Clinical Implications of T Cell Receptor Repertoire Analysis after Allogeneic Stem Cell Transplantation

References

• Teshima, T. and Ferrara, J.L. (2002) "Understanding the alloresponse: new approaches to graft-versus-host disease prevention", Semin. Hematol. 39, 15–22.
   PubMed Web of Science ®Google Scholar
• Ratanatharathorn, V, Ayash, L., Lazarus, H.M., Fu, J. and Uberti, J.P. (2001) "Chronic graft-versus-host disease: clinical manifestation and therapy", Bone Marrow Transplant. 28, 121–129.
   PubMed Web of Science ®Google Scholar
• Goker, H., Haznedaroglu, I.C. and Chao, N.J. (2001) "Acute graft-vs-host disease: pathobiology and manage-ment", Exp. Hematol. 29, 259–277.
   PubMed Web of Science ®Google Scholar
• Ferrara, J.L., Cooke, K.R., Pan, L. and Krenger, W. (1996) "The immunopathophysiology of acute graft-versus-host-disease", Stem Cells 14, 473–489.
   PubMed Web of Science ®Google Scholar
• Godthelp, B.C., van Tol, M.J., Vossen, J.M. and van den Elsen, P.J. (1999) "T-Cell immune reconstitution in pediatric leukemia patients after allogeneic bone marrow transplan-tation with T-cell-depleted or unmanipulated grafts: evaluation of overall and antigen-specific T-cell repertoires", Blood 94, 4358–4369.
   PubMed Web of Science ®Google Scholar
• Hirokawa, M., Horiuchi, T., Kitabayashi, A., Kawabata, Y., Matsutani, T., Suzuki, R., Chihara, J. and Miura, A.B. (2000) "Delayed recovery of CDR3 complexity of the T-cell receptor-beta chain in recipients of allogeneic bone marrow transplants who had virus-associated interstitial pneumonia: monitor of T-cell function by CDR3 spectratyping", J. Allergy Clin. Immunol. 106, S32—S39.
   PubMed Web of Science ®Google Scholar
• Wu, C.J., Chillemi, A., Alyea, E.P., Orsini, E., Neuberg, D., Soiffer, R.J. and Ritz, J. (2000) "Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism", Blood 95, 352–359.
   PubMed Web of Science ®Google Scholar
• Chan, A. and Mak, T.W. (1989) "Genomic organization of the T cell receptor", Cancer Detect. Prey. 14, 261–267.
   PubMedGoogle Scholar
• Moss, P.A., Rosenberg, W.M. and Bell, J.I. (1992) "The human T cell receptor in health and disease", Annu. Rev. Immunol. 10, 71–96.
   PubMed Web of Science ®Google Scholar
• Garcia, K.C., Teyton, L. and Wilson, I.A. (1999) "Structural basis of T cell recognition", Annu. Rev. Immunol. 17,369–397.
   PubMed Web of Science ®Google Scholar
• Arstila, T.P., Casrouge, A., Baron, V, Even, J., Kanellopoulos, J. and Kourilsky, P. (2000) "Diversity of human alpha beta T cell receptors", Science 288, 1135.
   PubMedGoogle Scholar
• Champlin, R.E., Passweg, J.R., Zhang, M.J., Rowlings, P.A., Pelz, C.J., Atkinson, K.A., Barrett, A.J., Cahn, J.Y., Drobyski, W.R., Gale, R.P., Goldman, J.M., Gratwohl, A., Gordon-Smith, E.C., Henslee-Downey, P.J., Herzig, R.H., Klein, J.P., Marmont, A.M., O'Reilly, R.J., Ringden, O., Slavin, S., Sobocinski, K.A., Speck, B., Weiner, R.S. and Horowitz, M.M. (2000) "T-cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings: advantage of T-cell antibodies with narrow specificities", Blood 95, 3996–4003.
   PubMed Web of Science ®Google Scholar
• Gorski, J., Yassai, M., Zhu, X., Kissela, B., Kissella, B., Keever, C. and Flomenberg, N. (1994) "Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status", J. Immunol. 152, 5109–5119.
   PubMed Web of Science ®Google Scholar
• Breit, T.M., Verschuren, M.C., Wolvers-Tettero, IL., Gastel-Mol, E.J., Hahlen, K. and van Dongen, J.J. (1997) "Human T cell leukemias with continuous V(D)J recombi-nase activity for TCR-delta gene deletion", J. Immunol. 159, 4341–4349.
