Cytokines in Sickle Cell Disease

References

• Serjeant, G.R. (1992) Sickle Cell Disease (Oxford University Press, Oxford, England).
   Google Scholar
• Bun, H.F. and Forget, B.G. (1986) Hemoglobin: Molecular, Genetic and Clinical Aspects (W.B. Saunders, Philadelphia).
   Google Scholar
• Embury, S.H., Hebbel, R.P., Mohandas, N. and Steinberg, M.H. (1994) Sickle Cell Disease: Basic Principles and Clinical Practice (Raven Press, New York, NY).
   Google Scholar
• Wang, W.C. and Lukens, J.N. (1999) "Sickle cell anemia and other sickling syndromes", In: Lee, G.R., Foerster, J., Lukens, J., Paraskevas, F., Greer, J.P. and Rodgers, G.M., eds, Wintrobe's Clinical Hematology, 10th Ed. (Williams & Wilkins, Baltimore, Maryland, USA) Vol. 1, pp 1346–1398.
   Google Scholar
• Hillery, C.A. (1998) "Potential therapeutic approaches for the treatment of vaso-occlusion in sickle cell disease", Curr. Opin. Hematol. 5, 151–155.
   PubMedGoogle Scholar
• Cherry-Peppers, G., Davis, V. and Atkinson, J.C. (1992) "Sickle-cell anemia: a case report and literature review", Clin. Prey. Dent. 14, 5–9.
   PubMedGoogle Scholar
• Haynes, J. and Obiako, B. (2002) "Activated polymorpho-nuclear cells increase sickle red blood cell retention in lung: role of phospholipids", Am. J. Physiol. Heart. Circ. Physiol. 282, H122—H130.
   PubMed Web of Science ®Google Scholar
• Dreyer, Z.E. (1996) "Chest infection and syndromes in sickle cell disease of childhood", Semin. Respir. Infect. 11, 163–172.
   PubMedGoogle Scholar
• Vichinsky, E.P., Styles, L.A., Colangelo, L.H., Wright, E.C., Castro, O., Nickerson, B. and the Cooperative Study of Sickle Cell Disease (1997) "Acute chest syndrome in sickle cell disease: clinical presentation and course", Blood 89, 1787–1792.
   PubMed Web of Science ®Google Scholar
• Fabry, M.E. and Kaul, D.K. (1991) "Sickle cell vaso-occlusion", Hematol./Oncol. Clin. N. Am. 5, 375–398.
   PubMed Web of Science ®Google Scholar
• Hebbel, R.P. (1997) "Adhesive interactions of sickle erythrocytes with endothelium", J. Clin. Investig. 100, S83—S86.
   PubMed Web of Science ®Google Scholar
• Hebbel, R.P. (1980) "Abnormal adherence of sickle erythro-cytes to cultured vascular endothelium", J. Clin. Investig. 65, 154–160.
   PubMed Web of Science ®Google Scholar
• Swerlick, R., Eckman, J., Kumar, A., Jeitler, M. and Wick, T. (1993) "Alpha 4 beta 1 expression on sickle reticulocytes: vascular cell adhesion molecule 1 dependent binding to the endothelium", Blood 82, 1891–1899.
   PubMed Web of Science ®Google Scholar
• Wun, T., Paglieroni, T., Field, CI., Welborn, J., Cheung, A., Walker, N.J. and Tablin, E (1999) "Platelet-erythrocyte adhesion in sickle cell disease", J. Investig. Med. 47, 121–127.
   PubMed Web of Science ®Google Scholar
• Sugihara, K., Sugihara, T., Mohandas, N. and Hebbel, R.P. (1992) "Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells", Blood 80,2634–2642.
   PubMed Web of Science ®Google Scholar
• Brittain, HA., Eckman, JR., Swerlick, R.A., Howard, R.J. and Wick, T.M. (1993) "Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vaso-occlusion", Blood 81, 2137–2143.
   PubMed Web of Science ®Google Scholar
• Joneckis, C.C., Shock, D.D., Cunningham, MI., Orringer, E.P. and Parise, L.V. (1996) "Glycoprotein IV-independent adhesion of sickle red blood cells to immobilized thrombo-spondin under flow conditions", Blood 87, 4862–4870.
   PubMed Web of Science ®Google Scholar
• Lee, S.P., Cunningham, MI., Hines, P.C., Joneckis, C.C., Orringer, E.P. and Parise, L.V. (1998) "Sickle cell adhesion to laminin: potential role for the «5 chain", Blood 92, 2951–2958.
