554
Views
47
CrossRef citations to date
0
Altmetric
Articles

Application of the Molecular Analysis of the T-Cell Receptor Repertoire in the Study of Immune-Mediated Hematologic Diseases

, &
Pages 173-181 | Published online: 04 Sep 2013

References

  • Arden, B., Clark, ST., Kabelitz, D. and Mak, T.W. (1995) "Human T-cell receptor variable gene segment families", Immunogenetics 42, 455–500.
  • Arstila, T.P., Casrouge, A., Baron, V, et al. (2000) "Diversity of human alpha beta T cell receptors", Science 288, 1135.
  • Moss, P.A., Rosenberg, W.M. and Bell, J.I. (1992) "The human T cell receptor in health and disease", Annu. Rev. Immunol. 10, 71–96.
  • Gorski, J., Yassai, M., Zhu, X., et al. (1994) "Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status", J. Immunol. 152,5109–5119.
  • Garcia, K.C., Teyton, L. and Wilson, I.A. (1999) "Structural basis of T cell recognition", Annu. Rev. Immunol. 17, 369–397.
  • Pannetier, C., Even, J. and Kourilsky, P. (1995) "T-cell repertoire diversity and clonal expansions in normal and clinical samples", Immunol. Today 16, 176–181.
  • van den, B.R., Boor, PP., van Lochem, E.G., et al. (2000) "Flow cytometric analysis of the Vbeta repertoire in healthy controls", Cytometry 40, 336–345.
  • Matsutani, T., Yoshioka, T., Tsuruta, Y., et al. (2000) "Quantitative analysis of the usage of human T-cell receptor alpha and beta chain variable regions by reverse dot-blot hybridization", Methods Mol. Biol. 134, 81–101.
  • Dietrich, P.Y., Caignard, A., Lim, A., et al. (1994) "In vivo T-cell clonal amplification at time of acute graft-versus-host disease", Blood 84, 2815–2820.
  • Kang, J.A., Mohindru, M., Kang, B.S., Park, S.H. and Kim, B.S. (2000) "Clonal expansion of infiltrating T cells in the spinal cords of SJL/J mice infected with Theiler's virus", J. Immunol. 165, 583–590.
  • Nakashima, M., Kong, Y.M. and Davies, T.F. (1996) "The role of T cells expressing TcR V beta 13 in autoimmune thyroiditis induced by transfer of mouse thyroglobulin-activated lymphocytes: identification of two common CDR3 motifs", Clin. Immunol. Immunopathol. 80, 204–210.
  • Hong, J., Zang, Y.C., Tejada-Simon, M.V, et al. (1999) "A common TCR V-D-J sequence in V beta 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis", J. Immunol. 163, 3530–3538.
  • Luppi, P., Zanone, M.M., Hyoty, H., et al. (2000) "Restricted TCR V beta gene expression and enterovirus infection in type I diabetes: a pilot study", Diabetologia 43, 1484–1497.
  • Goodall, J.C., Bledsoe, P. and Gaston, J.S. (1999) "Tracking antigen-specific human T lymphocytes in rheumatoid arthritis by T cell receptor analysis", Hum. Immunol. 60, 798–805.
  • Mima, T., Ohshima, S., Sasai, M., et al. (1999) "Dominant and shared T cell receptor beta chain variable regions of T cells inducing synovial hyperplasia in rheumatoid arthritis", Biochem. Biophys. Res. Commun. 263, 172–180.
  • Inada, H., Yoshizawa, K., Ota, M., et al. (2000) "T cell repertoire in the liver of patients with primary biliary cirrhosis", Hum. Immunol. 61, 675–683.
  • Bour, H., Puisieux, I., Even, J., et al. (1999) "T-cell repertoire analysis in chronic plaque psoriasis suggests an antigen-specific immune response", Hum. Immunol. 60, 665–676.
  • Lamy, T. and Loughran, T.P. Jr (1999) "Current concepts: large granular lymphocyte leukemia", Blood Rev. 13, 230–240.
  • Langerak, A.W., van den, B.R., Wolvers-Tettero, IL., et al. (2001) "Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalphabeta T-cell proliferations", Blood 98, 165–173.