   PubMed Web of Science ®Google Scholar
• Verschuren, M.C., Wolvers-Tettero, IL., Breit, T.M., Noordzij, J., van Wering, E.R. and van Dongen, J.J. (1997) "Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells", J. Immunol. 158, 1208–1216.
   PubMed Web of Science ®Google Scholar
• Livak, F. and Schatz, D.G. (1996) "T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymo-cytes and mature T cells", Mol. Cell. Biol. 16, 609–618.
   PubMed Web of Science ®Google Scholar
• Takeshita, S., Toda, M. and Yamagishi, H. (1989) "Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus", EMBO J. 8, 3261–3270.
   PubMed Web of Science ®Google Scholar
• Kong, F.K., Chen, C.L., Six, A., Hockett, R.D. and Cooper, M.D. (1999) "T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool", Proc. Natl Acad. Sci. USA 96, 1536–1540.
   PubMed Web of Science ®Google Scholar
• Douek, D.C., McFarland, R.D., Keiser, P.H., Gage, E.A., Massey, J.M., Haynes, B.F., Polis, M.A., Haase, A.T., Feinberg, M.B., Sullivan, J.L., Jamieson, B.D., Zack, J.A., Picker, L.J. and Koup, R.A. (1998) "Changes in thymic function with age and during the treatment of HIV infection", Nature 396, 690–695.
   PubMed Web of Science ®Google Scholar
• Talvensaari, K., Clave, E., Douay, C., Rabian, C., Garderet, L., Busson, M., Gander, F., Douek, D., Gluckman, E., Charron, D. and Toubert, A. (2002) "A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation", Blood 99, 1458–1464.
   PubMed Web of Science ®Google Scholar
• Altman, J.D., Moss, P.A., Goulder, P.J., Barouch, D.H., McHeyzer-Williams, M.G., Bell, J.I., McMichael, A.J. and Davis, M.M. (1996) "Phenotypic analysis of antigen-specific T lymphocytes", Science 274, 94–96.
   PubMed Web of Science ®Google Scholar
• Mutis, T., Gillespie, G., Schrama, E., Falkenburg, J.H., Moss, P. and Goulmy, E. (1999) "Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cyto-toxic T lymphocytes in patients with graft-versus-host disease", Nat. Med. 5, 839–842.
   PubMed Web of Science ®Google Scholar
• Romero, P., Dunbar, P.R., Valmori, D., Pittet, M., Ogg, G.S., Rimoldi, D., Chen, J.L., Lienard, D., Cerottini, J.C. and Cerundolo, V. (1998) "Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes", J. Exp. Med. 188, 1641–1650.
   PubMed Web of Science ®Google Scholar
• Hutchings, P.R., Cambridge, G., Tite, J.P., Meager, T. and Cooke, A. (1989) "The detection and enumeration of cytokine-secreting cells in mice and man and the clinical application of these assays", J. Immunol. Methods 120, 1–8.
   PubMed Web of Science ®Google Scholar
• Suni, M.A., Picker, L.J. and Maino, V.C. (1998) "Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry", J. Immunol. Methods 212, 89–98.
   PubMed Web of Science ®Google Scholar
• Nomura, L.E., Walker, J.M. and Maecker, H.T. (2000) "Optimization of whole blood antigen-specific cytokine assays for CD4(+) T cells", Cytometry 40, 60–68.
   PubMedGoogle Scholar
• Wang, W., Meadows, L.R., den Haan, J.M., Sherman, N.E., Chen, Y., Blokland, E., Shabanowitz, J., Agulnik, Al., Hendrickson, R.C. and Bishop, C.E. (1995) "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein", Science 269, 1588–1590.
   PubMed Web of Science ®Google Scholar
• Maecker, H.T., Maino, V.C. and Picker, L.J. (2000) "Immuno-fluorescence analysis of T-cell responses in health and disease", J. Clin. Immunol. 20, 391–399.
   PubMed Web of Science ®Google Scholar
• Dickinson, A.M., Wang, X.N., Sviland, L., Vyth-Dreese, F.A., Jackson, G.H., Schumacher, T.N., Haanen, J.B., Mutis, T. and Goulmy, E. (2002) "In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompat-ibility antigens", Nat. Med. 8, 410–414.
