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Erythropoiesis

Comparison of Cytotoxic Aldehyde Generation in Beta-Thalassemia Patients Chelated with Deferoxamine or Deferiprone (L1) Versus NO Chelation

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Pages 67-76 | Received 10 May 1999, Published online: 13 Jul 2016

References

  • Lynch, S. R. (1995). Iron overload: prevalence and impact on health. Nutr. Rev., 53, 255–260.
  • Aldouri, M. A., Hoffbrand, A. V., Flynn, D. M., Ward, S. E., Agnew, J. E. and Hilson, A. J. W. (1994). High incidence of cardiomyopathy in beta-thalassemia patients receiving regular transfusions and chelation: reversal by intensified chelation. Acta. Haematol., 84, 113–123.
  • Herbert, V., Shaw, S., Jayatilleke, E. and Stopler-Kasdan, T. (1994). Most free-radical injury is iron-related: it is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin. Stem Cells, 12, 289–303.
  • Lesnefsky, E. J. (1994). Tissue iron overload and mechanisms of iron-catalyzed oxidative injury. Adv. Exp. Med. Biol., 366, 129–146.
  • Halliwell, B. and Gutteridge, J. M. C. (1990). Role of free radicals and catalytic metal ions in human disease. An overview. Meth. Enzymol., 186, 1–85.
  • Burkitt, M. J., Kadiiska, M. B., Hanna, P. M., Jordan, S. J. and Mason, R. P. (1992). Electron spin resonance spin-trapping investigation into the effects of paraquat and desferrioxamine on hydroxyl radical generation duringacute iron poisoning. Mol. Pharmacol., 43, 257–263.
  • Burkitt, M. J. and Mason, R. P. (1991). Direct evidence for in vivo hydroxyl radical generation in experimental iron overload: an ESR spin-trapping investigation. Proc. Natl. Acad. Sci. U.S.A., 88, 8440–8444.
  • Kang, J. O., Slivka, A., Slater, G. and Cohen, G. (1989). In vivo formation of hydroxyl radicals following intragastric administration of ferrous salts in rats. J. Inorg. Biochem., 35, 55–69.
  • Scott, M. D., van den Berg, J. J. M., Repka, T., Rouyer-Fessard, P., Hebbel, R. P., Beuzard, Y. and Lubin, B. H. (1993). Effect of excess α-hemoglobin chains on cellular and membrane oxidation in model β-thalassaemic erythrocytes. J. Clin. Invest., 91, 1706–1712.
  • Shinar, E. and Rachmilewitz, E. A. (1990). Oxidative denaturation of red blood cells in thalassemia. Semin. Hematol., 27, 70–82.
  • Grinberg, L. N., Rachmilewitz, E. A., Kitrossky, N. and Chevion, M. (1995). Hydroxyl radical generation in β-thalassemic red blood cells. Free Radio. Biol. Med., 18, 611–615.
  • Repka, T. and Hebbel, R. P. (1991). Hydroxyl radical formation by sickle erythrocyte membranes: Role of pathologic iron deposits and cytoplasmic reducing agents. Blood, 78, 2753–2758.
  • Brunori, M. G., Falcioni, E., Fioretti, E., Giardina, B. and Rotilio, G. (1975). Formation of superoxide in the autooxidation of the isolated α- and β-chains of human hemoglobin and its involvement in hemichrome precipitation. Eur. J. Biochem., 53, 99–104.
  • Bartfay, W. J., Dawood, F., Wen, W. H., Lehotay, D. C., Hou, D., Bartfay, E., Luo, X. P., Backx, P. H. and Liu, P. P. (1999). Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload. Cardiovasc. Res., (in press).
  • Houglum, K., Filip, M., Witzutum, B. and Choiker, M. (1990). Malondialdehyde and 4-hydroxynoneal protein adducts in plasma and liver of rat with iron overload. J. Clin. Invest., 86, 1991–1998.
  • Young, I. S., Trouton, T. G., Tomey, J. J., McMaster, D., Callender, M. and Trimble, E. R. (1994). Antioxidant status and lipid peroxidation in hereditary hemochromatosis. Free Radio. Biol. Med., 16, 393–397.