   PubMed Web of Science ®Google Scholar
• Gupta, K., Gupta, P, Solovey, A. and Hebbel, R.P. (1999) "Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin", Biochim. Biophys. Acta 1453, 63–73.
   PubMed Web of Science ®Google Scholar
• Harlan, J.M. (2000) "Anti-adhesion therapy in sickle cell disease", Blood 95, 365–367.
   PubMed Web of Science ®Google Scholar
• Hofrichter, J., Ross, PD. and Eaton, WA. (1974) "Kinetics and mechanism of deoxyhemoglobin S gelation: a new approach to understanding sickle cell disease", Proc. Natl Acad. Sci. USA 71, 4864–4868.
   PubMed Web of Science ®Google Scholar
• Mozzarelli, A., Hofrichter, J. and Eaton, WA. (1987) "Delay time of hemoglobin S polymerization prevents most cell from sickling in vivo", Science 237, 500–506.
   PubMed Web of Science ®Google Scholar
• Kaul, D.K., Fabry, M.E. and Nagel, R.L. (1986) "Vaso-ocdusion by sickle cells: evidence for selective trapping of dense red cells", Blood 68, 1162–1166.
   PubMed Web of Science ®Google Scholar
• Kaul, D.K., Fabry, M.E. and Nagel, R.L. (1989) "Micro-vascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: patho-physiological implications", Proc. Natl Acad. Sci. USA 86, 3356–3360.
   PubMed Web of Science ®Google Scholar
• Kaul, D.K., Chen, D. and Zhan, J. (1994) "Adhesion of sickle cells to vascular endothelium is critically dependent on changes in density and shape of the cells", Blood 83, 3006–3017.
   PubMed Web of Science ®Google Scholar
• Platt, OS., Thorington, B.D., Brambilla, D.J., Milner, P.F., Rosse, W.F., Vichinsky, E. and Kinney, T.R. (1991) "Pain in sickle cell disease-rates and risk factors", N. Engl. J. Med. 325, 11–16.
   PubMed Web of Science ®Google Scholar
• Hebbel, R., Boogarets, M., Eaton, J. and Steinberg, M. (1980) "Erythrocyte adherence to the endothelium in sickle cell anemia: a possible determinant of disease severity", N. Engl. J. Med. 302, 992–995.
   PubMed Web of Science ®Google Scholar
• Hebbel, R.P. (2000) "Blockade of adhesion of sickle cells to endothelium by monoclonal antibodies", N. Engl. J. Med. 342, 1910–1911.
   PubMed Web of Science ®Google Scholar
• Hebbel, R.P. and Vercellotti, G.M. (1997) "The endothelial biology of sickle cell disease", J. Lab. Clin. Med. 129,288–293.
   PubMed Web of Science ®Google Scholar
• Stockman, J.A., Nigro, MA., Mishkin, M.M. and Oski, F.A. (1972) "Occlusion of the large cerebral vessels in sickle-cell anemia", N. Engl. J. Med. 287, 846–849.
   PubMed Web of Science ®Google Scholar
• Russell, MO., Goldberg, HI. and Hodson, A. (1984) "Effect of transfusion therapy on arteriographic abnormalities and on recurrence of stroke in sickle cell disease", Blood 63, 162–169.
   PubMed Web of Science ®Google Scholar
• Rothman, S.M., Fulling, K.H. and Nelson, J.S. (1986) "Sickle cell anemia and central nervous system infarction: a neuropathological study", Ann. Neurol. 20, 684–690.
   PubMed Web of Science ®Google Scholar
• Blei, E, Fancher, T. and Guarini, L. (1994) "Elevated levels of circulating molecules of potential endothelial origin in sickle cell disease [abstract]", Blood 81(Suppl 1), 409.
   Google Scholar
• Sowemimo-Coker, SO., Meiselman, H.J. and Francis, R.B. Jr, (1989) "Increased circulating endothelial cells in sickle cell crisis", Am. J. Hematol. 31, 263–265.
   PubMed Web of Science ®Google Scholar
• George, E, Toulon, P., Sampol, J. and Sultan, Y. (1992) "Detection of high levels of circulating endothelial cells in patients with sickle cell crisis [abstract]", Blood 80( Suppl), 12.
   Google Scholar
• Solovey, A., Lin, Y., Browne, P., Choong, S., Wayner, E. and Hebbel, R.P. (1997) "Circulating activated endothelial cells in sickle cell anemia", N. Engl. J. Med. 337, 1584–1590.
