Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review)

References

• Anderson, R. G., 1998, The caveolae membrane system. Annal Reviews in Biochemistry, 67, 199 -225.
   PubMed Web of Science ®Google Scholar
• Anderson, R. G. and Jacobson, K., 2002, A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science, 296, 1821 -1825.
   PubMed Web of Science ®Google Scholar
• Bai, J. and Pagano, R. E., 1997, Measurement of spontaneous transfer and transbilayer movement of BODIPY-labeled lipids in lipid vesicles. Biochemistry, 36, 8840 -8848.
   PubMed Web of Science ®Google Scholar
• Bell, R. M., Ballas, L. M. and Coleman, R. A., 1981, Lipid topogenesis. Journal of Lipid Research, 22, 391 -403.
   PubMed Web of Science ®Google Scholar
• Birchmeier, W., Lanz, J. H., Winterhalter, K. H. and Conrad, M. J., 1979, ATP-induced endocytosis in human erythrocyte ghosts. Characterization of the process and isolation of the endocytosed vesicles. Journal of Biological Chemistry, 254, 9298 -9304.
   Google Scholar
• Bishop, W. R. and Bell, R. M., 1985, Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transpor- ter. Cell, 42, 51 -60.
   PubMed Web of Science ®Google Scholar
• Boggs, J. M., 1987, Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function. Biochimica et Biophysica Acta, 906, 353 -404.
   PubMed Web of Science ®Google Scholar
• Bretscher, M. S., 1973, Membrane structure: some general princi- ples. Science, 181, 622 -629.
   PubMed Web of Science ®Google Scholar
• Bretscher, M. S. and Munro, S., 1993, Cholesterol and the Golgi apparatus. Science, 261, 1280 -1281.
   PubMed Web of Science ®Google Scholar
• Brown, D. A. and London, E., 1998, Functions of lipid rafts in biological membranes. Annual Reviews in Cell Development Biology, 14, 111 -136.
   PubMed Web of Science ®Google Scholar
• Brown, D. A., Crise, B. and Rose, J. K., 1989, Mechanism of membrane anchoring affects polarized expression of two proteins in MDCK cells. Science, 245, 1499 -1501.
   PubMedGoogle Scholar
• Brugger, B., Sandhoff, R., Wegehingel, S., Gorgas, K., Malsam, J., Helms, J. B., Lehmann, W. D., Nickel, W. and Wieland, F. T., 2000, Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. Journal of Cell Biology, 151, 507 -518.
   PubMed Web of Science ®Google Scholar
• Bull, L. N., van Eijk, M. J., Pawlikowska, L., DeYoung, J. A., Juijn, J. A., Liao, M., Klomp, L. W., Lomri, N., Berger, R., Scharschmidt, B. F., Knisely, A. S., Houwen, R. H. and Freimer, N. B., 1998,. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Natural Genetics, 18, 219–219.
   Google Scholar
• Burger, K. N. J., van der Bijl, P. and van Meer, G., 1996, Topology of sphingolipid galactosyltransferases in ER and Golgi: transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis. Journal of Cell Biology, 133, 15 - 28.
   PubMed Web of Science ®Google Scholar
• Buton, X., Herve, P., Kubelt, J., Tannert, A., Burger, K. N., Fellmann, P., Muller, P., Herrmann, A., Seigneuret, M. and Devaux, P. F., 2002, Transbilayer movement of monohexosylsphingolipids in endoplasmic reticulum and Golgi membranes. Biochemistry, 41, 13106 -13115.
   PubMed Web of Science ®Google Scholar
• Buton, X., Morrot, G., Fellmann, P. and Seigneuret, M., 1996, Ultrafast glycerophospholipid-selective transbilayer motion mediated by a protein in the endoplasmic reticulum membrane. Journal of Biological Chemistry, 271, 6651 -6657.
   PubMed Web of Science ®Google Scholar
• Chen, C. Y., Ingram, M. F., Rosal, P. H. and Graham, T. R., 1999, Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function. Journal of Cell Biology, 147, 1223 -1236.
   PubMed Web of Science ®Google Scholar
• Cole, N. B., Ellenberg, J., Song, J., DiEuliis, D. and Lippincott- Schwartz, J., 1998, Retrograde transport of Golgi-localized proteins to the ER. Journal of Cell Biology, 140, 1 -15.