   PubMed Web of Science ®Google Scholar
• van den Beemd, R., Boor, PP., van Lochem, E.G., Hop, W.C., Langerak, A.W., Wolvers-Tettero, LL., Hooijkaas, H. and van Dongen, J.J. (2000) "Flow cytometric analysis of the Vbeta repertoire in healthy controls", Cytometry 40,336–345.
   PubMedGoogle Scholar
• Plasilova, M., Risitano, A. and Maciejewski, J.P. (2003) "Application of the molecular analysis of the T cell receptor repertoire in the study of immune-mediated hematologic disease", Hematol. J. 8, 173–181.
   Google Scholar
• Risitano, A.M., Kook, H., Zeng, W., Chen, G., Young, N.S. and Maciejewski, J.P. (2002) "Significance of oligoclonal and polydonal expansion within CD8 and CD4 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by VB CDR3 spectratyping and flow ctyometry", Blood, 178–183.
   PubMed Web of Science ®Google Scholar
• Zaia, J.A., Sissons, J.G., Riddell, S., Diamond, D.J., Wills, M.R., Carmichael, A.J., Weekes, M.P., Gandhi, M., Rosa, C.L., Villacres, M., Lacey, S., Markel, S. and Sun, J. (2000) "Status of Cytomegalovirus Prevention and Treat-ment in 2000", Hematology (Am. Soc. Hematol. Mu. Program), 339–355.
   Google Scholar
• Kuzushima, K., Hoshino, Y., Fujii, K., Yokoyama, N., Fujita, M., Kiyono, T., Kimura, H., Morishima, T., Morishima, Y. and Tsurumi, T. (1999) "Rapid determination of Epstein-Barr virus-specific CD8(+) T-cell frequencies by flow cytometry", Blood 94, 3094–3100.
   PubMed Web of Science ®Google Scholar
• Gillespie, G.M., Wills, M.R., Appay, V, O'Callaghan, C., Murphy, M., Smith, N., Sissons, P., Rowland-Jones, S., Bell, J.I. and Moss, P.A. (2000) "Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors", J. Virol. 74, 8140–8150.
   PubMed Web of Science ®Google Scholar
• Weekes, M.P., Carmichael, A.J., Wills, M.R., Mynard, K. and Sissons, J.G. (1999) "Human CD28-CD8+ T cells contain greatly expanded functional virus-specific memory CTL clones", J. Immunol. 162, 7569–7577.
   PubMed Web of Science ®Google Scholar
• Singhal, S., Shaw, J.C., Ainsworth, J., Hathaway, M., Gillespie, G.M., Paris, H., Ward, K., Pillay, D., Moss, P.A. and Mutimer, D.J. (2000) "Direct visualization and quanti-tation of cytomegalovirus-specific CD8+ cytotoxic T-lymphocytes in liver transplant patients", Transplantation 69, 2251–2259.
   PubMed Web of Science ®Google Scholar
• Hong, J., Zang, Y.C., Tejada-Simon, M.V., Kozovska, M., Li, S., Singh, R.A., Yang, D., Rivera, V.M., Killian, J.K. and Zhang, J.Z. (1999) "A common TCRV-D-J sequence in V beta 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis", J. Immunol. 163, 3530–3538.
   PubMed Web of Science ®Google Scholar
• Luppi, P., Zanone, M.M., Hyoty, H., Rudert, W.A., Haluszczak, C., Alexander, A.M., Bertera, S., Becker, D. and Trucco, M. (2000) "Restricted TCR V beta gene expression and enterovirus infection in type I diabetes: a pilot study", Diabetologia 43, 1484–1497.
   PubMed Web of Science ®Google Scholar
• Zoumbos, N.C., Ferris, W.O., Hsu, S.M., Goodman, S., Griffith, P., Sharrow, SO., Humphries, R.K., Nienhuis, A.W. and Young, N. (1984) "Analysis of lymphocyte subsets in patients with aplastic anaemia", Br. J. Haematol. 58, 95–105.
   PubMed Web of Science ®Google Scholar
• Bour, H., Puisieux, I., Even, J., Kourilsky, P., Favrot, M., Musette, P. and Nicolas, J.F. (1999) "T-cell repertoire analysis in chronic plaque psoriasis suggests an antigen-specific immune response", Hum. Immunol. 60, 665–676.
   PubMed Web of Science ®Google Scholar
• Manz, C.Y., Dietrich, P.Y., Schnuriger, V, Nissen, C. and Wodnar-Filipowicz, A. (1997) "T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia", Blood Cells Mol. Dis. 23, 110–122.
