Anti-inflammatory, Analgesic Activity and Toxicity of Two Pelargonium inquinans Ait Essential Oils: Wild and Cultivated

References

• Harvey, A.L. (2008). Natural products in drug discovery. Drug Disc. Today. 13(19-20): 894-901. doi: 10.1016/j.drudis.2008.07.004
   PubMed Web of Science ®Google Scholar
• Dias, D.A., Urban, S., Roessner, U. (2012). A historical overview of natural products in drug discovery. Metabolites. 2: 303-336. doi: 10.3390/metabo2020303
   PubMedGoogle Scholar
• Matasyoh, L., Matasyoh, J., Wachira, F., Kinyua, M., Muigai, A., Mukiama, T. (2007). Chemical composition and antimicrobial activity of the essential oil of Ocimum gratissimum L. growing in Eastern Kenya. Afri. J. Biotech. 6(6): 760-765.
   Google Scholar
• Matsuzaki, Y., Tsujisawa, T., Nishihara, T., Nakamura, M., Kakinoki, Y. (2013). Antifungal activity of chemotype essential oils from rosemary against Candida albicans. J. Stomat. 3(2): 176-182.
   Google Scholar
• Hatami, M., Ghafarzadegan, R., Ghorbanpour, M. (2013). Essential oil compositions and photosynthetic pigments content of Pelargonium graveolens in response to nanosilver application. J. Med. Plants. 13(49): 5-14.
   Google Scholar
• Ghannadi, A., Abedi, D., Jalali, M., Absalan, B., Sadeghi, N. (2012). Antibacterial activity and composition of essential oils from Pelargonium graveolens L ‘ Her and Vitex agnus-castus L. Iranian J. Microbio. 4: 171-176.
   PubMedGoogle Scholar
• Saraswathi, J., Venkatesh, K., Baburao, N., Hilal, M.H., Rani, A.R. (2011). Phytopharmacological importance of Pelargonium species. J. Med. Plants Res. 25(13): 2587-2598.
   Google Scholar
• Piao, X., Piao, X., Hyun, Y.K., Eun, J.C. (2008). Antioxidative activity of geranium (Pelargonium inquinans Ait) and its active component, 1,2,3,4,6-penta-O-galloyl-β-D-glucose. Phyto. Res. 22: 534-538. doi: 10.1002/ptr.2398
   Google Scholar
• Ji, M.S., Piao, X.L., Jin, Y.L., Park, R.D. (2005). Anticoagulant 1,2,3,4,6-pentagalloyl-beta-D-glucopyranose isolated from geranium (Pelargonium inquinans Ait). Arch. Pharm. Res. 28(9): 1037-1041. doi: 10.1007/BF02977398
   PubMed Web of Science ®Google Scholar
• Barbosa, P., Lima, A.S., Vieira, P., Dias, L.S., Tinoco, M.T., Barroso, J.G., Mota, M. (2010). Nematicidal activity of essential oils and volatiles derived from Portuguese aromatic flora against the pinewood nematode, Bursaphelenchus xylophilus. J. Nematol. 42(1): 8-16.
   PubMed Web of Science ®Google Scholar
• Kokkini, S., Hanlidou, E., Karousou, R., Lanaras, T. (2004). Clinal variation of Mentha pulegium essential oils along the climatic gradient of Greece. J. Essential Oil Res. 16: 588-593. doi: 10.1080/10412905.2004.9698805
   Web of Science ®Google Scholar
• Rungqu, P., Oyedeji, O.O., Avoseh, O.N., Aremu, S.O., Nkeh-Chungag, B.N., Songca, S.P., Oluwafemi, S.O., Oyedeji, A.O. (2016). Anti-inflammatory activity of the essential oils of Cymbopogon validus (Stapf) Stapf ex Burtt Davy from Eastern Cape, South Africa. Asian Pacific J. Trop. Med. 2016: 1-6.
   Google Scholar
• Adams, R.P. (2007). Identification of Essential Oil Components GC/Mass Spectroscopy. 4th Ed. Allured Publishing Corporation, 336 Gunderson Drive, Suite A, Carol Stream, IL, USA.
   Google Scholar
• ESO, (2000). The complete database of essential oil B.A.C.I.S. The Netherlands. 1999.
   Google Scholar
• Joulain, D., Koenig, W.A. (1989). The atlas of spectral data of sesquiterpene hydrocarbons. E.B. Verlag Hamburg, Germany.
