83
Views
2
CrossRef citations to date
0
Altmetric
Malignancy

Induction of Apoptosis in Human Leukaemia Cells is Differentially Regulated by Vitamin D Derivatives and Retinoids

, &
Pages 289-301 | Received 17 Jul 1997, Published online: 13 Jul 2016

References

  • Williams, G. T. and Smith, C. A. (1991). Cell, 74, 777–779.
  • Lane, D. P. (1992). p53, guardian of the genome. Nature, 358, 15–16.
  • Gottlieb, T. M. and Oren, M. (1996). p53 in Growth Control and Neoplasia. Biochim. et Biophys. Acta, 1287, 77–102.
  • Jacobson, M. D. and Evan, G. I. (1994). Apoptosis: Breaking the ICE. Curr. Biol., 4, 337–340.
  • Cosman, D. (1994). A family of ligands for the TNF receptor superfamily. Stem Cells, 12, 440–455.
  • Yang, E. and Korsmeyer, S. J. (1996). Molecular thanatopsis: a discourse on the bcl-2 family and cell death. Blood, 88, 386–401.
  • Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E. and Croce, C. M. (1985). The t(14;18). chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science, 229, 1390–1393.
  • Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O. and Korsmeyer, S. J. (1991). bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67, 879–888.
  • Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P. and Korsmeyer, S. J. (1990). Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol., 144, 3602–3610.
  • Miyashita, T. and Reed, J. C. (1993). bcl-2 oncoprotein blocks chemotherapy induced apoptosis in a human leukemia cell line. Blood, 81, 151–157.
  • Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nuñez, G. and Thompson, C. B. (1993). bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597–608.
  • Hengartner, M. O., Ellis, R. E. and Horvitz, H. R. (1992). Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature, 356, 494–499.
  • Oltvai, Z. N., Milliman, C. L. and Korsmeyer, S. J. (1993). Bcl-2 heterodimerises in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609–619.
  • Yang, E., Zha, J., Jockel, J., Boise, L. H., Thompson, C. B. and Korsmeyer, S. J. (1995). Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces Bax and promotes cell death. Cell, 80, 285–291.
  • Kiefer, M. C., Brauer, M. J., Powers, V. C., Wu, J. J., Umansky, S. R., Tomei, L. D. and Barr, P. J. (1995). Modulation of apoptosis by the widely distributed bcl-2 homologue bak. Nature, 374, 736–739.
  • Chittenden, T., Harrington, E. A., O'Connor, R., Flemington, C., Lutz, R. J., Evan, G. I. and Guild, B. C. (1995). Induction of apoptosis by the Bcl-2 homologue Bak. Nature, 374, 733–736.
  • Delia, D., Aiello, A., Soligo, D., Fontanella, E., Melani, C., Pezella, F., Pierotti, M. A. and Porta, G. D. (1992). Bcl-2 protoncogene expression in normal and neoplastic human myeloid cells. Blood, 79, 1291–1298.
  • Naumovski, L. and Cleary, M. L. (1994). Bcl-2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood, 83, 2261–2267.
  • Park, J. R., Robertson, K., Hickstein, D. D., Tsai, S., Hockenbery, D. M. and Collins, S. J. (1994). Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes. Blood, 84, 440–445.
  • Huang, M. E., Ye, Y. C., Chen, S. R., Chai, J. R., Lu, J. X., Zhoa, L., Gu., H. T. and Wang, Z. Y. (1988). Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 72, 567–572.
  • Miller, W. H., Jakubowski, A., Tong, W. P., Miller, V. A., Rigas, J. R., Benedetti, F., Gill, G. M., Truglia, J. A., Ulm, E., Shirley, M. and Warrell, R. P. (1995). 9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia. Blood, 85, 3021–3027.
  • Koeffler, H. P., Hirji, K., Itri, L. and Southern California Group (1985). 1,25-dihydroxyvitamin D3 in vitro and in vivo effects on human preleukemic and leukemic cells. Cancer Treat. Rep., 69, 1399–1407.
  • Richard, C., Mazo, E., Cuadrado, M. A., Iriondo, A., Bello, C., Gandarillas, M. and Zubizarreta, A. (1986). Treatment of myelodysplastic syndrome with 1,25-dihydroxyvitamin D3. Am. J. Hemat., 23, 175–178.
