Central noradrenaline transporter availability is linked with HPA axis responsiveness and copeptin in human obesity and non-obese controls

References

• Abraham, S.B. , Rubino, D. , Sinaii, N. , Ramsey, S. , & Nieman, L.K . (2013). Cortisol, obesity, and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature. Obesity (Silver Spring, Md.), 21, E105–E117. doi:10.1002/oby.20083
   PubMed Web of Science ®Google Scholar
• Aguilera, G . (2011). Regulation of the hypothalamic-pituitary-adrenal axis by neuropeptides. Hormone Molecular Biology and Clinical Investigation, 7, 327–336. doi:10.1515/HMBCI.2011.123
   PubMedGoogle Scholar
• Aihara, M. , Ida, I. , Yuuki, N. , Oshima, A. , Kumano, H. , Takahashi, K. , … Mikuni, M . (2007). HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions. Psychiatry Research, 155, 245–256. doi:10.1016/j.pscychresns.2006.11.002
   PubMed Web of Science ®Google Scholar
• Arnsten, A.F.T . (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience, 10, 410–422. doi:10.1038/nrn2648
   PubMed Web of Science ®Google Scholar
• Astrup, A. , Madsbad, S. , Breum, L. , Jensen, T.J. , Kroustrup, J.P. , & Larsen, T.M . (2008). Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: A randomised, double-blind, placebo-controlled trial. The Lancet, 372, 1906–1913. doi:10.1016/S0140-6736(08)61525-1
   PubMed Web of Science ®Google Scholar
• Bailey, M.A . (2017). 11β-Hydroxysteroid dehydrogenases and hypertension in the metabolic syndrome. Current Hypertension Reports, 19, 100. doi:10.1007/s11906-017-0797-z
   PubMed Web of Science ®Google Scholar
• Bains, J.S. , Wamsteeker Cusulin, J.I. , & Inoue, W . (2015). Stress-related synaptic plasticity in the hypothalamus. Nature Reviews Neuroscience, 16, 377–388. doi:10.1038/nrn3881
   PubMed Web of Science ®Google Scholar
• Bangasser, D.A. , Reyes, B.A.S. , Piel, D. , Garachh, V. , Zhang, X.-Y. , Plona, Z.M. , … Valentino, R.J . (2013). Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression. Molecular Psychiatry, 18, 166–173. doi:10.1038/mp.2012.24
   PubMed Web of Science ®Google Scholar
• Bjorntorp, P. , & Rosmond, R . (2000). Obesity and cortisol. Nutrition (Burbank, Los Angeles County, Calif.), 16, 924–936. doi:10.1016/S0899-9007(00)00422-6
   PubMed Web of Science ®Google Scholar
• Boundy, V.A. , & Cincotta, A.H . (2000). Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 279, R505–R514. doi:10.1152/ajpregu.2000.279.2.R505
   PubMed Web of Science ®Google Scholar
• Cooper, M.S. , & Stewart, P.M . (2009). 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation. The Journal of Clinical Endocrinology and Metabolism, 94, 4645–4654. doi:10.1210/jc.2009-1412
   PubMed Web of Science ®Google Scholar
• Derogatis, L.R. , Lipman, R.S. , & Covi, L . (1973). SCL-90: An outpatient psychiatric rating scale–preliminary report. Psychopharmacology Bulletin, 9, 13–28.
   PubMedGoogle Scholar
• Enhörning, S. , Struck, J. , Wirfält, E. , Hedblad, B. , Morgenthaler, N.G. , & Melander, O . (2011). Plasma copeptin, a unifying factor behind the metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism, 96, E1065. doi:10.1210/jc.2010-2981
   PubMed Web of Science ®Google Scholar
• Epel, E. , Lapidus, R. , McEwen, B. , & Brownell, K . (2001). Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology, 26, 37–49. doi:10.1016/S0306-4530(00)00035-4
   PubMed Web of Science ®Google Scholar
• Farr, O.M. , Li, C-sR. , & Mantzoros, C.S . (2016). Central nervous system regulation of eating: Insights from human brain imaging. Metabolism: Clinical and Experimental, 65, 699–713. doi:10.1016/j.metabol.2016.02.002
   PubMed Web of Science ®Google Scholar
• Feldman, S. , & Weidenfeld, J . (2004). Involvement of endogeneous glutamate in the stimulatory effect of norepinephrine and serotonin on the hypothalamo-pituitary-adrenocortical axis. Neuroendocrinology, 79, 43–53. doi:10.1159/000076044
   PubMed Web of Science ®Google Scholar
• Hautzinger, M . (1991). The Beck Depression Inventory in clinical practice. Nervenarzt, 62, 689–696.
