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Stress
The International Journal on the Biology of Stress
Volume 19, 2016 - Issue 4: Smolenice Symposium
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Review Article

Stress, catecholaminergic system and cancer

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Pages 419-428 | Received 07 Dec 2015, Accepted 28 May 2016, Published online: 11 Jul 2016

References

  • Abdin AA, Soliman NA, Saied EM. (2014). Effect of propranolol on IL-10, visfatin, Hsp70, iNOS, TLR2, and survivin in amelioration of tumor progression and survival in solid ehrlich carcinoma-bearing mice. Pharmacol Rep 66:1114–21.
  • Akbar S, Alsharidah MS. (2014). Are beta blockers new potential anticancer agents? Asian Pac J Cancer Prev 15:9567–74.
  • Albinana V, Villar Gomez de Las Heras K, Serrano-Heras G, Segura T, Perona-Moratalla AB, Mota-Perez M, de Campos JM, Botrella LM. (2015). Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients. Orphanet J Rare Dis 10:118.
  • Altemus M. (2006). Sex differences in depression and anxiety disorders: potential biological determinants. Horm Behav 50:534–8.
  • Al-Wadei HA, Al-Wadei MH, Schuller HM. (2009). Prevention of pancreatic cancer by the beta-blocker propranolol. Anticancer Drugs 20:477–82.
  • Al-Wadei HA, Al-Wadei MH, Ullah MF, Schuller HM. (2012). Gamma-amino butyric acid inhibits the nicotine-imposed stimulatory challenge in xenograft models of non-small cell lung carcinoma. Curr Cancer Drug Targets 12:97–106.
  • Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, Stefanek M, Sood AK. (2006). The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 6:240–8.
  • Arias-Stella J, Valcarcel J. (1973). The human carotid body at high altitudes. Pathol Microbiol (Basel) 39:292–7.
  • Baker JG, Hill SJ, Summers RJ. (2011). Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends Pharmacol Sci 32:227–34.
  • Barbieri A, Bimonte S, Palma G, Luciano A, Rea D, Giudice A, Scognamiglio G, et al. (2015). The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo. Int J Oncol 47:527–34.
  • Bavadekar S, Budajaja F, Patel K, Vansal S. (2013). Epinephrine stimulates secretion of VEGF by human prostate cancer cells, LNCaP, through a beta2-adrenergic receptor-mediated pathway. FASEB J 27:1105–11.
  • Borcherding DC, Tong W, Hugo ER, Barnard DF, Fox S, LaSance K, Shaughnessy E, Ben-Jonathan N. (2016). Expression and therapeutic targeting of dopamine receptor-1 (D1R) in breast cancer. Oncogene 35:3103–13.
  • Chakroborty D, Sarkar C, Basu B, Dasgupta PS, Basu S. (2009). Catecholamines regulate tumor angiogenesis. Cancer Res 69:3727–30.
  • Chang A, Yeung S, Thakkar A, Huang KM, Liu MM, Kanassatega RS, Parsa C, et al. (2015a). Prevention of skin carcinogenesis by the beta-blocker carvedilol. Cancer Prev Res (Phila) 8:27–36.
  • Chang PY, Huang WY, Lin CL, Huang TC, Wu YY, Chen JH, Kao CH. (2015b). Propranolol reduces cancer risk a population-based cohort study. Medicine (Baltimore) 94:e1097.
  • Chen-Izu Y, Xiao RP, Izu LT, Cheng H, Kuschel M, Spurgeon H, Lakatta EG. (2000). G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels. Biophys J 79:2547–56.
  • Chida Y, Hamer M, Wardle J, Steptoe A. (2008). Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol 5:466–75.
  • Chiesa IJ, Castillo LF, Luthy IA. (2008). Contribution of alpha2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells. J Steroid Biochem Mol Biol 110:170–5.
  • Chin CC, Li JM, Lee KF, Huang YC, Wang KC, Lai HC, Cheng CC, et al. (2016). Selective β2-AR blockage suppresses colorectal cancer growth through regulation of EGFR-Akt/ERK1/2 signaling, G1-phase arrest, and apoptosis. J Cell Physiol 231:459–72.
  • Chiu YE, Drolet BA, Blei F, Carcao M, Fangusaro J, Kelly ME, Krol A, et al. (2012). Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon. Pediatr Blood Cancer 59:934–8.
  • Choi MJ, Cho KH, Lee S, Bae YJ, Jeong KJ, Rha SY, Choi EJ, et al. (2015). hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. Oncogene 34:3402–12.
