The Proteasome: A Novel Therapeutic Target in Haematopoietic Malignancy

References

• Li, B. and Dou, Q.P. (2000) "Box degradation by the ubiquitin proteasome-dependent pathway: Involvement in tumour survival and progression", Proceedings of the National Academy of Sciences 97, 3850–3855.
   PubMed Web of Science ®Google Scholar
• Hideshima, T., Chauhan, D., Podar, K., Schlossman, R.L., Richardson, P and Anderson, K.C. (2001) "Novel therapies targeting the myeloma cell and its bone marrow microenvi-ronment", Seminars in Oncology 28, 607–612.
   PubMed Web of Science ®Google Scholar
• Goldberg, A.L. and Rock, K.L. (1992) "Proteolysis, protea-somes and antigen presentation", Nature 357, 375–379.
   PubMed Web of Science ®Google Scholar
• Hershko, A. and Ciechanover, A. (1998) "The ubiquitin system", Annual Reviews in Biochemistry 67, 425–479.
   PubMed Web of Science ®Google Scholar
• Finley, D. and Chau, V. (1991) "Ubiquitination", Annual Reviews in Cell Biology 7, 25–69.
   PubMedGoogle Scholar
• Ciechanover, A., Breitschopf, K., Hatoum, O.A. and Bengal, E. (1999) "Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination", Molecular Biology Reports 26, 59–64.
   PubMed Web of Science ®Google Scholar
• Coffino, P. (2001) "Antizyme, a mediator of ubiquitin-independent proteasomal degradation", Biochimie 83, 319–323.
   PubMed Web of Science ®Google Scholar
• Kamitani, T., Kito, K., Fudaka-Kamitani, T. and Yeh, E.T. (2001) "Targeting of NEDD8 and its conjugates for proteasomal degradation of NUB1", The Journal of Biological Chemistry 276, 46655–46660.
   PubMed Web of Science ®Google Scholar
• Murakami, Y., Mutsufuji, S., Kameji, T., Hayashi, S., Igarashi, K., Tumara, T., Tanaka, K. and Ichihara, A. (1992) "Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination", Nature 360, 597–599.
   PubMed Web of Science ®Google Scholar
• Ciechanover, A. (1994) "The ubiquitin—proteasome proteo-lytic pathway", Cell 79, 13–21.
   PubMed Web of Science ®Google Scholar
• Dahlmarm, B., Kopp, F., Kuehn, L., Niedel, B., Pfeifer, G., Hegerl, R. and Baumeister, W. (1989) "The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria", FEBS Letters 251, 125–131.
   PubMed Web of Science ®Google Scholar
• Groll, M., Bajorek, M., Kohler, A., Moroder, L., Rubin, D.M., Glickman, H.M. and Finley, D. (2000) "A gated channel into the proteasome core particle", Nature Structural Biology 7, 1062–1067.
   PubMedGoogle Scholar
• Groll, M., Ditzel, L., Lowe, J., Stock, D., Bochtler, M., Bartunik, H. and Huber, R. (1997) "Structure of 20S proteasome from yeast at 2.4A resolution", Nature 386, 463–471.
   PubMed Web of Science ®Google Scholar
• Orlowski, M. (1990) "The multicatalytic proteinase complex: a major extralysosomal proteolytic system", Biochemistry 29, 10289–10297.
   PubMed Web of Science ®Google Scholar
• Kisselev, A.F., Akopian, IN., Castillo, V. and Goldberg, A.L. (1999) "Proteasome active sites allosterically regulate each other, suggesting a cyclical bite—chew mechanism for protein breakdown", Molecular Cell 4, 395–402.
   PubMed Web of Science ®Google Scholar
• Chen, P. and Hochstrasser, M. (1996) "Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly", Cell 86, 961–972.
   PubMed Web of Science ®Google Scholar
• Rock, K.L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D. and Goldberg, A.L. (1994) "Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class 1 molecules", Cell 78, 761–771.
