References
- Kuhn L, Meddows-Taylor S, Gray G, Tiemessen C. Human immunodeficiency virus (HIV)-specific cellular immune responses in newborns exposed to HIV in utero. Clin Infect Dis 2002; 34:267–276
- Kuhn L, Coutsoudis A, Moodley D, et al. 1-helper cell responses to HIV envelope peptides in cord blood: protection against intrapartum and breast-feeding transmission.Aids 2001; 15:1–9
- Schramm DB, Meddows-Taylor S, Gray GE, Kuhn L, Tiemessen CT. Low maternal viral loads and reduced granulocyte-macrophage colony-stimulating factor levels characterize exposed, uninfected infants who develop protective human immunodeficiency virus type 1-specific responses. Clin Vaccine Immunol 2007; 14: 348–354
- Shalekoff S, Meddows-Taylor S, Gray GE, et al. Identification of human immunodeficiency virus-1 specific CD8+ and CD4+ T cell responses in perinatally-infected infants and their mothers.Aids 2009; 23:789–798
- Kuhn L, Meddows-Taylor S, Gray G, et al. Reduced HIV-stimulated T-helper cell reactivity in cord blood with short-course antiretroviral treatment for prevention of maternal-infant transmission. Clin Exp Immunol 2001; 123:443–450
- Schramm DB, Kuhn L, Gray GE, Tiemessen CT. In vivo effects of HIV-1 exposure in the presence and absence of single-dose nevirapine on cellular plasma activation markers of infants born to HIV-1-seropositive mothers. J Acquir Immune Defic Syndr 2006; 42: 545–553
- Shalekoff S, Meddows-Taylor S, Schramm DB, et al. Single-dose nevirapine exposure affects T cell response and cytokine levels in HIV type 1-infected women. AIDS Res Hum Retroviruses 2009; 25:1049–1053
- Schramm DB, Anthony F, Mathebula B, et al. Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life. Open AIDS J 2010; 4:156–165
- Meddows-Taylor S, Donninger SL, Paximadis M, et al. Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission. J Gen Virol 2006; 87: 2055–2065
- Tiemessen CT, Shalekoff S, Meddows-Taylor S, et al. Cutting Edge: Unusual NK cell responses to HIV-1 peptides are associated with protection against maternal-infant transmission of HIV-1. J Immunol 2009; 182: 5914–5918
- Tiemessen CT, Shalekoff S, Meddows-Taylor S, et al. Natural killer cells that respond to human immunodeficiency virus type 1 (HIV-1) peptides are associated with control of HIV-1 infection. J Infect Dis 2010; 202:1444–1453
- Meddows-Taylor S, Shalekoff S, Kuhn L, Gray GE, Tiemessen CT. Development of a whole blood intracellular cytokine staining assay for mapping CD4(+) and CD8(+)1-cell responses across the HIV-1 genome. J Virol Methods 2007; 144:115–121
- Stratov I, Chung A, Kent SJ. Robust NK cell-mediated human immunodeficiency virus (HIV)-specific antibody-dependent responses in HIV-infected subjects. J Virol 2008; 82: 5450–5459
- O'Leary JG, Goodarzi M, Drayton DL, Von Andrian UH. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 2006; 7:507–516
- Sun JC, Beilke JN, Lanier LL.Adaptive immune features of natural killer cells. Nature 2009; 457: 557–561
- Tiemessen CT, Paximadis M, Minevich G, et al. Natural killer cell responses to HIV-1 peptides are associated with more activating KIR genes and HLA-C genes of the C1 allotype. J Acquir Immune Defic Syndr (in press)
- Paximadis M, Minevich G, Winchester R, et al. KIR-HLA and maternal-infant HIV-1 transmission in sub-Saharan Africa. PLoS One 2011; 6: e16541
- Gonzalez E, Kulkarni H, Bolivar H, et al. The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility. Science 2005; 307:1434–1440
- Townson JR, Barcellos LF, Nibbs RJ. Gene copy number regulates the production of the human chemokine CCL3-L1. Eur J Immunol 2002; 32: 3016–3026
- Kuhn L, Schramm DB, Donninger S, et al. African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine. Aids 2007; 21: 1753-1761
- Tiemessen CT, Kuhn L. CC chemokines and protective immunity: insights gained from mother-to-child transmission of HIV. Nat Immunol 2007; 8:219–222
- Paximadis M, Mohanlal N, Gray GE, Kuhn L, Tiemessen CT. Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. Int J lmmunogenet 2009; 36:21–32
- Dolan MJ, Kulkarni H, Camargo JF, et al. CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat Immunol 2007; 8:1324–1336
- Shalekoff S, Meddows-Taylor S, Schramm DB, et al. Host CCL3L1 gene copy number in relation to HIV-1-specific CD4+ and CD8+ 1-cell responses and viral load in South African women. J Acquir Immune Defic Syndr 2008; 48: 245–254
- Catano G, Chykarenko ZA, Mangano A, et al. Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates. J Infect Dis 2011; 203: 263–272
- Picton AC, Paximadis M, Tiemessen Cl. Genetic variation within the gene encoding the HIV-1 CCR5 coreceptor in two South African populations. Infect Genet Evol 2010; 10:487–494
- Gonzalez E, Bamshad M, Sato N, et al. Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes. Proc Natl Acad Sci USA 199996:12004-12009
- Flutter G, Nowak D, Mossner M, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med 2009; 360: 692–698
- Allers K, Flutter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 2011; 117:2791–2799
- Sun JC, Lanier LL. Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity? Eur J Immunol 2009; 39: 2059–2064