Molecular Demonstration of BCR/ABL Fusion in a Patient with Chronic Myelogenous Leukemia with Basophilia Carrying a Variant t(16;22) (q24;q11) Philadelphia Chromosome

References

• Rowley, J. D. (1973). A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature, 243, 290–293.
   PubMed Web of Science ®Google Scholar
• Heisterkamp, N., Stephenson, J. R., Groffen, J., Hansen, P. F., de Klein, A., Bartram, C. R. and Grosveld, G. (1983). Localization of the c-abl oncogene adjacent to a translocation breakpoint in chronic myelocytic leukemia. Nature, 306, 239–242.
   PubMed Web of Science ®Google Scholar
• Heisterkamp, N., Stam, K., Groffen, J., de Klein, A. and Grosveld, G. (1985). Structural organization of the bcr gene and its role in the Ph’ translocation. Nature, 315, 758–761.
   PubMed Web of Science ®Google Scholar
• Shtivelman, E., Lifshitz, B., Gale, R. P., Roe, B. and Canaani, E. (1986). Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. Cell, 47, 277–284.
   PubMed Web of Science ®Google Scholar
• Witte, O. N. (1993). Role of the BCR-ABL oncogene in human leukemia. Cancer Res, 53, 485–489.
   PubMed Web of Science ®Google Scholar
• Daley, G. Q., Van Etten, R. A. and Baltimore, D. (1990). Induction of chronic myelogenous leukemia in mice by the p210 gene of the Philadelphia chromosome. Science, 247, 824–830.
   PubMed Web of Science ®Google Scholar
• De Braekeleer, M. (1987). Variant Philadelphia translocation in chronic myeloid leukemia. Cytogenet Cell Genet, 44, 215–222.
   PubMedGoogle Scholar
• Heim, S., Billstrom, R., Kristoffersson, U., Mandahl, N., Strombeck, B. and Mitelman, F. (1985). Variant Ph translocations in chronic myeloid leukemia. Cancer Genet Cytogenet, 18, 215–227.
   PubMed Web of Science ®Google Scholar
• Hagemeijer, A., Bartram, C. R., Smit, E. M., van Agthoven, A. J. and Bootsma, D. (1984). Is the chromosomal region 9q34 always involved in variants of the Ph translocation? Cancer Genet Cytogenet, 13, 1–16.
   PubMed Web of Science ®Google Scholar
• Morris, C. M., Rosman, I., Archer, S. A., Cochrane, J. M. and Fitzgerald, P. H. (1988). A cytogenetic and molecular analysis of five variant Philadelphia translocations in chronic myeloid leukemia. Cancer Genet Cytogenet, 35, 179–197.
   PubMed Web of Science ®Google Scholar
• Cervantes, F., Ballesta, F., Mila, M. and Rozman, C. (1986). Cytogenetic studies in blast crisis of Ph-positive chronic granulocytic leukemia: results and prognostic evaluation in 52 patients. Cancer Genet Cytogenet, 21, 239–246.
   PubMed Web of Science ®Google Scholar
• Browett, P. J., Cooke, H. M. G., Seeker-Walker, L. M. and Norton, J. D. (1989). Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. Cancer Genet Cytogenet, 37, 169–177.
   PubMed Web of Science ®Google Scholar
• Zaccaria, A., Testoni, N., Tassinari, A., Celso, B., Rassool, F., Saglio, G., Guerrasio, A., Rosti, G. and Tura, S. (1989). Cytogenetic and molecular studies in patients with chronic myeloid leukemia and variant translocations. Cancer Genet Cytogenet, 42, 191–201.
   PubMedGoogle Scholar
• Therapel, S. A., Vnecnak-Jones, C. L., Whitlock, J. A. and Jain, R. (1992). Molecular confirmation of BCR. ABL fusion in a chronic myeloid leukemia with a complex translocation involving chromosomes 9, 15 and 22. Genes Chromosom Cancer, 4, 343–345.