   Google Scholar
• National Institute of Health (NIH) Publication No. 85. (1985). Guide for the Care and Use of Laboratory Animals, 8th edition. National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Washington (DC): National Academies Press (US); 2011. https://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals
   Google Scholar
• Lorke D. (1983). A new approach to practical acute toxicity testing. Arch. Toxicol. 54(4): 275–287. doi: 10.1007/BF01234480
   PubMed Web of Science ®Google Scholar
• Gonzalez-Trujano, M.E., Carrera, D., Ventura-Martinez, R., Cedillo-Portugal, E., Navarrete, A. (2006). Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice. J. Ethnopharmacol. 106(1): 129-135. doi: 10.1016/j.jep.2005.12.014
   PubMed Web of Science ®Google Scholar
• Viana, G.S., Bandeira, M.A., Matos, F.J. (2003). Analgesic and anti-inflammatory effects of chalcones isolated from Myracrodruon urundeuva Allem. Phytomed. 10(2-3): 189-95. doi: 10.1078/094471103321659924
   PubMed Web of Science ®Google Scholar
• Silva, J., Abebe, W., Sousa, S.M., Duarte, V.G., Machado, M.I.L., Matos, F.J.A. (2003). Analgesic and anti-inflammatory effects of essential oil of Eucalyptus. J. Ethnopharmacol. 89(2): 277-283. doi: 10.1016/j.jep.2003.09.007
   PubMed Web of Science ®Google Scholar
• Winter, C.A., Risley, E.A., Nuss, G.W. (1962). Carrageenan-induced edema in hind paws of the rat as an assay for anti-inflammatory drugs. Proceedings for the Society of Experimental Biology and Medicine. 111: 544-547. doi: 10.3181/00379727-111-27849
   PubMed Web of Science ®Google Scholar
• Olajide, A.O., Awe, S.O., Makinde, J.M., Ekhelar, A.I., Olusola, A., Morebise, O., and Okpako, D.T. (2000). Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stern bark. J. Ethnopharmacol. 71: 179-186. doi: 10.1016/S0378-8741(99)00200-7
   PubMed Web of Science ®Google Scholar
• Oyemitan, I.A., Kolawole, F., Oyedeji, A.O. (2014). Acute Toxicity, Antinociceptive and Anti-inflammatory Activity of the Essential Oil of Fresh Fruits of Piper guineense Schum & Thonn (Piperaceae) in Rodents. J. Med. Plants Res. 8(40): 1191-1197.
   Google Scholar
• Asgarpanah, J., Ramezanloo, F. (2015). An overview on phytopharmacology of Pelargonium graveolens L. Indian J. Trad. Knowl. 14(4): 558-563.
   Web of Science ®Google Scholar
• Sharopov, F.S., Zhang, H., Setzer, W.N. (2014). Composition of geranium (Pelargonium graveolens) essential oil from Tajikistan. Am. J. Essential Oils Nat. Prod. 2(2): 13-16.
   Google Scholar
• Abd EL-Lateef Gharib, F. (2005). Changes in regeneration and oil accumulation of Pelargonium nervosum under various culture conditions. J. Biol. Sc. 5(5): 670-677. doi: 10.3923/jbs.2005.670.677
   Google Scholar
• Elisabetsky, E., Amador, T.A., Albuquerque, R.R., Nunes, D.S. (1995). Analgesic activity of Psychotria colorata (wild. ex R. & S.) Muell. Arg. Alkaloids. J. Ethnopharmacol. 48: 77-83. doi: 10.1016/0378-8741(95)01287-N
   PubMed Web of Science ®Google Scholar
• Adzu, B., Amos, S., Kapu, S.D., Gamaniel, K.S. (2003). Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis. J. Ethnopharmacol. 84: 169-173. doi: 10.1016/S0378-8741(02)00295-7
   PubMed Web of Science ®Google Scholar
• Anosike, C.A., Obidoa, O., Ezeanyika, L.U.S. (2012). The antiinflammatory activity of garden egg (Solanum aethiopicum) on egg albumin-induced oedema and granuloma tissue formation in rats. Asian Pac. J. Tropical Med. 5(1): 62-66. doi: 10.1016/S1995-7645(11)60247-2
   PubMed Web of Science ®Google Scholar
• Zhou, M., Wang, H., Suolangjiba, K.J., Yu, B. (2008). Antinociceptive and anti-inflammatory activities of Aquilaria sinensis (Lour.) Gilg. Leaves extract. J. Ethnopharmacol. 117: 345-350. doi: 10.1016/j.jep.2008.02.005
   PubMed Web of Science ®Google Scholar
• Ribeiro, R.A., Vale, M.L., Thomazzi, S.M., Paschoalato, A.B., Poole, S., Ferreira, S.H., Cunha, F.Q. (2000). Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. Pharmacol. 38 (1): 111–118. doi: 10.1016/S0014-2999(99)00790-6
   Google Scholar
• Kaushik, D., Kumar, A., Kaushik, P., Rana, A.C. (2012). Analgesic and Anti-Inflammatory Activity of Pinus roxburghii Sarg. Adv. Pharmacol. Sci. 6 pages.