  • Kelsey, S. M., Newland, A. C., Cunningham, J., Makin, H. L. J., Coldwell, R. D., Mills, M. J. and Grant, I. R. (1992). Sustained haematological response to high-dose oral alfacalcidol in patients with myelodysplastic syndromes. Lancet, 340, 316–317.
  • Colston, K. W., Mackay, A. G., James, S. Y., Binderup, L., Chander, S. and Coombes, R. C. (1992). EB1089: A new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro. Biochem. Pharm., 44, 2273–2280.
  • Colston, K. W., Mackay, A. G. and James, S. Y. (1995). Vitamin D3 derivatives and breast cancer. In Ernst Schering Research Foundation Workshop 14: Apoptosis in Hormone-Dependent Cancer, edited by M. Tenniswood and H. Michna, pp. 201–224. Berlin, Heidelberg: Springer-Verlag.
  • Simboli-Campbell, M., Narvaez, C. J., Tenniswood, M. and Welsh, J. (1996). 1,25-dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells. J. Steroid Biochem. Molec. Biol., 58, 367–376.
  • James, S. Y., Mackay, A. G. and Colston, K. W. (1995). Vitamin D derivatives in combination with 9-cis retinoic acid promote active cell death in breast cancer cells. J. Molec. Endo., 14, 391–394.
  • James, S. Y., Mackay, A. G. and Colston, K. W. (1996). Effects of 1,25 dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells. J. Steroid Biochem. Molec. Biol., 58, 395–410.
  • Elstner, E., Linker-Israeli, M., Said, J., Umiel, T., de Vos, S., Shintaku, I. P., Heber, D., Binderup, L., Uskokovic, M. and Koeffler, H. P. (1995). 20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines. Cancer Res., 55, 2822–2830.
  • Munker, R., Norman, A. and Koeffler, H. P. (1986). Vitamin D compounds. Effects on clonal proliferation and differentiation of human myeloid cells. J. Clin. Invest., 78, 424–430.
  • Elstner, E., Lee, Y. Y., Hashiya, M., Pakkala, S., Binderup, L., Norman, A. W., Okamura, W. H. and Koeffler, H. P. (1994). 1α, 25-dihydroxy-20-epi-vitamin D3: an extraordinarly potent inhibitor of leukemic cell growth in vitro. Blood, 84, 1960–1967.
  • Defacque, H., Dornand, J., Commes, T., Cabane, S., Sevilla, C. and Marti, J. (1994). Different combinations of retinoids and vitamin D3 analogues efficiently promote growth inhibition and differentiation of myelomonocytic leukaemia cell lines. J. Pharm. Exp. Therap., 271, 193–199.
  • Kliewer, S. A., Umesono, S. A., Mangelsdorf, D. F. and Evans, R. M. (1992). Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D signalling. Nature, 355, 446–449.
  • Schmid, I., Uittenbogaart, C. H., Keld, B. and Giorgi, J. V. (1994). A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry. J. Immunol. Methods, 170, 145–157.
  • Philpott, N. J., Turner, A. J. C., Scopes, J., Westby, M., Marsh, J. C. W., Gordon-Smith, E. C., Dalgleish, A. G. and Gibson, F. M. (1996). The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood, 87, 2244–2251.
  • Bradford, M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein dye binding. Anal. Biochem., 72, 248–254.
  • James, S. Y., Williams, M. A., Kelsey, S. M., Newland, A. C. and Colston, K. W., (1997). Interaction of vitamin D derivatives and granulocyte-macrophage colony stimulating factor in leukaemic cell differentiation. Leukemia, 11, 1017–1025.
  • James, S. Y., Williams, M. A., Kelsey, S. M., Newland, A. C. and Colston, K. W. (1997). The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells. Biochem. Pharm., in press.
  • Thompson, C. B. (1995). Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456–1462.
  • Yin, X-M, Oltvai, Z. N. and Korsmeyer, S. J. (1994). BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerisation with bax. Nature, 369, 321–323.