  • Gutteridge, J. M. C., Rowley, D. A., Griffiths, E. and Halliwell, B. (1985). Low-molecular-weight ironcomplexes and oxygen radical reactions in idiopathic haemochromatosis. Clin. Sci., 68, 463–467.
  • Livrea, M. A., Tesoriere, L., Pintaudi, A. M., Calabrese, A., Maggio, A., Freisleben, H. J., D-Arpa, D., D'Anna, R. and Bongiomo, A. (1996). Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood, 88, 3608–3614.
  • Jewell, A. P. and Marcus, R. E. (1984). Platelet derived malondialdehyde production in patients with thalassemia major. J. Clin. Pathol., 37, 1043–1045.
  • Ursini, F. and Bindoli, A. (1987). The role of selenium in the protection of membranes against oxidative damage of membranes. Chem. Phys. Lipids, 44, 255–276.
  • Hill, K. E. and Burke, R. F. (1984). Influence of vitamin E and selenium on glutathione-dependent protection against microsomal lipid peroxidation. Biochem. Pharmacol., 33, 1065–1068.
  • Brittenham, G. M., Farrell, D. E., Harris, J. W., Feldman, E. S., Danish, E. H., Muir, W. A., Tripp, J. H. and Bellon, E. M. (1982). Magnetic-susceptibility measurement of human iron stores. New Engl. J. Med., 307, 1671–1675.
  • McMaster, D., Bell, N., Anderson, P. and Love, A. H. (1990). Automated measurement of two indicators of human selenium status, and applicability to population study. Clin. Chem., 36, 211–216.
  • Bartfay, W. J., Hou, D., Brittenham, G. M., Bartfay, E., Sole, M. J., Lehotay, D. C. and Liu, P. P. (1998). The synergistic effects of vitamin E and selenium in iron-loaded mouse hearts. Can. J. Cardiol., 14, 937–941.
  • Luo, X. P., Yazdanpanah, M., Bhooi, N. and Lehotay, D. C. (1995). Determination of aldehydes and otherlipid peroxidation products in biological samples by gas chromatography-mass spectrometry. Anal. Biochem., 228, 294–298.
  • Esterbauer, H. (1993). Cytotoxicity and genotoxicity of lipid-peroxidation products. Am. J. Clin. Nutr., 57, 779S–786S.
  • Halliwell, B. and Chirico, S. (1993). Lipid peroxidation: its mechanism, measurement, and significance. Am. J. Clin. Nutr., 57, 715S–725S.
  • Cheeseman, K. H. (1993). Mechanisms and effects of lipid peroxidation. Mol. Aspects Med., 14, 191–197.
  • Benedetti, A., Casini, A. F., Ferrali, M. and Comporti, M. (1979). Effects of diffusible products of peroxidation on rat liver microsomal lipids. Biochem. J., 180, 303–312.
  • Kozlov, A. B., Ostrachovitch, E. A. and Afanas'ev, I. B. (1994). Mechanism of inhibitory effects of chelating drugs on lipid peroxidation in rat brain homogenates. Biochem. Pharmacol., 47, 795–799.
  • Menasche, P., Grousset, C., Gaudel, Y., Mouas, C. and Piwnica, A. (1987). Prevention of hydroxyl radical formation: a critical concept for improving cardioplegia. Protective effects of deferoxamine. Circulation, 76(V), 906–915.
  • Olivieri, N. F. and Brittenham, G. M. (1997). Iron-chelating therapy and the treatment of thalassemia.Blood, 89, 281–284.
  • Hoffbrand, A. V. (1995). Iron chelation therapy. Curr. Opin. Hematol., 2, 153–158.
  • Mostert, L. J., Van Dorst, J. A., Koster, J. F., van Eijk, H. G. and Kontoghiorghes, G. J. (1987). Free radical and cytotoxic effects of chelators and their iron complexes in hepatocyte. Free Radic. Res. Commun., 3, 379–388.
  • Loebstein, R., Lehotay, D. C., Lou, X. P., Bartfay, W., Tyler, B. and Sher, G. D. (1998). Diabetic nephropathy in hypertransfused patients with β-thalassemia: The role of oxidative stress. Diabetes Care, 21, 1306–1309.
  • Shalev, O., Repka, T., Goldfarb, A., Grinberg, L., Abrahamov, A., Oliveri, N. F., Rachmilewitz, E. A. and Hebbel, R. P. (1995). Deferiprone (L1) chelates pathologic iron deposits from membrane of intact thalassemic and sickle red blood cells both in vitro and in vivo. Blood, 86, 2008–2013.