   PubMed Web of Science ®Google Scholar
• Sessarego, M., Martinelli, G., Chiamenti, A., Defferrari, R., Fugazza, G., Bruzzone, R., Ajmar, F. and Pignatti, P. F. (1993). Molecular analysis of six variant Philadelphia chromosome translocations in chronic myeloid leukemia. Cancer Genet Cytogenet, 67, 50–54. 13. Sambrook, J., Fritsch, E. F., Maniatis, T. (1989). Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
   Google Scholar
• Tosi, S., Cabot, G., Giudici, G., Attuati, V., Morandi, P., Rambaldi, A., Dohner, H. and Biondi, A. (1996). Detection of the breakpoint cluster region-abl fusion in chronic myeloid leukemia with variant Philadelphia chromosome translocations by in situ hybridization. Cancer Genet Cytogenet, 88, 153–156.
   Google Scholar
• Mantzourani, M., Stamatopoulos, K., Abazis, D., Kontopidou, F., Viniou, N. A., Pangalis, G. A., Pangalos, C. and Loukopoulos, D. (1996). Molecular demonstration of bcr-abl fusion in two cases with chronic myeloproliferative disorder carrying variant t(14;22) Philadelphia chromosomes. Cancer Genet Cytogenet, 91, 82–87.
   PubMed Web of Science ®Google Scholar
• Abazis, D., Mantzourani, M., Stavroyianni, N., Stamatopoulos, K., Yataganas, X., Loukopoulos, D. and Pangalos, C. (1998). Analysis of six variant Philadelphia translocations in patients with chronic myelogenous leukemia. Brit J Haematol, 102, 185.
   Web of Science ®Google Scholar
• Sessarego, M., Defferrari, R., Panarelo, C., Frassoni, F., Mandich, P. and Ajmar, F. (1988). Variant Philadelphia chromosomes in CML: Correlation with fragile sites. Cancer Genet Cytogenet, 31, 105–112.
   PubMedGoogle Scholar
• Stopera, S. A., Ray, M., Riordan, D., Christie, N. and Wickstrom, D. (1990). Variant Philadelphia translocations in chronic myeloid leukemia: correlation with cancer breakpoints, fragile sites and oncogenes. Cancer Lett, 55, 249–253.
   PubMed Web of Science ®Google Scholar
• Rogers, J. (1985). Oncogene chromosome breakpoints and ALU sequences. Nature, 317, 559.
   PubMed Web of Science ®Google Scholar
• Krowczynska, A. M., Rudders, R. A. and Krontiris, T. G. (1990). The human minisatellite consensus at breakpoints of oncogene translocations. Nucleic Acids Res, 18, 1121–1127.
   PubMed Web of Science ®Google Scholar
• Nanjagut, G., Kadam, P. R., Saikia, T., Bhisey, A. N., Kumar, A., Gopal, R., Chopra, H., Nair, C. N. and Advani, S. H. (1994). Karyotypic findings as an independent prognostic marker in chronic myeloid leukemia blast crisis. Leukemia Res, 18, 385–392.
   PubMed Web of Science ®Google Scholar
• Athens, J. W. (1993). Eosinophils and basophils. In Wintrobe's Clinical Hematology, 9th ed., (Lee, G. R., Bithell, T. C., Foerster, J., Athens, J. W., Lukens, J. N., eds.), Lea and Febiger, Philadelphia, pp. 299–310.
   Google Scholar
• Pearson, M. G., Vardiman, J. W., LeBeau, M. M., Rowley, J. D., Scwarz, S., Kerman, S. L., Cohen, M. M. Fleischman, E. W. and Prigorina, E. L. (1985). increased numbers of marrow basophils may be associated with a t(6;9) in ANLL. Am J Hematol, 18, 393–403.
   PubMed Web of Science ®Google Scholar
• Second MIC Cooperative Study Group (1988). Morphologic, immunologic and cytogenetic (MIC) working classification of the acute myeloid leukemias. Cancer Genet Cytogenet, 30, 1–16.
   PubMed Web of Science ®Google Scholar
• Drummond, R. (1995). Haemopoietic stem cells and basophils. Med Hypotheses, 43, 160–162
   Web of Science ®Google Scholar
• McKusick, V. A. (7/1997). Mendelian inheritance in man on CD-ROM: A catalog of human genes and genetic disorders. The Johns Hopkins University Press, Baltimore, MD.
   Google Scholar