Hemochromatosis gene mutations may affect the survival of patients with myelodysplastic syndrome

References

• Gattermann N, Rachmilewitz EA. Iron overload in MDS-pathophysiology, diagnosis, and complications. Ann Hematol 2011;90(1):1–10. PubMed PMID: 20938663. doi: 10.1007/s00277-010-1091-1
   PubMed Web of Science ®Google Scholar
• Malcovati L. Impact of transfusion dependency and secondary iron overload on the survival of patients with myelodysplastic syndromes. Leukemia Res 2007;31(Suppl. 3):S2–S6. PubMed PMID: 18037415. doi: 10.1016/S0145-2126(07)70459-9
   PubMedGoogle Scholar
• Neukirchen J, Fox F, Kundgen A, Nachtkamp K, Strupp C, Haas R, et al. Improved survival in MDS patients receiving iron chelation therapy – a matched pair analysis of 188 patients from the Dusseldorf MDS registry. Leukemia Res 2012;36(8):1067–70. PubMed PMID: 22564985. doi: 10.1016/j.leukres.2012.04.006
   PubMed Web of Science ®Google Scholar
• Delforge M, Selleslag D, Beguin Y, Triffet A, Mineur P, Theunissen K, et al. Adequate iron chelation therapy for at least six months improves survival in transfusion-dependent patients with lower risk myelodysplastic syndromes. Leukemia Res 2014;38(5):557–63. PubMed PMID: 24661630. doi: 10.1016/j.leukres.2014.02.003
   PubMed Web of Science ®Google Scholar
• Lyons RM, Marek BJ, Paley C, Esposito J, Garbo L, DiBella N, et al. Comparison of 24-month outcomes in chelated and non-chelated lower-risk patients with myelodysplastic syndromes in a prospective registry. Leukemia Res 2014;38(2):149–54. PubMed PMID: 24314590. doi: 10.1016/j.leukres.2013.11.004
   PubMed Web of Science ®Google Scholar
• Varkonyi J, Tarkovacs G, Karadi I, Andrikovics H, Varga F, Varga F, et al. High incidence of hemochromatosis gene mutations in the myelodysplastic syndrome: the Budapest Study on 50 patients. Acta Haematol 2003;109(2):64–7. PubMed PMID: 12624489. doi: 10.1159/000068487
   PubMed Web of Science ®Google Scholar
• Nearman ZP, Szpurka H, Serio B, Warshawksy I, Theil K, Lichtin A, et al. Hemochromatosis-associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts. Am J Hematol 2007;82(12):1076–9. PubMed PMID: 17654685. doi: 10.1002/ajh.20995
   PubMed Web of Science ®Google Scholar
• Speletas M, Kioumi A, Mandala E, Katodritou E, Papaioannou G, Ritis K, et al. Prevalence of hemochromatosis gene (HFE) mutations in Greek patients with myelodysplastic syndromes. Acta Haematol 2003;110(1):53–4. PubMed PMID: 12975562. doi: 10.1159/000072419
   PubMed Web of Science ®Google Scholar
• Nie L, Ai XF, Zheng YZ, Li QH, Yang L, Xiao ZJ. [Study on HFE gene mutations in patients with myelodysplastic syndromes and aplastic anemia]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2009 Apr;30(4):223–8. PubMed PMID: 19731820.
   Google Scholar
• Burt MJ, George PM, Upton JD, Collett JA, Frampton CM, Chapman TM, et al. The significance of haemochromatosis gene mutations in the general population: implications for screening. Gut 1998;43(6):830–6. PubMed PMID: 9824612. Pubmed Central PMCID: 1727339. doi: 10.1136/gut.43.6.830
   PubMed Web of Science ®Google Scholar
• Jackson HA, Carter K, Darke C, Guttridge MG, Ravine D, Hutton RD, et al. HFE mutations, iron deficiency and overload in 10,500 blood donors. Brit J Haematol 2001;114(2):474–84. PubMed PMID: 11529872. doi: 10.1046/j.1365-2141.2001.02949.x
   PubMed Web of Science ®Google Scholar
• Raddatz D, Legler T, Lynen R, Addicks N, Ramadori G. HFE genotype and parameters of iron metabolism in German first-time blood donors – evidence for an increased transferrin saturation in C282Y heterozygotes. Z Gastroenterol 2003;41(11):1069–76. PubMed PMID: 14648375. doi: 10.1055/s-2003-44299
   PubMed Web of Science ®Google Scholar
• Rossi E, Bulsara MK, Olynyk JK, Cullen DJ, Summerville L, Powell LW. Effect of hemochromatosis genotype and lifestyle factors on iron and red cell indices in a community population. Clin Chem 2001;47(2):202–8. PubMed PMID: 11159767.
   PubMed Web of Science ®Google Scholar
• Whitfield JB, Cullen LM, Jazwinska EC, Powell LW, Heath AC, Zhu G, et al. Effects of HFE C282Y and H63D polymorphisms and polygenic background on iron stores in a large community sample of twins. Am J Hum Genet 2000;66(4):1246–58. PubMed PMID: 10739755. Pubmed Central PMCID: 1288192. doi: 10.1086/302862
   PubMed Web of Science ®Google Scholar
• Lucijanic M, Petrovecki M. Analysis of censored data. Biochem Med 2012;22(2):151–5. PubMed PMID: 22838181. Pubmed Central PMCID: 4062335. doi: 10.11613/BM.2012.018
   Web of Science ®Google Scholar
• Ristic S, Makuc J, Starcevic N, Logar N, Brajenovic-Milic B, Stepec S, et al. Hemochromatosis gene mutations in the Croatian and Slovenian populations. Clin Genet 2003;64(5):444–6. PubMed PMID: 14616770. doi: 10.1034/j.1399-0004.2003.00169.x
   PubMed Web of Science ®Google Scholar
• Piperno A. Molecular diagnosis of hemochromatosis. Expert opinion on medical diagnostics 2013;7(2):161–77. PubMed PMID: 23530886. doi: 10.1517/17530059.2013.763794
   PubMedGoogle Scholar
• Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13(4):399–408. PubMed PMID: 8696333. doi: 10.1038/ng0896-399
   PubMed Web of Science ®Google Scholar
• Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12(10):1161–208. PubMed PMID: 15892631. doi: 10.2174/0929867053764635
   PubMed Web of Science ®Google Scholar
• Morris CJ, Earl JR, Trenam CW, Blake DR. Reactive oxygen species and iron – a dangerous partnership in inflammation. Int J Biochem Cell B 1995;27(2):109–22. PubMed PMID: 7767779. doi: 10.1016/1357-2725(94)00084-O
   PubMed Web of Science ®Google Scholar
• Tien Kuo M, Savaraj N. Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers. Mol Carcinogen 2006;45(9):701–9. PubMed PMID: 16652372. doi: 10.1002/mc.20240
   PubMed Web of Science ®Google Scholar
• Grady JK, Chen Y, Chasteen ND, Harris DC. Hydroxyl radical production during oxidative deposition of iron in ferritin. J Biol Chem 1989;264(34):20224–9. PubMed PMID: 2555348.
   PubMed Web of Science ®Google Scholar
• Farquhar MJ, Bowen DT. Oxidative stress and the myelodysplastic syndromes. Int J Hematol 2003;77(4):342–50. PubMed PMID: 12774921. doi: 10.1007/BF02982641
   PubMed Web of Science ®Google Scholar