   PubMed Web of Science ®Google Scholar
• Arendt, C.S. and Hochstrasser, M. (1997) "Identification of the yeast 20S proteasome catalytic centers and subunit inter-actions required for active-site formation", Proceedings of the National Academy of Sciences 94, 7156–7161.
   PubMed Web of Science ®Google Scholar
• Orlowski, M., Cardozo, C. and Michaud, C. (1993) "Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids", Biochemistry 32, 1563–1572.
   PubMed Web of Science ®Google Scholar
• Duggleby, H.J., Tolley, S.P., Hill, C.P., Dodson, E.J., Dodson, G. and Moody, P.C.E. (1995) "Penicillin acylase has a single-amino-acid catalytic centre", Nature 373, 264–265.
   PubMed Web of Science ®Google Scholar
• Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J. and Schreiber, S.L. (1995) "Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin", Science 268, 726–731.
   PubMed Web of Science ®Google Scholar
• Wollenberg, K. and Swaffield, J.C. (2001) "Evolution of proteasomal ATPases", Molecular Biology and Evolution 18, 962–974.
   PubMed Web of Science ®Google Scholar
• Kohler, A., Cascio, P., Leggett, D.S., Woo, K.M., Goldberg, A.L. and Finley, D. (2001) "The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release".
   Google Scholar
• Braun, B.C., Glickman, M., Kraft, R., Dahlmarm, B., Kloetzel, P.M., Finley, D. and Schmidt, M. (1999) "The base of the proteasome exhibits chaperone-like activity", Nature Cell Biology 1,221–226.
   PubMed Web of Science ®Google Scholar
• Dubiel, W., Pratt, G., Ferrell, K. and Rechsteiner, M. (1992) "Purification of an 11S regulator of the multicatalytic protease", The Journal of Biological Chemistry 267, 22369–22377.
   PubMed Web of Science ®Google Scholar
• DeMartino, G.N. and Slaughter, C.A. (1999) "The proteasome, a novel protease regulated by multiple mechanisms", Journal of Biological Chemistry 274, 22123–22136.
   PubMed Web of Science ®Google Scholar
• Fruh, K. and Yang, Y. (1999) "Antigen presentation by MHC class I and its regulation by interferon gamma", Current Opinion in Immunology 11, 76–81.
   PubMed Web of Science ®Google Scholar
• Rock, K.L. and Goldberg, A.L. (1999) "Degradation of cell proteins and the generation of MHC class I-presented peptides", Annual Reviews in Immunology 17, 739–779.
   PubMed Web of Science ®Google Scholar
• Wilk, S. and Orlowski, M. (1983) "Evidence that pituitary cation-sensitive neutral endopeptidase is a multicatalytic protease complex", Journal of Neurochemistry 40, 842–849.
   PubMed Web of Science ®Google Scholar
• Tsubuki, S., Saito, Y., Tomioka, M., Ito, H. and Kawashima, S. (1996) "Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine", Journal of Biochemistry 119, 572–576.
   PubMed Web of Science ®Google Scholar
• Figueredo-Pereira, ME., Berg, K.A. and Wilk, S. (1994) "A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin protein conjugates in a neuronal cell", Journal of Neurochemistry 63, 1578–1581.
   PubMed Web of Science ®Google Scholar
• Mori, S., Tanaka, K., Omura, S. and Saito, Y. (1992) "Degradation process of ligan-stimulated platelet derived growth factor beta receptor involves ubiquitin proteasome proteolytic pathway", Journal of Biological Chemistry 270, 29447–294452.
   Google Scholar
• Lynas, J., Harriott, P., Healy, A., McKervey, A. and Walker, B. (1998) "Inhibitors of the chymotrypsin like activity of the proteasome based on di- and tri-peptidyl a-keto aldehydes (glyoxals)", Bioorganic and Medicinal Chemistry Letters 8, 373–378.