   PubMed Web of Science ®Google Scholar
• Connor, J., Pak, C. H., Zwaal, R. F. A. and Schroit, A. J., 1992, Bidirectional transbilayer movement of phospholipid analogs in human red blood cells. Journal of Biological Chemistry, 267, 19412-19417.
   PubMed Web of Science ®Google Scholar
• Daleke, D. L. and Lyles, J. V., 2000, Identification and purification of aminophospholipid flippases. Biochimica et Biophysica Acta, 1486, 108 -127.
   PubMed Web of Science ®Google Scholar
• Daum, G. and Vance, J. E., 1997, Import of lipids into mitochondria. Progress in Lipid Research, 36, 103 -103.
   Google Scholar
• Decottignies, A., Grant, A. M., Nichols, J. W., de Wet, H., McIntosh, D. B. and Goffeau, A., 1998, ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. Journal of Biological Chemistry, 273, 12612 -12622.
   PubMed Web of Science ®Google Scholar
• Devaux, P. F., 1991, Static and dynamic lipid asymmetry in cell membranes. Biochemistry, 30, 1163 -1173.
   PubMed Web of Science ®Google Scholar
• Dietrich, C., Bagatolli, L. A., Volovyk, Z. N., Thompson, N. L., Levi, M., Jacobson, K. and Gratton, E., 2001, Lipid rafts reconstituted in model membranes. Biophysics Journal, 80, 1417 -1428.
   PubMed Web of Science ®Google Scholar
• Emoto, K. and Umeda, M., 2000, An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. Journal of Cell Biol- ogy, 149, 1215 -1224.
   PubMed Web of Science ®Google Scholar
• Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A., Ezekewitz, R. A. and Henson, P. M., 2000, A receptor for phosphatidylserine- specific clearance of apoptotic cells. Nature, 405, 85 -90.
   PubMed Web of Science ®Google Scholar
• Farge, E., Ojcius, D. M., Subtil, A. and Dautry-Varsat, A., 1999, Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells. American Journal of Physiology, 276, C725–C733.
   PubMedGoogle Scholar
• Feldman, M. F., Marolda, C. L., Monteiro, M. A., Perry, M. B., Parodi, A. J. and Valvano, M. A., 1999, The activity of a putative polyisoprenol-linked sugar translocase (Wzx) involved in Escher- ichia coli O antigen assembly is independent of the chemical structure of the O repeat. Journal of Biological Chemistry, 274, 35129–35138.
   PubMed Web of Science ®Google Scholar
• Fivaz, M., Vilbois, F., Thurnheer, S., Pasquali, C., Abrami, L., Bickel, P. E., Parton, R. G. and van der Goot, F. G., 2002, Differential sorting and fate of endocytosed GPI-anchored proteins. EMBO Journal, 21, 3989 -4000.
   PubMed Web of Science ®Google Scholar
• Folsch, H., Ohno, H., Bonifacino, J. S. and Mellman, I., 1999, A novel clathrin adaptor complex mediates basolateral targeting in polar- ized epithelial cells. Cell, 99, 189 -198.
   PubMed Web of Science ®Google Scholar
• Fra, A. M., Williamson, E., Simons, K. and Parton, R. G., 1994, Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. Journal of Biological Chemistry, 269, 30745–30748.
   PubMed Web of Science ®Google Scholar
• Funato, K. and Riezman, H., 2001, Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast. Journal of Cell Biology, 155, 949 -959.
   PubMed Web of Science ®Google Scholar
• Gall, W. E., Geething, N. C., Hua, Z., Ingram, M. F., Liu, K., Chen, S.I. and Graham, T. R., 2002, Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo. Current Biology, 12, 1623 -1627.
   PubMed Web of Science ®Google Scholar
• Gkantiragas, I., Brugger, B., Stuven, E., Kaloyanova, D., Li, X. Y., Lohr, K., Lottspeich, F., Wieland, F. T. and Helms, J. B., 2001, Sphingomyelin-enriched microdomains at the Golgi complex. Molecular Biology of the Cell, 12, 1819 -1833.
   PubMed Web of Science ®Google Scholar
• Gome` s, E., Jakobsen, M. K., Axelsen, K. B., Geisler, M. and Palmgren, M. G., 2000, Chilling tolerance in Arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocases. Plant Cell, 12, 2441 -2454.
