7
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Power consumption and mixing in a miniaturised bioreactor*

, &
Pages 117-123 | Published online: 19 Mar 2007

References

  • Kato , Y. , Hiraoka , S. Tada , Y. 1999 . “ Performance of a shaking vessel with current pole ” . In In : the 3rd Int. Symposium on Mixing in Industrial Processes 349 – 356 . Osaka, , Japan
  • Buchs , J. 2001 . Introduction to advantages and problems of shaken cultures . Biochem. Eng. J. , 7 : 91 – 98 .
  • Anderlei , T. and Buchs , J. 2001 . Device for sterile online measurements of oxygen transfer rate in shaking flasks . Biochem. Eng. J. , 7 : 157 – 162 .
  • Weuster-Botz , D. , Altenbach-Rehem , J. and Arnold , M. 2001 . Parallel substrate feeding and pH-control in shaking-flasks . Biochem. Eng. J. , 7 : 163 – 170 .
  • Duetz , W. A. and Witholt , B. 2001 . Effectiveness of orbital shaking for the aeration of suspended bacterial cultures in square-deep well microtitre plates . Biochem. Eng.J. , 7 : 113 – 115 .
  • Girard , P. , Jordan , M. Tsao , M. 2001 . Small-scale bioreactor system for process development and optimization . Biochem. Eng. J. , 7 : 117 – 119 .
  • Doig , S. D. , Pickering , S. C. R. Lye , G. J. 2002 . The use of microscale processing technologies for quantification of biocatalytic Baeyer-Villiger oxidation kinetics . Biotechnol. Bioengm. , 80 : 42 – 49 .
  • Walther , I. , van der schoot , B. H. Jeanneret , S. 1994 . Development of a miniature biorecator for continuous culture in a space laboratory . J. Biotechnol. , 38 : 21 – 32 .
  • Kostov , Y. , Harms , P. Randers-Eichhorn , L. 2001 . Low-cost microbioreactor for high-throughtput bioproceesing . Biotechnol. Bioeng. , 72 : 346 – 352 .
  • Doig , S. D. , Diep , A. and Baganz , F. 2005 . Characterisation of a novel miniaturised bubble column bioreactor for high throughtput cell cultivation . Biochem. Eng. J. , 23 : 97 – 105 .
  • Puskeiler , R. , Kaufmann , K. and Wesuster-Botz , D. 2005 . Development, parallelization, and automation of a gas-including millilitre-scale bioreactor for high-throughput bioprocess design . Biotech, Bioeng. , 89 ( 5 ) : 512 – 523 .
  • Zhang , H. , Lamping , S. R. and Ayazi Shamlou , P. 2002 . Numerical simulation of mixing in a micro-well scale bioreactor by computational fluid dynamics . Chemical Research in Chinese Universities , 18 ( 2 ) : 113 – 116 .
  • Lamping , S. R. , Zhang , H. and Ayazi Shamlou , P. 2003 . Design of a prototype micro-litre bioreactor for high throughtput automated bioprocessing . Chem. Eng. Sci. , 58 : 747 – 758 .
  • Zhang , H. and Ayazi Shamlou , P. 2004 . Characterisation of the engineering flow in a miniaturised bioreactor by computational fluid dynamics . Chem. Res. Chin. Uni. , 20 ( 4 ) : 489 – 493 .
  • Humphrey , A. Shake flask to fermentor: What have we learned . Biotech. Prog. , 14 3 – 7 .
  • Menter , F. R. 1996 . A comparison of some recent eddy-viscosity turbulencemodels . ASME J. Fluid Eng. , 118 : 514 – 519 .
  • Uhl , V. W. and Gray , J. B. 1996 . “ Mixing- Theory and Practice ” . New York : Academic Press .
  • Rushton , J. H. , Costich , E. W. and Everett , H. J. 1950 . Power characteristics of mixing impellers . Chem. eng. prog. , 46 ( 8 ) : 395 – 476 .
  • Rutherford , K. , Lee , K. C. Mahmudi , S. M. S. 1996 . Hydrodynamic characteristics of dual Rushton impeller stirred vessels . AIChE J. , 42 : 332 – 346 .
  • Mishra , V. P. and Joshi , J. B. 1994 . Flow generated by a disc turbine Part IV: Multiple-impellers . Chem. Eng. Res. Des. , 73 : 657 – 668 .
  • Wu , H. and Patterson , G. K. 1989 . LDA measurements of turbulent flow parameters in a stirred mixer . Chem. Eng. Sci. , 44 ( 10 ) : 2207 – 2221 .
  • Chen , K. Y. , Hajduk , J. C. and Johnson , J. W. 1988 . Laser-Doppler anemometry in a baffled mixing tank . Chem. Eng. Commn. , 72 : 141 – 157 .
  • Cutter , L. A. 1967 . Flow and turbulence in a stirred tank . AIChEJ , 12 : 35 – 45 .
  • Rutherford , K. , Mahmoudi , S. M. S. Lee , K. C. 1996 . The influence of Rushton impeller blade and disk thickness on the mixing characteristics of stirred vessels . Chem. Eng. Res. Des. , 74 ( A3 ) : 369 – 378 .
  • Mahouast , M. , Cognet , G. and David , R. 1989 . Two-component LDV measurements in a stirred tank . AICHE J. , 35 ( 11 ) : 1770 – 1778 .
  • Rammohan , A. R. , Kemoun , A. Al-Dahhan , M. H. 2001 . Characterization of single phase flows in stirred tanks via computer automated radioactive particle tracking (carpt) . Chem. Eng. Res. Des. , 79 : 831 – 844 .
  • Dyster , K. N. , Koutsakos , E. Jawoeshi , Z. 1993 . An LDA study of the radial discharge velocities generated by a Rushton turbine: Newtonian fluids, Re > 5 . Trans. IChemE , 71 ( A ) : 11 – 23 .
  • Cooper , R. G. and Wolf , D. 1968 . Velocity profiles and pumping capacities for turbine type impellers . Can. J. Chem. Eng. , 46 : 94 – 100 .
  • Aiba , S. 1958 . Flow patterns of liquids in agitated vessels . AIChE J. , 4 : 485 – 489 .
  • Bujalski , W. , Nienow , A. W. Chatwin , S. 1987 . The dependency on scale of power numbers of Rushton disc turbines . Chem. Eng. Sci. , 42 ( 2 ) : 317 – 326 .
  • Chapple , D. , Kresta , S. M. Wall , A. 2002 . The effect of impeller and tank geometry on power number for a pitched blade turbine . Chem. Eng. Res. Des. , 80 : 364 – 372 .
  • Sano , Y. and Usui , H . 1985 . “ Interrelations among mixing time, power number and discharge flow rate number in baffled mixing vessels ” . In J. Chem. Eng Vol. 18 , 47 – 52 . Japan
  • Schilling , B. M. , Pfefferele , W. Bachmann , B. 1999 . A special reactor design for investigations of mixing time effects in a scaled-down industrial L-Lysine fed-batch fermentation proces . Biotech. Bio-eng. , 64 : 599 – 606 .
  • Theobald , U. , Mailingre , W. Baltes , M. 1997 . In vivo analysis of metablic dynamics in Saccharomyces cerevisiae: I . Biotechnol. Bioeng. , 55 : 305 – 316 . Epxerimental observation

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.