Allspice (Pimenta dioica) essential oil mediates sphingosine kinase inhibition and subsequent induction of apoptosis in gastric cancer cells

References

• Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 68(6): 394-424.
   PubMed Web of Science ®Google Scholar
• Sharma, A., & Radhakrishnan, V. (2011). Gastric cancer in India. Indian journal of medical and paediatric oncology: official journal of Indian Society of Medical & Paediatric Oncology. 32(1): 12-16. doi: 10.4103/0971-5851.81884
   PubMedGoogle Scholar
• Mathur, P., Sathishkumar, K., Chaturvedi, M., Das, P., Sudarshan, K.L., Santhappan, S., Nallasamy, V., John, A., Narasimhan, S., Roselind, F.S. and Icmr-Ncdir-Ncrp Investigator Group. (2020). Cancer Statistics, 2020: Report From National Cancer Registry Programme, India. JCO Global Oncology. 6: 1063-1075. doi: 10.1200/GO.20.00122
   PubMedGoogle Scholar
• Rawla, P., & Barsouk, A. (2019). Epidemiology of gastric cancer: global trends, risk factors and prevention. Przeglad gastroenterologiczny. 14(1): 26-38.
   PubMed Web of Science ®Google Scholar
• Yusefi, A.R., Bagheri Lankarani, K., Bastani, P., Radinmanesh, M., & Kavosi, Z. (2018). Risk factors for gastric cancer: a systematic review. Asian Pacific Journal of Cancer Prevention. 19(3): 591-603.
   PubMedGoogle Scholar
• Joshi, S.S., & Badgwell, B.D. (2021). Current treatment and recent progress in gastric cancer. CA: A Cancer Journal for Clinicians. 71(3): 264-279.
   PubMed Web of Science ®Google Scholar
• Desiderio, J., Sagnotta, A., Terrenato, I., Annibale, B., Trastulli, S., Tozzi, F., D’Andrea, V., Bracarda, S., Garofoli, E., Fong, Y., & Woo, Y. (2021). Gastrectomy for stage IV gastric cancer: a comparison of different treatment strategies from the SEER database. Scientific Reports, 11(1): 7150. doi: 10.1038/s41598-021-86352-6
   PubMed Web of Science ®Google Scholar
• Marin, J.J., Al-Abdulla, R., Lozano, E., Briz, O., Bujanda, L., Banales, J.M., & Macias, R.I. (2016). Mechanisms of resistance to chemotherapy in gastric cancer. Anticancer Agents in Medicinal Chemistry. 16(3): 318-334. doi: 10.2174/1871520615666150803125121
   PubMed Web of Science ®Google Scholar
• Choudhari, A.S., Mandave, P.C., Deshpande, M., Ranjekar, P., & Prakash, O. (2020). Phytochemicals in cancer treatment: from preclinical studies to clinical practice. Frontiers in Pharmacology. 10(1614). doi: 10.3389/fphar.2019.01614
   PubMed Web of Science ®Google Scholar
• Seca, A.M.L., & Pinto, D.C.G.A. (2018). Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application. International Journal of Molecular Science. 19(1): 263. doi: 10.3390/ijms19010263
   PubMed Web of Science ®Google Scholar
• Sharma, M., Grewal, K., Jandrotia, R., Batish, D.R., Singh, H.P., & Kohli, R.K. (2022). Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement. Biomedicine & Pharmacotherapy. 146: 112514. doi: 10.1016/j.biopha.2021.112514