   PubMed Web of Science ®Google Scholar
• Brittain, H.A., Eckman, J.R. and Wick, T.M. (1992) "Sickle erythrocyte adherence to large vessel and microvascular endothelium under physiologic flow is qualitatively different", J. Lab. Clin. Med. 120, 538–545.
   PubMed Web of Science ®Google Scholar
• Joneckis, C.C., Ackley, R.L., Orringer, E.P., Wayner, E.A. and Parise, L.V. (1993) "Integrin «4131 and glycoprotein IV (CD36) are expressed on circulating reticulocytes in sickle cell anemia", Blood 82, 3548–3555.
   PubMed Web of Science ®Google Scholar
• Hillery, CA., Du, MC., Montgomery, R.R. and Scott, J.P. (1996) "Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin", Blood 87, 4879–4886.
   PubMed Web of Science ®Google Scholar
• Udani, M., Zen, Q., Coffman, M., Leonard, N., Jefferson, S., Daymont, C., Truskey, G. and Telen, M.J. (1998) "Basal cell adhesion molecule /lutheran protein. The receptor critical for sickle cell adhesion to laminin", J. Clin. Investig. 101, 2550–2558.
   PubMed Web of Science ®Google Scholar
• Pathare, A.V., Al Kindi, S., Alnaqdy, A.A., Mohite, U., Hiwase, D., Dennison, D., Daar, D. and Knox-Macaulay, H.H. (2002) "Cytokine profile of sickle cell disease patients from Oman in acute crisis v/s steady state. [Abst. 3565]", Blood 100, 28h.
   Web of Science ®Google Scholar
• Harlan, J.M. (1985) "Leukocyte—endothelial interactions", Blood 65, 513–525.
   PubMed Web of Science ®Google Scholar
• Pober, J.S. (1988) "TNF as an activator of vascular endothelium", Ann. Inst. Pasteur. Immun. 193, 317–323.
   Google Scholar
• Francis, R., Jr and Haywood, L.J. (1992) "Elevated immunoreactive tumor necrosis factor and interleukin-1 in sickle cell disease", J. Natl Med. Assoc. 84, 611–615.
   PubMed Web of Science ®Google Scholar
• Malave, I., Perdomo, Y., Escalona, E., Rodriguez, E., Anchustegui, M., Malave, H. and Arends, T. (1993) "Levels of tumor necrosis factor /cachectin (TNFek) in sera from patients with sickle cell disease", Acta Haematol. 90, 172–176.
   PubMed Web of Science ®Google Scholar
• Lipowsky, H.H. and Chien, S. (1989) "Role of leukocyte-endothelium adhesion in affecting recovery from ischemic episodes", Ann. NY Acad. Sci. 565, 308.
   PubMed Web of Science ®Google Scholar
• Croizat, H. (1994) "Circulating cytokines in sickle cell patients during steady state", Br. J. Haematol. 87, 592.
   PubMed Web of Science ®Google Scholar
• Shiu, YT., Udden, M.M. and McIntire, L.V. (2000) "Perfusion with sickle erythrocytes up-regulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells", Blood 95, 3232–3241.
   PubMed Web of Science ®Google Scholar
• Kasschau, M.R., Barabino, G.A., Bridges, K.R. and Golan, D.E. (1993) "Adhesion of sickle neutrophils and erythrocytes to fibronectin", Blood 87, 771–780.
   Google Scholar
• Kumar, A., Eckmam, JR., Swerlick, R.A. and Wick, T.M. (1996) "Phorbol ester stimulation increases sickle erythro-cyte adherence to endothelium: a novel pathway involving alpha 4 beta 1 integrin receptors on sickle reticulocytes and fibronectin", Blood 88, 4348–4358.
   PubMed Web of Science ®Google Scholar
• Gee, B.E. and Platt, OS. (1995) "Sickle reticulocytes adhere to V-CAM-I", Blood 85, 268–274.
   PubMed Web of Science ®Google Scholar
• Vordermeier, S., Singh, S., Biggerstaff, J., Harrison, P., Grech, H., Pearson, T.C., Dumonde, D.C. and Brown, K.A. (1992) "Red blood cells from patients with sickle cell disease exhibit an increased adherence to cultured endothelium pretreated with tumor necrosis factor (TNF)", Br. J. Hematol. 81, 591–597.
