Arginine Supplementation Improves Rotorod Performance in Sickle Transgenic Mice

References

• Nagel, R.L., Platt, O., et al. (2001) "General pathophysiology of sickle cell anemia", In: Steinberg, M., Forget, B.G. and Higgs, D., eds, Disorders of Hemoglobin (Cambridge University Press, Cambridge), pp 494–526.
   Google Scholar
• Hebbel, R.P. (1997) "Adhesive interactions of sickle erythro-cytes with endothelium", J. Clin. Investig. 100(11 Suppl), S83—S86.
   PubMed Web of Science ®Google Scholar
• Powars, D., Wilson, B., Imbus, C., Pegelow, C. and Allen, J. (1978) "The natural history of stroke in sickle cell disease", Am. J. Med. 65(3), 461–471.
   PubMed Web of Science ®Google Scholar
• Pavlakis, S.C., Bello, J., Prohovnik, I., et al. (1988) "Brain infarction in sickle cell anemia: magnetic resonance imaging correlates", Ann. Neurol. 23(2), 125–130.
   PubMed Web of Science ®Google Scholar
• Armstrong, F.D., Thompson, R.J., Jr., Wang, W., et al. (1996) "Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease. Neuropsychol-ogy committee of the cooperative study of sickle cell disease", Pediatrics 97(6 Pt 1), 864–870.
   PubMed Web of Science ®Google Scholar
• Craft, S., Schatz, J., Glauser, T.A., Lee, B. and DeBaun, M.R. (1993) "Neuropsychologic effects of stroke in children with sickle cell anemia", J. Pediatr. 123(5), 712–717.
   PubMed Web of Science ®Google Scholar
• Francis, Jr., R.B. and Johnson, CS. (1991) "Vascular occlusion in sickle cell disease: current concepts and unanswered questions", Blood 77(7), 1405–1414.
   PubMed Web of Science ®Google Scholar
• Powars, D.R., Wong, W.Y. and Vachon, L.A. (2001) "Incom-plete cerebral infarctions are not silent", J. Pediatr. Hematol. Oncol. 23(2), 79–83.
   PubMed Web of Science ®Google Scholar
• Ryan, T.M., Townes, T.M., Reilly, M.P., et al. (1990) "Human sickle hemoglobin in transgenic mice", Science 247(4942), 566–568.
   PubMed Web of Science ®Google Scholar
• Trudel, M., Saadane, N., Garel, M.C., et al. (1991) "Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD", EMBO J. 10(11), 3157–3165.
   PubMed Web of Science ®Google Scholar
• Fabry, M.E., Costantini, F., Pachnis, A., et al. (1992) "High expression of human beta 5- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia", Proc. Natl. Acad. Sci. USA 89(24), 12155–12159.
   PubMed Web of Science ®Google Scholar
• Fabry, M.E., Sengupta, A., Suzuka, S.M., et al. (1995) "A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity", Blood 86(6), 2419–2428.
   PubMed Web of Science ®Google Scholar
• Ryan, T.M., Ciavatta, D.J. and Townes, T.M. (1997) "Knock-out-transgenic mouse model of sickle cell disease", Science 278(5339), 873–876.
   PubMed Web of Science ®Google Scholar
• Fabry, M.E., Suzuka, S.M., Weinberg, R.S., et al. (2001) "Second generation knockout sickle mice: the effect of HbF", Blood 97(2), 410–418.
   PubMed Web of Science ®Google Scholar
• Monplaisir, N., Merault, G., Poyart, C., et al. (1986) "Hemoglobin S Antilles: a variant with lower solubility than hemoglobin S and producing sickle cell disease in heterozygotes", Proc. Natl Acad. Sci. USA 83(24), 9363–9367.
   PubMed Web of Science ®Google Scholar
• Fabry, M.E., Nagel, R.L., Pachnis, A., Suzuka, S.M. and Costantini, F. (1992) "High expression of human beta 5- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences", Proc. Natl Acad. Sci. USA 89(24), 12150–12154.
   PubMed Web of Science ®Google Scholar
• Rubin, E.M., Witkowska, H.E., Spangler, E., et al. (1991) "Hypoxia-induced in vivo sickling of transgenic mouse red cells", J. Clin. Investig. 87(2), 639–647.
   PubMed Web of Science ®Google Scholar
• Skow, L.C., Burkhart, B.A., Johnson, F.M., et al. (1983) "A mouse model for beta-thalassemia", Cell 34(3), 1043–1052.
   PubMed Web of Science ®Google Scholar
• Enwonwu, C.O., Xu, X.X. and Turner, E. (1990) "Nitrogen metabolism in sickle cell anemia: free amino acids in plasma and urine", Am. J. Med. Sci. 300(6), 366–371.
   PubMed Web of Science ®Google Scholar
• Romero, J.R., Suzuka, S.M., Nagel, R.L. and Fabry, M.E. (2002) "Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity", Blood 99(4), 1103–1108.
   PubMed Web of Science ®Google Scholar
• Bank, N., Aynedjian, H.S., Qiu, J.H., et al. (1996) "Renal nitric oxide synthases in transgenic sickle cell mice", Kidney Int. 50(1), 184–189.
   PubMed Web of Science ®Google Scholar
• Bank, N., Kiroycheva, M., Singhal, P.C., Anthony, G.M., Southan, G.J. and Szabo, C. (2000) "Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys", Kidney Int. 58(1), 82–89.
   PubMed Web of Science ®Google Scholar
• Norflus, F., Tifft, C.J., McDonald, M.P., et al. (1998) "Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease mice", J. Clin. Investig. 101(9), 1881–1888.
   PubMed Web of Science ®Google Scholar
• Gerlai, R., Thibodeaux, H., Palmer, J.T., van Lookeren Campagne, M. and Van Bruggen, N. (2000) "Transient focal cerebral ischemia induces sensorimotor deficits in mice", Behav. Brain Res. 108(1), 63–71.
   PubMed Web of Science ®Google Scholar
• Osei, S.Y., Ahima, R.S., Fabry, M.E., Nagel, R.L. and Bank, N. (1996) "Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: the effect of hypoxia", Blood 88(9), 3583–3588.
   PubMed Web of Science ®Google Scholar
• Iadecola, C., Pelligrino, D.A., Moskowitz, M.A. and Lassen, N.A. (1994) "Nitric oxide synthase inhibition and cerebrovascular regulation", J. Cereb. Blood Flow Metab. 14(2), 175–192.
   PubMed Web of Science ®Google Scholar
• Gladwin, M.T., Schechter, A.N., Ognibene, F.P., et al. (2003) "Divergent nitric oxide bioavailability in men and women with sickle cell disease", Circulation 107(2), 271–278.
   PubMed Web of Science ®Google Scholar
• French, J.A., II, Kenny, D., Scott, J.P., et al. (1997) "Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition", Blood 89(12), 4591–4599.
   PubMed Web of Science ®Google Scholar