Evaluation of dietary Pancreatin as an exogenous enzyme on growth performance, gene expression, immunological responses, serum immunoglobins, and intestinal morphology in cockerels

References

• Abudabos AM. 2012. Effect of enzyme supplementation to normal and low density broiler diets based on corn-soybean meal. Asian J Anim Vet Adv. 7(2):139–148. https://doi.org/10.3923/ajava.2012.139.148.
   Google Scholar
• Aderibigbe A, Cowieson A, Sorbara JO, Adeola O. 2020. Intestinal starch and energy digestibility in broiler chickens fed diets supplemented with α-amylase. Poult Sci. 99(11):5907–5914. https://doi.org/10.1016/j.psj.2020.08.036.
   PubMed Web of Science ®Google Scholar
• Al-Marzooqi W, Leeson S. 1999. Evaluation of dietary supplements of lipase, detergent, and crude porcine pancreas on fat utilization by young broiler chicks. Poult Sci. 78(11):1561–1566. https://doi.org/10.1093/ps/78.11.1561.
   PubMed Web of Science ®Google Scholar
• Attia YA, Al-Khalaifah H, Abd El-Hamid HS, Al-Harthi MA, El-shafey AA. 2020. Effect of different levels of multienzymes on immune response, blood hematology and biochemistry, antioxidants status and organs histology of broiler chicks fed standard and low-density diets. Front Vet Sci. 6:510. https://doi.org/10.3389/fvets.2019.00510/full.
   PubMed Web of Science ®Google Scholar
• Baumgarth N. 2011. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol. 11(1):34–46. https://doi.org/10.1038/nri2901.
   PubMed Web of Science ®Google Scholar
• Cervantes M, Gómez R, Fierro S, Barrera MA, Morales A, Araiza BA, Zijlstra RT, Sánchez JE, Sauer WC. 2011. Ileal digestibility of amino acids, phosphorus, phytate and energy in pigs fed sorghum-based diets supplemented with phytase and pancreatin®. J Anim Physiol Anim Nutr (Berl). 95(2):179–186. https://doi.org/10.1111/j.1439-0396.2010.01038.x.
   PubMed Web of Science ®Google Scholar
• Cowieson AJ, Kluenter AM. 2019. Contribution of exogenous enzymes to potentiate the removal of antibiotic growth promoters in poultry production. Anim Feed Sci Technol. 250:81–92. https://doi.org/10.1016/j.anifeedsci.2018.04.026.
   Web of Science ®Google Scholar
• Cunningham CH. 1971. Acribia, editor. Virologia practica. 6th ed. Spain: Zaragoza; p. 260.
   Google Scholar
• D’Haese JG, Ceyhan GO, Demir IE, Layer P, Uhl W, Löhr M, Rychlik R, Pirilis K, Zöllner Y, Gradl B, et al. 2014. Pancreatic enzyme replacement therapy in patients with exocrine pancreatic insufficiency due to chronic pancreatitis. Pancreas. 43(6):834–841. https://doi.org/10.1097/MPA.0000000000000131.
   PubMed Web of Science ®Google Scholar
• Eraud C, Duriez O, Chastel O, Faivre B. 2005. The energetic cost of humoral immunity in the collared dove, streptopelia decaocto: is the magnitude sufficient to force energy-based trade-offs? Funct Ecol. 19(1):110–118. https://doi.org/10.1111/j.0269-8463.2005.00934.x.
   Web of Science ®Google Scholar
• Gitoee A, Janmohammadi H, Taghizadeh A, Rafat SA. 2015. Effects of a multi-enzyme on performance and carcass characteristics of broiler chickens fed corn-soybean meal basal diets with different metabolizable energy levels. J Appl Anim Res. 43(3):295–302. https://doi.org/10.1080/09712119.2014.963103.
