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Current Clinical Practice

Hyposplenism: A comprehensive review. Part II: Clinical manifestations, diagnosis, and management

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Pages 89-98 | Published online: 04 Sep 2013

References

  • Brigden ML, Pattullo AL. Prevention and management of overwhelming postsplenectomy infection-an update. Crit Care Med 1999;27:836–842.
  • O’Donnell JF. The value of splenectomy in Band’s disease. Br Med J 1929;1:854.
  • King H, Shumacker HB, Jr.. Splenic studies I. Susceptibility to infection after splenectomy performed in infancy. Ann Surg 1952;136:239–242.
  • Eraldis AJ, Kevy SV, Diamond LK, Gross RE. Hazard of overwhelming infection after splenectomy in childhood. N Engl J Med 1967;276:1225–1229.
  • Evans DI. Postsplenectomy sepsis 10 years or more after operation. J Clin Pathol 1985;38:309–311.
  • Eraklis AJ, Kevy SV, Diamond LK, Gross RE. Hazard of overwhelming infection after splenectomy in childhood. N Engl J Med 1967;276:1225–1229.
  • Gopal V, Bisno AL. Fulminant pneumococcal infections in “normal” asplenic hosts. Arch Intern Med 1977;137: 1526–1530.
  • Schilling RF. Hereditary spherocytosis: A study of splenecto-mized persons. Semin Hematol 1976;13:169–176.
  • Schilling RF. Estimating the risk for sepsis after splenectomy in hereditary spherocytosis. Ann Intern Med 1995;122: 187–188.
  • Sumaraju V, Smith LG, Smith SM. Infectious complications in asplenic hosts. Infect Dis Clin North Am 2001;15: 551–565.
  • Chilcote RR, Dampier C. Overwhelming pneumococcal septicemia in a patient with HbSC disease and splenic dysfunction. J Pediatr 1984;104:734–736.
  • Parr LJ, Shipton EA, Holland EH. A fatal case of Still’s disease associated with Waterhouse-Friderichsen syndrome due to pneumococcal septicaemia. Med J Aust 1953;1: 300–305.
  • Guyton JR, Zumwalt RE. Letter: Pneumococcemia with sarcoid-infiltrated spleen. Ann Intern Med 1975;82: 847–848.
  • O’Donoghue DJ. Fatal pneumococcal septicaemia in coeliac disease. Postgrad Med J 1986;62:229–230.
  • Foster KJ, Devitt N, Gallagher PJ, Abbott RM. Over-whelming pneumococcal septicaemia in a patient with ulcerative colitis and splenic atrophy. Gut 1982;23:630–632.
  • Dillon AM, Stein HB, English RA. Splenic atrophy in systemic lupus erythematosus. Ann Intern Med 1982;96:40–43.
  • Dailey MO, Coleman CN, Kaplan HS. Radiation-induced splenic atrophy in patients with Hodgkin’s disease and non-Hodgkin’s lymphomas. N Engl J Med 1980;302:215–217.
  • Bensinger TA, Keller AR, Merrell LF, O’Leary DS. Thorotrast-induced reticuloendothelial blockade in man. Clinical equivalent of the experimental model associated with patent pneumococcal septicemia. Am J Med 1971;51: 663–668.
  • Doll DC, List AF, Yarbro JW. Functional hyposplenism. South Med J 1987;80:999–1006.
  • Sumaraju V, Smith LG, Smith SM. Infectious complications in asplenic hosts. Infect Dis Clin North Am 2001;15: 551–565.
  • Ward KM, Celebi Fr, Gmyrek R, Grossman ME. Acute infectious purpura fulminans associated with asplenism or hyposplenism. J Am Acad Dermatol 2002;47:493–496.
  • Izumiyama K, Hashino S, Takahata M, Chiba K, Mori A, Suzuki S, et al. Pneumococcal purulent genual arthritis after allogeneic bone marrow transplantation. Ann Hematol 2002;81:282–284.
  • Eshel Y, Sarova-Pinhas I, Lampl Y, Jedwab M. Autosple-nectomy complicating pneumococcal meningitis in an adult. Arch Intern Med 1991;151:998–999.
  • Boughton BJ, Simpson A, Chandler S. Functional hypos-plenism during pneumococcal infection. Lancet 1983;1: 121–122.
  • Picard C, Puel A, Bustamante J, Ku CL, Casanova JL. Primary immunodeficiencies associated with pneumococcal disease. Curr Opin Allergy Clin Immunol 2003;3:451–459.