   PubMed Web of Science ®Google Scholar
• Zeng, W., Nakao, S., Takamatsu, H., Yachie, A., Takami, A., Kondo, Y., Sugimori, N., Yamazaki, H., Miura, Y., Shiobara, S. and Matsuda, T. (1999) "Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia", Blood 93, 3008–3016.
   PubMed Web of Science ®Google Scholar
• Epperson, D.E., Nakamura, R., Saunthararajah, Y., Melenhorst, J. and Barrett, A.J. (2001) "Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process", Leuk. Res. 25, 1075–1083.
   PubMed Web of Science ®Google Scholar
• Storek, J., Joseph, A., Dawson, M.A., Douek, D.C., Storer, B. and Maloney, D.G. (2002) "Factors influencing T-lympho-poiesis after allogeneic hematopoietic cell transplantation", Transplantation 73, 1154–1158.
   PubMed Web of Science ®Google Scholar
• Storek, J., Joseph, A., Espino, G., Dawson, M.A., Douek, D.C., Sullivan, K.M., Flowers, M.E., Martin, P., Mathioudakis, G., Nash, R.A., Storb, R., Appelbaum, F.R. and Maloney, D.G. (2001) "Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation", Blood 98, 3505–3512.
   PubMed Web of Science ®Google Scholar
• Haynes, BE, Markert, M.L., Sempowski, G.D., Patel, D.D. and Hale, L.P. (2000) "The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection", Annu. Rev. Immunol. 18, 529–560.
   PubMed Web of Science ®Google Scholar
• Dumont-Girard, F., Roux, E., van Lier, R.A., Hale, G., Helg, C., Chapuis, B., Starobinski, M. and Roosnek, E. (1998) "Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants", Blood 92, 4464–4471.
   PubMed Web of Science ®Google Scholar
• Roux, E., Dumont-Girard, E, Starobinski, M., Siegrist, C.A., Helg, C., Chapuis, B. and Roosnek, E. (2000) "Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity", Blood 96, 2299–2303.
   PubMed Web of Science ®Google Scholar
• Eyrich, M., Croner, T., Leiler, C., Lang, P., Bader, P., Klingebiel, T., Niethammer, D. and Schlegel, P.G. (2002) "Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors", Blood 100, 1915–1918.
   PubMed Web of Science ®Google Scholar
• Hochberg, E.P., Chillemi, AC., Wu, C.J., Neuberg, D., Canning, C., Hartman, K., Alyea, E.P., Soiffer, R.J., Kalams, S.A. and Ritz, J. (2001) "Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplan-tation in adults", Blood 98, 1116–1121.
   PubMed Web of Science ®Google Scholar
• Weinberg, K., Blazar, BR., Wagner, J.E., Agura, E., Hill, B.J., Smogorzewska, M., Koup, R.A., Betts, MR., Collins, R.H. and Douek, D.C. (2001) "Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation", Blood 97, 1458–1466.
   PubMed Web of Science ®Google Scholar
• Verfuerth, S., Peggs, K., Vyas, P., Barnett, L., O'Reilly, R.J. and Mackinnon, S. (2000) "Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell-depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire", Blood 95, 3990–3995.
   PubMed Web of Science ®Google Scholar
• Matsutani, T., Yoshioka, T., Tsuruta, Y, Iwagami, S., Toyosaki-Maeda, T., Horiuchi, T., Miura, A.B., Watanabe, A., Takada, G., Suzuki, R. and Hirokawa, M. (2000) "Restricted usage of T-cell receptor alpha-chain variable region (TCRAV) and T-cell receptor beta-chain variable region (TCRBV) repertoires after human allogeneic haematopoietic trans-plantation", Br. J. Haematol. 109, 759–769.
   PubMed Web of Science ®Google Scholar
• Bellucci, R., Alyea, E.P., Weller, E., Chillemi, A., Hochberg, E., Wu, C.J., Canning, C., Schlossman, R., Soiffer, R.J., Anderson, K.C. and Ritz, J. (2002) "Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma", Blood 99, 4610–4617.
   PubMed Web of Science ®Google Scholar
• Dietrich, P.Y., Caignard, A., Lim, A., Chung, V, Pico, J.L., Pannetier, C., Kourilsky, P., Hercend, T., Even, J. and Triebel, E (1994) "In vivo T-cell clonal amplification at time of acute graft-versus-host disease", Blood 84, 2815–2820.
