Decreased levels of Th17 cells are associated with invasion fungal infections after allogeneic hematopoietic stem cell transplantation

References

• Barnes PD, Marr KA. Risks, diagnosis and outcomes of invasive fungal infections in haematopoietic stem cell transplant recipients. Br J Haematol. 2007;139(4):519–531. doi: 10.1111/j.1365-2141.2007.06812.x
   PubMed Web of Science ®Google Scholar
• Salit RB, Shea YR, Gea-Banacloche J, et al. Death by edible mushroom: first report of Volvariella volvacea as an etiologic agent of invasive disease in a patient following double umbilical cord blood transplantation. J Clin Microbiol. 2010;48(11):4329–4332. doi: 10.1128/JCM.01222-10
   PubMed Web of Science ®Google Scholar
• Mehta RS, Rezvani K. Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection. Virulence. 2016;7(8):901–916. doi: 10.1080/21505594.2016.1208866
   PubMed Web of Science ®Google Scholar
• Beltrame M P, Malvezzi M, Bonfim C, et al. Immune reconstitution in patients with Fanconi anemia after allogeneic bone marrow transplantation. Cytotherapy. 2014;16(7):976–989. doi: 10.1016/j.jcyt.2014.02.015
   PubMed Web of Science ®Google Scholar
• Peggs KS, Mackinnon S. Immune reconstitution following haematopoietic stem cell transplantation. Br J Haematol. 2004;124(4):407–420. doi: 10.1046/j.1365-2141.2003.04767.x
   PubMed Web of Science ®Google Scholar
• Puissant-Lubrano B, Huynh A, Attal M, et al. Evolution of peripheral blood T lymphocyte subsets after allogenic or autologous hematopoietic stem cell transplantation. Immunobiology. 2014;219(8):611–618. doi: 10.1016/j.imbio.2014.03.012
   PubMed Web of Science ®Google Scholar
• Schmitt N, Ueno H. Regulation of human helper T cell subset differentiation by cytokines. Curr Opin Immunol. 2015;34:130–136. doi: 10.1016/j.coi.2015.03.007
   PubMed Web of Science ®Google Scholar
• Szabo SJ, Sullivan BM, Peng SL, et al. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol. 2003;21:713–758. doi: 10.1146/annurev.immunol.21.120601.140942
   PubMed Web of Science ®Google Scholar
• Murphy KM, Reiner SL. Decision making in the immune system: the lineage decisions of helper T cells. Nat Rev Immunol. 2002;2(12):933–944. doi: 10.1038/nri954
   PubMed Web of Science ®Google Scholar
• Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010;140(6):845–858. doi: 10.1016/j.cell.2010.02.021
   PubMed Web of Science ®Google Scholar
• Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057–1061. doi: 10.1126/science.1079490
   PubMed Web of Science ®Google Scholar
• Romani L. Immunity to fungal infections. Nat Rev Immunol. 2011;11(4):275–288. doi: 10.1038/nri2939
   PubMed Web of Science ®Google Scholar
• Romani L, Puccetti P. Protective tolerance to fungi: the role of IL-10 and tryptophan catabolism. Trends Microbiol. 2006;14(4):183–189. doi: 10.1016/j.tim.2006.02.003
   PubMed Web of Science ®Google Scholar
• Ahlgren KM, Moretti S, Lundgren BA, et al. Increased IL-17A secretion in response to Candida albicans in autoimmune polyendocrine syndrome type 1 and its animal model. Eur J Immunol. 2011;41(1):235–245. doi: 10.1002/eji.200939883
   PubMed Web of Science ®Google Scholar
• Wang L, Zhao P, Song L, et al. Correlation of Tc17 cells at early stages after allogeneic hematopoietic stem cell transplantation with acute graft-versus-host disease. Int Immunopharmacol. 2016;41:122–126. doi: 10.1016/j.intimp.2016.11.003
   PubMed Web of Science ®Google Scholar
• Zhao P, Gao D, Wang Q, et al. Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4. Cell Mol Immunol. 2015;12(6):692–699. doi: 10.1038/cmi.2014.108
   PubMed Web of Science ®Google Scholar
• Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100(6):655–669. doi: 10.1016/S0092-8674(00)80702-3
   PubMed Web of Science ®Google Scholar
• Zhu J, Min B, Hu-Li J, et al. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol. 2004;5(11):1157–1165. doi: 10.1038/ni1128
   PubMed Web of Science ®Google Scholar
• Han L, Yang J, Wang X, et al. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells. J Biol Chem. 2014;289(37):25546–25555. doi: 10.1074/jbc.M114.565291
   PubMed Web of Science ®Google Scholar
• Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity. 2009;30(6):899–911. doi: 10.1016/j.immuni.2009.03.019
   PubMed Web of Science ®Google Scholar
• Okamoto T, Okada M, Mori A, et al. Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients. Int J Hematol. 1997;66(3):345–351. doi: 10.1016/S0925-5710(97)00042-X
   PubMed Web of Science ®Google Scholar
• Geiselhart LA, Humphries CA, Gregorio TA, et al. IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation. J Immunol. 2001;166(5):3019–3027. doi: 10.4049/jimmunol.166.5.3019
   PubMed Web of Science ®Google Scholar
• Garcia-Vidal C, Viasus D, Carratala J. Pathogenesis of invasive fungal infections. Curr Opin Infect Dis. 2013;26(3):270–276. doi: 10.1097/QCO.0b013e32835fb920
   PubMed Web of Science ®Google Scholar
• Zhu J, Paul WE. Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev. 2010;238(1):247–262. doi: 10.1111/j.1600-065X.2010.00951.x
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang F, Tompkins KC, et al. Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99. Am J Pathol. 2009;175(6):2489–2500. doi: 10.2353/ajpath.2009.090530
   PubMed Web of Science ®Google Scholar
• Muller U, Stenzel W, Kohler G, et al. IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol. 2007;179(8):5367–5377. doi: 10.4049/jimmunol.179.8.5367
   PubMed Web of Science ®Google Scholar
• Ferreira MC, de Oliveira RT, da Silva RM, et al. Involvement of regulatory T cells in the immunosuppression characteristic of patients with paracoccidioidomycosis. Infect Immun. 2010;78(10):4392–4401. doi: 10.1128/IAI.00487-10
   PubMed Web of Science ®Google Scholar
• Sainz T, Serrano-Villar S, Diaz L, et al. The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults. AIDS. 2013;27(9):1513–1516. doi: 10.1097/QAD.0b013e32835faa72
   PubMed Web of Science ®Google Scholar
• Leung V, Gillis J, Raboud J, et al. Predictors of CD4:CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy. PLoS ONE. 2013;8(10):e77665. doi: 10.1371/journal.pone.0077665
   PubMed Web of Science ®Google Scholar