   PubMed Web of Science ®Google Scholar
• Hesse, S. , Becker, G.-A. , Rullmann, M. , Bresch, A. , Luthardt, J. , Hankir, M.K. , … Sabri, O . (2017). Central noradrenaline transporter availability in highly obese, non-depressed individuals. European Journal of Nuclear Medicine and Molecular Imaging, 44, 1056–1064. doi:10.1007/s00259-016-3590-3
   Web of Science ®Google Scholar
• Heuser, I. , Yassouridis, A. , & Holsboer, F . (1994). The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders. Journal of Psychiatric Research, 28, 341–356. doi:10.1016/0022-3956(94)90017-5
   PubMed Web of Science ®Google Scholar
• Hilbert, A. , & Tuschen-Caffier, B . (2006). Eating disorder examination: Deutschsprachige Übersetzung. Münster: Verlag für Psychotherapie Retrieved from http://www.vfp-muenster.de/publikationen/online.html
   Google Scholar
• Incollingo, R.A.C. , Epel, E.S. , White, M.L. , Standen, E.C. , Seckl, J.R. , & Tomiyama, A.J . (2015). Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: A systematic review. Psychoneuroendocrinology, 62, 301–318. doi:10.1016/j.psyneuen.2015.08.014
   PubMed Web of Science ®Google Scholar
• Katan, M. , Fluri, F. , Morgenthaler, N.G. , Schuetz, P. , Zweifel, C. , Bingisser, R. , … Christ-Crain, M . (2009). Copeptin: A novel, independent prognostic marker in patients with ischemic stroke. Annals of Neurology, 66, 799–808. doi:10.1002/ana.21783
   PubMed Web of Science ®Google Scholar
• Keck, M.E. , Wigger, A. , Welt, T. , Muller, M.B. , Gesing, A. , Reul, J.M.H.M. , … Neumann, I.D . (2002). Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: Implications for pathogenesis of affective disorders. Neuropsychopharmacology, 26, 94–105. doi:10.1016/S0893-133X(01)00351-7
   PubMed Web of Science ®Google Scholar
• Künzel, H.E. , Binder, E.B. , Nickel, T. , Ising, M. , Fuchs, B. , Majer, M. , … Modell, S . (2003). Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test. Neuropsychopharmacology, 28, 2169–2178. doi:10.1038/sj.npp.1300280
   PubMed Web of Science ®Google Scholar
• Lee, C.M. , Javitch, J.A. , & Snyder, S.H . (1983). Recognition sites for norepinephrine uptake: Regulation by neurotransmitter. Science (New York, N.Y.), 220, 626–629. doi:10.1126/science.6301013
   PubMed Web of Science ®Google Scholar
• Li, C-sR. , Potenza, M.N. , Lee, D.E. , Planeta, B. , Gallezot, J.-D. , Labaree, D. , … Neumeister, A . (2014). Decreased norepinephrine transporter availability in obesity: Positron emission tomography imaging with (S,S)-(11)CO-methylreboxetine. NeuroImage, 86, 306–310. doi:10.1016/j.neuroimage.2013.10.004
   PubMed Web of Science ®Google Scholar
• Liu, J.P. , Clarke, I.J. , Funder, J.W. , & Engler, D . (1994). Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. Journal of Clinical Investigation , 93, 1439–1450. doi:10.1172/JCI117121
   PubMed Web of Science ®Google Scholar
• Mandela, P. , & Ordway, G.A . (2006). The norepinephrine transporter and its regulation. Journal of Neurochemistry, 97, 310–333. Retrieved from http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2006.03717.x/full
   PubMed Web of Science ®Google Scholar
• Melasch, J. , Rullmann, M. , Hilbert, A. , Luthardt, J. , Becker, G.A. , Patt, M. , … Pleger, B . (2016). The central nervous norepinephrine network links a diminished sense of emotional well-being to an increased body weight. International Journal of Obesity ( Obesity), 40, 779–787. doi:10.1038/ijo.2015.216
   PubMed Web of Science ®Google Scholar