   PubMed Web of Science ®Google Scholar
• Grove, S. N., Bracker, C. E. and Morre´, D. J., 1968, Cytomembrane differentiation in the endoplasmic reticulum-Golgi apparatus- vesicle complex. Science, 161, 171 -173.
   PubMed Web of Science ®Google Scholar
• Guillas, I., Kirchman, P. A., Chuard, R., Pfefferli, M., Jiang, J. C., Jazwinski, S. M. and Conzelmann, A., 2001, C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO Journal, 20, 2655 -2665.
   PubMed Web of Science ®Google Scholar
• Hamon, Y., Broccardo, C., Chambenoit, O., Luciani, M. F., Toti, F., Chaslin, S., Freyssinet, J. M., Devaux, P. F., McNeish, J., Marguet, D. and Chimini, G., 2000, ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidyl-serine. Natural Cell Biology, 2, 399 -406.
   PubMed Web of Science ®Google Scholar
• Harder, T., Scheiffele, P., Verkade, P. and Simons, K., 1998, Lipid domain structure of the plasma membrane revealed by patching of membrane components. Journal of Cell Biology, 141, 929 - 942.
   PubMed Web of Science ®Google Scholar
• Helenius, J., Ng, D. T., Marolda, C. L., Walter, P., Valvano, M. A. and Aebi, M., 2002, Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature, 415,447 -450.
   Web of Science ®Google Scholar
• Holthuis, J. C. M., Pomorski, T., Raggers, R. J., Sprong, H. and Van Meer, G., 2001, The organizing potential of sphingolipids in intracellular membrane transport. Physiology Review, 81, 1689 -1723.
   PubMed Web of Science ®Google Scholar
• Hua, Z., Fatheddin, P. and Graham, T. R., 2002, An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar sys- tem. Molecular Biology of the Cell, 13, 3162 -3177.
   PubMed Web of Science ®Google Scholar
• Ikonen, E. and Simons, K., 1998, Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells. Seminars in Cell Development Biology, 9, 503 -509.
   PubMed Web of Science ®Google Scholar
• Kato, U., Emoto, K., Fredriksson, C., Nakamura, H., Ohta, A., Kobayashi, T., Murakami-Murofushi, K. and Umeda, M., 2002, A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae. Journal of Biological Chemistry, 277, 37855–37862.
   PubMed Web of Science ®Google Scholar
• Keenan, T. W. and Morre´, D. J., 1970, Phospholipid class and fatty acid composition of Golgi apparatus isolated from rat liver and comparison with other cell fractions. Biochemistry, 9, 19 -25.
   PubMed Web of Science ®Google Scholar
• Kenworthy, A. K. and Edidin, M., 1998, Distribution of a glycosylpho- sphatidylinositol-anchored protein at the apical surface of MDCK cells examined at a resolution of B100 A using imaging fluorescence resonance energy transfer. Journal of Cell Biology,142, 69 -84.
   PubMed Web of Science ®Google Scholar
• Kol, M. A., de Kroon, A. I., Rijkers, D. T., Killian, J. A. and de Kruijff, B., 2001, Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner mem- brane of E. coli. Biochemistry, 40, 10500–10506.
   PubMed Web of Science ®Google Scholar
• Kol, M. A., van Laak, A. N. C., Rijkers, D. T., Killian, J. A., de Kroon,A. I. and de Kruijff, B., 2003, Phospholipid flop induced by transmembrane peptide in model membranes is modulated by lipid composition. Biochemistry, 42, 231 -237.
   PubMed Web of Science ®Google Scholar
• Lang, T., Bruns, D., Wenzel, D., Riedel, D., Holroyd, P., Thiele, C. and Jahn, R., 2001, SNAREs are concentrated in cholesterol- dependent clusters that define docking and fusion sites for exocytosis. EMBO Journal, 20, 2202 -2213.
   PubMed Web of Science ®Google Scholar
• Ledesma, M. D., Simons, K. and Dotti, C. G., 1998, Neuronal polarity: essential role of protein-lipid complexes in axonal sorting. Proceedings of the National Academy of Sciences (USA), 95, 3966–3971.
