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Research Article

A field case of pig poisoning by accidental feed contamination by alkaloid-rich lupin seeds

ORCID Icon, & ORCID Icon
Pages 725-731 | Received 04 Jun 2021, Accepted 08 Nov 2022, Published online: 06 Dec 2022

References

  • Abraham EM, Parissi Z, Ganopoulos I, Mylona P, Madesis P, Mavromatis A, Nianiou-Obeidat I, Polidoros A, Tani E, Vlachostergios D. 2019. The use of lupin as a source of protein in animal feeding: genomic tools and breeding approaches. Int J Mol Sci. 20:851.
  • ACAF. Advisory Committee on Animal Feedingstuffs. 2000. The use of sweet lupins in animal feed. Fifth ACAF Meeting. ACAF/00/26.
  • ACNFP. 1996. ACNFP Report on seeds from narrow leafed lupin, Appendix IX. London: MAFF Publications. p. 107.
  • Aniszewski T. 1993. Nutritive quality of the alkaloid-poor Washington lupin (Lupinus polyphyllus lindl var SF/TA) as a potential protein crop. J Sci Food Agric. 61:409–421.
  • ANZFA. 2001. Lupin alkaloids in food. A toxicological review and risk assessment. Technical Report Series 3; p. 1–21.
  • Boschin G, Annicchiarico P, Resta D, D'Agostina A, Arnoldi A. 2008. Quinolizidine alkaloids in seeds of lupin genotypes of different origins. J Agric Food Chem. 56:3657–3663.
  • Boschin G, Resta D. 2013. Alkaloids derived from lysine: quinolizidine, a focus on lupin alkaloids. In: Ramawat KG, Merillon JM, Henry M, editors. Natural products – phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Berlin Heidelberg: Springer-Verlag; p. 381–403.
  • Bulletin. 1998. Bulletin Officiel 98/27 du Conseil superieur d’hygiene publique de France, 1998.
  • Butler WH, Ford GP, Creasy DM. 1996. A 90-day feeding study of lupin (Lupinus angustifolius) flour spiked with lupin alkaloids in the rat. Food Chem Toxicol. 34:531–536.
  • Casper HH, Berg IE, Crenshaw JD, Colville JL, Wass WM. 1991. Lupin bean meal toxicosis in swine. J Vet Diagn Invest. 3:172–173.
  • Di Grande A, Paradiso R, Amico S, Fulco G, Fantauzza B, Noto P. 2004. Anticholinergic toxicity associated with lupin seed ingestion: case report. Eur J Emerg Med. 11:119–120.
  • Frick KM, Kamphuis LG, Singh KB, Siddique KHM, Foley RC. 2017. Quinolizidine alkaloid biosynthesis in lupins and prospects for grain quality improvement. Front Plant Sci. 8:87.
  • Godfrey NW, Mercy AR, Emms Y, Payne HG. 1985. Tolerance of growing pigs to lupin alkaloids. Aust J Exp Agric. 25:791–795.
  • Hama JR, Strobel BW. 2020. Natural alkaloids from narrow-leaf and yellow lupins transfer to soil and soil solution in agricultural fields. Environ Sci Eur. 32:126.
  • Hanczakowska E, Księżak J, Świątkiewicz M. 2017. Efficiency of lupine seed (Lupinus angustifolium and Lupinus luteus) in sow, piglet and fattener feeding. Agric Food Sci. 26:1–15.
  • Huyghe C. 1997. White lupin (Lupinus albus L.). Field Crops Res. 53:147–160.
  • Jędrejek D, Levic J, Wallace J, Oleszek W. 2016. Animal by-products for feed: characteristics, European regulatory framework, and potential impacts on human and animal health and the environment. J Anim Feed Sci. 25:189–202.
  • Kasprowicz-Potocka M, Chilomer K, Zaworska A, Nowak W, Frankiewicz A. 2013. The effect of feeding raw and germinated Lupinus luteus and Lupinus angustifolius seeds on the growth performance of young pigs. J Anim Feed Sci. 22:116–121.
  • Kasprowicz-Potocka M, Zaworska A, Kaczmarek S, Hejdysz M, Mikula R, Rutkowski A. 2017. The effect of Lupinus albus seeds on digestibility, performance and gastrointestinal tract indices in pigs. J Anim Physiol Anim Nutr. 101:e216–e224.