   Web of Science ®Google Scholar
• Hafeez A, Shah SAA, Khan RU, Ullah Q, Naz S. 2020. Effect of diet supplemented with phytogenics and protease enzyme on performance, serum biochemistry and muscle histomorphology in broilers. J Appl Anim Res. 48(1):326–330. https://doi.org/10.1080/09712119.2020.1789648.
   Web of Science ®Google Scholar
• Hashem NM, Soltan YA, El-Desoky NI, Morsy AS, Sallam SMA. 2019. Effects of moringa oleifera extracts and monensin on performance of growing rabbits. Livest Sci. 228:136–143. https://doi.org/10.1016/j.livsci.2019.08.012.
   Web of Science ®Google Scholar
• Hussein EOS, Suliman GM, Alowaimer AN, Ahmed SH, Abd El-Hack ME, Taha AE, Swelum AA. 2020. Growth, carcass characteristics, and meat quality of broilers fed a low-energy diet supplemented with a multienzyme preparation. Poult Sci. 99(4):1988–1994. https://doi.org/10.1016/j.psj.2019.09.007.
   PubMed Web of Science ®Google Scholar
• Iji PA, Khumalo K, Slippers S, Gous RM. 2003. Intestinal function and body growth of broiler chickens on diets based on maize dried at different temperatures and supplemented with a microbial enzyme. Reprod Nutr Dev. 43(1):77–90. https://doi.org/10.1051/rnd:2003007.
   PubMedGoogle Scholar
• Jabbar A, Tahir M, Alhidary IA, Abdelrahman MA, Albadani H, Khan RU, Selvaggi M, Laudadio V, Tufarelli V. 2021a. Impact of microbial protease enzyme and dietary crude protein levels on growth and nutrients digestibility in broilers over 15–28 days. Animals (Basel). 11(9):2499. https://doi.org/10.3390/ani11092499.
   PubMedGoogle Scholar
• Jabbar A, Tahir M, Khan RU, Ahmad N. 2021b. Interactive effect of exogenous protease enzyme and dietary crude protein levels on growth and digestibility indices in broiler chickens during the starter phase. Trop Anim Health Prod. 53(1):1–5. https://doi.org/10.1007/s11250-020-02466-5.
   Web of Science ®Google Scholar
• Jha R, Woyengo TA, Li J, Bedford MR, Vasanthan T, Zijlstra RT. 2015. Enzymes enhance degradation of the fiber–starch–protein matrix of distillers dried grains with solubles as revealed by a porcine in vitro fermentation model and microscopy. J Anim Sci. 93(3):1039–1051. https://doi.org/10.2527/jas.2014-7910.
   PubMed Web of Science ®Google Scholar
• Jiang J, Wu H, Zhu D, Yang J, Huang J, Gao S, Lv G. 2020. Dietary supplementation with phytase and protease improves growth performance, serum metabolism status, and intestinal digestive enzyme activities in meat ducks. Animals (Basel). 10(2):268. https://doi.org/10.3390/ani10020268.
   PubMedGoogle Scholar
• Kaczmarek SA, Rogiewicz A, Mogielnicka M, Rutkowski A, Jones RO, Slominski BA. 2014. The effect of protease, amylase, and nonstarch polysaccharide-degrading enzyme supplementation on nutrient utilization and growth performance of broiler chickens fed corn-soybean meal-based diets. Poult Sci. 93(7):1745–1753. https://doi.org/10.3382/ps.2013-03739.
   PubMed Web of Science ®Google Scholar
• Kalantar M, Schreurs NM, Raza SHA, Khan R, Ahmed JZ, Yaghobfar A, Shah MA, Kalantar MH, Hosseini SM, Rahman SU. 2019. Effect of different cereal-based diets supplemented with multi-enzyme blend on growth performance villus structure and gene expression (SGLT1, GLUT2, PepT1 and MUC2) in the small intestine of broiler chickens. Gene Reports. 15:100376. https://doi.org/10.1016/j.genrep.2019.100376.