   PubMed Web of Science ®Google Scholar
• Lester, R. L., Wells, G. B., Oxford, G. and Dickson, R. C., 1993, Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphin-golipid structures. Journal of Biological Chemistry, 268, 845 -856.
   Google Scholar
• Levine, T. P., Wiggins, C. A. and Munro, S., 2000, Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Molecular Biology of the Cell, 11, 2267 -2281.
   PubMed Web of Science ®Google Scholar
• Li, X., Xie, Z. and Bankaitis, V. A., 2000, Phosphatidylinositol/ phosphatidylcholine transfer proteins in yeast. Biochimica et Biophysica Acta, 1486, 55 -71.
   PubMed Web of Science ®Google Scholar
• Lisanti, M. P., Sargiacomo, M., Graeve, L., Saltiel, A. R. and Rodriguez-Boulan, E., 1988, Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithe- lial cell line. Proceedings of the National Academy of Sciences (USA), 85, 9557–9561.
   PubMed Web of Science ®Google Scholar
• Liscum, L. and Munn, N. J., 1999, Intracellular cholesterol transport. Biochimica et Biophysica Acta, 1438, 19 -37.
   PubMed Web of Science ®Google Scholar
• Marx, U., Polakowski, T., Pomorski, T., Lang, C., Nelson, H., Nelson, N. and Herrmann, A., 1999, Rapid transbilayer movement of fluorescent phospholipid analogs in the plasma membrane of endocytosis-deficient yeast cells does not require the Drs2 protein. European Journal of Biochemistry, 263, 254 -263.
   PubMedGoogle Scholar
• Maulik, P. R. and Shipley, G. G., 1996, Interactions of N-stearoyl sphingomyelin with cholesterol and dipalmitoylphosphatidylcho- line in bilayer membranes. Biophysics Journal, 70, 2256 -2265.
   PubMed Web of Science ®Google Scholar
• Maxfield, F. R. and Mayor, S., 1997, Cell surface dynamics of GPI- anchored proteins. Advances in Experimental Medical Biology, 419, 355 -364.
   PubMed Web of Science ®Google Scholar
• Mays, R. W., Siemers, K. A., Fritz, B. A., Lowe, A. W., van Meer, G. and Nelson, W. J., 1995, Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells. Journal of Cell Biology, 130, 1105 -1115.
   Google Scholar
• Meguro, M., Kashiwagi, A., Mitsuya, K., Nakao, M., Kondo, I., Saitoh, S. and Oshimura, M., 2001, A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome. Natural Genetics, 28, 19 - 20.
   PubMed Web of Science ®Google Scholar
• Melkonian, K. A., Ostermeyer, A. G., Chen, J. Z., Roth, M. G. and Brown, D. A., 1999, Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated. Journal of Biological Chemistry, 274, 3910 -3917.
   PubMed Web of Science ®Google Scholar
• Menon, A. K., 1995, Flippases. Trends in Cell Biology, 5, 355 -360.
   PubMed Web of Science ®Google Scholar
• Menon, A. K., Watkins, W. E. and Hrafnsdottir, S., 2000, Specific proteins are required to translocate phosphatidylcholine bidirec- tionally across the endoplasmic reticulum. Current Biology, 10, 241 -252.
   PubMed Web of Science ®Google Scholar
• Muller, P., Pomorski, T. and Herrmann, A., 1994, Incorporation of phospholipid analogues into the plasma membrane affects ATP- induced vesiculation of human erythrocyte ghosts. Biochemistry and Biophysics Research Communications, 199, 881 -887.
   PubMed Web of Science ®Google Scholar
• Munro, S., 1995, An investigation of the role of transmembrane domains in Golgi protein retention. EMBO Journal, 14, 4695- 4704.
   PubMed Web of Science ®Google Scholar
• Nezil, F. A. and Bloom, M., 1992, Combined influence of cholesterol and synthetic amphiphillic peptides upon bilayer thickness in model membranes. Biophysics Journal, 61, 1176 -1183.
   PubMed Web of Science ®Google Scholar
• Nichols, B. J., Kenworthy, A. K., Polishchuk, R. S., Lodge, R., Roberts, T. H., Hirschberg, K., Phair, R. D. and Lippincott- Schwartz, J., 2001, Rapid cycling of lipid raft markers between the cell surface and Golgi complex. Journal of Cell Biology, 153, 529 -541.