  • Schwartz PE, Sterioff S, Mucha P, Melton LJ, III, Offord KP. Postsplenectomy sepsis and mortality in adults. JAMA 1982;248:2279–2283.
  • Zarrabi MH, Rosner F. Serious infections in adults following splenectomy for trauma. Arch Intern Med 1984;144: 1421–1424.
  • Gopal V, Bisno AL. Fulminant pneumococcal infections in “normal” asplenic hosts. Arch Intern Med 1977;137: 1526–1530.
  • Evans DI. Postsplenectomy sepsis 10 years or more after operation. J Clin Pathol 1985;38:309–311.
  • Holdsworth RJ, Irving AD, Cuschieri A. Postsplenectomy sepsis and its mortality rate: Actual versus perceived risks. Br J Surg 1991;78:1031–1038.
  • Styrt B. Complications of asplenia and hyposplenism-persistent uncertainties. West J Med 1992;157:461–463.
  • Workman MR, Philpott-Howard J, Bellingham AJ. Managing patients with an absent or dysfunctional spleen. Guidelines should highlight risk of Salmonella infection in sickle cell disease. BMJ 1996;312:1359–1360.
  • Shute PG. Letter: Splenectomy and susceptibility to malaria and babesia infection. Br Med J 1975;1:516.
  • Rosner F, Zarrabi MH, Benach JL, Habicht GS. Babesiosis in splenectomized adults. Review of 22 reported cases. Am J Med 1984;76:696–701.
  • Crosby WH. Hyposplenism: An inquiry into normal functions of the spleen. Annu Rev Med 1963;14:349–370.
  • Dameshek W. Hyposplenism (Letter). JAMA 1955;157:163.
  • Eicluier ER. Splenic function: Normal, too much and too little. Am J Med 1979;66:311–320.
  • McBride JA, Dacie JV, Shapley R. The effect of splenectomy on the leucocyte count. Br J Haematol 1968;14:225–231.
  • Rudders RA, Howard JP. Clinical and cell surface marker characterization of the early phase of chronic lymphocytic leukemia. Blood 1978;52:25–35.
  • Wilkinson LS, Tang A, Gjedsted A. Marked lymphocytosis suggesting chronic lymphocytic leukemia in three patients with hyposplenism. Am J Med 1983;75:1053–1056.
  • Hasen HB, Raines SL. Priapism associated with sickle cell disease. J Urol 1962;88:71–76.
  • Welford C, Spies SM, Green D. Priapism in primary thrombocythemia. Arch Intern Med 1981;141:807–808.
  • Singlial PC, Lynn RI, Scharschmidt LA. Priapism and dialysis. Am J Nephrol 1986;6:358–361.
  • Atala A, Amin M, Harty II, Liu YK, Keeling MM. Priapism associated with asplenic state. Urology 1992;40:371–373.
  • Jackson N, Franklin IM, Hughes MA. Recurrent priapism following splenectomy for thalassaemia intermedia. Br J Surg 1986;73:678.
  • Gross EM, Levin PD, Landau EH. Post-splenectomy veno-occlusive priapism in a child with idiopathic thrombocyto-penic purpura. Isr Med Assoc J 2002;4:1084–1085.
  • Jackson N, Franklin IM, Hughes MA. Recurrent priapism following splenectomy for thalassaemia intermedia. Br J Surg 1986;73:678.
  • Spirer Z, Hauser GJ, Hazaz B, Joshua H. Autoimmune antibodies after splenectomy. Acta Haematol 1980;63: 230–233.
  • Robertson DA, Simpson FG, Gowland G, Losowsky MS. Splenectomy causes auto-antibody formation. J Clin Lab Immunol 1983;11:63–65.
  • Nielsen JL, Andersen P, Ellegaard J. Influence of residual splenic tissue on autoantibodies in splenectomized patients. Scand J Haematol 1982;28:273–277.
  • Balsalobre B, Hernandez-Godoy J, Planelles D. Autoanti-bodies in splenectomized patients as a consequence of abdominal trauma. J Investig Allergol Clin Immunol 1992;2: 91–95.
  • Nielsen JL, Andersen P, Ellegaard J. Influence of residual splenic tissue on autoantibodies in splenectomized patients. Scand J Haematol 1982;28:273–277.