  • Kim JC, Pluske JR, Mullan BP. 2007. Lupins as a protein source in pig diets. CAB Rev. 2. 3:1–12.
  • Lee ST, Cook D, Panter KE, Gardner DR, Ralphs MH, Motteram ES, Pfister JA, Gay CC. 2007. Lupine induced “crooked calf disease” in Washington and Oregon: identification of the alkaloid profiles in Lupinus sulfureus, Lupinus leucophyllus, and Lupinus sericeus. J Agric Food Chem. 55:10649–10655.
  • Litkey J, Dailey MW. 2007. Anticholinergic toxicity associated with the ingestion of lupini beans. Am J Emerg Med. 25:215–217.
  • Lucas MM, Pueyo JJ, Stoddard FL, Annicchiarico P, Frias J, Martinez-Villaluenga C, Sussmann D, Duranti M, Seger A, Zander PM. 2015. The future of lupin as a protein crop in Europe. Front Plant Sci. 6:705.
  • Magalhães SCQ, Fernandes F, Cabrita ARJ, Fonseca AJM, Valentao P, Andrade PB. 2017. Alkaloids in the valorization of European Lupinus spp. seeds crop. Ind Crops Prod. 95:286–295.
  • Modra H, Svobodova Z. 2009. Incidence of animal poisoning cases in the Czech Republic: current situation. Interdiscip Toxicol. 2:48–51.
  • Panter KE, James LF, Gardner DR. 1999. Lupines, poison-hemlock and Nicotiana spp: toxicity and teratogenicity in livestock. J Nat Toxins. 8:117–134.
  • Pilegaard K, Gry J. 2009. Alkaloids in edible lupin seeds: a toxicological review and recommendations. Copenhagen: Nordic Council of Ministers. TemaNord. p. 605.
  • Pothier J, Cheav SL, Galand N, Dormeau C, Viel C. 1998. A comparative study of the effects of sparteine, lupanine and lupine extract on the central nervous system of the mouse. J Pharm Pharmacol. 50:949–954.
  • Regulation. 2009. Commission Regulation (EC) No 1121/2009; p. 27–64.
  • Regulation. 2013. Commission Regulation (EU) No 68/2013 of the Catalogue of feed materials; p. 1–64.
  • Reinhard H, Rupp H, Sager F, Streule M, Zoller O. 2006. Quinolizidine alkaloids and phomopsins in lupin seeds and lupin containing food. J Chromatogr A. 1112:353–360.
  • Resta D, Boschin G, D'Agostina A, Arnoldi A. 2008. Evaluation of total quinolizidine alkaloids content in lupin flours, lupin-based ingredients, and foods. Mol Nutr Food Res. 52:490–495.
  • Rotkiewicz T, Stanek M, Wisniewska M, Otrocka-Domagala L, Bogusz J, Purwin C, Bomba G. 2007. Pathomorphological and histochemical examinations of the digestive tracts and some internalorgans of pigs fed diets containing narrow-leaved lupin (Lupinus angustifolius) seeds. Ann Anim Sci. 7:83–88.
  • Sapkota AR, Lefferts LY, McKenzie S, Walker P. 2007. What do we feed to food-production animals? A review of animal feed ingredients and their potential impacts on human health. Environ Health Perspect. 115:663–670.
  • EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain) Schrenk D, Bodin L, Chipman JK, del Mazo J, Grasl-Kraupp B, Hogstrand C, Hoogenboom L, Leblanc JC, Nebbia CS, Nielsen E, et al. 2019. Scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids in feed and food, in particular in lupins and lupin-derived products. EFSA J. 17(11):05860. 113 pp.
  • Wasilewko J, Buraczewska L, Lechowski R, Wysocka W. 1997. Effect of dietary lupanine on nutrient digestibility and on blood indices in pigs. EAAP Publ. 88:430–433.
  • Wink M, Meißner C, Witte L. 1995. Patterns of quinolizidine alkaloids in 56 species of the genus Lupinus. Phytochemistry. 38:139–153.
  • Zaworska-Zakrzewska A, Kasprowicz-Potocka M, Mikuła R, Frankiewicz A, Taciak M, Pruszyńska-Oszmałek E. 2020. Growth performance, gut environment and physiology of the gastrointestinal tract in weaned piglets fed a diet supplemented with raw and fermented narrow-leafed lupine seeds. Animals (Basel). 10:2084.