   PubMed Web of Science ®Google Scholar
• Adams, J., Behnke, M., Chen, S., Cruickshank, A.A., Dick, L.R., Grenier, L., Klunder, J.M., Ma, Y.T., Plamondon, L. and Stein, R.L. (1998) "Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids", Bioorganic and Medicinal Chemistry Letters 8, 333–338.
   PubMed Web of Science ®Google Scholar
• Omura, S., Fujimoto, T., Otoguro, K., Matsuzaki, K., Moriguchi, R., Tanaka, H. and Sasaki, Y. (1991) "Lactacystin, a novel microbial metabolite induces neuritogenosis of neuroblastoma cells", Journal of Antibiotics 44, 113–116.
   PubMed Web of Science ®Google Scholar
• Dick, L.R., Cruikshank, A.A., Destree, AT., Grevier, L., McCormack, TA., Melandri, ED., Nunes, S.L., Palombella, VJ., Parent, L.A., Plamondon, L., et al. (1997) "Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells", Journal of Biological Chemistry 272, 182–188.
   PubMed Web of Science ®Google Scholar
• Ostrowska, H., Wojcik, C., Omura, S. and Worowski, K. (1997) "Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A like enzyme", Biochemical and Biophysical Research Communications 234, 729–732.
   PubMed Web of Science ®Google Scholar
• Palmer, J.T., Rasnick, D., Klaus, J.L. and Bromne, D. (1995) "Vinyl sulfones as mechanism-based cysteine protease inhibitors", Journal of Medicinal Chemistry 38, 3193–3196.
   PubMed Web of Science ®Google Scholar
• Bogyo, M., McMaster, J.S., Gaczynska, M., Tortorella, D., Goldberg, A.L. and Ploegh, H. (1997) "Covalent modification of the active site Thr of proteasome beta-subunits and the E. coli homologue HsIV by a new class of inhibitors", Proceedings of the National Academy of Sciences 94, 6629–6634.
   PubMed Web of Science ®Google Scholar
• Glotzer, M., Murray, A.W. and Kirschner, MN. (1991) "Cyclin is degraded by the ubiquitin pathway", Nature 366, 355–357.
   Google Scholar
• Loda, M., Cukor, B., Tam, S.W., Lavin, E, Fiorention, M., Draetta, GE, Jessup, J.M. and Pagano, M. (1997) "Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas", Nature Medcine 3, 231–234.
   PubMed Web of Science ®Google Scholar
• Catzavelos, C., Bhattacharya, N., Ung, Y.C., Wilson, J.A., Roncari, L., Sandhu, C., Shaw, P., Yeger, H., Morava-Protzner, I., Kapusta, L., Franssen, E., Pritchard, K.I. and Slingerland, J.M. (1997) "Decreased levels of the cell cycle inhibitor p27 Kip1 protein: progrnostic implications in breast cancer", Nature Medicine 2, 227–230.
   Web of Science ®Google Scholar
• Kumatori, A., Tanaka, K., Inamura, N., Ogura, T., Matsumoto, T., Tachikawa, T., Shin, S. and Ichihara, A. (1990) "Abnor-mally high expression of proteasomes in human leukaemic cells", Proceedings of the National Academy of Sciences 87, 7071–7075.
   PubMed Web of Science ®Google Scholar
• Shimbara, N., Orino, E., Sone, S., Ogura, T., Takashina, M., Shono, M., Tamura, T., Yasuda, H., Tanaka, K. and Ichihara, A. (1992) "Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells", The Journal of Biological Chemistry 267, 18100–18109.
   PubMed Web of Science ®Google Scholar
• Imajoh-Ohmi, S., Kawaguchi, T., Sugiyama, S., Tanaka, K., Omura, S. and Kikuchi, H. (1995) "Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells", Biochemical and Biophysical Research Communications 217, 1070–1077.
   PubMed Web of Science ®Google Scholar
• Masdehors, P., Omura, S., Merle-Beral, H., Mentz, F., Cosset, J.M., Dumont, J., Magdelenat, H. and Delic, J. (1999) "Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin", British Journal of Haematology 105, 752–757.