   PubMed Web of Science ®Google Scholar
• Gaschet, J., Gallot, G., Ibisch, C., Lim, A., Even, J., Vivien, R., Hallet, M.M., Milpied, N. and Vie, H. (1998) "Acute graft-versus-host disease after bone marrow transplantation with a single HLA-DPB1*1001 mismatch: involvement of differ-ent TCRBV subsets", Bone Marrow Transplant. 22, 385–392.
   PubMed Web of Science ®Google Scholar
• Gaschet, J., Lim, A., Liem, L., Vivien, R., Hallet, M.M., Harousseau, J.L., Even, J., Goulmy, E., Bonneville, M., Milpied, N. and Vie, H. (1996) "Acute graft versus host disease due to T lymphocytes recognizing a single HLA-DPB1*0501 mismatch", J. Clin. Investig. 98, 100–107.
   PubMed Web of Science ®Google Scholar
• Jiang, Y.Z., Mavroudis, D.A., Dermime, S., Molldrem, J., Hensel, N.F. and Barrett, A.J. (1997) "Preferential usage of T cell receptor (TCR) V beta by allogeneic T cells recognizing myeloid leukemia cells: implications for separating graft-versus-leukemia effect from graft-versus-host disease", Bone Marrow Transplant. 19, 899–903.
   PubMed Web of Science ®Google Scholar
• Mavroudis, D.A., Dermime, S., Molldrem, J., Jiang, Y.Z., Raptis, A., van Rhee, E, Hensel, N., FeBowes, V, Eliopoulos, G. and Barrett, A.J. (1998) "Specific depletion of alloreactive T cells in HLA-identical siblings: a method for separating graft-versus-host and graft-versus-leukaemia reactions", Br. J. Haematol. 101, 565–570.
   PubMed Web of Science ®Google Scholar
• Epperson, D.E., Margolis, D.A., McOlash, L., Janczak, T. and Barrett, A.J. (2001) "In vitro T-cell receptor V beta repertoire analysis may identify which T-cell V beta families mediate graft-versus-leukaemia and graft-versus-host responses after human leucocyte antigen-matched sibling stem cell transplantation", Br. J. Haematol. 114, 57–62.
   PubMed Web of Science ®Google Scholar
• Gaschet, J., Milpied, N., Denis, C., Hallet, M.M., Davodeau, F., Bonneville, M. and Vie, H. (1995) "Oligoclonal T-cell repertoire and graft-versus-host disease after allogeneic bone marrow transplantation", Ann. N. Y. Acad. Sci. 756, 435–437.
   PubMed Web of Science ®Google Scholar
• Gaschet, J., Gallot, G., Ibisch, C., Lim, A., Even, J., Vivien, R., Hallet, M.M., Milpied, N. and Vie, H. (1998) "Acute graft-versus-host disease after bone marrow transplantation with a single HLA-DPB1*1001 mismatch: involvement of differ-ent TCRBV subsets", Bone Marrow Transplant. 22, 385–392.
   PubMed Web of Science ®Google Scholar
• Hirokawa, M., Matsutani, T., Saitoh, H., Ichikawa, Y, Kawabata, Y., Horiuchi, T., Kitabayashi, A., Yoshioka, T., Tsuruta, Y., Suzuki, R., Miura, A.B. and Sawada, K. (2002) "Distinct TCRAV and TCRBV repertoire and CDR3 sequence of T lymphocytes clonally expanded in blood and GVHD lesions after human allogeneic bone marrow transplan-tation", Bone Marrow Transplant. 30, 915–923.
   PubMed Web of Science ®Google Scholar
• Douek, D.C., Vescio, R.A., Betts, M.R., Brenchley, J.M., Hill, B.J., Zhang, L., Berenson, J.R., Collins, R.H. and Koup, R.A. (2000) "Assessment of thymic output in adults after haematopoietic stem-cell transplantation and predic-tion of T-cell reconstitution", Lancet 355, 1875–1881.
   PubMed Web of Science ®Google Scholar
• Roncarolo, M.G., Bacchetta, R., Bordignon, C., Narula, S. and Levings, M.K. (2001) "Type 1 T regulatory cells", Immunol. Rev. 182, 68–79.
   PubMed Web of Science ®Google Scholar
• Horowitz, M.M., Gale, RE, Sondel, P.M., Goldman, J.M., Kersey, J., Kolb, H.J., Rimm, A.A., Ringden, O., Rozman, C. and Speck, B. (1990) "Graft-versus-leukemia reactions after bone marrow transplantation", Blood 75, 555–562.