   PubMed Web of Science ®Google Scholar
• Tissot Van Patot, M.C., MacKenzie, S., Tucker, A. and Voelkel, N.F. (1996) "Endotoxin-induced adhesion of red blood cells to pulmonary artery endothelial cells", Am. J. Physiol. 270, 28–36.
   Google Scholar
• Sowemimo-Coker, S., Haywood, L.J., Meiselman, H.J. and Francis, R.B. Jr, (1989) "Interleukin-1 increases adherence of normal and sickle erythrocytes to endothelial cells (abstract)", Blood 74( Suppl), 313a.
   Google Scholar
• Natarajan, M., Udden, M.M. and McIntire, L.V. (1996) "Adhesion of sickle red blood cells and damage to interleukin-1 beta stimulated endothelial cells under flow in vitro", Blood 87, 4845–4852.
   PubMed Web of Science ®Google Scholar
• Schroder, J.M. and Christophers, E. (1989) "Secretion of novel and homologous neutrophil-activating peptides by LPS-stimulated human endothelial cells", J. Immunol. 142, 244–251.
   PubMed Web of Science ®Google Scholar
• Luster, A.D. (1998) "Chemokines- chemotactic cytokines that mediate inflammation", N. Engl. J. Med. 338, 436–445.
   PubMed Web of Science ®Google Scholar
• Hagiwara, T., Suzuki, H., Kono, I., Kashiwagi, H., Akiyama, Y. and Onozaki, K. (1998) "Regulation of fibronectin synthesis by interleukin-1 and interleukin-6 in rat hepato-cytes", Am. J. Pathol. 136, 39–47.
   Google Scholar
• Osborn, L., Hession, C., Tizard, R., Vassalo, C., Luhowsky, J.S., Chi-Rosso, G. and Lobb, R. (1989) "Direct cloning of vascular cell adhesion molecule-I, a cytokine induced endothelial protein that binds to lymphocytes", Cell 59, 1203–1211.
   PubMed Web of Science ®Google Scholar
• Chen, C.C. and Manning, A.M. (1995) "Transcriptional regulation of endothelial cell adhesion molecules: a dominant role for NF-B [review]", Agents Actions Suppl. 47, 135–144.
   PubMedGoogle Scholar
• Paszty, C., Brion, C.M., Manci, E., Witkowska, H.E., Stevens, M.E., Mohandas, N. and Rubin, E.M. (1997) "Transgenic knockout mice with exclusive human sickle hemoglobin and sickle cell disease", Science 278, 876–878.
   PubMed Web of Science ®Google Scholar
• Zachlederova, M. and Jarolim, P (2003) "Gene expression profiles of microvascular endothelial cells after stimuli implicated in the pathogenesis of vasoocclusion", Blood Cells, Molecules and Diseases 30, 70–81.
   PubMed Web of Science ®Google Scholar
• Kulcielka, G.L., Hawkins, H.K., Michael, L., et al. (1993) "Regulation of intercellular adhesion molecule 1 (ICAM-1) in ischemic and reperfused canine myocardium", J. Clin. Investig. 92, 1504.
   PubMed Web of Science ®Google Scholar
• Voraberger, G., Schafer, R. and Stratowa, C. (1991) "Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester", J. Immunol. 147, 2777.
   PubMed Web of Science ®Google Scholar
• Cornelius, L.A., Taylor, J.T., Degitz, K., Li, L.J., Lawley, T.J. and Caughman, S.W. (1993) "A 5' portion of the ICAM-1 gene confers tissue-specific differential expression levels and cytokine responsiveness", J. Invest. Dermatol. 100, 753.
   PubMed Web of Science ®Google Scholar
• Iademarco, M.F., McQuillan, J.J., Rosen, G.D. and Dean, D.C. (1992) "Characterization of the promoter for vascular cell adhesion molecule-1", J. Biol. Chem. 267, 16,323.
   PubMedGoogle Scholar
• Neish, AS., Williams, A.J., Palmer, H.J., Whitley, M.Z. and Collins, T. (1992) "Functional analysis of the human vascular cell adhesion molecule 1 promoter", J. Exp. Med. 176, 1583.
   PubMed Web of Science ®Google Scholar
• Brittain, J.E., Ivilinar, Kj., Anderson, C.S., Orringer, E.P. and Parise, L.V. (2001) "Activation of sickle red blood cell adhesion via integrin-associated protein/CD47-induced signal transduction", J. Clin. Investig. 107, 1555–1562.