  • Robertson DA, Simpson FG, Gowland G, Losowsky MS. Splenectomy causes auto-antibody formation. J Clin Lab Immunol 1983;11:63–65.
  • Nielsen JL, Andersen P, Ellegaard J. Influence of residual splenic tissue on autoantibodies in splenectomized patients. Scand J Haematol 1982;28:273–277.
  • Robertson DA, Bullen A, Field H, Simpson FG, Losowsky MS. Suppressor cell activity, splenic function and HLA B8 status in man. J Clin Lab Immunol 1982;9: 133–138.
  • Robertson DA, Bullen A, Field H, Simpson FG, Losowsky MS. Suppressor cell activity, splenic function and HLA B8 status in man. J Clin Lab Immunol 1982;9: 133–138.
  • Robertson DA, Sullen A, Field H, Simpson FG, Losowsky MS. Suppressor cell activity, splenic function and HLA B8 status in man. J Clin Lab Immunol 1982;9: 133–138.
  • Balsalobre B, Hernandez-Godoy J, Planelles D. Autoanti-bodies in splenectomized patients as a consequence of abdominal trauma. J Investig Allergol Clin Immunol 1992;2:91–95.
  • Matsuno S, Tamaoka A, Yoshizawa K, Watanabe M, Shoji S. A case with Myasthenia Gravis (MG) emerging after splenectomy for idiopathic thrombocytopenic purpura (ITP): Possible effects of thymectomy on autoantibodies. J Med 2000;31:327–332.
  • Fuse I, Higuchi W, Narita M, Watanabe T, Hattori A, Aizawa Y. Overproduction of antiplatelet antibody against glycoprotein IIb after splenectomy in a patient with Evans syndrome resulting in acquired thrombasthenia. Acta Haematol 1998;99:83–88.
  • Morino M, Inami K, Shibuya A, Sasaki N. IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: A case report. Pediatr Nephrol 1994;8:345–346.
  • Joppich R, Anders D, Eife R, Lampert F. Interstital nephritis in autoimmune hemolytic anemia. Z Kinderheilkd 1975; 119:161–167.
  • Corner M, Bucknall RC. Digital vasculitis after splenectomy in a patient with Felty’s syndrome. Ann Rheum Dis 1992; 51:908–909.
  • Levene NA, Varon D, Shtalrid M, Berrebi A. Chronic active hepatitis following splenectomy for autoimmune thrombocy-topenia. Isr J Med Sci 1991;27:199–201.
  • Spencer RP, Mittal P. Reticuloendothelial “activation” noted after splenectomy for ITP and presence of a post-poliomyelitis asymmetry. Clin Nucl Med 1998;23:8–9.
  • Nielsen JL, Romer FK, Ellegaard J. Serum angiotensin-converting enzyme and blood monocytes in splenectomized individuals. Acta Haematol 1982;67:132–135.
  • Robertson DA, Simpson FG, Losowsky MS. Blood viscosity after splenectomy. Br Med J (Clin Res Ed) 1981;283: 573–575.
  • Foster PN, Losowsky MS. Hyposplenism-a review. J R Coll Physicians Lond 1987;21:188–191.
  • Dawson AA, Bennett B, Jones PF, Munro A. Thrombotic risks of staging laparotomy with splenectomy in Hodgkin’s disease. Br J Surg 1981;68:842–845.
  • Dawson AA, Bennett B, Jones PF, Munro A. Thrombotic risks of staging laparotomy with splenectomy in Hodgkin’s disease. Br J Surg 1981;68:842–845.
  • Butler MJ, Matthews F, Irving MH. The incidence of post-operative deep vein thrombosis after splenectomy. Clin Oncol 1977;3:51–56.
  • Robinette CD, Fraumeni JF, Jr.. Splenectomy and sub-sequent mortality in veterans of the 1939–45 war. Lancet 1977;2: 127–129.
  • Asai K, Kuzuya M, Naito M, Funaki C, Kuzuya F. Effects of splenectomy on serum lipids and experimental atherosclero-sis. Angiology 1988;39:497–504.
  • Caligiuri G, Nicoletti A, Poirier B, Hansson GK. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 2002;109:745–753.
  • van’t Riet M, Burger JW, van Muiswinkel JM, Kazemier G, Schipperus MR, Bonjer HJ. Diagnosis and treatment of portal vein thrombosis following splenectomy. Br J Surg 2000;87:1229–1233.