   PubMed Web of Science ®Google Scholar
• Mukarram, M., Choudhary, S., Khan, M.A., Poltronieri, P., Khan, M.M.A., Ali, J., Kurjak, D., & Shahid, M. (2021). Lemongrass essential oil components with antimicrobial and anticancer activities. Antioxidants. 11(1): 20. doi: 10.3390/antiox11010020
   Web of Science ®Google Scholar
• Zhou, X., Zhou, X., Wang, C., & Zhou, H. (2023). Environmental and human health impacts of volatile organic compounds: A perspective review. Chemosphere. 313: 137489. doi: 10.1016/j.chemosphere.2022.137489
   PubMed Web of Science ®Google Scholar
• Cheng, H., Wang, J., & Xie, J. (2023). Progress on odor deterioration of aquatic products: Characteristic volatile compounds, analysis methods, and formation mechanisms. Food Bioscience. 53: 102666. doi: 10.1016/j.fbio.2023.102666
   Web of Science ®Google Scholar
• Cascaes, M.M., Silva, S.G., Cruz, J.N., Santana de Oliveira, M., Oliveira, J., Moraes, A.A.B.D., Costa, F.A.M.D., da Costa, K.S., Diniz do Nascimento, L., & Helena de Aguiar Andrade, E. (2022). First report on the Annona exsucca DC. Essential oil and in silico identification of potential biological targets of its major compounds. Natural Product Research, 36(15): 4009-4012. doi: 10.1080/14786419.2021.1893724
   PubMed Web of Science ®Google Scholar
• Mesquita, K.D.S.M., Feitosa, B.D.S., Cruz, J.N., Ferreira, O.O., Franco, C.D.J.P., Cascaes, M.M., Oliveira, M.S.D. and Andrade, E.H.D.A. (2021). Chemical composition and preliminary toxicity evaluation of the essential oil from Peperomia circinnata Link var. circinnata. (Piperaceae) in Artemia salina Leach. Molecules. 26(23): 7359.
   PubMed Web of Science ®Google Scholar
• de Oliveira, M.S., Cruz, J.N., Ferreira, O.O., Pereira, D.S., Pereira, N.S., Oliveira, M.E.C., Venturieri, G.C., Guilhon, G.M.S.P., Souza Filho, A.P.D.S. and Andrade, E.H.D.A. (2021). Chemical composition of volatile compounds in Apis mellifera Propolis from the Northeast Region of Pará State, Brazil. Molecules. 26(11): 3462. doi: 10.3390/molecules26113462
   PubMed Web of Science ®Google Scholar
• Zhang, L., & Lokeshwar, B.L. (2012). Medicinal properties of the Jamaican pepper plant Pimenta dioica and Allspice. Curr. Drug Targets. 13(14): 1900-1906. doi: 10.2174/138945012804545641
   PubMed Web of Science ®Google Scholar
• Velazquez Silva, A., Robles Yerena, L., & Barrera Necha, L.L. (2021). Chemical profile and antifungal activity of plant extracts on Colletotrichum spp. isolated from fruits of Pimenta dioica (L.) Merr. Pesticide Biochemistry and Physiology. 179: 104949. doi: 10.1016/j.pestbp.2021.104949
   PubMed Web of Science ®Google Scholar
• Merida-Reyes, M.S., Munoz-Wug, M.A., Oliva-Hernandez, B.E., Gaitan-Fernandez, I.C., Simas, D.L.R., Ribeiro da Silva, A.J., & Perez-Sabino, J.F. (2020). Composition and Antibacterial activity of the essential oil from Pimenta dioica (L.) Merr. from Guatemala. Medicines (Basel). 7(10): 59.
