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Original

Regulation of expression and function of Lck tyrosine kinase by high cell density

, &
Pages 363-372 | Received 17 Jan 2005, Published online: 09 Jul 2009

References

  • Straus DB, Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 1992; 70: 585–593
  • Latour S, Veillette A. Proximal protein tyrosine kinases in immunoreceptor signalling. Curr Opin Immunol 2001; 13: 299–306
  • Samelson LA. Signal transduction mediated by the T cell antigen receptor: The role of adapter proteins. Ann Rev Immunol 2002; 20: 371–394
  • Cantrell DA. GTPases and T cell activation. Immunol Rev 2003; 192: 122–130
  • Shenoy-Scaria AM, Gauen LKT, Kwong J, Shaw AS, Lublin DM. Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins. Mol Cell Biol 1993; 13: 6385–6392
  • Koegl M, Zlatkine P, Ley SC, Courtneidge SA, Magee AI. Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem J 1994; 303: 749–753
  • Kabouridis PS, Magee AI, Ley SC. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J 1997; 16: 4983–4998
  • Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997; 387: 569–572
  • Janes PW, Ley SC, Magee AI, Kabouridis PS. The role of lipid rafts in T cell antigen receptor (TCR) signalling. Sem Immunol 2000; 12: 23–34
  • Xavier R, Seed B. Membrane compartmentation and the response to antigen. Curr Opin Immunol 1999; 11: 265–269
  • Langlet C, Bernard AM, Drevot P, He HT. Membrane rafts and signalling by the multichain immune recognition receptors. Curr Opin Immunol 2000; 12: 250–253
  • Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Ann Rev Cell Dev Biol 1997; 13: 513–609
  • Xu W, Doshi A, Lei M, Eck MJ, Harrison SC. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Molec Cell 1999; 3: 629–638
  • Yamaguchi H, Hendrickson WA. Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation. Nature 1996; 384: 484–489
  • Rodgers W, Rose JK. Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains. J Cell Biol 1996; 135: 1515–1523
  • Kabouridis PS, Janzen J, Magee AL, Ley SC. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signalling pathways in T lymphocytes. Eur J Immunol 2000; 30: 954–963
  • Kabouridis PS. Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells. Biochem J 2003; 371: 907–915
  • Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med 2000; 191: 1591–1604
  • Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 2000; 404: 999–1003
  • Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H. Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci USA 2002; 99: 3794–3799
  • Hawash IY, Kesavan KP, Magee AI, Geahlen RL, Harrison ML. The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl. J Biol Chem 2002; 277: 5683–5691
  • Vinals F, Pouyssegur J. Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity. Mol Cell Biol 1999; 19: 2763–2772
  • Batt DB, Roberts TM. Cell density modulates protein-tyrosine phosphorylation. J Biol Chem 1998; 273: 3408–3414
  • Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E. Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J Cell Sci 1997; 110: 2065–2077
  • Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, Orsenigo F, Cattelino A, Kemler R, Daniel TO, Dejana E. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol 2003; 161: 793–804
  • Hardwick JS, Sefton BM. Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394. Proc Natl Acad Sci USA 1995; 92: 4527–4531
  • Watts JD, Sanghera JS, Pelech SL, Aebersold R. Phosphorylation of serine 59 of p56lck in activated T cells. J Biol Chem 1993; 268: 23275–23282
  • Ponniah S, Wang DZ, Lim KL, Pallen CJ. Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn. Curr Biol 1999; 9: 535–538
  • Hakak Y, Martin GS. Ubiquitin-dependent degradation of active Src. Curr Biol 1999; 9: 1039–1042
  • Harris KF, Shoji I, Cooper EM, Kumar S, Oda H, Howley PM. Ubiquitin-mediated degradation of active Src tyrosine kinase. Proc Natl Acad Sci USA 1999; 96: 13738–13743
  • Fagerholm S, Hilden TJ, Gahmberg CG. Lck tyrosine kinase is important for activation of the CD11a/CD18-integrins in human T lymphocytes. Eur J Immunol 2002; 32: 1670–1678
  • Heissmeyer V, Macian F, Im SH, Varma R, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signalling proteins. Nat Immunol 2004; 5: 255–265

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