  • Coelho M, Moz M, Correia G, Teixeira A, Medeiros R, Ribeiro L. (2015). Antiproliferative effects of β-blockers on human colorectal cancer cells. Oncol Rep 33:2513–20.
  • Daly CJ, McGrath JC. (2011). Previously unsuspected widespread cellular and tissue distribution of β-adrenoceptors and its relevance to drug action. Trends Pharmacol Sci 32:219–26.
  • Deng GH, Liu J, Zhang J, Wang Y, Peng XC, Wei YQ, Jiang Y. (2014). Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model. J Exp Clin Cancer Res 33:21.
  • Eng JW, Kokolus KM, Reed CB, Hylander BL, Ma WW, Repasky EA. (2014). A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response. Cancer Immunol Immunother 63:1115–28.
  • Erguven M, Yazihan N, Aktas E, Sabanci A, Li CJ, Oktem G, Bilir A. (2010). Carvedilol in glioma treatment alone and with imatinib in vitro. Int J Oncol 36:857–66.
  • Fajardo G, Zhao M, Powers J, Bernstein D. (2006). Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy. J Mol Cell Cardiol 40:375–83.
  • Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D. (2011). β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways. J Mol Cell Cardiol 51:781–9.
  • Fitzgerald PJ. (2012). Beta blockers, norepinephrine, and cancer: an epidemiological viewpoint. Clin Epidemiol 4:151–6.
  • Fuchs R, Schwach G, Stracke A, Meier-Allard N, Absenger M, Ingolic E, Haas HS, et al. (2015). The anti-hypertensive drug prazosin induces apoptosis in the medullary thyroid carcinoma cell line TT. Anticancer Res 35:31–8.
  • Fukuhara K, Kvetnansky R, Weise VK, Ohara H, Yoneda R, Goldstein DS, Kopin IJ. (1996). Effects of continuous and intermittent cold (SART) stress on sympathoadrenal system activity in rats. J Neuroendocrinol 8:65–72.
  • Furtado M, Katzman MA. (2015). Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders. Psychiatry Res 229:37–48.
  • Gao G, Sun J, Gao J, Xiong L, Yu L, Gao Y. (2013). Chronic stress promoted the growth of ovarian carcinoma via increasing serum levels of norepinephrine and interleukin-10 and altering nm23 and NDRG1 expression in tumor tissues in nude mice. Biosci Trends 7:56–63.
  • Gerra G, Zaimovic A, Mascetti GG, Gardini S, Zambelli U, Timpano M, Raggi MA, Brambilla F. (2001). Neuroendocrine responses to experimentally-induced psychological stress in healthy humans. Psychoneuroendocrinology 26:91–107.
  • Goldstein DS, Kopin IJ. (2008). Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: a meta-analysis. Endocr Regul 42:111–19.
  • Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, et al. (2011). Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression. Bioorg Med Chem Lett 21:2113–15.
  • Guan XM, Amend A, Strader CD. (1995). Determination of structural domains for G protein coupling and ligand binding in beta 3-adrenergic receptor. Mol Pharmacol 48:492–8.
  • Hering D, Lachowska K, Schlaich M. (2015). Role of the sympathetic nervous system in stress-mediated cardiovascular disease. Curr Hypertens Rep 17:80.
  • Hieble JP, Bondinell WE, Ruffolo RR Jr. (1995). Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem 38:3415–44.
  • Hudecova S, Sedlakova B, Kvetnansky R, Ondrias K, Krizanova O. (2010). Modulation of the sodium-calcium exchanger in the rat kidney by different sequential stressors. Stress 13:15–21.
  • Jansen L, Hoffmeister M, Arndt V, Chang-Claude J, Brenner H. (2014). Stage-specific associations between beta blocker use and prognosis after colorectal cancer. Cancer 120:1178–86.
  • Ji Y, Chen S, Xu C, Li L, Xiang B. (2015). The use of propranolol in the treatment of infantile haemangiomas: an update on potential mechanisms of action. Br J Dermatol 172:24–32.
  • Jochmanová I, Yang C, Zhuang Z, Pacak K. (2013). Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction. J Natl Cancer Inst 105:1270–83.
  • Jochmanová I, Zhuang Z, Pacak K. (2015). Pheochromocytoma: gasping for air. Horm Cancer 6:191–205.
  • Kaapu KJ, Ahti J, Tammela TL, Auvinen A, Murtola TJ. (2015). Sotalol, but not digoxin is associated with decreased prostate cancer risk: a population-based case-control study. Int J Cancer 137:1187–95.