  • Winslow ER, Brunt LM, Drebin JA, Soper NJ, Klingensmith ME. Portal vein thrombosis after splenectomy. Am J Surg 2002;184:631–635.
  • Fujita F, Lyass S, Otsuka K, Giordano L, Rosenbaum DL, Khalili TM, et al. Portal vein thrombosis following splenectomy: Identification of risk factors. Am Surg 2003; 69:951–956.
  • Atichartakarn V, Likittanasombat K, Chuncharunee S, Chandanamattha P, Worapongpaiboon S, Angchaisuksiri P, et al. Pulmonary arterial hypertension in previously splenectomized patients with beta-thalassemic disorders. Int J Hematol 2003;78:139–145.
  • Hull CC, Galloway P, Gordon N, Gerson SL, Hawkins N, Stellato TA. Splenectomy and the induction of murine colon cancer. Arch Surg 1988;123:462–464.
  • Hull CC, Stellato TA, Galloway PG, Gordon N, Hawkins N. Splenectomy and the induction of cancer of the colon in rats. Curr Surg 1988;45:12–15.
  • Hull CC, Galloway P, Gordon N, Gerson SL, Hawkins N, Stellato TA. Splenectomy and the induction of murine colon cancer. Arch Surg 1988;123:462–464.
  • Davis CJ, Ilstrup DM, Pemberton JH. Influence of splenectomy on survival rate of patients with colorectal cancer. Am J Surg 1988;155:173–179.
  • Brady MS, Rogatko A, Dent LL, Shin MH. Effect of splenectomy on morbidity and survival following curative gastrectomy for carcinoma. Arch Surg 1991;126:359–364.
  • Schilling V. Uber die diagnose einer milzatrophie durch den befund von kernkugelin als teilersche teilerscheiung plur-iglandularer insuffzienz. Klin Wochenschr 1924;43: 1960–1962.
  • Lipson RL, Bayrd ED, Watkins CH. The postsplenectomy blood picture. Am J Clin Pathol 1959;32:526–532.
  • Pearson HA, Johnston D, Smith KA, Touloukian RJ. The born-again spleen. Return of splenic function after splenect-omy for trauma. N Engl J Med 1978;298:1389–1392.
  • Holroyde CP, Gardner FH. Acquisition of autophagic vacuoles by human erythrocytes. Physiological role of the spleen. Blood 1970;36:566–575.
  • Schnitzer B, Rucknagel DL, Spencer HH, Aikawa M. Erythrocytes: Pits and vacuoles as seen with transmission and scanning electron microscopy. Science 1971;173:251–252.
  • Holroyde CP, Gardner FH. Acquisition of autophagic vacuoles by human erythrocytes. Physiological role of the spleen. Blood 1970;36:566–575.
  • Holroyde CP, Oski FA, Gardner FH. The “pocked” erythrocyte. Red-cell surface alterations in reticuloendothe-lial immaturity of the neonate. N Engl J Med 1969; 281:516–520.
  • Corazza GR, Bullen AW, Hall R, Robinson PJ, Losowsky MS. Simple method of assessing splenic function in coeliac disease. Clin Sci (Lond) 1981;60:109–113.
  • Doll DC, List AF, Yarbro JW. Functional hyposplenism. South Med J 1987;80:999–1006.
  • Holroyde CP, Oski FA, Gardner FH. The “pocked” erythrocyte. Red-cell surface alterations in reticuloendothe-lial immaturity of the neonate. N Engl J Med 1969;281: 516–520.
  • Casper JT, Koethe S, Rodey GE, Thatcher LG. A new method for studying splenic reticuloendothelial dysfunction in sickle cell disease patients and its clinical application: A brief report. Blood 1976;47:183–188.
  • Corazza GR, Bullen AW, Hall R, Robinson PJ, Losowsky MS. Simple method of assessing splenic function in coeliac disease. Clin Sci (Lond) 1981;60:109–113.
  • Corazza GR, Ginaldi L, Zoli G, Frisoni M, Lalli G, Gasbarrini G, et al. Howell-Jolly body counting as a measure of splenic function. A reassessment. Clin Lab Haematol 1990;12:269–275.
  • Pearson HA, Johnston D, Smith KA, Touloukian RJ. The born-again spleen. Return of splenic function after splenect-omy for trauma. N Engl J Med 1978;298:1389–1392.
  • Holroyde CP, Gardner FH. Acquisition of autophagic vacuoles by human erythrocytes. Physiological role of the spleen. Blood 1970;36:566–575.