  • Bannister, J. V., Bannister, W. H. and Thomalley, D. (1984). The effect of ferritin iron loading on hydroxyl radical production. Life Chem. Rep., 84(2), 64–72.
  • Carlin, G. and Djursater, R. (1984). Xanthine oxidase induced depolymerization of hyaluronic acid in the presence of ferritin. FEBS Lett., 117, 27–30.
  • Grootveld, M., Bell, J. D., Halliwell, B., Aruoma, O. I., Bomford, A. and Sadler, P. J. (1989). Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. J. Biol. Chem., 264, 4417–4422.
  • Hershko, C., Graham, G., Bates, G. W. and Rachmilewitz, E. A. (1978). Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity. Br. J. Haematol., 40, 255–263.
  • Wagstaff, M., Peters, S. W., Jones, B. M. and Jacobs, A. (1986). Free-iron and iron toxicity in iron overload. Br. J. Haematol., 67, 566–567.
  • Wang, W. C., Ahmed, N. and Hanna, M. (1986). Non-transferrin-bound iron in long-term transfusion in children with congenital anemias. J. Pediatr., 108, 552–557.
  • Al-Refaie, F. N., Wickens, D. G., Wonke, B., Konto-ghiorghes, G. J. and Hoffbrand, A. V. (1992). Serumnon-transferrin-bound iron in beta-thalassaemia major patients treated with desferrioxamine and L1. Br. J. Haematol., 82, 431–436.
  • Craven, C. M., Alexander, J., Eldridge, M., Kusher, J. P., Berstein, S. and Kaplan, J. (1987). Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for haemochromatosis. Proc. Natl. Acad. Sci. U.S.A., 84, 3457–3461.
  • Link, G., Pinson, A. and Hershko, C. H. (1985). Heart cells in culture: a model of myocardial iron overload and chelation. J. Lab. Clin. Med., 106, 147–153.
  • Ahmed, N. K., Hanna, M. and Wang, W. (1986). Non-transferrin-bound iron in thalassemia and sickle cell patients. Int. J. Biochem., 18, 953–956.
  • Zanninelli, G., Choudury, R., Loreal, O., Guyader, D., Lescoat, G., Arnaud, J., Verna, R., Cosson, B., Singh, S., Hider, R. C. and Brissot, P. (1997). Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats. J. Hepatol., 27, 176–184.
  • Starke, P. E. and Faber, J. L. (1985). Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide-evidenced for the participation of hydroxyl radicals formed by iron-catalyzed Haber Weiss reaction. J. Biol. Chem., 260, 10099–10104.
  • Byler, R. M., Sherman, N. A., Wallner, J. S. and Horwitz, L. D. (1994). Hydrogen peroxide cytotoxicityis iron dependent. Am. J. Physiol. (Heart Circ. Physiol.), 35, H121–H127.
  • Samuni, A., Winkelsberg, D., Pinson, A., Hahn, S. M., Mitchell, J. B. and Russo, A. (1991). Nitroxide stable radicals protects beating cardiomyocytes against oxidative damage. J. Clin. Invest., 87, 526–530.
  • Grelloni, F., Gabbianelli, R., Santroni, A. M. and Falcioni, G. (1993). Inactivation of glutathione peroxidase following entrapment of purified alpha or beta hemoglobin chains in human erythrocytes. Clin. Chim. Acta,217, 187–192.
  • Brenneisen, P., Briviba, K., Wlaschek, M., Wenk, J. and Scharffetter-Kochanenk, K. (1997). Hydrogen peroxide (H2O2) increases the steady-state mRNA levels of collagenase/MMP-1 in human dermal fibroblasts. Free Radic. Biol. Med., 22, 515–524.
  • Ben-Yoseph, O., Boxer, P. A. and Ross, B. D. (1994). Oxidative stress in the central nervous system: monitoring the metabolic response using the pentose phosphate pathway. Dev. Neurosci., 16, 328–336.
  • Pucheu, S., Coudray, C., Tresallet, N., Favier, A. and de Leiris, J. (1993). Effect of iron overload in the isolated and reperfused rat heart. Cardiovasc. Drugs Ther., 7, 701–711.

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