  • Kang F, Ma W, Ma X, Shao Y, Yang W, Chen X, Li L, Wang J. (2014). Propranolol inhibits glucose metabolism and F-18-FDG uptake of breast cancer through posttranscriptional downregulation of hexokinase-2. J Nucl Med 55:439–45.
  • Khalili A, Hassan ZM, Shahabi S, Pourfathollah AA, Ostad SN, Noori S, Mahdavi M, et al. (2013). Long acting propranolol and HSP-70 rich tumor lysate reduce tumor growth and enhance immune response against fibrosarcoma in Balb/c mice. Iran J Immunol 10:70–82.
  • Kim YS, Kang SH, Song KY, Cho ML, Her YM, Huh JW, Lee J. (2013). The immunomodulatory role of esmolol in patients undergoing laparoscopic gastrectomy due to gastric cancer. Anaesthesia 68:924–30.
  • Kozanoglu I, Yandim MK, Cincin ZB, Ozdogu H, Cakmakoglu B, Baran Y. (2013). New indication for therapeutic potential of an old well-known drug (propranolol) for multiple myeloma. J Cancer Res Clin Oncol 139:327–35.
  • Krizanova O, Holotnakova T, Jurkovicova D, Polakova E, Zahradnikova A, Lacinova L, Kvetnansky R, et al. (2008). Type 1 and 2 IP3 receptors respond differently to catecholamines and stress. Ann N Y Acad Sci 1148:331–7.
  • Kvetnansky R, Mikulaj L. (1970). Adrenal and urinary catecholamines in rats during adaptation to repeated immobilization stress. Endocrinology 87:738–43.
  • Lamkin DM, Sloan EK, Patel AJ, Chiang BS, Pimentel MA, Ma JC, Arevalo JM, et al. (2012). Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling. Brain Behav Immun 26:635–41.
  • Lamkin DM, Sung HY, Yang GS, David JM, Ma JC, Cole SW, Sloan EK. (2015). α2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression. Psychoneuroendocrinology 51:262–70.
  • Lamy S, Lachambre MP, Lord-Dufour S, Béliveau R. (2010). Propranolol suppresses angiogenesis in vitro: inhibition of proliferation, migration, and differentiation of endothelial cells. Vasc Pharmacol 53:200–8.
  • Laukova M, Tillinger A, Novakova M, Krizanova O, Kvetnansky R, Myslivecek J. (2014). Repeated immobilization stress increases expression of β3 -adrenoceptor in the left ventricle and atrium of the rat heart. Stress Health 30:301–9.
  • Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Endocrine Society, et al. (2014). Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99:1915–42.
  • Lenders JW, Eisenhofer G, Mannelli M, Pacak K. (2005). Phaeochromocytoma. Lancet 366:665–75.
  • Li P, Guo Z, Gao Y, Pan W. (2015). Propranolol represses infantile hemangioma cell growth through the beta 2-adrenergic receptor in a HIF-1 alpha-dependent manner. Oncol Rep 33:3099–107.
  • Li S, Sun Y, Gao D. (2013). Role of the nervous system in cancer metastasis. Oncol Lett 5:1101–11.
  • Liao X, Che X, Zhao W, Zhang D, Bi T, Wang G. (2010a). The β-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor κB signaling. Oncol Rep 24:1669–76.
  • Liao X, Che X, Zhao W, Zhang D, Long H, Chaudhary P, Li H. (2010b). Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro. Radiat Oncol 5:98.
  • Lin CS, Lin WS, Lin CL, Kao CH. (2015). Carvedilol use is associated with reduced cancer risk: a nationwide population-based cohort study. Int J Cardiol 184:9–13.
  • Liu X, Wu WK, Yu L, Sung JJ, Srivastava G, Zhang ST, Cho CH. (2008). Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway. J Cell Biochem 105:53–60.
  • Lu YJ, Geng ZJ, Sun XY, Li YH, Fu XB, Zhao XY, Wei B. (2015). Isoprenaline induces epithelial-mesenchymal transition in gastric cancer cells. Mol Cell Biochem 408:1–13.
  • Lutgendorf SK, De Geest K, Bender D, Ahmed A, Goodheart MJ, Dahmoush L, Zimmerman MB, et al. (2012). Social influences on clinical outcomes of patients with ovarian cancer. J Clin Oncol 30:2885–90.
  • Lutgendorf SK, Johnsen EL, Cooper B, Anderson B, Sorosky JI, Buller RE, Sood AK. (2002). Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 95:808–15.