  • Casper JT, Koethe S, Rodey GE, Thatcher LG. A new method for studying splenic reticuloendothelial dysfunction in sickle cell disease patients and its clinical application: A brief report. Blood 1976;47:183–188.
  • Sills RH, Oski FA. RBC surface pits in the sickle hemogjobinopathies. Am J Dis Child 1979;133:526–527.
  • Tham KT, Teague MW, Howard CA, Chen SY. A simple splenic reticuloendothelial function test: Counting erythro-cytes with argyrophilic inclusions. Am J Clin Pathol 1996; 105:548–552.
  • Kruetzmann S, Rosado MM, Weber H, Germing U, Tournilhac O, Peter HH, et al. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infec-tions are generated in the spleen. J Exp Med 2003;197: 939–945.
  • Di Sabatino A, Rosado MM, Ciccocioppo R, Cazzola P, Morera R, Corazza GR, et al. Depletion of immunoglobulin M memory B cells is associated with splenic hypofunction in inflammatory bowel disease. Am J Gastroenterol 2005;100: 1788–1795.
  • Pettit JE. Spleen function. Clin Haematol 1977;6:639–656.
  • Peters AM, Ryan PF, Klonizakis I, Elkon KB, Lewis SM, Hughes GR. Measurement of splenic function in humans using heat damaged autologous red blood cells. Scand J Haematol 1981;27:374–380.
  • Gorg C, Eichkorn M, Zugmaier G. The small spleen: Sonographic patterns of functional hyposplenia or asplenia. J Clin Ultrasound 2003;31:152–155.
  • Chauhan R, Kapoor V, Vohra PA, Jhala PJ, Upadhyaya AK, Pathak KJ. The “small spleen” in malaria. J Assoc Physicians India 1996;44:483–485.
  • Pereira JL, Hughes LE, Young HL. Spleen size in patients with inflammatory bowel disease. Does it have any clinical significance? Dis Colon Rectum 1987;30:403–409.
  • Suzuki S, Takizawa K, Nakajima Y, Katayama M, Sagawa F. CT findings in hepatic and splenic amyloidosis. J Comput Assist Tomogr 1986;10:332–334.
  • Powsner RA, Simms RW, Chudnovsky A, Lee VW, Skinner M. Scintigraphic functional hyposplenism in amyloidosis. J Nucl Med 1998;39:221–223.
  • Spencer RP, Gupta SM. The spleen: Diagnosis of splenic diseases using radiolabeled tracers. Crit Rev Clin Lab Sci 1989;27:299–318.
  • Doll DC, List AF, Yarbro JW. Functional hyposplenism. South Med J 1987;80:999–1006.
  • Rutland MD. Correlation of splenic function with the splenic uptake rate of Tc-colloids. Nucl Med Commun 1992;13:843–847.
  • Silberstein EB, DeLong S, Cline J. Tc-99m diphosphonate and sulfur colloid uptake by the spleen in sickle disease: Interrelationship and clinical correlates: Concise communi-cation. J Nucl Med 1984;25: 1300–1303.
  • Hicks RJ, Young W, Shapiro B, Kuhl DE. Absent splenic uptake of indium-111-oxine-labeled autologous leukocytes in functional asplenia. J Nucl Med 1991;32:524–526.
  • Waghorn DJ. Overwhelming infection in asplenic patients: Current best practice preventive measures are not being followed. J Clin Pathol 2001;54:214–218.
  • Waghorn DJ, Mayon-White RT. A study of 42 episodes of overwhelming post-splenectomy infection: Is current gui-dance for asplenic individuals being followed? J Infect 1997;35:289–294.
  • Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. BMJ 1996;312:430–434.
  • Davies JM, Barnes R, Milligan D. Update of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Clin Med 2002;2:440–443.
  • CDC, Prevention of pneumococcal disease: Recommen-dations of the Advisory Committee on Immunization Practices (ACIP) MMWR Recomm Rep, 46 1997. p 1–24.
  • Butler JC, Shapiro ED, Carlone GM. Pneumococcal vaccines: History, current status, and future directions. Am J Med 1999;107:69S–76S.
  • Butler JC, Shapiro ED, Carlone GM. Pneumococcal vaccines: History, current status, and future directions. Am J Med 1999;107:69S–76S.