   PubMedGoogle Scholar
• Sarathambal, C., Rajagopal, S., & Viswanathan, R. (2021). Mechanism of antioxidant and antifungal properties of Pimenta dioica (L.) leaf essential oil on Aspergillus flavus. Journal of Food Science and Technology. 58(7): 2497-2506. doi: 10.1007/s13197-020-04756-0
   PubMed Web of Science ®Google Scholar
• Lorenzo-Leal, A.C., Palou, E., Lopez-Malo, A., & Bach, H. (2019). Antimicrobial, cytotoxic, and anti-inflammatory activities of Pimenta dioica and Rosmarinus officinalis essential oils. Biomed Research International. 2019: 1639726. doi: 10.1155/2019/1639726
   PubMed Web of Science ®Google Scholar
• Doyle, B.J., Lawal, T.O., Locklear, T.D., Hernandez, L., Perez, A.L., Patel, U., Patel, S. and Mahady, G.B. (2018). Isolation and identification of three new chromones from the leaves of Pimenta dioica with cytotoxic, oestrogenic and anti-oestrogenic effects. Pharmaceutical Biology. 56(1): 235-244. doi: 10.1080/13880209.2018.1448873
   PubMed Web of Science ®Google Scholar
• Gomes da Rocha Voris, D., dos Santos Dias, L., Alencar Lima, J., dos Santos Cople Lima, K., Pereira Lima, J.B., & dos Santos Lima, A. L. (2018). Evaluation of larvicidal, adulticidal, and anticholinesterase activities of essential oils of Illicium verum Hook. f., Pimenta dioica (L.) Merr., and Myristica fragrans Houtt. against Zika virus vectors. Environmental Science and Pollution Research. 25(23): 22541-22551. doi: 10.1007/s11356-018-2362-y
   PubMed Web of Science ®Google Scholar
• Morsy, N.F.S., & Hammad, K.S.M. (2018). Volatile constituents, radical scavenging and cytotoxic activities of Mexican allspice (Pimenta dioica L. Merrill) berries essential oil. Journal of Essential Oil Bearing Plants. 21(4): 859-868. doi: 10.1080/0972060X.2018.1524793
   Web of Science ®Google Scholar
• Narayanankutty, A., Kuttithodi, A.M., Alfarhan, A., Rajagopal, R., & Barcelo, D. (2021). Chemical composition, insecticidal and mosquito larvicidal activities of allspice (Pimenta dioica) essential oil. Molecules. 26(21): 6698. doi: 10.3390/molecules26216698
   PubMed Web of Science ®Google Scholar
• Lorenzo-Leal, A.C., Palou, E., & López-Malo, A. (2019). Evaluation of the efficiency of allspice, thyme and rosemary essential oils on two foodborne pathogens in in-vitro and on alfalfa seeds, and their effect on sensory characteristics of the sprouts. International Journal of Food Microbiology. 295: 19-24. doi: 10.1016/j.ijfoodmicro.2019.02.008
   PubMed Web of Science ®Google Scholar
• Perumal, A., AlSalhi, M.S., Kanakarajan, S., Devanesan, S., Selvaraj, R., & Tamizhazhagan, V. (2021). Phytochemical evaluation and anticancer activity of rambutan (Nephelium lappaceum) fruit endocarp extracts against human hepatocellular carcinoma (HepG-2) cells. Saudi Journal of Biological Sciences. 28(3): 1816-1825. doi: 10.1016/j.sjbs.2020.12.027
   PubMed Web of Science ®Google Scholar
• Kim, Y.O., Narayanankutty, A., Kuttithodi, A.M., Kim, H.J., Na, S.W., Kunnath, K., Rajagopal, R., & Alfarhan, A. (2022). Azima tetracantha leaf methanol extract inhibits gastric cancer cell proliferation through induction of redox imbalance and cytochrome C Release. Applied Sciences. 12(1): 120. doi: 10.3390/app12010120
   Google Scholar
• Kim, H.J., Narayanankutty, A., Sasidharan, A., Job, J.T., Kim, Y.O., Na, S.W., Rajagopal, R., Alfarhan, A., & Al-Munqedhi, B., (2021). Methanolic extract of coconut (Cocos nucifera L.) haustorium mitigates pro-oxidant-mediated apoptotic cell death via Nrf-2 pathway and lipopolysaccharide-induced cytokine release in cells. Journal of King Saud University - Science. 101715.