  • Melenhorst, J.J., Sorbara, L., Kirby, M., Hensel, N.F. and Barrett, A.J. (2001) "Large granular lymphocyte leukaemia is characterized by a clonal T-cell receptor rearrangement in both memory and effector CD8(+) lymphocyte populations", Br. J. Haematol. 112, 189–194.
  • Mollet, L., Fautrel, B., Leblond, V, et al. (1999) "Leukemic CD3+ LGL share functional properties with their CD8+ CD57+ cell counterpart expanded after BMT", Leukemia 13, 230–240.
  • McHeyzer-Williams, L.J., Panus, J.F., Mikszta, J.A. and McHeyzer-Williams, M.G. (1999) "Evolution of antigen-spe-cific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs", J. Exp. Med. 189, 1823–1838.
  • Kim, G., Tanuma, N., Kojima, T., et al. (1998) "CDR3 size spectratyping and sequencing of spectratype-derived TCR of spinal cord T cells in autoimmune encephalomyelitis", J. Immunol. 160, 509–513.
  • Dulphy, N., Peyrat, M.A., Tieng, V, et al. (1999) "Common intra-articular T cell expansions in patients with reactive arthritis: identical beta-chain junctional sequences and cytotoxicity toward HLA-B27", J. Immunol. 162, 3830–3839.
  • Prinz, J.C., Vollmer, S., Boehncke, W.H., et al. (1999) "Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris", Fur. J. Immunol. 29, 3360–3368.
  • Epperson, D.E., Margolis, D.A., McOlash, L., Janczak, T. and Barrett, A.J. (2001) "In vitro T-cell receptor V beta repertoire analysis may identify which T-cell V beta families mediate graft-versus-leukaemia and graft-versus-host responses after human leucocyte antigen-matched sibling stem cell trans-plantation", Br. J. Haematol. 114, 57–62.
  • Kondo, Y, Shiobara, S. and Nakao, S. (2001) "Identification of T-cell clones showing expansion associated with graft-vs-leukemia effect on chronic myelogenous leukemia in vivo and in vitro", Exp. Hematol. 29, 471–476.
  • Orsini, E., Alyea, E.P., Schlossman, R., et al. (2000) "Changes in T cell receptor repertoire associated with graft-versus-tumor effect and graft-versus-host disease in patients with relapsed multiple myeloma after donor lymphocyte infu-sion", Bone Marrow Transplant. 25, 623–632.
  • Peggs, KS., Verfuerth, S., D'Sa, S., Yong, K. and Mackinnon, S. (2003) "Assessing diversity: immune reconstitution and T-cell receptor BV spectratype analysis following stem cell transplantation", Br. J. Haematol. 120, 154–165.
  • Lima, M., Almeida, J., Santos, A.H., et al. (2001) "Immuno-phenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease", Am. J. Pathol. 159, 1861–1868.
  • Gillespie, G.M., Wills, M.R., Appay, V, et al. (2000) "Functional heterogeneity and high frequencies of cyto-megalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors", J. Virol. 74, 8140–8150.
  • Kuzushima, K., Hoshino, Y, Fujii, K., et al. (1999) "Rapid determination of Epstein—Barr virus-specific CD8(+) T-cell frequencies by flow cytometry", Blood 94, 3094–3100.
  • Peggs, K., Verfuerth, S., Pizzey, A., et al. (2002) "Charac-terization of human cytomegalovirus peptide-specific CD8(+) T-cell repertoire diversity following in vitro restimu-lation by antigen-pulsed dendritic cells", Blood 99, 213–223.
  • Stears, R.L., Getts, R.C. and Gullans, S.R. (2000) "A novel, sensitive detection system for high-density microarrays using dendrimer technology", Physiol. Genomics 3, 93–99.
  • Weekes, M.P., Wills, M.R., Mynard, K., et al. (1999) "Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+", Immunology 98, 443–449.
  • Sood, R., Stewart, C.C., Aplan, P.D., et al. (1998) "Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persist-ence of abnormal cells", Blood 91, 3372–3378.
  • Kwong, Y.L. and Wong, K.F. (1998) "Association of pure red cell aplasia with T large granular lymphocyte leukaemia", J. Clin. Pathol. 51, 672–675.