   PubMed Web of Science ®Google Scholar
• Pascher, I., 1976, Molecular arrangements in sphingolipids. Con- formation and hydrogen bonding of ceramide and their implication on membrane stability and permeability. Biochimica et Biophysica Acta, 455, 433 -451.
   PubMed Web of Science ®Google Scholar
• Patton, J. L. and Lester, R. L., 1991, The phosphoinositol sphingo- lipids of Saccharomyces cerevisiae are highly localized in the plasma membrane. Journal of Bacteriology, 173, 3101 -3108.
   PubMed Web of Science ®Google Scholar
• Pelham, H. R., 2001, Traffic through the Golgi apparatus. Journal of Cell Biology, 155, 1099 -1101.
   PubMed Web of Science ®Google Scholar
• Phillips, M. C., Johnson, W. J. and Rothblat, G. H., 1987, Mechanism and consequences of cellular cholesterol exchange and transfer. Biochimica et Biophysica Acta, 906, 223 -276.
   PubMed Web of Science ®Google Scholar
• Pomorski, T., Lombardi, R., Riezman, H., Devaux, P. F., van Meer, G. and Holthuis, J. C. M., 2003, Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Molecular Biology of the Cell, 14, 1240 -1254. Published online 25 December 2002. 10.1091/mbc.E02-08-0545.
   PubMed Web of Science ®Google Scholar
• Pralle, A., Keller, P., Florin, E. L., Simons, K. and Horber, J. K., 2000, Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. Journal of Cell Biology,148, 997 -1008.
   Google Scholar
• Puri, V., Watanabe, R., Dominguez, M., Sun, X., Wheatley, C. L., Marks, D. L. and Pagano, R. E., 1999, Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid- storage diseases. Natural Cell Biology, 1, 386 -388.
   PubMed Web of Science ®Google Scholar
• Raggers, R. J., Pomorski, T., Holthuis, J. C., Kalin, N. and van Meer, G., 2000, Lipid traffic: the ABC of transbilayer movement. Traffic, 1, 226 -234.
   PubMed Web of Science ®Google Scholar
• Rosing, J., Tans, G., Govers-Riemslag, J. W., Zwaal, R. F. and Hemker, H. C., 1980, The role of phospholipids and factor Va in the prothrombinase complex. Journal of Biological Chemistry, 255, 274 -283.
   PubMed Web of Science ®Google Scholar
• Rothberg, K. G., Ying, Y.-S., Kamen, B. A. and Anderson, R. G., 1990, Cholesterol controls the clustering of the glycophospholipid- anchored membrane receptor for 5-methyltetrahydrofolate. Jour-nal of Cell Biology, 111, 2931 -2938.
   PubMed Web of Science ®Google Scholar
• Ruetz, S. and Gros, P., 1994, Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell, 77, 1 -20.
   Web of Science ®Google Scholar
• Schneiter, R., Brugger, B., Sandhoff, R., Zellnig, G., Leber, A., Lampl, M, Athenstaedt, K, Hrastnik, C., Eder, S., Daum, G., Paltauf, F., Wieland, F. T. and Kohlwein, S. D., 1999, Electro- spray ionization tandem mass spectrometry (ESI-MS/MS) analy- sis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of dis- tinct molecular species en route to the plasma membrane. Journal of Cell Biology, 146, 741 -754.
   PubMed Web of Science ®Google Scholar
• Schutz, G. J., Kada, G., Pastushenko, V. P. and Schindler, H., 2000, Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy. EMBO Journal, 19, 892 -901.
   PubMed Web of Science ®Google Scholar
• Seigneuret, M. and Devaux, P. F., 1984, ATP-dependent asym- metric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes. Proceedings of the National Academy of Sciences (USA), 81, 3751–3755.
   PubMed Web of Science ®Google Scholar
• Siegmund, A., Grant, A., Angeletti, C., Malone, L., Nichols, J. W. and Rudolph, H. K., 1998, Loss of Drs2p does not abolish transfer of fluorescence-labeled phospholipids across the plasma membrane of Saccharomyces cerevisiae. Journal of Biological Chemistry, 273, 34399–34405.