  • Watson DA, Musher DM. A brief history of the pneumo-coccus in biomedical research. Semin Respir Infect 1999; 14:198–208.
  • CDC, Prevention of pneumococcal disease: Recommen-dations of the Advisory Committee on Immunization Practices (ACIP) MMWR Recomm Rep, 46 1997. p 1–24.
  • Shapiro ED, Berg AT, Austrian R, Schroeder D, Parcells V, Margolis A, et al. The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N Engl J Med 1991;325:1453–1460.
  • Butler JC, Breiman RF, Campbell JF, Lipman HB, Broome CV, Facklam RR. Pneumococcal polysaccharide vaccine efficacy. An evaluation of current recommendations. JAMA 1993;270:1826–1831.
  • Guinamard R, Okigaki M, Schlessinger J, Ravetch JV. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol 2000;1:31–36.
  • Kruetzmann S, Rosado MM, Weber H, Germing U, Tournilhac O, Peter HH, et al. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infec-tions are generated in the spleen. J Exp Med 2003;197: 939–945.
  • Pedersen FK. Antibody response to pneumococcal vaccine in splenectomized children. Acta Pathol Microbiol Immunol Scand [C] 1983;91:169–180.
  • Ammann AJ, Addiego J, Wara DW, Lubin B, Smith WB, Mentzer WC. Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy. N Engl J Med 1977;297:897–900.
  • McKinley M, Leibowitz S, Bronzo R, Zanzi I, Weissman G, Schiffman G. Appropriate response to pneumococcal vaccine in celiac sprue. J Clin Gastroenterol 1995;20:113–116.
  • Landgren O, Bjorkholm M, Konradsen HB, Soderqvist M, Nilsson B, Gustavsson A, et al. A prospective study on antibody response to repeated vaccinations with pneumo-coccal capsular polysaccharide in splenectomized individuals with special reference to Hodgkin’s lymphoma. J Intern Med 2004;255:664–673.
  • Hosea SW, Burch CG, Brown EJ, Berg RA, Frank MM. Impaired immune response of splenectomised patients to polyvalent pneumococcal vaccine. Lancet 1981;1:804–807.
  • Waghom DJ. Overwhelming infection in asplenic patients: Current best practice preventive measures are not being followed. J Cfin Pathol 2001;54:214–218.
  • Goebel WF, Avery OT Chemoimmunological studies on conjugated carbohydrate proteins II. Immunological speci-ficity of synthetic sugar proteins. J Exp Med 1929;50: 533–550.
  • Obaro SK. The new pneumococcal vaccine. Clin Microbiol Infect 2002;8:623–633.
  • Pelton SI, Dagan R, Gaines BM, Klugman KP, Laufer D, O’Brien K, et al. Pneumococcal conjugate vaccines: Proceedings from an Interactive Symposium at the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Vaccine 2003;21: 1562–1571.
  • CDC, Prevention of pneumococcal disease: Recommen-dations of the Advisory Committee on Immunization Practices (ACIP) MMWR Recomm Rep, 46 1997. p 1–24
  • Insel RA, Anderson PW. Response to oligosaccharide-protein conjugate vaccine against Hemophilus influenzae b in two patients with IgG2 deficiency unresponsive to capsular polysaccharide vaccine. N Engl J Med 1986;315:499–503.
  • Breukels MA, Zandvoort A, van Den Dobbelsteen GP, van Den MA, Lodewijk ME, Beurret M, et al. Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides. Infect Immun 2001;69:7583–7587.
  • Castagnola E, Fioredda F. Prevention of life-threatening infections due to encapsulated bacteria in children with hyposplenia or asplenia: A brief review of current recommen-dations for practical purposes. Eur J Haematol 2003;71: 319–326.
  • Breukels MA, Zandvoort A, van Den Dobbelsteen GP, van Den MA, Lodewijk ME, Beurret M, et al. Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides. Infect Immun 2001;69:7583–7587.
  • Davies JM, Barnes R, Milligan D. Update of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Clin Med 2002;2:440–443.
  • Castagnola E, Fioredda F. Prevention of life-threatening infections due to encapsulated bacteria in children with hyposplenia or asplenia: A brief review of current recommen-dations for practical purposes. Eur J Haematol 2003;71: 319–326.
  • Davies JM, Barnes R, Milligan D. Update of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Clin Med 2002;2:440–443.
  • Grant MD, Horowitz HI, Lorian V, Brodman HR. Water-house-Friderichsen syndrome induced by pneumococcemic shock. JAMA 1970;212:1373–1374.