   PubMed Web of Science ®Google Scholar
• Masdehors, P., Merle-Beral, H., Maloum, K., Omura, S., Magdelenat, H. and Delic, J. (2000) "Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes", Blood 96, 269–274.
   PubMed Web of Science ®Google Scholar
• Chandra, J., Niemer, I. and Gilbreath, J. (1998) "Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes", Blood 92, 4220–4229.
   PubMed Web of Science ®Google Scholar
• Delic, J., Masdehors, P., Omura, S., Dumont, J., Binet, J.L., Cosset, J.M. and Magdelenat, H. (1998) "The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo-and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-a-initiated apoptosis", British Journal of Cancer 77, 1103–1107.
   PubMed Web of Science ®Google Scholar
• Ogata, A., Chauhan, D., Urashima, M., Teoh, G., Treon, S.P. and Anderson, K.C. (1997) "Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells", Clinical Cancer Research 3, 1017–1022.
   PubMed Web of Science ®Google Scholar
• Guzman, M.L., Neering, S.J., Upchurch, D., Grimes, B., Howard, D.S., Rizzieri, D.A., Luger, S.M. and Jordan, C.T. (2001) "Nuclear factor-kappa B is constitutively activated in primitive human acute myelogenous leukemia cells", Blood 98, 2301–2307.
   PubMed Web of Science ®Google Scholar
• Garg, A. and Aggarwal, B.B. (2002) "Nuclear transcription factor-kappaB as a target for cancer drug development", Leukemia 16, 1053–1068.
   PubMed Web of Science ®Google Scholar
• Wang, M., Cusack, J.C.J., Liu, R. and Baldwin, AS., Jr (1999) "Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB", Nature Medicine 5, 412–417.
   PubMed Web of Science ®Google Scholar
• Meriin, A.B., Gabai, V.L., Yaglom, J., Shifrin, VI. and Sherman, M.Y. (1998) "Proteasome inhibitors activate stress kinases and induces Hsp72. Diverse effects on apoptosis", The Journal of Biological Chemistry 273, 6373–6379.
   PubMed Web of Science ®Google Scholar
• Sunwoo, J.B., Chen, Z., Dong, G., Yeh, N., Bancroft, C.C., Sausville, E., Adams, J., Elliot, P. and Van Waes, C. (2001) "Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-KB, cell survival, tumor growth and angiogen-esis in squamous cell carcinoma", Clinical Cancer Research 7, 1419–1428.
   PubMed Web of Science ®Google Scholar
• McGahon, A., Bissonnett, R., Schmitt, M., Cotter, M., Green, D.R. and Cotter, T.G. (1994) "BCR-ABL maintains resistance of chronic myelogenous leukaemia cells to apoptotic cell death", Blood 83, 1179–1187.
   PubMed Web of Science ®Google Scholar
• Bedi, A., Zehnbauer, B.A., Barber, J.P., Sharkis, S.J. and Jones, R.J. (1994) "Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia", Blood 83, 2038–2044.
   PubMed Web of Science ®Google Scholar
• Dou, Q.P., McGuire, T.F., Peng, Y.B. and An, B. (1999) "Proteasome inhibition leads to significant reduction of Bcr-Abl expression and subsequent induction of apoptosis in K562 human chronic myelogenous leukemia cells", Journal of Pharmacology and Experimental Therapeutics 289, 781–790.
   PubMed Web of Science ®Google Scholar
• Dai, Z. and Pendergast, A.M. (1995) "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity", Genes and Development 9, 2569–2582.
   PubMed Web of Science ®Google Scholar
• Dai, Z., Quackenbush, R.C., Courtney, K.D., Grove, M., Cortez, D., Reuther, G.W. and Pendergast, A.M. (1998) "Oncogenic Abl and Src tyrosine ldnases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway", Genes and Development 12, 1415–1424.