   Web of Science ®Google Scholar
• Livak, K.J., & Schmittgen, T.D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT Method. Methods. 25(4): 402-408. doi: 10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• Chaudhari, A.K., Singh, V.K., Dwivedy, A.K., Das, S., Upadhyay, N., Singh, A., Dkhar, M.S., Kayang, H., Prakash, B., & Dubey, N.K. (2020). Chemically characterised Pimenta dioica (L.) Merr. essential oil as a novel plant based antimicrobial against fungal and aflatoxin B(1) contamination of stored maize and its possible mode of action. Natural Product Research. 34(5): 745-749. doi: 10.1080/14786419.2018.1499634
   PubMed Web of Science ®Google Scholar
• Marzouk, M. S., Moharram, F.A., Mohamed, M.A., Gamal-Eldeen, A.M., & Aboutabl, E.A. (2007). Anticancer and antioxidant tannins from Pimenta dioica leaves. Zeitschrift für Naturforschung C: A Journal of Biosciences. 62(7-8): 526-536. doi: 10.1515/znc-2007-7-811
   PubMed Web of Science ®Google Scholar
• Bayala, B., Bassole, I.H., Scifo, R., Gnoula, C., Morel, L., Lobaccaro, J.-M.A., & Simpore, J. (2014). Anticancer activity of essential oils and their chemical components - a review. American Journal of Cancer Research. 4(6): 591-607.
   PubMed Web of Science ®Google Scholar
• Jaganathan, S.K., & Supriyanto, E. (2012). Anti-proliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells. Molecules (Basel, Switzerland). 17(6): 6290-6304. doi: 10.3390/molecules17066290
   PubMed Web of Science ®Google Scholar
• Abdullah, M.L., Hafez, M.M., Al-Hoshani, A., & Al-Shabanah, O. (2018). Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells. BMC Complementary and Alternative Medicine. 18(1): 321. doi: 10.1186/s12906-018-2392-5
   PubMed Web of Science ®Google Scholar
• Fathy, M., Fawzy, M.A., Hintzsche, H., Nikaido, T., Dandekar, T., & Othman, E.M. (2019). Eugenol exerts apoptotic effect and modulates the sensitivity of HeLa cells to cisplatin and radiation. Molecules. 24(21): 3979. doi: 10.3390/molecules24213979
   PubMed Web of Science ®Google Scholar
• Islam, S.S., Al-Sharif, I., Sultan, A., Al-Mazrou, A., Remmal, A., & Aboussekhra, A. (2018). Eugenol potentiates cisplatin anti-cancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-κB signaling pathway. Molecular Carcinogenesis. 57(3): 333-346. doi: 10.1002/mc.22758
   PubMed Web of Science ®Google Scholar
• Alam, M.M. (2023). Synthesis and anticancer activity of novel Eugenol derivatives against breast cancer cells. Natural Product Research. 37(10): 1632-1640. doi: 10.1080/14786419.2022.2103809
   PubMed Web of Science ®Google Scholar
• Brentnall, M., Rodriguez-Menocal, L., De Guevara, R.L., Cepero, E., & Boise, L.H. (2013). Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biology. 14(1): 32. doi: 10.1186/1471-2121-14-32
   PubMedGoogle Scholar
• Shi, Y. (2004). Caspase activation, inhibition, and reactivation: a mechanistic view. Protein science: a publication of the Protein Society. 13(8): 1979-1987. doi: 10.1110/ps.04789804
   PubMed Web of Science ®Google Scholar
• Sarkar, A., Das, S., Rahaman, A., Das Talukdar, A., Bhattacharjee, S., & Mandal, D.P. (2020). Eugenol and capsaicin exhibit anti-metastatic activity via modulating TGF-β signaling in gastric carcinoma. Food and Function. 11(10): 9020-9034. doi: 10.1039/D0FO00887G
   PubMed Web of Science ®Google Scholar
• Woodcock, J. (2006). Sphingosine and ceramide signalling in apoptosis. IUBMB Life. 58(8): 462-466. doi: 10.1080/15216540600871118
   PubMed Web of Science ®Google Scholar
• Abdel Hadi, L., Di Vito, C., Marfia, G., Ferraretto, A., Tringali, C., Viani, P., & Riboni, L. (2015). Sphingosine kinase 2 and ceramide transport as key targets of the natural flavonoid luteolin to induce apoptosis in colon cancer cells. PLoS One. 10(11): e0143384-e0143384. doi: 10.1371/journal.pone.0143384
   PubMed Web of Science ®Google Scholar