   PubMed Web of Science ®Google Scholar
• Browne, P.V., Mosher, D.F., Steinberg, M.H. and Hebbel, R.P. (1996) "Disturbance of plasma and platelet thrombospondin levels in sickle cell disease", Am. J. Hematol. 51, 296–301.
   PubMed Web of Science ®Google Scholar
• Asch, AS., Tepler, I., Sibiger, S. and Nachman, R.I. (1991) "Cellular attachment to thrombospondin. Cooperative interactions between receptors systems", J. Biol. Chem. 266, 1740–1745.
   PubMed Web of Science ®Google Scholar
• Kaul, D.K., Nagel, R.L., Chen, D. and Tsai, H.M. (1993) "Sickle erythrocyte-endothelial interactions in microcircula-tion: the role of von Willebrand factor and implications for vasoocclusion", Blood 81, 2429–2438.
   PubMed Web of Science ®Google Scholar
• Wick, T.M. and Eckman, J.R. (1996) "Molecular basis of sickle cell-endothelial cell interactions", Curr. Opin. Hematol. 3, 118–124.
   PubMedGoogle Scholar
• Shetty, N.Y., Rao, A.K. and Stuart, M.J. (2001) "Thrombo-philia in sickle cell disease: the red cell connection", Blood 98, 3228–3233.
   PubMedGoogle Scholar
• Wood, B.L., Gibson, D.F. and Tait, J.F. (1996) "Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flow-cytometric measurement and clinical associa-tions", Blood 88, 1873–1880.
   PubMed Web of Science ®Google Scholar
• Zwaal, R.F.A. and Schroit, A.J. (1997) "Pathophysiologic implications of membrane phospholipid asymmetry in blood cells: a review", Blood 89, 1121–1132.
   PubMed Web of Science ®Google Scholar
• Manodori, A.B., Barabino, GA., Lubin, B.H. and Kuypers, FA. (1999) "Adherence of phosphatidylserine-exposing erythrocytes to endothelial matrix thrombospondin", Blood 95, 1293–1300.
   Web of Science ®Google Scholar
• Belcher, J.D., Marker, PH., Weber, J.P., Hebbel, R.P. and Vercellotti, G.M. (2000) "Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion", Blood 96, 2451–2459.
   PubMed Web of Science ®Google Scholar
• Wun, T., Cordoba, M., Rangaswami, A., Cheung, A.W. and Paglieroni, T. (2002) "Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease", Clin. Lab. Haematol. 24, 81–88.
   PubMedGoogle Scholar
• Collins, T. (1993) "Endothelial nuclear factor-KB and the initiation of the atherosclerotic lesion", Lab. Invest. 68, 499–508.
   PubMed Web of Science ®Google Scholar
• Beg, A.A., Ruben, S.M., Scheinman, R.I., Haskill, S., Rosen, C.A. and Baldwin, AS. (1992) "IKB interacts with the nuclear localization sequences of the subunits of NF-KB: a mechanism for cytoplasmic retention", Genes Dev. 6, 1899–1913.
   PubMed Web of Science ®Google Scholar
• Henkel, T., Zabel, U., Van Zee, K., Muller, J.M., Fanning, E. and Baeuerle, P. (1992) "Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-KB subunit", Cell 68, 1121–1133.
   PubMed Web of Science ®Google Scholar
• Solovey, A., Lin, Y, Browne, P., Choong, S., Wayner, E. and Hebbel, R.P. (1997) "Circulating activated endothelial cells in sickle cell anemia", N. Engl. J. Med. 337, 1584–1590.
   PubMed Web of Science ®Google Scholar
• Solovey, A., Gui, L., Key, N.S. and Hebbel, RE (1998) "Tissue factor expression by endothelial cells in sickle cell anemia", J. Clin. Investig. 101, 1899–1904.
   PubMed Web of Science ®Google Scholar
• Springer, T. (1994) "Traffic signals for lymphocyte recircula-tion and leukocyte emigration: the multistep paradigm", Cell 76, 301–314.
   PubMed Web of Science ®Google Scholar
• Carlos, T.M. and Harlan, J.M. (1994) "Leukocyte-endothelial adhesion molecules", Blood 84, 2068–2101.
   PubMed Web of Science ®Google Scholar
• Mann, K.G., van't Veer, C., Cawthern, K. and Butenas, S. (1998) "The role of the tissue factor pathway in initiation of coagulation", Blood Coagul Fibrinolysis 9\(suppl 1), S3—S7.
