581
Views
0
CrossRef citations to date
0
Altmetric
HEMATOLOGICAL MALIGNANCY

‘Real-life’ study of imatinib therapy in chronic phase-chronic myeloid leukemia: A novel retrospective observational longitudinal analysis

, , , , , , & show all

References

  • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031–7. doi: 10.1056/NEJM200104053441401
  • Kantarjian H, O'Brien S, Jabbour E, Garcia-Manero G, Quintas-Cardama A, Shan J, et al. Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single institution historical experience. Blood 2012;119:1981–7. doi: 10.1182/blood-2011-08-358135
  • O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, et al. Imatinib compared with interferon low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348:994–1004. doi: 10.1056/NEJMoa022457
  • Hochhaus A, Shah NP, Cortes J, Baccarani M, Bradley-Garelik MB, Dejardin D, et al. Dasatinib versus imatinib (IM) in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): DASISION 3-year follow-up. J Clin Oncol. 2012;30:6504.
  • Larson RA, Hochhaus A, Hughes TP, Clark RE, Etienne G, Kim D-W, et al. Nilotinib versus imatinib in patients with newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 36-month follow-up. Leukemia 2012;26:2197–203. doi: 10.1038/leu.2012.134
  • Marin D. Initial choice of therapy among plenty for newly diagnosed chronic myeloid leukemia. Hematol Am Soc Hematol Educ Progr. 2012:115–21.
  • Marin D. Patient with chronic myeloid leukemia in complete cytogenetic response: what does it mean, and what does one do next?. J Clin Oncol. 2014;32(5):379–84. doi: 10.1200/JCO.2013.52.9230
  • Cross NC, White HE, Muller MC, Saglio G, Hochhaus A. Standardized definitions of molecular response in chronic myeloid leukemia. Leukemia 2012;26:2172–5. doi: 10.1038/leu.2012.104
  • Hughes T, Deininger M, Hochhaus A, Branford S, Radich J, Kaeda J, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006;108:28–37. doi: 10.1182/blood-2006-01-0092
  • Gabert J, Billard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, et al. Standardization and quality control studies of “real time” quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual d ase detection in leukemia – a Europe against cancer program. Leukemia 2003;17:2318–57. doi: 10.1038/sj.leu.2403135
  • Ross DM, Branford S, Seymour JF, Schwarer AP, Arthur C, Bartley PA, et al. Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR. Leukemia 2010;24:1719–24. doi: 10.1038/leu.2010.185
  • Cullis JO, Marks DI, Schwarer AP, Barrett AJ, Hows JM, Swirsky DM, et al. Relapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia: a report of five cases. Br J Haematol. 1992;81:378–82. doi: 10.1111/j.1365-2141.1992.tb08243.x
  • Rousselot P, Charbonnier A, Cony-Makhoul P, Agape P, Nicolini FE, Varet B, et al. Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor therapy in patients with chronic-phase chronic myelogenous leukemia who have stopped imatinib after durable undetectable disease. J Clin Oncol. 2014;32(5):424–30. doi: 10.1200/JCO.2012.48.5797
  • Horn M, Glauche I, Müller MC, Hehlmann R, Hochhaus A, Loeffler M, et al. Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Blood 2013;121(2):378–84. doi: 10.1182/blood-2012-07-441956
  • Efficace F, Baccarani M, Breccia M, Alimena G, Rosti G, Cottone F, et al. Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population. Blood 2011;118(17):4554–60. doi: 10.1182/blood-2011-04-347575
  • Latagliata R, Breccia M, Carmosino I, Cannella L, De Cuia R, Diverio D, et al. “Real-life” results of front-line treatment with imatinib in older patients (≥65 years) with newly diagnosed chronic myelogenous leukemia. Leuk Res. 2010;34:1472–5. doi: 10.1016/j.leukres.2010.07.001
  • Gugliotta G, Castagnetti F, Apolinari M, Pirondi S, Cavo M, Baccarani M, et al. First-line treatment of newly diagnosed elderly patients with chronic myeloid leukemia: current and emerging strategies. Drugs 2014;74:627–43. doi: 10.1007/s40265-014-0207-7
  • Russo D, Martinelli G, Malagola M, Skert C, Soverini S, Iacobucci I, et al. Effects and outcome of a policy of intermittent imatinib treatment in elderly patients with chronic myeloid leukemia. Blood 2013;121(26):5138–44. doi: 10.1182/blood-2013-01-480194