   Web of Science ®Google Scholar
• Kianfar R, Alahyari-Shahrasb M, Moravej H, Kim WK. 2013. Comparative apparent metabolizable energy values of soaking, fermentation with lactobacillus and enzyme treatment of barley in cockerels and quails. J Food Process Preserv. 37(6):1060–1067. https://doi.org/10.1111/j.1745-4549.2012.00806.x.
   Web of Science ®Google Scholar
• Kim BG, Tian JZ, Lim JS, Kil DY, Jeon HY, Chung YK, Kim YY. 2004. Influences of enzyme complex supplementation on growth, ileal and apparent fecal digestibility and morphology of small intestine in pigs. Asian-Australasian J Anim Sci. 17(12):1729–1735. https://doi.org/10.5713/ajas.2004.1729.
   Web of Science ®Google Scholar
• Kim J, Shim Y, Ingale SL, Hosseindoust A, Lee S, Rathi PC, Choi Y, Kim M, Chae B. 2018. The microbial pH-stable exogenous multienzyme improved growth performance and intestinal morphology of weaned pigs fed a corn–soybean-based diet. J Appl Anim Res. 46(1):559–565. https://doi.org/10.1080/09712119.2017.1358628.
   Web of Science ®Google Scholar
• Lewis SM, Williams A, Eisenbarth SC. 2019. Structure and function of the immune system in the spleen. Sci Immunol. 4(33):6085. https://doi.org/10.1126/sciimmunol.aau6085.
   Web of Science ®Google Scholar
• Lhoste E. 1993. Effects of dietary proteins on some pancreatic mRNAs encoding digestive enzymes in the pig. J Nutr Biochem. 4(3):143–152. https://doi.org/10.1016/0955-2863(93)90042-U.
   Web of Science ®Google Scholar
• Liu N, Wang JQ, Gu KT, Deng QQ, Wang JP. 2017. Effects of dietary protein levels and multienzyme supplementation on growth performance and markers of gut health of broilers fed a miscellaneous meal based diet. Anim Feed Sci Technol. 234(1):110–117. https://doi.org/10.1016/j.anifeedsci.2017.09.013.
   Google Scholar
• Liu S, Feng L, Jiang WD, Liu Y, Jiang J, Wu P, Zeng YY, Xu CD, Kuang SY, Tang L, et al. 2016. Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (ctenopharyngodon idella). Fish Shellfish Immunol. 55:88–105. https://doi.org/10.1016/j.fsi.2016.05.006.
   PubMed Web of Science ®Google Scholar
• Moftakharzadeh SA, Moravej H, Shivazad M. 2018. Influence of nutrient matrix values application for exogenous enzymes and feeding wheat/barley on performance, gastrointestinal characteristics, viscosity of jejunal digesta, litter moisture and water consumption of broilers. Livest Res Rural Dev. 30(21). http://www.lrrd.org/lrrd30/2/moft30021.html.
   Google Scholar
• Nishiyama H, Nagai T, Kudo M, Okazaki Y, Azuma Y, Watanabe T, Goto S, Ogata H, Sakurai T. 2018. Supplementation of pancreatic digestive enzymes alters the composition of intestinal microbiota in mice. Biochem Biophys Res Commun. 495(1):273–279. https://doi.org/10.1016/j.bbrc.2017.10.130.
   PubMed Web of Science ®Google Scholar
• Rengman S, Fedkiv O, Botermans J, Svendsen J, Weström B, Pierzynowski S. 2020. The growth of exocrine pancreatic insufficient young pigs fed an elemental diet is dependent on enteral pancreatin supplementation. Livest Sci. 134(1–3):50–52.
   Google Scholar
• Romero LF, Parsons CM, Utterback PL, Plumstead PW, Ravindran V. 2013. Comparative effects of dietary carbohydrases without or with protease on the ileal digestibility of energy and amino acids and AMEn in young broilers. Anim Feed Sci Technol. 181(1–4):35–44. https://doi.org/10.1016/j.anifeedsci.2013.02.001.