   PubMed Web of Science ®Google Scholar
• Weiden, Pi., Sullivan, K.M., Flournoy, N., Storb, R. and Thomas, E.D. (1981) "Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation", N. Engl. J. Med. 304, 1529–1533.
   PubMed Web of Science ®Google Scholar
• Fefer, A., Sullivan, K.M., Weiden, P., Buckner, C.D., Schoch, G., Storb, R. and Thomas, E.D. (1987) "Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation", Prog. Clin. Biol. Res. 244, 401–408.
   PubMedGoogle Scholar
• Kolb, H.J. (1998) "Donor leukocyte transfusions for treat-ment of leukemic relapse after bone marrow transplantation. EBMT Immunology and Chronic Leukemia Working Parties", Vox Sang 74\(Suppl. 2), 321–329.
   PubMedGoogle Scholar
• Collins, R.H., Jr, Goldstein, S., Giralt, S., Levine, J., Porter, D., Drobyski, W., Barrett, J., Johnson, M., Kirk, A., Horowitz, M. and Parker, P. (2000) "Donor leukocyte infusions in acute lymphocytic leukemia", Bone Marrow Transplant. 26, 511–516.
   PubMed Web of Science ®Google Scholar
• Kolb, H.J., Schattenberg, A., Goldman, J.M., Hertenstein, B., Jacobsen, N., Arcese, W., Ljungman, P., Ferrant, A., Verdonck, L. and Niederwieser, D. (1995) "Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia", Blood 86, 2041–2050.
   PubMed Web of Science ®Google Scholar
• Collins, R.H., Jr, Shpilberg, O., Drobyski, W.R., Porter, D.L., Giralt, S., Champlin, R., Goodman, S.A., Wolff, S.N., Hu, W., Verfaillie, C., List, A., Dalton, W., Ognoskie, N., Chetrit, A., Antin, J.H. and Nemunaitis, J. (1997) "Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation", J. Clin. Oncol. 15, 433–444.
   PubMed Web of Science ®Google Scholar
• Fassas, A.B., Morris, C., Bathos, A., van Rhee, F. and Tricot, G. (2002) "Separating graft-versus-tumor from graft-versus-host reactions", Leuk. Lymphoma 43, 725–733.
   PubMed Web of Science ®Google Scholar
• Patterson, A.E. and Korngold, R. (2001) "Infusion of select leukemia-reactive TCR Vbeta + T cells provides graft-versus-leukemia responses with minimization of graft-versus-host disease following murine hematopoietic stem cell transplantation", Biol. Blood Marrow Transplant. 7, 187–196.
   PubMed Web of Science ®Google Scholar
• Kondo, Y., Shiobara, S. and Nakao, S. (2001) "Identification of T-cell clones showing expansion associated with graft-vs-leukemia effect on chronic myelogenous leukemia in vivo and in vitro", Exp. Hematol. 29, 471–476.
   PubMed Web of Science ®Google Scholar
• Claret, E.J., Alyea, E.P., Orsini, E., Pickett, C.C., Collins, H., Wang, Y, Neuberg, D., Soiffer, R.J. and Ritz, J. (1997) "Characterization of T cell repertoire in patients with graft-versus-leukemia after donor lymphocyte infusion", J. Clin. Investig. 100, 855–866.
   PubMed Web of Science ®Google Scholar
• Michalek, J., Collins, R.H., Durrani, H.P., Vaclavkova, P., Ruff, L.E., Douek, D.C. and Vitetta, E.S. (2003) "Definitive separation of graft-versus-leukemia- and graft-versus-host-specific CD4+ T cells by virtue of their receptor beta loci sequences", Proc. Natl Acad. Sci. USA 100, 1180–1184.
   PubMed Web of Science ®Google Scholar
• Morgan, R.A., Dudley, M.E., Yu, Y.Y., Zheng, Z., Robbins, P.F., Theoret, M.R., Wunderlich, J.R., Hughes, M.S., Restifo, N.P. and Rosenberg, S.A. (2003) "High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens", J. Immunol. 171, 3287–3295.
   PubMed Web of Science ®Google Scholar
• Nakao, S. (2002) "Identification of novel minor histocompat-ibility antigens responsible for graft-versus-leukemia (GVL) effect on chronic myeloid leukemia: usefulness of determin-ing the clonotype of T cells associated with GVL effect after donor leukocyte infusion", Int. J. Hematol. 76\(Suppl. 1), 274–276.
