–1382.
  • Chernomordik, L., Kozlov, M. and Zimmerberg, J. 1995a, Lipids in biological membrane fusion. Journal of Membrane Biology, 146, 1–14.
  • Chernomordik, L. V., Leikina, E., Frolov, V., Bronk, P. and Zimmerberg, J. 1997, An early stage of membrane fusion mediated by the low pH conformation of influenza hemagglutinin depends upon membrane lipids. Journal of Cell Biology, 136, 81–94.
  • Chernomordik, L., Leikina, E. and Zimmerberg, J. 1995c, Control of baculovirus gp64-induced syncytia formation by membrane lipid composition. Journal of Virology, 69, 3049–3058.
  • Chernomordik, L. V., Melikyan, G. B., Abidor, I. G., Markin, V. S. and Chizmadzhev, Y. A. 1985, The shape of lipid molecules and monolayer membrane fusion. Biochimica et Biophysica Acta, 812, 643–655.
  • Chernomordik, L. V., Melikyan, G. B. and Chizmadzhev, Y. A. 1987, Biomembrane fusion: a new concept derived from model studies using two interacting planar lipid bilayers. Biochimica et Biophy-sica Acta, 906, 309–352.
  • Chernomordik, L. V., Vogel, S. S., Sokoloff, A., Onaran, H. O., Leikina, E. A. and Zimmerberg, J. 1993, Lysolipids reversibly inhibit Ca(2+)-, GTP-and pH-dependent fusion of biological membranes. FEBS Letters, 318, 71–76.
  • Doms, R. W., Helenius, A. and White, J. 1985, Membrane fusion activity of the influenza virus hemagglutinin. The low pH-induced conformational change. Journal of Biological Chemistry, 260, 2973–2981.
  • Gaudin, Y., Ruigrok, R. W. H. and Brunner, J. 1995, Low-pH induced conformational changes in viral fusion proteins: implications for the fusion mechanism. Journal of General Virology, 76, 1541–1556.
  • Gunther-Ausborn, S. and Stegmann, T. 1997, How lysophosphati-dylcholine inhibits cell-cell fusion mediated by the envelope glycoprotein of human immunodeficiency virus. Virology, 235, 201–208.
  • Gunther-Ausborn, S., Praetor, A. and Stegmann, T. 1995, Inhibition of influenza-induced membrane fusion by lysophosphatidylcho-line. Journal of Biological Chemistry, 270, 29279–29285.
  • Haest, C. W., Plasa, G. and Deuticke, B. 1981, Selective removal of lipids from the outer membrane layer of human erythrocytes without hemolysis. Consequences for bilayer stability and cell shape. Biochimica Biophysica Acta, 649, 701–708.
  • Helfrich, W. I. 1989, Hats and saddles in lipid membranes. Liquid Crystals, 5, 1647–1658.
  • Kemble, G. W., Danieli, T. and White, J. M. 1994, Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell, 76, 383–391.
  • Kozlov, M. and Chernomordik, L. 1998, A mechanism of protein-mediated fusion: coupling between refolding of the influenza hemagglutinin and lipid rearrangements. Biophysical Journal, 75, 1384–1396.
  • Kozlov, M. M. and Markin, V. S. 1983, Possible mechanism of membrane fusion. Biofizika, 28, 255–261.
  • Kozlov, M. M., Leikin, S. L., Chernomordik, L. V., Markin, V. S. and Chizmadzhev, Y. A. 1989, Stalk mechanism of vesicle fusion. Intermixing of aqueous contents. European Biophysical Journal, 17, 121–129.
  • Lee, J. and Lentz, B. R. 1997, Evolution of lipidic structures during model membrane fusion and the relation of this process to cell membrane fusion. Biochemistry, 36, 6251–6259.
  • Lowy, R. J., Sarkar, D. P., Whitnall, M. H. and Blumenthal, R. 1995, Differences in dispersion of influenza virus lipids and proteins during fusion. Experimental Cell Research, 216, 411–421.
  • Martin, I., Dubois, M. C., Saermark, T., Epand, R. M. and Ruysschaert, J. M. 1993, Lysophosphatidylcholine mediates the mode of insertion of the NH2-terminal SIV fusion peptide into the lipid bilayer. FEBS Letters, 333, 325–330.
  • McIntosh, T. J., Advani, S., Burton, R. E., Zhelev, D. V., Needham, D. and Simon, S. A. 1995, Experimental tests for protrusion and undulation pressures in phospholipid bilayers. Biochemistry, 34, 8520–8532.
  • Melikyan, G. B., Brener, S. A., Ok, D. C. and Cohen, F. S. 1997, Inner but not outer membrane leaflets control the transition from glycosylphosphatidylinositol-anchored influenza hemagglutinin-in-duced hemifusion to full fusion. Journal of Cell Biology, 136, 995–1005.
  • Melikyan, G. B., White, J. M. and Cohen, F. S. 1995, GPI-anchored influenza hemagglutinin induces hemifusion to both red blood cell and planar bilayer membranes. Journal of Cell Biology, 131, 679–691.