  • Brigden ML. Detection, education and management of the asplenic or hyposplenic patient. Am Earn Physician 2001;63(499-506):508.
  • Picard C, Puel A, Bustamante J, Ku CL, Casanova IL. Primary immunodeficiencies associated with pneumococcal disease. Curr Opin Allergy Clin Immunol 2003;3:451–459.
  • Schwartz PE, Sterioff S, Mucha P, Melton LJ, III, Offord KP. Postsplenectomy sepsis and mortality in adults. JAMA 1982;248:2279–2283.
  • Zarrabi MH, Rosner F. Serious infections in adults following splenectomy for trauma. Arch Intern Med 1984;144: 1421–1424.
  • Gopal V, Bisno AL. Fulminant pneumococcal infections in “normal” asplenic hosts. Arch Intern Med 1977;137: 1526–1530.
  • Evans DI. Postsplenectomy sepsis 10 years or more after operation. J Clin Pathol 1985;38:309–311.
  • Schwartz PE, Sterioff S, Mucha P, Melton LJ, III, Offord KP. Postsplenectomy sepsis and mortality in adults. JAMA 1982; 248:2279–2283.
  • Zarrabi MH, Rosner F. Serious infections in adults following splenectomy for trauma. Arch Intern Med 1984;144: 1421–1424.
  • Gopal V, Bisno AL. Fulminant pneumococcal infections in “normal” asplenic hosts. Arch Intern Med 1977;137: 1526–1530.
  • Evans DI. Postsplenectomy sepsis 10 years or more after operation. J Clin Pathol 1985;38:309–311.
  • Holdsworth RJ, Irving AD, Cuschieri A. Postsplenectomy sepsis and its mortality rate: Actual versus perceived risks. Br J Surg 1991;78:1031–1038.
  • Styrt B. Complications of asplenia and hyposplenism-persistent uncertainties. West J Med 1992;157:461–463.
  • Workman MR, Philpott-Howard J, Bellingham AJ. Managing patients with an absent or dysfunctional spleen. Guidelines should highlight risk of Salmonella infection in sickle cell disease. BM]. 1996;312:1359–1360.
  • Mahrer S, Raik E. Capnocytophaga canimorsus septicemia associated with cat scratch. Pathology 1992;24:194–196.
  • CDC, Capnocytophaga canimorsus sepsis misdiagnosed as plague-New Mexico, 1992 MMWR Morb Mortal Wkly Rep, 42 1993. p 72–73
  • Hinrichs JH, Dunkelberg WE. DE-2 septicemia after splenectomy: Epidemiology and immunologic response. South Med J 198073:1638-1640.
  • Fish HR, Chia JK, Shakir KM. Postsplenectomy sepsis caused by group B streptococcus (S. agalactiae) in an adult patient with diabetes mellitus. Diabetes Care 1985;8: 608–609.
  • Haldane EV, Van Rooyen CE. Treatment of severe bacteroides infections with parenteral clindamycin. Can Med Assoc J 1972;107:1177–1181.
  • Schwartz RA, Gallardo MA, Kapila R, Gascon P, Herscu J, Siegel I, et al. Bacillary angiomatosis in an HIV seronegative patient on systemic steroid therapy. Br J Dermatol 1996;135: 982–987.
  • Peloux Y, Carcassonne Y, Quilichini F. Report of a case of subcutaneous abscess due to Eikenella corrodens in a splenectomized patient (author’s transl). Pathol Biol (Paris) 1977;25:245–246.
  • Clark RB, Westby GR, Spector H, Soricelli RR, Young CL. Fatal Plesiomonas shigelloides septicaemia in a splenectomised patient. J Infect 1991;23:89–92.
  • Curti AJ, Lin JH, Szabo K. Overwhelming post-splenectomy infection with Plesiomonas shigelloides in a patient cured of Hodgkin’s disease. A case report. Am J Clin Pathol 1985;83: 522–524.
  • Garre M, le Henaff C, Tande AJ, Chailloux J, Bensousan T, Garo B, et al. Fulminant Eubacterium plautii infection following dog bite in asplenic man. Lancet 1991;338: 384–385.
  • Hoc TS, Deng CT, Khuzaiah R. Melioidosis in a splenectomized boy with beta-thalassemia major. Southeast Asian J Trop Med Public Health 1993;24:601–602.

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