634
Views
0
CrossRef citations to date
0
Altmetric
HEMATOLOGICAL MALIGNANCY

Increased expression of HERG K+ channels contributes to myelodysplastic syndrome progression and displays correlation with prognosis stratification

ORCID Icon, , , , &

References

  • Shieh CC, Coghlan M, Sullivan JP, Gopalakrishnan M. Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev. 2000;52:557–94.
  • Jehle J, Schweizer PA, Katus HA, Thomas D. Novel roles for hERG K(+) channels in cell proliferation and apoptosis. Cell Death Dis. 2001;2:e193. doi: 10.1038/cddis.2011.77
  • Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP. hERG K(+) channels: structure, function, and clinical significance. Physiol Rev. 2012;92:1393–478. doi: 10.1152/physrev.00036.2011
  • Sanguinetti MC, Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature. 2006;440:463–9. doi: 10.1038/nature04710
  • Wang Z. Roles of K+ channels in regulating tumor cell proliferation and apoptosis. Pflugers Arch. 2004;448:274–86. doi: 10.1007/s00424-004-1258-5
  • Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, et al. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia. 2002;16:1791–8. doi: 10.1038/sj.leu.2402572
  • Pillozzi S, Brizzi MF, Bernabei PA, Bartolozzi B, Caporale R, Basile V, et al. VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome. Blood. 2007;110:1238–50. doi: 10.1182/blood-2006-02-003772
  • Pillozzi S, Masselli M, De Lorenzo E, Accordi B, Cilia E, Crociani O, et al. Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers. Blood. 2011;117:902–14. doi: 10.1182/blood-2010-01-262691
  • Corey SJ, Minden MD, Barber DL, Kantarjian H, Wang JC, Schimmer AD. Myelodysplastic syndromes: the complexity of stem-cell diseases. Nat Rev Cancer. 2007;7:118–29. doi: 10.1038/nrc2047
  • Pellagatti A, Boultwood J. The molecular pathogenesis of the myelodysplastic syndromes. Eur J Haematol. 2015;95:3–15.
  • Tefferi A, Vardiman JW. Myelodysplastic syndromes. N Engl J Med. 2009;361:1872–85. doi: 10.1056/NEJMra0902908
  • Pellagatti A, Cazzola M, Giagounidis A, Perry J, Malcovati L, Della Porta MG, et al. Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells. Leukemia. 2010;24:756–64. doi: 10.1038/leu.2010.31
  • Raza A, Galili N. The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes. Nat Rev Cancer. 2012;12:849–59. doi: 10.1038/nrc3321
  • Tang G, DiNardo C, Zhang L, Ravandi F, Khoury JD, Huh YO, et al. MLL gene amplification in acute myeloid leukemia and myelodysplastic syndromes is associated with characteristic clinicopathological findings and TP53 gene mutation. Hum Pathol. 2015;46:65–73. doi: 10.1016/j.humpath.2014.09.008
  • Tao JL, Li LJ, Fu R, Wang HQ, Jiang HJ, Yue LZ, et al. Elevated TIM3+ hematopoietic stem cells in untreated myelodysplastic syndromes displayed aberrant differentiation, overproliferation and decreased apoptosis. Leuk Res. 2014;38:714–21. doi: 10.1016/j.leukres.2014.03.018
  • Xie W, Li X, Chen X, Huang S, Huang S. Decreased expression of PRDM2 (RIZ1) and its correlation with risk stratification in patients with myelodysplastic syndrome. Br J Haematol. 2010;150:242–4.
  • Li H, Liu L, Guo L, Zhang J, Du W, Li X, et al. HERG K+ channel expression in CD34+/CD38-/CD123(high) cells and primary leukemia cells and analysis of its regulation in leukemia cells. Int J Hematol. 2008;87:387–92. doi: 10.1007/s12185-008-0056-9
  • Zheng F, Li J, Du W, Wang N, Li H, Huang S. Human ether-a-go-go-related gen K+ channels regulate shedding of leukemia cell-derived microvesicles. Leuk Lymphoma. 2012;53:1592–8. doi: 10.3109/10428194.2012.661855
  • Li H, Du YM, Guo L, Jie S, Zhang S, Du W, et al. The role of hERG1 K+ channels and a functional link between hERG1 K+ channels and SDF-1 in acute leukemic cell migration. Exp Cell Res. 2009;315:2256–64. doi: 10.1016/j.yexcr.2009.04.017
  • Lastraioli E, Guasti L, Crociani O, Polvani S, Hofmann G, Witchel H, et al. herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells. Cancer Res. 2004;64:606–11. doi: 10.1158/0008-5472.CAN-03-2360
  • Ding XW, Luo HS, Luo B, Xu DQ, Gao S. Overexpression of hERG1 in resected esophageal squamous cell carcinomas: a marker for poor prognosis. J Surg Oncol. 2008;97:57–62. doi: 10.1002/jso.20891
  • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414:105–11. doi: 10.1038/35102167
  • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730–7. doi: 10.1038/nm0797-730
  • Greenberg PL, Young NS, Gattermann N. Myelodysplastic syndromes. Hematol Am Soc Hematol Educ Program. 2002:136–61.
  • Wang H, Zhang Y, Cao L, Han H, Wang J, Yang B, et al. HERG K+ channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res. 2002;62:4843–8.
  • Afrasiabi E, Hietamäki M, Viitanen T, Sukumaran P, Bergelin N, Törnquist K. Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration. Cell Signal. 2010;22:57–64. doi: 10.1016/j.cellsig.2009.09.010
  • Crociani O, Guasti L, Balzi M, Becchetti A, Wanke E, Olivotto M, et al. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem. 2003;278:2947–55. doi: 10.1074/jbc.M210789200
  • Patanѐ S. HERG-targeted therapy in both cancer and cardiovascular system with cardiovascular drugs. Int J Cardiol. 2014;176:1082–5. doi: 10.1016/j.ijcard.2014.07.129

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.