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Research Article

Carica Papaya modulates the organ histology, biochemicals, estrous cycle and fertility of Bandicota bengalensis rats

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Pages 289-298 | Received 18 Jan 2021, Accepted 18 Apr 2022, Published online: 04 May 2022

References

  • Adebiyi A, Adaikan PG, Prasad RN. 2002. Papaya (Carica papaya) consumption is unsafe in pregnancy: fact or fable? scientific evaluation of a common belief in some parts of Asia using a rat model. Brit J Nutr. 88:199–203.
  • Adebiyi A, Adaikan PG, Prasad RN. 2004. Effect of benzyl isothiocyanate on spontaneous and induced force of rat uterine contraction. Pharmacol Res. 49(5):415–422.
  • Adebiyi A, Ganesan Adaikan P, Prasad RN. 2003. Tocolytic and toxic activity of papaya seed extract on isolated rat uterus. Life Sci 74:581–592.
  • Agular BM, Vinggaar AM, Vind C. 1992. Regulation by dexamethasone of the 3β-hydroxy steroid dehydrogenase activity in adult rat Leydig cells. J Steroid BiochemMol Biol. 43:565–571.
  • Aritonang TR, Rahayu S, Sirait LI, Karo BR, Simanjuntak TP, Natzir R, Sinrang AW, Massi NM, Hatta M, Kamelia E. 2017. The role of FSH, LH, estradiol and progesterone hormone on estrous cycle of female rats. Int J Sci Basic Appl Res. 35:92–100.
  • Bessey OA, Lowry OH, Bruck MJ. 1946. A method for the rapid determination of alkaline phosphatase with five millimeters of serum. J Biol Chem. 164:321–329.
  • Biswal S. 2014. Phytochemical analysis and a study on the antiestrogenic antifertility effect of leaves of Piper betel in female albino rat. Anc Sci Life. 34:16–22.
  • Chinoy NJ, Dilip T, Harsha J. 1995. Effect of Carica papaya seed extract on female rat ovaries and uteri. Phytother Res. 9:169–175.
  • Chinoy NJ, Dilip T, Harsha J. 2006. Effect of Carica papaya seed extract on female rat ovaries and uteri. Phytother Res. 9:169–175. doi:10.1002/ptr.2650090303.
  • Chinoy NJ, Joshi H, Ghosh S. 1997. Antifertility investigations of alcoholic papaya seed extract in female rats. J Med Arom Plant Sci. 19:422–426.
  • Cora MC, Kooistra L, Travlos G. 2015. Vaginal cytology of the laboratory rat and mouse: review and criteria for the staging of the estrous cycle using stained vaginal smears. Toxicol Pathol. 43:776–793.
  • Dhar P, Singla N. 2014. Effect of triptolide on reproduction of female lesser bandicoot rat, Bandicota bengalensis. Drug Chem Toxicol. 37:448–458.
  • Dosumu O, Akinola B, Oremosu A, Noronha C, Okanlawon A. 2008. Antifertility effects of the aqueous extract of Carica papaya seeds on estrous cycle and ovulation of adult cyclic Sprague–Dawley rats. Niger J Health Sci. 27:31–33.
  • Ekhator CN, Shelu JO. 2015. An experimental study on the abortifacient potentials of unripe seed extract of Carica papaya in adult female Wistar rats. Open Sci J Pharm Pharmacol. 3:61–65.
  • Estella OE, Ogoamaka OP, Emmanuel EF. 2020. Evaluation of the oxytocic and haematological effects of leaves of Carica papaya Linn (Caricaceae). World J Adv Res Rev. 6(2):212–226.
  • Goldman JM, Murr AS, Cooper RL. 2007. The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res Part B: Dev Reprod Toxicol. 80:84–97.
  • Gunnannavar T, Prakash DP, Hipparagi K, Satish D, Gandolkar K, Sagar BS, Ryavalad S. 2017. Performance of papaya varieties for growth parameters under northern dry zone of Karnataka, India. Int J CurrMicrobiol App Sci. 6:2398–2404.
  • Hakameri CS T, Usman E. 2020. Effect of giving young papaya (Carica papaya L.) fruit extract on endometrial histology of female rats (Rattus norvegicus). Sci Midwifery. 9:181–186.
  • Julaeha E, Permatasari Y, Mayanti T, Diantini A. 2015. Antifertility compound from the seeds of Carica papaya. Procedia Chem. 17:66–69.
  • Kaur H, Singla N, Mahal AK. 2021. Antifertility effect of cereal based bait containing papaya (Carica papaya L.) seed powder in male lesser bandicoot rat, Bandicota bengalensis and its reversibility. Indian J Exp Biol. 59:448–456.
  • Keshri G, Singh MM, Vijai Lakshmi Gupta DN, Kamboj VP. 1993. Post-coital antifertility activity of the seeds of Carica papaya Linn. in female rats. Indian Drugs. 30:453–457.
  • Kumari S, Kumar R, Singh VN. 2017. Contraceptive effects of aqueous extract of Carica papaya(Linn.) seed on seminal profile of Swiss albino mice. Int J Sci Res. 6:1963–1965.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall AJ. 1951. Protein measurement with Folin phenol reagent. J Biol Chem. 193:265–275.
  • Memudu AE, Oluwole TJ. 2021. The contraceptive potential of Carica papaya seed on oestrus cycle, progesterone, and histomorphology of the Utero-ovarian tissue of adult Wistar rats. JBRA Assisted Reprod. 25(1):34–43.