  • Taimi, M., Chateau, M-T, Cabane, S. and Marti, J. (1991). Synergistic effect of retinoic acid and 1,25-dihydroxy-vitamin D3 on the differentiation of the human monocytic cell line U937. Leuk. Res., 15, 1145–1152.
  • Park, J. R., Bernstein, I. D. and Hockenbery, D. M. (1995). Primitive human hematopoietic precursors express bcl-x but not bcl-2. Blood, 86, 868–876.
  • Sanz, C., Benito, A., Silva, M., Albella, B., Richard, C., Segovia, J. C., Insunza, A., Bueren, J. A. and Fernández-Luna, J. L. (1997). The expression of bcl-x is downregulated during differentiation of human hematopoietrix progenitor cells along the granulocyte but not the monocyte/macrophage lineage. Blood, 89, 3199–3204.
  • Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M. and Korsmeyer, S. J. (1991). Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA, 88, 6961–6965.
  • Blagosklonny, M. V., Alvarez, M., Fojo, A. and Neckers, L. M. (1996). bcl-2 protein down-regulation is not required for differentiation of multidrug resistant HL-60 leukemia cells. Leuk. Res., 20, 101–107.
  • Xu, H-M, Tepper, C. G., Jones, J. B., Fernandez, C. E. and Studzinski, G. P. (1993). 1,25-Dihydroxyvitamin D3 protects HL-60 cells against apoptosis but down regulates the expression of the bcl-2 gene. Exp. Cell Res., 209, 367–374.
  • Brown, G., Bunce, C. M., Rowlands, D. C. and Williams, G. R. (1994). All-trans retinoic acid and lα, 25-dihydroxyvitamin D3 co-operate to promote differentiation of the human promyeloid leukaemia cell line HL-60 to monocytes. Leukemia, 8, 806–815.
  • Wallington, L. A., Bunce, C. M., Durham, J. and Brown, G. (1995). Particular combinations of signals, by retinoic acid and 1α, 25-Dihydroxyvitamin D3, promote apoptosis of HL-60 cells. Leukemia, 9, 1185–1190.
  • Elstner, E., Linker-Israeli, M., Umiel, T., Le, J., Grillier, I., Said, J., Shintaku, I. P., Krajewski, S., Reed, J. C., Binderup, L. and Koeffler, H. P. (1996). Combination of potent 20-epi-vitamin D3 analogue (KH1060). with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-6 leukemic cells. Cancer Res., 56, 3570–3576.
  • Elstner, E., Linker-Israeli, M., Le, J., Umiel, T., Michl, P., Said, J. W., Binderup, L., Reed, J. C. and Koeffler, H. P. (1997). Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid. J. Clin. Invest., 99, 349–360.
  • Evans, R. M. (1988). The steroid and thyroid hormone receptor superfamily. Science, 240, 889–895.
  • Collins, S. J., Robertson, K. A. and Mueller, L. (1990). Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-α). Mol. Cell. Biol., 10, 2154–2163.
  • Dawson, M. I., Elstner, E., Kizaki, M., Chen, D-L, Pakkala, S., Kerner, B. and Koeffler, H. P. (1994). Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway. Blood, 84, 446–452.
  • Nagy, L., Thomázy, V. A., Shipley, G. L., Fésüs, L., Lamph, W., Heyman, R. A., Chandraratna, R. A. S. and Davies, P. J. A. (1995). Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Mol. Cell Biol., 15, 3540–3551.
  • Mehta, K., McQueen, T., Neamati, N., Collins, S. and Andreeff, M. (1996). Activation of retinoid receptors RARα and RXRα, induces differentiation and apoptosis, respectively, in HL-60 cells. Cell Growth Diff., 7, 179–186.
  • Agarwal, N. and Mehta, K. (1997). Possible involvement of bcl-2 pathway in retinoid X receptor alpha induced apoptosis of HL-60 cells. Biochem. Biophys. Res. Commun., 230, 251–253.
  • Defacque, H., Commes, T., Legouffe, E., Sevilla, C., Rossi., J. F., Rochette-Egly, C. and Marti, J. (1996). Expression of retinoid X receptor α is increased upon monocytic cell differentiation. Biochem. Biophys. Res. Commun., 220, 315–322.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.