   PubMedGoogle Scholar
• Mutis, T. and Goulmy, E. (2002) "Hematopoietic system-specific antigens as targets for cellular immunotherapy of hematological malignancies", Semin. Hematol. 39, 23–31.
   PubMed Web of Science ®Google Scholar
• den Haan, J.M., Sherman, N.E., Blokland, E., Huczko, E., Koning, E, Drijfhout, J.W., Skipper, J., Shabanowitz, J., Hunt, D.F. and Engelhard, V.H. (1995) "Identification of a graft versus host disease-associated human minor histo-compatibility antigen", Science 268, 1476–1480.
   PubMed Web of Science ®Google Scholar
• Goulmy, E., Schipper, R., Pool, J., Blokland, E., Falkenburg, J.H., Vossen, J., Grathwohl, A., Vogelsang, GB., van Houwelingen, H.C. and van Rood, J.J. (1996) "Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation", N. Engl. J. Med. 334,281–285.
   PubMed Web of Science ®Google Scholar
• Bocchia, M., Korontsvit, T., Xu, Q., Mackinnon, S., Yang, S.Y., Sette, A. and Scheinberg, D.A. (1996) "Specific human cellular immunity to bcr—abl oncogene-derived peptides", Blood 87, 3587–3592.
   PubMed Web of Science ®Google Scholar
• Yang, X.F., Wu, C.J., Chen, L., Alyea, E.P., Canning, C., Kantoff, P., Soiffer, R.J., Dranoff, G. and Ritz, J. (2002) "CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells", Cancer Res. 62, 5517–5522.
   PubMed Web of Science ®Google Scholar
• Molldrem, J.J., Kant, S., Jiang, W. and Lu, S. (2002) "The basis of T-cell-mediated immunity to chronic myelogenous leukemia", Oncogene 21, 8668–8673.
   PubMed Web of Science ®Google Scholar
• Molldrem, J.J., Clave, E., Jiang, Y.Z., Mavroudis, D., Raptis, A., Hensel, N., Agarwala, V. and Barrett, A.J. (1997) "Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units", Blood 90,2529–2534.
   PubMed Web of Science ®Google Scholar
• Molldrem, J.J., Lee, PP., Wang, C., Felio, K., Kantarjian, H.M., Champlin, R.E. and Davis, M.M. (2000) "Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia", Nat. Med. 6, 1018–1023.
   PubMed Web of Science ®Google Scholar
• Clark, R.E., Dodi, IA., Hill, S.C., Lill, J.R., Aubert, G., Macintyre, A.R., Rojas, J., Bourdon, A., Bonner, EL., Wang, L., Christmas, SE., Travers, P.J., Creaser, CS., Rees, R.C. and Madrigal, J.A. (2001) "Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein", Blood 98,2887–2893.
   PubMed Web of Science ®Google Scholar
• Yotnda, P., Firat, H., Garcia-Pons, F., Garcia, Z., Gourru, G., Vernant, J.P., Lemonnier, EA., Leblond, V. and Langlade-Demoyen, P. (1998) "Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia", J. Clin. Investig. 101, 2290–2296.
   PubMed Web of Science ®Google Scholar
• Molldrem, J.J., Kant, S., Lu, S., Rios, R., Streicher, H., Wang, C., Giralt, S., O'Brien, S., Cortes, J., Champlin, R., Martin, T. and Wieder, E. (2002) "Peptide Vaccination with PR1 Elicits Active T Cell Immunity That Induces Cytogenetic Remission in Acute Myelogenous Leukemia", Blood 100, 6a.
   Web of Science ®Google Scholar
• Solache, A., Morgan, C.L., Dodi, Al., Morte, C., Scott, I., Baboonian, C., Zal, B., Goldman, J., Grundy, J.E. and Madrigal, J.A. (1999) "Identification of three HLA-A*0201-restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus", J. Immunol. 163, 5512–5518.
   PubMed Web of Science ®Google Scholar
• Chen, EE., Aubert, G., Travers, P., Dodi, IA. and Madrigal, J.A. (2002) "HLA tetramers and anti-CMV immune responses: from epitope to immunotherapy", Cytotherapy 4,41–48.
   PubMed Web of Science ®Google Scholar
• Cwynarski, K., Ainsworth, J., Cobbold, M., Wagner, S., Mahendra, P., Apperley, J., Goldman, J., Craddock, C. and Moss, P.A. (2001) "Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation", Blood 97, 1232–1240.