  • Martucci VL, Pacak K. (2014). Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment. Curr Probl Cancer 38:7–41.
  • McCarty MF. (2014). A role for cAMP-driven transactivation of EGFR in cancer aggressiveness – therapeutic implications. Med Hypotheses 83:142–7.
  • Micheli A, Ciampichini R, Oberaigner W, Ciccolallo L, de Vries E, Izarzugaza I, Zambon P, et al. (2009). The advantage of women in cancer survival: an analysis of EUROCARE-4 data. Eur J Cancer 45:1017–27.
  • Moreno-Smith M, Lee SJ, Lu C, Nagaraja AS, He G, Rupaimoole R, Han HD, et al. (2013). Biologic effects of dopamine on tumor vasculature in ovarian carcinoma. Neoplasia 15:502–10.
  • Moreno-Smith M, Lu C, Shahzad MM, Pena GN, Allen JK, Stone RL, Mangala LS, et al. (2011). Dopamine blocks stress-mediated ovarian carcinoma growth. Clin Cancer Res 17:3649–59.
  • Moretti S, Massi D, Farini V, Baroni G, Parri M, Innocenti S, Cecchi R, Chiarugi P. (2013). β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines. Lab Invest 93:279–90.
  • Nagaraja AS, Dorniak PL, Sadaoui NC, Kang Y, Lin T, Armaiz-Pena G, Wu SY, et al. (2016). Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. Oncogene. 35:2390–7.
  • Nkontchou G, Aout M, Mahmoudi A, Roulot D, Bourcier V, Grando-Lemaire V, Ganne-Carrie N, et al. (2012). Effect of long-term propranolol treatment on hepatocellular carcinoma incidence in patients with HCV-associated cirrhosis. Cancer Prev Res (Phila) 5:1007–14.
  • Noda H, Miyaji Y, Nakanishi A, Konishi F, Miki Y. (2007). Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers. Br J Cancer 96:383–90.
  • Nosrati A, Wei ML. (2014). Sex disparities in melanoma outcomes: the role of biology. Arch Biochem Biophys 563:42–50.
  • Obeid EI, Conzen SD. (2013). The role of adrenergic signaling in breast cancer biology. Cancer Biomark 13:161–9.
  • Pacak K, Palkovits M. (2001). Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocr Rev 22:502–48.
  • Pacak K. (2011). Phaeochromocytoma: a catecholamine and oxidative stress disorder. Endocr Regul 45:65–90.
  • Palm D, Lang K, Niggemann B, Drell TL 4th, Masur K, Zaenker KS, Entschladen F. (2006). The norepinephrine driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 118:2744–9.
  • Pan W, Li P, Guo ZT, Huang Q, Gao Y. (2015). Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. Pediatr Blood Cancer 62:1414–20.
  • Papadopoulou A, Siamatras T, Delgado-Morales R, Amin ND, Shukla V, Zheng YL, Pant HC, et al. (2015). Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression. Transl Psychiatry 5:e578.
  • Pérez-Sayáns M, Somoza-Martín JM, Barros-Angueira F, Gayoso-Diz P, Otero-Rey EM, Gándra-Rey JM, García-García A. (2012). Activity of β2-adrenergic receptor in oral squamous cell carcinoma is mediated by overexpression of the ADRBK2 gene: a pilot study. Biotech Histochem 87:179–86.
  • Persengiev SP, Green MR. (2003). The role of ATF/CREB family members in cell growth, survival and apoptosis. Apoptosis 8:225–8.
  • Philipp M, Brede M, Hein L. (2002). Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol – Regul Integr Comp Physiol 283:287–95.
  • Porcel Chacon R, del Boz Gonzalez J, Navarro Morón J. (2015). Delayed-onset of multiple cutaneous infantile hemangiomas due to propranolol: a case report. Pediatrics 135:1064–6.
  • Powe DG, Voss MJ, Habashy HO, Zänker KS, Green AR, Ellis IO, Entschladen F. (2011). Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast Cancer Res Treat 130:457–63.
  • Ragan AR, Lesniak A, Bochynska-Czyz M, Kosson A, Szymanska H, Pysniak K, Gajewska M, et al. (2013). Chronic mild stress facilitates melanoma tumor growth in mouse lines selected for high and low stress-induced analgesia. Stress 16:571–80.