  • Go, R.S., Li, C.Y., Tefferi, A. and Phyliky, R.L. (2001) "Acquired pure red cell aplasia associated with lymphopro-liferative disease of granular T lymphocytes", Blood 98, 483–485.
  • Shimamoto, T., Iguchi, T., Ando, K., et al. (2001) "Successful treatment with cyclosporin A for myelodysplastic syndrome with erythroid hypoplasia associated with T-cell receptor gene rearrangements", Br. J. Haematol. 114, 358–361.
  • Saunthararajah, Y., Molldrem, J.L., Rivera, M., et al. (2001) "Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiologi-cal features", Br. J. Haematol. 112, 195–200.
  • Karadimitris, A., Li, K., Notaro, R., et al. (2001) "Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): further evidence for a pathogenetic link between T cells, aplastic anaemia and PNH", Br. J. Haematol. 115, 1010–1014.
  • Greer, J.P., Kinney, M.C. and Loughran, T.P. Jr (2001) "T cell and NK cell lymphoproliferative disorders", Hematology (Am. Soc. Hematol. Educ. Prog.), 259–281.
  • Young, N.S. and Barrett, A.J. (1995) "The treatment of severe acquired aplastic anemia", Blood 85, 3367–3377.
  • Young, N.S. (2002) "Acquired aplastic anemia", Ann. Intern. Med. 136, 534–546.
  • Tisdale, J.F., Dunn, D.E. and Maciejewski, J. (2000) "Cyclo-phosphamide and other new agents for the treatment of severe aplastic anemia", Semin. Hematol. 37, 102–109.
  • Young, N.S. and Maciejewski, J. (1997) "The pathophysiology of acquired aplastic anemia", N. Engl. J. Med. 336, 1365–1372.
  • Hoffman, R., Zanjani, ED., Lutton, J.D., Zalusky, R. and Wasserman, L.R. (1977) "Suppression of erythroid-colony formation by lymphocytes from patients with aplastic anemia", N. Engl. J. Med. 296, 10–13.
  • Takaku, F., Suda, T., Mizoguchi, H., et al. (1980) "Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro—a cooperative work", Blood 55, 937–943.
  • Zoumbos, N.C., Ferris, W.O., Hsu, S.M., et al. (1984) "Analysis of lymphocyte subsets in patients with aplastic anaemia", Br. J. Haematol. 58, 95–105.
  • Maciejewski, J.P., Hibbs, JR., Anderson, S., Katevas, P. and Young, N.S. (1994) "Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure", Exp. Hematol. 22, 1102–1110.
  • Zoumbos, N.C., Gascon, P., Djeu, J.Y., Trost, S.R. and Young, N.S. (1985) "Circulating activated suppressor T lymphocytes in aplastic anemia", N. Engl. J. Med. 312, 257–265.
  • Manz, C.Y., Dietrich, P.Y., Schnuriger, V, Nissen, C. and Wodnar-Filipowicz, A. (1997) "T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia", Blood Cells. Mol. Dis. 23, 110–122.
  • Zeng, W., Nakao, S., Takamatsu, H., et al. (1999) "Character-ization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia", Blood 93, 3008–3016.
  • Zeng, W., Maciejewski, J.P., Chen, G. and Young, N.S. (2001) "Limited heterogeneity of T cell receptor BV usage in aplastic anemia", J. Clin. Investig. 108, 765–773.
  • Kook, H., Risitano, A.M., Zeng, W., et al. (2002) "Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens", Blood 99, 3668–3675.
  • Risitano, A.M., Kook, H., Zeng, W., et al. (2002) "Significance of oligoclonal and polyclonal expansion within CD8 and CD4 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by VB CDR3 spectratyping and flow cytometry", Blood, 178–183.
  • Epperson, D.E., Nakamura, R., Saunthararajah, Y., Melenhorst, J. and Barrett, A.J. (2001) "Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process", Leuk. Res. 25, 1075–1083.
  • Kook, H., Zeng, W., Guibin, C., et al. (2001) "Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia", Exp. Hematol. 29, 1270–1277.