  • Marin D, Bazeos A, Mahon FX, Eliasson L, Milojkovic D, Bua M, et al. Adherence is the critical factor for achieving molecular responses in chronic myeloid leukemia patients who achieve complete cytogenetic responses on imatinib. J Clin Oncol. 2010;24:2381–88. doi: 10.1200/JCO.2009.26.3087
  • Olshen A, Tang M, Cortes J, Gonen M, Hughes T, Branford S, et al. Dynamics of chronic myeloid leukemia response to dasatinib, nilotinib, and high-dose imatinib. Haematologica. Doi:10.3324/haematol.2014.085977
  • Merante S, Orlandi E, Bernasconi P, Calatroni S, Boni M, Lazzarino M. Outcome of four patients with chronic myeloid leukemia after imatinib mesylate discontinuation. Haematologica 2005;90:979–81.
  • Liang K-Y, Zeger S. Longitudinal data analysis using generalized linear models. Biometrika 1986;73(1):13–22. doi: 10.1093/biomet/73.1.13
  • Pan W. Akaike's informat ion criterion in generalized estimating equations. Biometrics 2001;57:120–5. doi: 10.1111/j.0006-341X.2001.00120.x
  • Cui J. QIC program and model selection in GEE analyses. Stata J. 2007;7(2):209–20.
  • Mahon FX, Rea D, Guilhot J, Guilhot F, Huguet F, Nicolini F, et al. Intergroupe Francais des Leucemies Myeloides Chroniques. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least two years: the prospective, multicentre, Stop IMatinib (STIM) trial. Lancet Oncol. 2010;11:1029–35. doi: 10.1016/S1470-2045(10)70233-3
  • Cortes J, O'Brien S, Kantarjian H. Discontinuation of imatinib therapy after achieving a molecular response. Blood 2004;104:2204–5. doi: 10.1182/blood-2004-04-1335
  • Ross DM, Branford S, Seymour JF, Arthur C, Yeung DT, Dang P, et al. Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study. Blood 2013;122:515–22. doi: 10.1182/blood-2013-02-483750
  • Koskenvesa P, Kreutzman A, Rohon P, Pihlman M, Vakkila E, Räsänen A, et al. Imatinib and pegylated IFN-a2b discontinuation in first-line chronic myeloid leukemia patients following a major molecular response. Eur J Haematol. 2014;92(5):413–20. doi: 10.1111/ejh.12258
  • Mahon FX, Nicolini FE, Noël MP, Escoffre M, Charbonnier A, Rea D, et al. Preliminary report of the STIM2 study: a multicenter stop imatinib trial for chronic phase chronic myeloid leukemia de novo patients on imatinib. Blood 2013. ASH Annual Meeting Abstract 654.
  • Ross MD, Hughes TP. How I determine if and when to recommend stopping tyrosine kinase inhibitor treatment for chronic myeloid leukaemia. Brit J Haematol. 2014;1:3–11. doi: 10.1111/bjh.12892
  • Wodarz D. Heterogeneity in chronic myeloid leukaemia dynamics during imatinib treatment: role of immune responses. Proc Royal Soc Biol. 2010;277:1875–80. doi: 10.1098/rspb.2009.2179
  • Wodarz D. Stem cell regulation and the development of blast crisis in chronic myeloid leukemia: Implications for the outcome of Imatinib treatment and discontinuation. Med. Hypotheses 2008;70:128–36. doi: 10.1016/j.mehy.2007.03.040
  • Hughes TP, Kaeda J, Branford S, Rudzki Z, Hochhaus A, Hensley ML, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med. 2003;349:1423–32. doi: 10.1056/NEJMoa030513
  • Malagola M, Breccia M, Skert C, Cancelli V, Soverini S, Iacobucci I, et al. Long term outcome of Ph+CML patients achieving complete cytogenetic remission with interferon based therapy moving from interferon to imatinib era. Am J Hematol. 2014;89(2):119–24. doi: 10.1002/ajh.23593
  • de Lavallade H, Apperley JF, Khorashad JS, Milojkovic D, Reid AG, Bua M, et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol. 2008;26:3358–63. doi: 10.1200/JCO.2007.15.8154
  • Branford S, Seymour JF, Grigg A, Arthur C, Rudzki Z, Lynch K, et al. BCR-ABL messenger RNA levels continue to decline in patients with chronic phase chronic myeloid leukemia treated with imatinib for more than 5 years approximately half of all first-line treated patients have stable undetectable BCR-ABL using strict sensitivity criteria. Clin Cancer Res. 2007;13:7080–5. doi: 10.1158/1078-0432.CCR-07-0844
  • Yilmaz M, Jabbour E. Tyrosine kinase inhibitors early in the disease course: lessons from chronic myelogenous leukemia. Semin Oncol. 2015;42(6):876–86. doi: 10.1053/j.seminoncol.2015.09.030

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.