  • Sardi I, Giunti L, Bresci C, Buccoliero AM, Degl'innocenti D, Cardellicchio S, Baroni G, et al. (2013). Expression of β-adrenergic receptors in pediatric malignant brain tumors. Oncol Lett 5:221–5.
  • Sastry KS, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, et al. (2007). Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem 282:14094–100.
  • Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, et al. (2013). Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol 9:271–6.
  • Schoder H, Silverman DH, Campisi R, Sayre JW, Phelps ME, Schelbert HR, Czernin J. (2000). Regulation of myocardial blood flow response to mental stress in healthy individuals. Am J Physiol – Heart Circ Physiol 278:360–6.
  • Schuller HM, Plummer HK 3rd, Bochsler PN, Dudric P, Bell JL, Harris RE. (2001). Co-expression of beta-adrenergic receptors and cyclooxygenase-2 in pulmonary adenocarcinoma. Int J Oncol 19:445–9.
  • Schuller HM, Al-Wadei HA, Ullah MF, Plummer HK 3rd. (2012). Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. Carcinogenesis 33:191–6.
  • Selye H. (1985). The nature of stress. Basal Facts 7:3–11.
  • Seyedi S, Andalib A, Rezaei A, Hosseini SM, Mohebbi SR, Zali MR, Vafai M, et al. (2012). The effects of isoproterenol and propranolol on cytokine profile secretion by cultured tumor-infiltrating lymphocytes derived from colorectal cancer patients. Cell J 13:281–93.
  • Shang ZJ, Liu K, Liang de F. (2009). Expression of beta2-adrenergic receptor in oral squamous cell carcinoma. J Oral Pathol Med 38:371–6.
  • Strange KS, Kerr LR, Andrews HN, Emerman JT, Weinberg J. (2000). Psychosocial stressors and mammary tumor growth: an animal model. Neurotoxicol Teratol 22:89–102.
  • Sun Y, Wang Y, Zhang L, Xu C, Liu Y, Kang S, Yan C, et al. (2014). Prevention of cardiac events caused by surgical stress in aged rats: simultaneously activating β2-adrenoceptor and inhibiting β1-adrenoceptor. Stress 17:373–81.
  • Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, Jennings NB, et al. (2006). Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12:939–44.
  • Tu JB, Ma RZ, Dong Q, Jiang F, Hu XY, Li QY, Pattar P, Zhang H. (2013). Induction of apoptosis in infantile hemangioma endothelial cells by propranolol. Exp Ther Med 6:574–8.
  • Vazquez SM, Mladovan AG, Perez C, Bruzzone A, Baldi A, Luthy IA. (2006). Human breast cell lines exhibit functional alpha2-adrenoceptors. Cancer Chemother Pharmacol 58:50–61.
  • Wolter JK, Wolter NE, Blanch A, Partridge T, Cheng L, Morgenstern DA, Podkowa M, et al. (2014). Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. Oncotarget 5:161–72.
  • Wolter NE, Wolter JK, Enepekides DJ, Irwin MS. (2012). Propranolol as a novel adjunctive treatment for head and neck squamous cell carcinoma. J Otolaryngol Head Neck Surg 41:334–44.
  • Xie H, Li C, He Y, Griffin R, Ye Q, Li L. (2015). Chronic stress promotes oral cancer growth and angiogenesis with increased circulating catecholamine and glucocorticoid levels in a mouse model. Oral Oncol 51:991–7.
  • Xie W, Xie H, Liu F, Li W, Dan J, Mei Y, Dan L, et al. (2013). Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147. Br J Dermatol 168:739–48.
  • Xu T, Xiao X, Zheng S, Zheng J, Zhu H, Ji Y, Yang S. (2013). Antiangiogenic effect of propranolol on the growth of the neuroblastoma xenografts in nude mice. J Pediatr Surg 48:2460–5.
  • Yan L, Vatner SF, Vatner DE. (2014). Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade. Am J Physiol Heart Circ Physiol 307:1521–8.
  • Yang EV, Sood AK, Chen M, Li Y, Eubank TD, Marsh CB, Jewell S, et al. (2006). Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 66:10357–64.
  • Yee EM, Pasquier E, Iskander G, Wood K, Black DS, Kuman N. (2013). Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. Bioorg Med Chem 21:1652–60.
  • Zhang D, Ma Q, Shen S, Hu H. (2009). Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist's anticancer effect in pancreatic cancer cell. Pancreas 38:94–100.
  • Ziolkowski N, Grover AK. (2010). Functional linkage as a direction for studies in oxidative stress: alpha-adrenergic receptors. Can J Physiol Pharmacol 88:220–32.

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