   Google Scholar
• Hu, X.J., Jin, H.Z., Xu, W.Z., Zhang, W., Liu, X.H., Yan, S.K., Chen, M., Li, J.Q., Zhang, W.D. (2008). Anti-inflammatory and analgesic effects of Daphne retusa Hemsl. J. Ethnopharmacol.120: 118-122. doi: 10.1016/j.jep.2008.07.010
   PubMed Web of Science ®Google Scholar
• Hernández-Pérez, M., Rabanal-Gallego, R.M. (2002). Evaluation of the antiinflammatory and analgesic activity of Sideritis canariensis var. pannosa in mice. J. Ethnopharmacol. 81: 43-47. doi: 10.1016/S0378-8741(02)00033-8
   PubMed Web of Science ®Google Scholar
• Sharma, C., Al Kaabi, J.M., Nurulain, S.M., Goyal, S.N., Mohammad Amjad Kamal, M.A., Ojha, S. (2016). Polypharmacological Properties and Therapeutic Potential of β-Caryophyllene: A Dietary Phytocannabinoid of Pharmaceutical Promise. Cur. Pharmace. Design. 22(46): 3237–3264. doi: 10.2174/1381612822666160311115226
   PubMedGoogle Scholar
• Santos, C.C.M.P., Salvadori, M.S., Mota, V.G., Costa, L.M., de Almeida, A.C.A., de Oliveira, G.A.L., Costa, J.P., de Sousa, D.P., de Freitas, R.M., de Almeida, R.N. (2013). Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models. Neuroscience J. 9 pages.
   Google Scholar
• Zhang, C., Qin, M.J., Shu, P., Hong, H.L., Lü, L., He, D.X. (2010). Chemical variations of the essential oils in flower heads of Chrysanthemum indicum L. from China. Chem. Biodivers. 7(12): 2951-2962 doi: 10.1002/cbdv.201000034
   PubMed Web of Science ®Google Scholar
• Valente, J., Zuzarte, M., Gonçalves, M.J., Lopes, M.C., Cavaleiro, C., Salgueiro, L., Cruz, M.T. (2013). Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oil. Food Chem. Toxicol. 62: 349-54. doi: 10.1016/j.fct.2013.08.083
   PubMed Web of Science ®Google Scholar
• Quintans-Junior, L.J., Barreto, R.S.S., Menezes, P.P., Almeida, J.R.G.S., Viana, A.F.S.C., Oliveira, R.C.M., Oliveira, A.P., Gelain, D.P., de Lucca Junior, W., Araujo, A.A.S. (2013). β-Cyclodextrin-complexed (-)-linalool produces antinociceptive effect superior to that of (-)-linalool in experimental pain protocols. Basic & Clinic Pharmacol. Toxicol. 113: 167-172. doi: 10.1111/bcpt.12087
   PubMed Web of Science ®Google Scholar
• Ghori, S.S., Ahmed, M.I., Arifuddin, M., Md Shoaibuddin Khateeb, M.S. (2016). Evaluation of analgesic and anti-inflammatory activities of formulation containing camphor, menthol and thymol. Int J. Pharm. Pharm. Sci. 8(1), 271-274.
   Google Scholar
• Zuccarini, P., Soldani, G. (2009). Camphor: benefits and risks of a widely used natural Product. Acta Biol. Szeged. 53(2): 77-82.
   Google Scholar
• Martin, D., Valdez, J., Boren, J., Mayersohn, M. (2014). Dermal absorption of camphor, menthol, and methyl salicylate in humans. J. Clini. Pharmacol. 44(10): 1151–7. doi: 10.1177/0091270004268409
   Google Scholar