  • Kochenderfer, J., Kobayashi, S., Wieder, E., Su, C. and Molldrem, J. "Loss of T lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression", Blood (2 A.D.) 100, 639–3745.
  • Shvidel, L., Duksin, C., Tzimanis, A., et al. (2002) "Cytoldne release by activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders", Hematol. J. 3, 32–37.
  • Araten, D.J., Nafa, K., Pakdeesuwan, K. and Luzzatto, L. (1999) "Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and pheno-type are present in normal individuals", Proc. Natl Acad. Sci. USA 96, 5209–5214.
  • Plasilova, M., Ristano, A., et al. (2002) "Paroxysmal nocturnal hemoglobinuria—in the search for disease-specific T-cell clones", Blood 100, 167A.
  • Zoumbos, N.C., Gascon, P., Djeu, J.Y. and Young, N.S. (1985) "Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo", Proc. Natl Acad. Sci. USA 82, 188–192.
  • Nistico, A. and Young, N.S. (1994) "gamma-Interferon gene expression in the bone marrow of patients with aplastic anemia", Ann. Intern. Med. 120, 463–469.
  • Tsuda, H. and Yamasald, H. (2000) "Type I and type II T-cell profiles in aplastic anemia and refractory anemia", Am. J. Hematol. 64, 271–274.
  • Symeonidis, A., Kourakli, A., Katevas, P., et al. (1991) "Immune function parameters at diagnosis in patients with myelodysplastic syndromes: correlation with the FAB classification and prognosis", Fur. J. Haematol. 47, 277–281.
  • Sloand, E., Maciejewski, J.P., Tisdale, J., Follman, D. and Young, N.S. (2002) "Intracellular Interferon-y (IFN-y) in circulating and marrow T Cells deteted by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia", Blood 100, 3129–3135.
  • Miescher, P.A., Favre, H. and Beris, P. (1991) "Autoimmune myelodysplasias", Semin. Hematol. 28, 322–330.
  • Karadimitris, A., Manavalan, J.S., Thaler, H.T., et al. (2000) "Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria", Blood 96, 2613–2620.
  • O'Keefe, C., Plasilova, M., et al. (2002) "Molecular analysis of T-cell receptor repertoire in large granular lymphocytic anemia", Blood 100, 236A.
  • Sloand, E., Fuhrer, M., Johnson, S., et al. (2002) "Preferential inhibition of trisomy 8 progenitor cell growth by autologous CD8+ V-beta-restricted T cells in patients with trisomy 8 and myelodysplasia", Blood 100, 166A.
  • Risitano, A., Maciejewski, J.P., et al. (2002) "TCR sequencing. The olecular signature of autoimmunity in aplastic anemia", Blood 100, 155A.
  • Matsutani, T., Yoshioka, T., Tsuruta, Y., et al. (2003) "Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypo-plasia", Leuk. Res. 27, 305–312.
  • Araten, D.J., Swirsky, D., Karadimitris, A., et al. (2001) "Cytogenetic and morphological abnormalities in paroxy-smal nocturnal haemoglobinuria", Br. J. Haematol. 115, 360–368.
  • Nakao, S., Takamatsu, H., Yachie, A., et al. (1995) "Establishment of a CD4+ T cell clone recognizing autologous hematopoietic progenitor cells from a patient with immune-mediated aplastic anemia", Exp. Hematol. 23, 433–438.
  • Nakao, S., Takami, A., Takamatsu, H., et al. (1997) "Isolation of a T-cell clone showing HLA-DRB1*0405-restricted cytotoxi-city for hematopoietic cells in a patient with aplastic anemia", Blood 89, 3691–3699.
  • Plasilova, M., O'Keefe, Ch., et al. (2002) "Comparison of TCR VB and CDR3 region repertoire in myelodysplastic syndrome and its similarity to other bone marrow failure states", Blood 100, 230A.
  • Chen, W. and Howell, C.D. (2002) "Oligoclonal expansion of T cell receptor V beta 2 and 3 cells in the livers of mice with graft-versus-host disease", Hepatology 35, 23–29.
  • Bitmansour, A.D., Waldrop, S.L., Pitcher, C.J., et al. (2001) "Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirus", J. Immunol. 167, 1151–1163.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.