   PubMed Web of Science ®Google Scholar
• Drexler, H.C. (1997) "Activation of the cell death program by inhibition of proteasome function", Proceedings of the National Academy of Sciences 94, 855–860.
   PubMed Web of Science ®Google Scholar
• Grimm, L.M., Goldberg, A.L., Poirier, G.G., Schwartz, L.M. and Osborne, B.A. (1996) "Structure of 20S proteasome from yeast at 2.4A resolution", EMBO Journal 15, 3835–3844.
   PubMed Web of Science ®Google Scholar
• Sadoul, R., Fernandez, P.A., Quiquerez, A.L., Martinou, I., Maki, M., Schroter, M., Becherer, J.D., Irmler, M., Tschopp, J. and Martinou, J.C. (1996) "Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons", EMBO Journal 15, 3845–3852.
   PubMed Web of Science ®Google Scholar
• Fleming, J.A., Lightcap, ES., Sadis, S., Thoroddsen, V, Bulawa, C.E. and Blackman, R.K. (2002) "Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341", Proceedings of the National Academy of Sciences 99, 1461–1466.
   PubMed Web of Science ®Google Scholar
• Mitsiades, N., Mitsiades, CS., Poulaki, V, Chauhan, D., Fanourakis, G., Gu, X., Bailey, C., Joseph, M., Libermarm, T.A., Treon, S.P., Munshi, N.C., Richardson, P.G., Hideshima, T. and Anderson, K.C. (2003) "Molecular sequelae of protea-some inhibition in human multiple myeloma cells", Proceed-ings of the National Academy of Sciences 99, 14374–14379.
   Web of Science ®Google Scholar
• Orlowski, R.Z., Eswara, J.R., Lafond-Walker, A., Greyer, M.R., Orlowski, M. and Dang, C.V. (1998) "Tumor growth inhibition induced in a marine model of human Burkitt's lymphoma by a proteasome inhibitor", Cancer Research 58, 4342–4348.
   PubMed Web of Science ®Google Scholar
• Wojcik, C., IVIlynarczuk, I., Hoser, G., Kawiak, J., Stoklosa, T., Golab, J. and Wilk, S. (1999) "A combination of retinoic acid and proteasome inhibitors for the treatment of leukaemias is potentially dangerous", Blood 94, 1827–1834.
   PubMed Web of Science ®Google Scholar
• Adams, J., Palombella, V.J., Sausville, E.A., Johnson, J., Destree, A., Lazurus, D.D., Maas, J., Pien, CS., Prakash, S. and Elliott, P.J. (1999) "Proteasome inhibitors: a novel class of potent and effective antitumour agents", Cancer Research 59, 2615–2622.
   PubMed Web of Science ®Google Scholar
• Teicher, B.A., Ara, G., Herbst, R., Palonbella, V.J. and Adams, J. (1999) "The proteasome inhibitor PS-341 in cancer therapy", Clinical Cancer Research 5, 2638–2645.
   PubMed Web of Science ®Google Scholar
• Tenev, T., Marani, M., Mc Neish, I. and Lemoine, N.R. (2001) "Pro-caspase overexpression sensitises ovarian cells to proteasome inhibitors", Cell Death and Differentiation 8, 256–264.
   PubMed Web of Science ®Google Scholar
• Shah, S.A., Potter, M.W., Mc Dade, T.P., Ricciardi, R., Perugini, R.A., Elliott, P.J., Adams, J. and Callery, M.P. (2001) "26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer", Journal of Cell Biochemistry 82, 110–122.
   PubMed Web of Science ®Google Scholar
• Ling, Y.H., Liebes, L., Jiang, J.D., Holland, J.F., Elliott, P.J., Adams, J., Muggia, F.M. and Perez-Soler, R. (2003) "Mechanisms of proteasome inhibitor PS-341 induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines", Clinical Cancer Research 9, 1145–1154.
   PubMed Web of Science ®Google Scholar