   PubMedGoogle Scholar
• Boghossian, S.H., Nash, G., Dormandy, J. and Bevan, D.H. (1991) "Abnormal neutrophil adhesion in sickle cell anaemia and crisis: relationship to blood rheology", Br. J. Haematol. 78, 437–441.
   PubMed Web of Science ®Google Scholar
• Fadlon, E., Vordermeier, S., Pearson, T.C., Mire-Sluis, A.R., Dumonde, D.C., Phillips, J., Fishlock, K. and Brown, K.A. (1998) "Blood polymorphonuclear leukocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64", Blood 91, 266–274.
   PubMed Web of Science ®Google Scholar
• Powars, D.R., Meiselman, J.H., Fishter, T.C., Hiti, A. and Johnson, C. (1994) "Beta-S gene cluster haplotypes modulate hematologic and hemorheologic expression in sickle cell anemia. Use in predicting clinical severity", Am. J. Pediatr. Hematol. Oncol. 16, 55–61.
   PubMedGoogle Scholar
• Lard, L.R., Mul, F.P., Hass, M., de Roos, D. and Duits, A.J. (1999) "Neutrophil activation in sickle cell disease", J. Leukoc. Biol. 66, 411–415.
   PubMed Web of Science ®Google Scholar
• Duits, Al., Schnog, J.B., Lard, L.R., Saleh, A.W. and Rojer, R.A. (1998) "Elevated IL-8 levels during sickle cell crisis", Fur. J. Haematol. 61, 302–305.
   PubMed Web of Science ®Google Scholar
• Platt, OS., Brambilla, D.J., Rosse, WE, Milner, P.F., Castro, O., Steinberg, M.H. and Klug, P.P. (1994) "Mortality in sickle cell disease: life expectancy and risk factors for early death", N. Engl. J. Med. 330, 1639–1644.
   PubMed Web of Science ®Google Scholar
• Miller, ST., Sleeper, L.A., Pegelow, C.H., Enos, L.E., Wang, W.C., Weiner, S.J., Wethers, D.L., Smith, J. and Kinney, T.R. (2000) "Prediction of adverse outcomes in children with sickle cell disease", N. Engl. J. Med. 342, 83–89.
   PubMed Web of Science ®Google Scholar
• Charache, S. (1997) "Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults", Semin. Hematol. 34, 15–21.
   PubMed Web of Science ®Google Scholar
• Benkerrou, M., Delarche, C., Brahimi, L., Fay, M., Vilmer, E., Elion, J., Gougerot-Pocidalo, M.A. and Elbim, C. (2002) "Hydroxyurea corrects the dysregulated L-selectin expression and increased H202 production of polymorpho-nuclear neutrophils from patients with sickle cell anemia", Blood 99, 2297–2303.
   PubMed Web of Science ®Google Scholar
• Anderson, D.C. and Springer, T.A. (1987) "Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150-95 glycoproteins", Annu. Rev. Med. 38, 175–194.
   PubMed Web of Science ®Google Scholar
• Bevilacqua, M.P. and Nelson, R.M. (1993) "Selectins", J. Clin. Investig. 91, 371–387.
   Web of Science ®Google Scholar
• Marx, J.L. (1987) "Oxygen free radicals linked to many diseases", Science 235, 529–531.
   PubMed Web of Science ®Google Scholar
• Wun, T. (1998) "Platelet activation in patients with sickle cell disease", Br. J. Hematol. 100, 741–744.
   PubMed Web of Science ®Google Scholar
• Lawler, J. (1986) "The structural and functional properties of thrombospondin", Blood 67, 1197–1209.
   PubMed Web of Science ®Google Scholar
• Su, S.B., Mukaida, N. and Matsushima, K. (1996) "Rapid secretion of intracellular pre-stored interleukin-8 from rabbit platelets upon activation", J. Leukoc. Biol. 59, 420–426.
   PubMed Web of Science ®Google Scholar
• Loppnow, H., Bil, R., Hirt, S., Sconbeck, U., Herzberg, M., Werdan, K., Rietschel, E.T., Brandt, E. and Had, H.D. (1998) "Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells", Blood 91, 134–139.
   PubMed Web of Science ®Google Scholar
• Tomer, A., Eckman, J.R. and Vroon, D.H. (1992) "Platelet activation and procoagulant activity in sickle cell disease (abstract)", Blood 24, 1111.