  • Monck, J. R. and Fernandez, J. M. 1994, The exocytotic fusion pore and neurotransmitter release. Neuron, 12, 707–716.
  • Monck, J. R. and Fernandez, J. M. 1996, The fusion pore and mechanisms of biological membrane fusion. Current Opinions in Cell Biology, 8, 524–533.
  • Nanavati, C., Markin, V. S., Oberhauser, A. F. and Fernandez, J. M. 1992, The exocytotic fusion pore modeled as a lipidic pore. Biophysical Journal, 63, 1118–1132.
  • Nussler, F., Clague, M. and Herrmann, A. 1997, Metastability of the hemifusion intermediate induced by glycosylphosphatidylinositol-anchored influenza hemagglutinin. Biophysical Journal, 73, 2280–2291.
  • Pak, C. C. and Blumenthal, R. 1996, Effect of X31 influenza virus fusion on phosphatidylserine asymmetry in erythrocytes. Biochi-mica Biophysica Acta, 1278, 98–104.
  • Pecheur, E. I., Hoekstra, D., Sainte-Marie, J., Maurin, L., Bienvenue, A. and Philippot, J. R. 1997, Membrane anchorage brings about fusogenic properties in a short synthetic peptide. Biochemistry, 36, 3773–3781.
  • Qiao, H., Pelletier, S. L., Hoffman, L., Hacker, J., Armstrong, R.T. and White, J. M. 1998, Journal of Cell Biology, 141, 1335-1347.
  • Scheiffele, P., Roth, M. G. and Simons, K., 1997, Interaction of influenza virus haemagglutinin with sphingolipid- cholesterol membrane domains via its transmembrane domain. EMBO Journal, 16, 5501–5508.
  • Schoch, C., Blumenthal, R. and Clague, M. J. 1992, A long-lived state for influenza virus-erythrocyte complexes committed to fusion at neutral pH. FEBS Letters, 311, 221–225.
  • Sellman, B. R., Kagan, B. L. and Tweten, R. K. 1997, Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin. Molecular Microbiology, 23, 551–558.
  • Shangguan, T., Alford, D., Bentz, J. 1996, Influenza-virus-liposome lipid mixing is leaky and largely insensitive to the material properties of the target membrane. Biochemistry, 35, 4956–4965.
  • Siegel, D. P. 1993, Energetics of intermediates in membrane fusion: comparison of stalk and inverted micellar intermediate mechan-isms. Biophysical Journal, 65, 2124–2140.
  • Siegel, D. P. and Epand, R. M. 1997, The mechanism of lamellar-to-inverted hexagonal phase transitions in phosphatidylethanola-mine: implications for membrane fusion mechanisms. Biophysical Journal, 73, 3089–3111.
  • Stegmann, T. 1993, Influenza hemagglutinin-mediated membrane fusion does not involve inverted phase lipid intermediates. Journal of Biological Chemistry, 268, 1716–1722.
  • Stegmann, T., Morselt, H. W., Scholma, J. and Wilschut, J. 1987, Fusion of influenza virus in an intracellular acidic compartment measured by fluorescence dequenching. Biochimica et Biophysica Acta, 904, 165–170.
  • Stegmann, T., White, J. M. and Helenius, A. 1990, Intermediates in influenza induced membrane fusion. EMBO Journal, 9, 4231–4241.
  • Tse, F. W., Iwata, A. and Almers, W. 1993, Membrane flux through the pore formed by a fusogenic viral envelope protein during cell fusion. Journal of Cell Biology, 121, 543–552.
  • van Meer, G., Davoust, J. and Simons, K. 1985, Parameters affecting low-pH-mediated fusion of liposomes with the plasma membrane of cells infected with influenza virus. Biochemistry, 24, 3593–3602.
  • Vogel, S. S., Leikina, E. A. and Chernomordik, L. V. 1993, Lysophosphatidylcholine reversibly arrests exocytosis and viral fusion at a stage between triggering and membrane merger. Journal of Biological Chemistry, 268, 25764–25768.
  • White, J. 1996, Membrane fusion: the influenza paradigm. Cold Spring Harbour Symposium, 60, 581–588.
  • White, J. M. and Wilson, I. A. 1987, Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin. Journal of Cell Biology, 105, 2887–2896.
  • Yang, E. and Huestis, W. H. 1993, Mechanism of intermembrane phosphatidylcholine transfer: effects of pH and membrane configuration. Biochemistry, 32, 12218–12228.
  • Yeagle, P. L., Smith, F. T., Young, J. E. and Flanagan, T. D. 1994, Inhibition of membrane fusion by lysophosphatidylcholine. Bio-chemistry, 33, 1820-1827.
  • Zimmerberg, J., Blumenthal, R., Sarkar, D. P., Curran, M. and Morris, S. J. 1994, Restricted movement of lipid and aqueous dyes through pores formed by influenza hemagglutinin during cell fusion. Journal of Cell Biology, 127, 1885-1894.

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