   PubMed Web of Science ®Google Scholar
• Hebart, H., Daginik, S., Stevanovic, S., Grigoleit, U., Dobler, A., Baur, M., Rauser, G., Sinzger, C., Jahn, G., Loeffler, J., Kanz, L., Rammensee, H.G. and Einsele, H. (2002) "Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-gamma-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation", Blood 99,3830–3837.
   PubMed Web of Science ®Google Scholar
• Gratama, J.W., van Esser, J.W., Lamers, C.H., Tournay, C., Lowenberg, B., Bolhuis, R.L. and Cornelissen, J.J. (2001) "Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection", Blood 98, 1358–1364.
   PubMed Web of Science ®Google Scholar
• Li, C.R., Greenberg, P.D., Gilbert, M.J., Goodrich, J.M. and Riddell, S.R. (1994) "Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: correlation with CMV disease and effect of ganciclovir prophylaxis", Blood 83, 1971–1979.
   PubMed Web of Science ®Google Scholar
• Khanna, R., Bell, S., Sherritt, M., Galbraith, A., Burrows, SR., Rafter, L., Clarke, B., Slaughter, R., Falk, M.C., Douglass, J., Williams, T., Elliott, S.L. and Moss, D.J. (1999) "Activation and adoptive transfer of Epstein-Barr virus-specific cyto-toxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease", Proc. Natl Acad. Sci. USA 96, 10391–10396.
   PubMed Web of Science ®Google Scholar
• Savoldo, B., Huls, M.H., Liu, Z., Okamura, T., Volk, H.D., Reinke, P., Sabat, R., Babel, N., Jones, J.F., Webster-Cyriaque, J., Gee, A.P., Brenner, M.K., Heslop, H.E. and Rooney, C.M. (2002) "Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBVinfection", Blood 100, 4059–4066.
   PubMed Web of Science ®Google Scholar
• Comoli, P., Labirio, M., Basso, S., Baldanti, F., Grossi, P., Furione, M., Vigano, M., Fiocchi, R., Rossi, G., Ginevri, F., Gridelli, B., Moretta, A., Montagna, D., Locatelli, E, Gerna, G. and Maccario, R. (2002) "Infusion of autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients with evidence of active virus replica-tion", Blood 99, 2592–2598.
   PubMed Web of Science ®Google Scholar
• Cohen, G.B., Islam, S.A., Noble, US., Lau, C., Brander, C., Altfeld, M.A., Rosenberg, ES., Schmitz, J.E., Cameron, T.O. and Kalams, S.A. (2002) "Clonotype tracking of TCR repertoires during chronic virus infections", Virology 304, 474–484.
   PubMed Web of Science ®Google Scholar
• van Rhee, E and Barrett, J. (2002) "Adoptive transfer of Ag-specific T cells to prevent CMV disease after allogeneic stem-cell transplantation", Cytotherapy 4, 3–10.
   PubMed Web of Science ®Google Scholar
• Peggs, KS. and Mackinnon, S. (2002) "Clinical trials with CMV-specific T cells", Cytotherapy 4, 21–28.
   PubMed Web of Science ®Google Scholar
• Einsele, H., Rauser, G., Grigoleit, U., Hebart, H., Sinzger, C., Riegler, S. and Jahn, G. (2002) "Induction of CMV-specific T-cell lines using Ag-presenting cells pulsed with CMV protein or peptide", Cytotherapy 4, 49–54.
   PubMed Web of Science ®Google Scholar
• Einsele, H. (2003) "Antigen-specific T cells for the treatment of infections after transplantation", Hematol. J. 4, 10–17.
   PubMedGoogle Scholar
• Solomon, SR., Tran, T., Carter, C.S., Donnelly, S., Hensel, N., Schindler, J., Bahceci, E., Ghetie, V., Michalek, J., Mavroudis, D., Read, E.J., Vitetta, ES. and Barrett, A.J. (2002) "Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation", Cytotherapy 4,395–406.
   PubMed Web of Science ®Google Scholar
• Mackay, I. and Rosen, ES. (2000) "The HLA system — first of two parts", NEJM 343, 702–709.
   PubMed Web of Science ®Google Scholar
• Davis, M.M. and Bjorkman, P.A. (1988) "T-cell antigen receptor gene and T-cell recognition", Nature 334, 395–402.
   PubMed Web of Science ®Google Scholar