   Google Scholar
• Weyrich, AS., Elstad, M.R., McEver, R.P., McIntyre, T.M., Moore, K.L., Morrissey, J.H., Prescott, S.M. and Zimmerman, G.A. (1996) "Activated platelets signal chemokine synthesis by human monocytes", J. Clin. Investig. 24, 1525–1534.
   Google Scholar
• Matsui, N.M., Borsig, L., Rosen, S.D., Yaghmai, M., Varki, A. and Embury, S.H. (2001) "P-selectin mediates the adhesion of sickle erythrocytes to the endothelium", Blood 98, 1955–1962.
   PubMed Web of Science ®Google Scholar
• Lawrence, M.B. and Springer, T.A. (1991) "Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins", Cell 65, 859–873.
   PubMed Web of Science ®Google Scholar
• Matsui, N.M., Varki, A. and Embury, S.H. (2002) "Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin", Blood 100, 3790–3796.
   PubMed Web of Science ®Google Scholar
• Stenberg, P.E., McEver, R.P., Shuman, M.A., Jacques, Y.V. and Bainton, D.E. (1985) "A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation", J. Cell. Biol. 101, 880–886.
   PubMed Web of Science ®Google Scholar
• Hattori, R., Hamilton, K.K., Fugate, RD., McEver, R.P. and Sims, P.J. (1989) "Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribu-tion to the cell surface of the intracellular granule membrane protein GMP-140", J. Biol. Chem. 264, 7768–7771.
   PubMed Web of Science ®Google Scholar
• Lorant, D.E., Patel, K.D., McIntyre, T.M., McEver, R.P., Prescott, S.M. and Zimmerman, G.A. (1991) "Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils", J. Cell Biol. 115, 223–234.
   PubMed Web of Science ®Google Scholar
• Closse, C., Seigneur, M., Renard, M., Pruvost, A., Dumain, P., Belloc, E and Boisseau, M.R. (1996) "Influence of hypoxia and hypoxia-reoxygenation on endothelial P-selectin expression", Haemostasis 26, 177–181.
   PubMedGoogle Scholar
• Adams, D.H. and Shaw, S. (1994) "Leucocyte-endothelial interactions and regulation of leucocyte migration", Lancet 343, 831–836.
   PubMed Web of Science ®Google Scholar
• Bach, F.H., Robson, S.C., Winkler, H., Ferran, C., Stuhlmeier, KM., Wrighton, C.J. and Hancock, W.W. (1995) "Barriers to xenotransplantation", Nat. Med. 1, 869–873.
   PubMed Web of Science ®Google Scholar
• Mantovani, A., Sozzani, A., Vecchi, A., Introna, M. and Allvena, P. (1997) "Cytokine activation of endothelial cells: new molecules for an old paradigm", Thromb. Haemost. 78, 406–414.
   PubMed Web of Science ®Google Scholar
• Pober, J.S., Orosz, C.G., Rose, Mi. and Savage, C.O. (1996) "Can graft endothelial cells initiate a host antigraft immune response?", Transplantation 61, 343–349.
   PubMed Web of Science ®Google Scholar
• Kopp, E. and Ghosh, S. (1994) "Inhibition of NF-B by sodium salicylate and aspirin", Science 265, 956–959.
   PubMed Web of Science ®Google Scholar
• Marx, J. (1995) "How the glucocorticoids suppress immu-nity", Science 270, 232–233.
   PubMed Web of Science ®Google Scholar
• Styles, L.A., Lubin, B., Vichinsky, E., Lawrence, M., Hua, M., Test, S. and Kuypers, F. (1997) "Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea", Blood 89, 2544–2559.
   Web of Science ®Google Scholar
• Bourantas, K.L., Dalekos, G.N., Makis, A., Chaidos, A., Tsiara, S. and Mavrides, A. (1998) "Cytokines and acute-phase proteins during the steady state of sickle cell disease", Fur. J. Hematol. 61, 49–54.
   Google Scholar
• Singhal, A., Doherty, IF., Raynes, LG., McAdam, K.P., Thomas, P.W., Serjeant, B.E. and Serjeant, G.R. (1993) "Is there an acute-phase response in steady-state sickle cell disease?", Lancet 341, 651–653.
   PubMed Web of Science ®Google Scholar
• Duits, A.J., Pieters, R.C., Saleh, A.W., van Rosmalen, E., Katerberg, H., Berend, K. and Rojer, R.A. (1996) "Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis", Clin. Immunol. Immunopathol. 81, 96–98.