  • Mukhtar Y, Abdu K, Abdulkadir AI, Galalain AM, Maigari AK, Yunusa UM. 2018. Sustainable use of botanical products in plant protection as a promising panacea to integrated pests management and control: issues, challenges, benefits and future prospects. Int J Adv Acad Res. 4(4):65–77.
  • Muthuviveganandavel V, Muthuraman P, Muthu S, Srikumar K. 2008. Study on low dose cypermethrin induced histopathology, lipid peroxidation and marker enzyme changes in male rat. Pestic Biochem Phys. 91:12–16.
  • Naik NR, Malleswari D, Indira P. 2015. Effect of Mesuaferrea flower and Carica papaya seed extracts on estrous cycle of female albino rats for fertility and antifertility activity. Biolife. 3:730–734.
  • Nattrass N, Stephens J, Loubser JJ. 2019. Animal welfare and ecology in the contested ethics of rodent control in Cape Town. J Urban Ecol. 1–10. https://doi.org/10.1093/jue/juz008.
  • Nayaka HB, Londonkar RL, Andumesh MK. 2014. Evaluation of Portulaca oleracea for anti-fertility effect in female albino rats. Int J Pharm Pharm Sci. 6:86–89.
  • Novitasari D, Triutomo DH, Arifah FH, Ivanawati A, Ulum Z, Murwanti R. 2018. Estrogenic activity of ethanolic extract of papaya peels (Carica papaya L.) on uterine weight and mammae gland proliferation onovariectomy rats. Indonesian J Cancer Chemoprevention. 9:86–91.
  • Nwaehujor CO, Ode JO, Ekwere MR, Udegbunam RI. 2014. Anti-fertility effects of fractions from Carica papaya (Pawpaw) Linn. methanol root extract in male Wistar rats. Arabian J Chem. 12:1563–1568.
  • Odirichukwu EO. 2015. Postcoitalanticonceptive activities of the aqueous methanolic extract of unripe Carica papaya fruits in rats. IOSR-JAVS. 8:17–21.
  • Odirichukwu EO, Uchechukwu NVS, Ogwu D. 2016. The aqueous methanolic extract of unripe Carica papaya (Pawpaw) fruit disrupts cycle in albino rats. IOSR-JAVS. 9:57–62.
  • Punitha N, Shettu N, Saravanan R. 2015. Effect of semi-ripe Carica papaya fruit extracts on the reproductive structures in female albino rats – a histological study. Int J Curr Res Life Sci. 4:241–245.
  • Raji Y, Morakinyo AO, Oloyo A, Stephen A. 2005. Impact of the chloroform extract of Carica papaya seed on cycle and fertility in female albino rats. J Med Sci. 5:337–343.
  • Sahu A, Maiti BR. 1978. Estrous cycle of the bandicoot rat – a rodent pest. Zool J Linn Soc. 63:309–314.
  • Sandhu KK, Singla N. 2019. Growth and breeding biology of female Indian gerbil (Tatera indica): reproductive, biochemical and histological evaluation. Indian J Anim Res. 54(5):534–542.
  • Satriyasa BK, Mahendra AN, Arijana IGK, Ruspawan DM. 2018. Unripe papaya seed ethanol extract (Carica papaya, Linn.) inhibits FSH and LH of male mice (Mus musculus). Biomed Pharmacol J. 11:979–984.
  • Sidhu A, Singla N, Lonare M, Mahal AK. 2020. Effect of quinestrol on body weight, vital organs, biochemicals and genotoxicity in adult male lesser bandicoot rat, Bandicota bengalensis. Pestic Biochem Physiol. 165:104544.
  • Sindhu G, Ragini G, Sreehari L, Gayathri G, Thejaswee A, Inthiyaz S, Usha Kiran Reddy T, Thyagaraju K. 2019. Pharmacognostical and pharmacological profile of Carica papaya – A review. World J Pharm Pharm Sci. 8:675–694.
  • Singla LD, Singla N, Parshad VR, Juyal PD, Sood NK. 2008. Rodents as reservoir of parasites in India. Integr Zool. 3:21–26.
  • Singla N. 2015. Anti-reproductive effects of total glycosides of Tripterygium wilfordii in male house rat, Rattus rattus. Appl Biol Res. 17(3):302–306.
  • Singla N, Babbar BK. 2010. Rodent damage and infestation in wheat and rice crop fields: District wise analysis in Punjab state. Indian J Ecol. 37(2):184–188.
  • Singla N, Dhar P, Singla LD, Gupta K. 2016. Patho-physiological observations in natural concurrent infections of helminth parasites of zoonotic importance in the wild rodents, Bandicota bengalensis. J Parasit Dis. 40(4):1435–1442.
  • Singla N, Parshad VR. 2002. Acceptance and efficacy of ready-to-use coumatetralyl paste and freshly prepared cereal bait based on coumatetralyl against Rattus rattus. Int Pest Contr. 44(4):178–181.
  • Smith R, Shore RF. 2015. Environmental impacts of rodenticides. In: Buckle A, Smith R, editors. Rodent pests and their control. 2nd ed. CAB International Publishers; p. 330–345. https://doi.org/10.1079/9781845938178.0330.
  • Tilly JL. 2003. Ovarian follicle counts – not as simple as 1, 2, 3. Reprod Biol Endocrinol. 1:11.
  • Uche-Nwachi EO, Mitchell CV, McEwen C. 2011. Steroidogenic enzyme histochemistry in the testis of Sprague Dawley rats following the administration of the water extracts from Carica papaya seed. Afr J Tradit Complement Alter Med. 8:69–78.
  • Udoh FV, Uodh PB, Umoh EE. 2005. Activity of alkaloid extract of Carica papaya seeds on reproductive functions in male Wistar rats. J Pharm Biol. 43(6):563–567.