   Web of Science ®Google Scholar
• Saleh AA, El-Far AH, Abdel-Latif MA, Emam MA, Ghanem R, Abd El-Hamid HS. 2018. Exogenous dietary enzyme formulations improve growth performance of broiler chickens fed a low-energy diet targeting the intestinal nutrient transporter genes. PLoS One. 13(5):e0198085. https://doi.org/10.1371/journal.pone.0198085.
   PubMed Web of Science ®Google Scholar
• Sarker N, Tsudzuki M, Nishibori M, Yasue H, Yamamoto Y. 2000. Cell-mediated and humoral immunity and phagocytic ability in chicken lines divergently selected for serum immunoglobulin M and G levels. Poult Sci. 79(12):1705–1709. https://doi.org/10.1093/ps/79.12.1705.
   PubMed Web of Science ®Google Scholar
• Sateri S, Seidavi A, Bouyeh M, Neumann P, Kutzler M, Laudadio V, Loperfido F, Tufarelli V. 2017. Effect of olive meal and supplemental enzymes on performance traits, blood biochemistry, humoral immunity response and caecal microbiota of broilers. S Afr J Anim Sci. 47(6):804–812. https://doi.org/10.4314/sajas.v47i6.8.
   Web of Science ®Google Scholar
• Seidavi A, Dadashbeiki M, Alimohammadi-Saraei M-H, van den Hoven R, Payan-Carreira R, Laudadio V, Tufarelli V. 2017. Effects of dietary inclusion level of a mixture of probiotic cultures and enzymes on broiler chickens immunity response. Environ Sci Pollut Res. 24(5):4637–4644. https://doi.org/10.1007/s11356-016-8206-8.
   PubMed Web of Science ®Google Scholar
• Singh AK, Berrocoso JFD, Dersjant-Li Y, Awati A, Jha R. 2017. Effect of a combination of xylanase, amylase and protease on growth performance of broilers fed low and high fiber diets. Anim Feed Sci Technol. 232:16–20. https://doi.org/10.1016/j.anifeedsci.2017.07.012.
   Web of Science ®Google Scholar
• Svihus B. 2014. Function of the digestive system. J Appl Poult Res. 23(2):306–314. https://doi.org/10.3382/japr.2014-00937.
   Web of Science ®Google Scholar
• Walk CL, Poernama F. 2019. Evaluation of phytase, xylanase, and protease in reduced nutrient diets fed to broilers. J Appl Poult Res. 28(1):85–93. https://doi.org/10.3382/japr/pfy022.
   Web of Science ®Google Scholar
• Watanabe T, Kudo M, Strober W. 2017. Immunopathogenesis of pancreatitis. Mucosal Immunol. 10(2):283–298. https://doi.org/10.1038/mi.2016.101.
   PubMed Web of Science ®Google Scholar
• Yuan L , Wang M , Zhang X , Wang Z. 2017. Effects of protease and non-starch polysaccharide enzyme on performance, digestive function, activity and gene expression of endogenous enzyme of broilers. PLoS One. 12(3):1–13. https://doi.org/10.1371/journal.pone.0173941.
   Web of Science ®Google Scholar
• Zhu HL, Hu LL, Hou YQ, Zhang J, Ding BY. 2014. The effects of enzyme supplementation on performance and digestive parameters of broilers fed corn-soybean diets. Poult Sci. 93(7):1704–1712. https://doi.org/10.3382/ps.2013-03626.
   PubMed Web of Science ®Google Scholar
• Zou XT, Qiao XJ, Xu ZR. 2006. Effect of β-Mannanase (Hemicell) on growth performance and immunity of broilers. Poult Sci. 85(12):2176–2179. https://doi.org/10.1093/ps/85.12.2176.
   PubMed Web of Science ®Google Scholar