   PubMedGoogle Scholar
• Saleh, A.W., Duits, A.J., Gerbers, A., de Vries, C. and Hillen, H.F. (1998) "Cytokines and soluble adhesion molecules in sickle cell anemia patients during hydroxyurea therapy", Acta Hematol. 100, 26–31.
   PubMed Web of Science ®Google Scholar
• Kuvibidila, S., Gardner, R., Ode, D., Yu, L., Lane, G. and Warner, R.P. (1997) "Tumor necrosis factor alpha in children with sickle cell disease in stable condition", J. Natl Med. Assoc. 89, 609–615.
   PubMed Web of Science ®Google Scholar
• Solovey, A., Lin, Y., Brown, P., Choong, S., Wayner, E. and Hebbel, R.P. (1997) "Circulating activated endothelial cells in sickle cell anemia", N. Engl. J. Med. 337, 1584–1590.
   PubMed Web of Science ®Google Scholar
• Hedo, C.C., Akinola, Y.A., Okpala, I.E., Durojaiye, A.O. and Sahimonu, L.S. (1993) "Acute phase reactants and severity of homozygous sickle cell disease", J. Intern. Med. 233,467–470.
   PubMed Web of Science ®Google Scholar
• Monnet, D., Diallo, I., Sangare, A. and Yapo, A.E. (1993) "Clinical value of C-reactive protein, alpha 1-glycoprotein acid and transferrin assay in homozygous sickle cell disease", Bull. Soc. Pathol. Exot. 86, 282–285.
   PubMed Web of Science ®Google Scholar
• Moore, C., Ehlayel, M., Inostroza, J., Leiva, L.E., Kuvibidila, S., Yu, L., Gardner, R., Ode, DL., Warner, R. and Sorensen, R.U. (1998) "Increased circulating levels of soluble HLA class I heterodimers in patients with sickle cell disease", J. Natl Med. Assoc. 90, 157–163.
   PubMed Web of Science ®Google Scholar
• Klug, P.P., Kay, N. and Jensen, W.N. (1982) "Endothelial cell and vascular damage in the sickle cell disorders", Blood Cells 8, 175–184.
   PubMedGoogle Scholar
• Nawroyh, P.P., Bank, I., Handley, D., Cassimeris, J., Chess, L. and Stern, D. (1986) "Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin-1", J. Exp Med. 163, 1363–1367.
   PubMed Web of Science ®Google Scholar
• Baumann, H. and Gauldie, J. (1994) "The acute phase response", Immunol. Today 15, 74–80.
   PubMedGoogle Scholar
• Rubycki, A.C., Musto, S., Swinson, G.L., Benjamin, L.J., Nagel, R.L. and Schwartz, R.S. (1991) "Increased levels of endothelin-1 in plasma of sickle cell anemia patients (abstract)", Blood 78, 202a.
   Google Scholar
• Hammerman, S.I., Kourembanas, S., Conca, T.J., Tucci, M., Brauer, M. and Farber, H.W. (1997) "Endothehin-1 production during the acute chest syndrome in sickle cell disease", Am. J. Respir. Crit. Care Med. 156, 280–285.
   PubMed Web of Science ®Google Scholar
• Werdehoff, S.G., Moore, R.B., Hoff, C.J., Filhingim, E. and Hackman, A.M. (1998) "Elevated plasma endothelin-1 levels in sickle cell anemia: relationships to oxygen saturation and left ventricular hypertrophy", Am. J. Hematol. 58, 195–199.
   PubMed Web of Science ®Google Scholar
• Graido-Gonzahez, E., Doherty, J.C., Bergreen, E.W., Organ, G., Telfer, M. and McMillen, M.A. (1998) "Plasma endothelin-1, cytokine, and prostaglandin E2 levels in sickle cell disease and acute vaso-occlusive sickle crisis", Blood 92, 2551–2555.
   PubMed Web of Science ®Google Scholar
• Kahaleh, M.B. and Fan, S. (1997) "Effects of cytokines on the production of endothelin by endothelial cells", Chin. Exp. Rheumatol. 15, 163–167.
   PubMed Web of Science ®Google Scholar
• Kruse-Elliott, K.T., VVhorton, A.R. and Olson, N.C. (1998) "Role of lipid-derived mediators in tumor necrosis factor-induced endothehin-1 release in vivo", Shock 9, 40–45.
   PubMed Web of Science ®Google Scholar