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Immune thrombocytopenia

Assessment of Th17/Treg cells and Th cytokines in an improved immune thrombocytopenia mouse model

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References

  • Cines DB, Bussel JB, Liebman HA, et al. The ITP syndrome: pathogenic and clinical diversity. Blood. 2009;113:6511–6521. doi: 10.1182/blood-2009-01-129155
  • Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood. 1991;78:2619–2625.
  • Semple JW, Milev Y, Cosgrave D, et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood. 1996;87:4245–4254.
  • Zhang J, Ma D, Zhu X, et al. Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura. Haematologica. 2009;94:1326–1329. doi: 10.3324/haematol.2009.007823
  • Yazdanbakhsh K, Zhong H, Bao W. Immune dysregulation in immune thrombocytopenia. Semin Hematol. 2013;50(Suppl 1):S63–S67. doi: 10.1053/j.seminhematol.2013.03.011
  • Talaat RM, Elmaghraby AM, Barakat SS, et al. Alterations in immune cell subsets and their cytokine secretion profile in childhood idiopathic thrombocytopenic purpura (ITP). Clin Exp Immunol. 2014;176:291–300. doi: 10.1111/cei.12279
  • Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev. 2014;13:668–677. doi: 10.1016/j.autrev.2013.12.004
  • Oyaizu N, Yasumizu R, Miyama-Inaba M, et al. (NZW x BXSB)F1 mouse. A new animal model of idiopathic thrombocytopenic purpura. J Exp Med. 1988;167:2017–2022. doi: 10.1084/jem.167.6.2017
  • Musaji A, Vanhoorelbeke K, Deckmyn H, et al. New model of transient strain-dependent autoimmune thrombocytopenia in mice immunized with rat platelets. Exp Hematol. 2004;32:87–94. doi: 10.1016/j.exphem.2003.09.024
  • Chow L, Aslam R, Speck ER, et al. A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. Blood. 2010;115:1247–1253. doi: 10.1182/blood-2009-09-244772
  • Dekel B, Marcus H, Shenkman B, et al. Human/BALB radiation chimera engrafted with splenocytes from patients with idiopathic thrombocytopenic purpura produce human platelet antibodies. Immunology. 1998;94:410–416. doi: 10.1046/j.1365-2567.1998.00516.x
  • Corash L, Levin J. The relationship between megakaryocyte ploidy and platelet volume in normal and thrombocytopenic C3H mice. Exp Hematol. 1990;18:985–989.
  • Song S, Crow AR, Freedman J, et al. Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: an alternative to IVIG. Blood. 2003;101:3708–3713. doi: 10.1182/blood-2002-10-3078
  • Crow AR, Song S, Semple JW, et al. IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity. Br J Haematol. 2001;115:679–686. doi: 10.1046/j.1365-2141.2001.03136.x
  • Katsman Y, Foo AH, Leontyev D, et al. Improved mouse models for the study of treatment modalities for immune-mediated platelet destruction. Transfusion. 2010;50:1285–1294. doi: 10.1111/j.1537-2995.2009.02558.x
  • Neschadim A, Branch DR. Mouse models of autoimmune diseases: immune thrombocytopenia. Curr Pharm Des. 2015;21:2487–2497. doi: 10.2174/1381612821666150316123436
  • Fried JH, Worth DB, Brice AK, et al. Type, duration, and incidence of pathologic findings after retroorbital bleeding of mice by experienced and novice personnel. J Am Assoc Lab Anim Sci. 2015;54:317–327.
  • McMillan R. Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Semin Hematol. 2000;37:239–248. doi: 10.1016/S0037-1963(00)90102-1
  • Yu J, Heck S, Patel V, et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood. 2008;112:1325–1328. doi: 10.1182/blood-2008-01-135335
  • Sakakura M, Wada H, Tawara I, et al. Reduced CD4+CD25+ T cells in patients with idiopathic thrombocytopenic purpura. Thromb Res. 2007;120:187–193. doi: 10.1016/j.thromres.2006.09.008
  • Nishimoto T, Kuwana M. CD4+CD25+Foxp3+ regulatory T cells in the pathophysiology of immune thrombocytopenia. Semin Hematol. 2013;50(Suppl 1):S43–S49. doi: 10.1053/j.seminhematol.2013.03.018
  • Liu H, Ouyang X, Li Y, et al. Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura. Thromb Res. 2013;132:196–201. doi: 10.1016/j.thromres.2013.04.025
  • Guo C, Chu X, Shi Y, et al. Correction of Th1-dominant cytokine profiles by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura. J Clin Immunol. 2007;27:557-562. doi: 10.1007/s10875-007-9111-1
  • Hu Y, Ma DX, Shan NN, et al. Increased number of Tc17 and correlation with Th17 cells in patients with immune thrombocytopenia. PLoS One. 2011;6:e26522. doi: 10.1371/journal.pone.0026522
  • Chow L, Aslam R, Speck ER, et al. A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. Blood. 2010;115:1247–1253. doi: 10.1182/blood-2009-09-244772
  • Aslam R, Hu Y, Gebremeskel S, et al. Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood. 2012;120:2127–2132. doi: 10.1182/blood-2012-02-413526
  • Bao W, Bussel JB, Heck S, et al. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood. 2010;116:4639–4645. doi: 10.1182/blood-2010-04-281717
  • Arandi N, Mirshafiey A, Jeddi-Tehrani M, et al. Alteration in frequency and function of CD4(+)CD25(+)FOXP3(+) regulatory T cells in patients with immune thrombocytopenic purpura. Iran J Allergy Asthma Immunol. 2014;13:85–92.
  • Liu B, Zhao H, Poon MC, et al. Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura. Eur J Haematol. 2007;78:139–143.
  • Ji L, Zhan Y, Hua F, et al. The ratio of Treg/Th17 cells correlates with the disease activity of primary immune thrombocytopenia. PLoS One. 2012;7:e50909. doi: 10.1371/journal.pone.0050909
  • Assoian RK, Komoriya A, Meyers CA, et al. Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 1983;258:7155–7160.
  • Fortunel NO, Hatzfeld A, Hatzfeld JA. Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis. Blood. 2000;96:2022–2036.
  • Cross D, Cambier JC. Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression. J Immunol. 1990;144:432–439.
  • Travis MA, Sheppard D. TGF-β Activation and Function in Immunity. Annu Rev Immunol. 2014;32:51–82. doi: 10.1146/annurev-immunol-032713-120257
  • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012;30:531–564. doi: 10.1146/annurev.immunol.25.022106.141623
  • Cretney E, Kallies A, Nutt SL. Differentiation and function of Foxp3+ effector regulatory T cells. Trends Immunol. 2013;34:74–80. doi: 10.1016/j.it.2012.11.002
  • Li J, Wang Z, Hu S, et al. Correction of abnormal T cell subsets by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura. Immunol Lett. 2013;154:42–48. doi: 10.1016/j.imlet.2013.08.006

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