   PubMed Web of Science ®Google Scholar
• Silvius, J. R., 1992, Cholesterol modulation of lipid intermixing in phospholipid and glycosphingolipid mixtures. Evaluation using fluorescent lipid probes and brominated lipid quenchers. Bio- chemistry, 31, 3398 -3408.
   Google Scholar
• Simons, K. and Ikonen, E., 1997, Functional rafts in cell membranes. Nature, 387, 569 -572.
   PubMed Web of Science ®Google Scholar
• Simons, K. and Toomre, D., 2000, Lipid rafts and signal transduction. Natural Reviews in Molecular Cell Biology, 1, 31 -39.Simons, K. and van Meer, G., 1988, Lipid sorting in epithelial cells. Biochemistry, 27, 6197 -6202.
   Google Scholar
• Sims, P. J. and Wiedmer, T., 2001, Unraveling the mysteries of phospholipid scrambling. Thrombosis and Haemostasis, 86, 266 -275.
   PubMed Web of Science ®Google Scholar
• Skrzypek, M., Lester, R. L. and Dickson, R. C., 1997, Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae. Journal of Bacteriology, 179, 1513 -1520.
   PubMed Web of Science ®Google Scholar
• Smit, J. J. M., Schinkel, A. H., Oude Elferink, R. P. J., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., Ottenhoff, R., van der Lugt, N. M. T., van Roon, M. A., van der Valk, M. A., Offerhaus, G. J. A., Berns, A. J. M. and Borst, P., 1993, Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell, 75, 451 -451.
   Google Scholar
• Spang, A., Matsuoka, K., Hamamoto, S., Schekman, R. and Orci, L., 1998, Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proceedings of the National Academy of Sciences (USA), 95, 11199–11204.
   PubMed Web of Science ®Google Scholar
• Steck, T. L., Kezdy, F. J. and Lange, Y., 1988, An activation-collision mechanism for cholesterol transfer between membranes. Journal of Biological Chemistry, 263, 13023–13031.
   PubMed Web of Science ®Google Scholar
• Tang, X., Halleck, M. S., Schlegel, R. A. and Williamson, P., 1996, A subfamily of P-type ATPases with aminophospholipid transporting activity. Science, 272, 1495 -1497.
   PubMed Web of Science ®Google Scholar
• Trotter, P. J. and Voelker, D. R., 1994, Lipid transport processes in eukaryotic cells. Biochimica et Biophysica Acta, 1213, 241 -262.
   Google Scholar
• van Helvoort, A., Smith, A. J., Sprong, H., Fritzsche, I., Schinkel, A. H., Borst, P. and van Meer, G., 1996, MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell, 87, 507–517.
   Google Scholar
• van Meer, G., 1998, Lipids of the Golgi membrane. Trends in Cell Biology, 8, 29 -33.
   PubMed Web of Science ®Google Scholar
• van Meer, G., Stelzer, E. H. K., Wijnaendts-van-Resandt, R. W. and Simons, K., 1987, Sorting of sphingolipids in epithelial (Madin- Darby canine kidney) cells. Journal of Cell Biology, 105, 1623- 1635.
   PubMed Web of Science ®Google Scholar
• Warren, G. and Wickner, W., 1996, Organelle inheritance. Cell, 84, 395 -400.
   PubMedGoogle Scholar
• Webb, R. J., East, J. M., Sharma, R. P. and Lee, A. G., 1998, Hydrophobic mismatch and the incorporation of peptides into lipid bilayers: a possible mechanism for retention in the Golgi. Biochemistry, 37, 673 -679.
   PubMed Web of Science ®Google Scholar
• Wu, C., Butz, S., Ying, Y. and Anderson, R. G., 1997, Tyrosine kinase receptors concentrated in caveolae-like domains from neuronal plasma membrane. Journal of Biological Chemistry, 272, 3554 -3559.
   PubMed Web of Science ®Google Scholar
• Zachowski, A., 1993, Phospholipids in animal eukaryotic mem- branes: transverse asymmetry and movement. Biochemical Journal, 294, 1–14.
   PubMed Web of Science ®Google Scholar
• Zachowski, A, Henry, J.-P. and Devaux, P. F., 1989, Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein. Nature, 340, 75 -76.
   PubMed Web of Science ®Google Scholar