• Moriguchi, S. , Yamada, M. , Takano, H. , Nagashima, T. , Takahata, K. , Yokokawa, K. , … Suhara, T . (2017). Norepinephrine transporter in major depressive disorder: A PET study. American Journal of Psychiatry, 174, 36–41. doi:10.1176/appi.ajp.2016.15101334
   PubMed Web of Science ®Google Scholar
• Myers, B. , Scheimann, J.R. , Franco-Villanueva, A. , & Herman, J.P . (2017). Ascending mechanisms of stress integration: Implications for brainstem regulation of neuroendocrine and behavioral stress responses. Neuroscience and Biobehavioral Reviews, 74, 366–375. doi:10.1016/j.neubiorev.2016.05.011
   PubMed Web of Science ®Google Scholar
• Nelson, D.L. , & Gehlert, D.R. Gehlert (2006). Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine, 29, 49–60. doi:10.1385/ENDO:29:1:49
   PubMed Web of Science ®Google Scholar
• Paeger, L. , Karakasilioti, I. , Altmüller, J. , Frommolt, P. , Brüning, J. , & Kloppenburg, P . (2017). Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. eLife, 6, pii: e25770. doi:10.7554/eLife.25770
   Web of Science ®Google Scholar
• Pasquali, R. , Vicennati, V. , Cacciari, M. , & Pagotto, U . (2006). The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome. Annals of the New York Academy of Sciences, 1083, 111–128. doi:10.1196/annals.1367.009
   PubMed Web of Science ®Google Scholar
• Plotsky, P.M. , Cunningham, E.T., JR. , & Widmaier, E.P . (1989). Catecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion. Endocrine Reviews, 10, 437–458. doi:10.1210/edrv-10-4-437
   PubMed Web of Science ®Google Scholar
• Radant, A. , Peskind, E.R. , Wilkinson, C.W. , Veith, R.C. , Dorsa, D.M. , Leake, R.D. , … Raskind, M.A . (1992). Neurohypophyseal and pituitary-adrenocortical responses to the alpha 1 agonist methoxamine in humans. Neuroendocrinology, 55, 361–366. doi:10.1159/000126145
   PubMed Web of Science ®Google Scholar
• Robertson, S.D. , Matthies, H.J.G. , Owens, W.A. , Sathananthan, V. , Christianson, N.S.B. , Kennedy, J.P. , … Galli, A . (2010). Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30, 11305–11316. doi:10.1523/JNEUROSCI.0126-10.2010
   PubMed Web of Science ®Google Scholar
• Rosmond, R. , & Bjorntorp, P . (2000). The hypothalamic-pituitary-adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke. Journal of Internal Medicine, 247, 188–197. doi:10.1046/j.1365-2796.2000.00603.x
   PubMed Web of Science ®Google Scholar
• Rothermel, J. , Kulle, A. , Holterhus, P.-M. , Toschke, C. , Lass, N. , & Reinehr, T . (2016). Copeptin in obese children and adolescents: Relationships to body mass index, cortisol and gender. Clinical Endocrinology, 85, 868–873. doi:10.1111/cen.13235
   PubMed Web of Science ®Google Scholar
• Saleem, U. , Khaleghi, M. , Morgenthaler, N.G. , Bergmann, A. , Struck, J. , Mosley, T.H. , & Kullo, I.J . (2009). Plasma carboxy-terminal provasopressin (copeptin): A novel marker of insulin resistance and metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism, 94, 2558–2564. doi:10.1210/jc.2008-2278
   PubMed Web of Science ®Google Scholar
• Schinke, C. , Hesse, S. , Stoppe, M. , Meyer, K. , Schmidt, E. , Orthgiess, J. , … Then Bergh, F . (2017). Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity. Psychoneuroendocrinology, 78, 39–47. doi:10.1016/j.psyneuen.2017.01.004
   PubMed Web of Science ®Google Scholar
• Schule, C . (2007). Neuroendocrinological mechanisms of actions of antidepressant drugs. Journal of Neuroendocrinology, 19, 213–226. doi:10.1111/j.1365-2826.2006.01516.x
   PubMed Web of Science ®Google Scholar
• Schule, C. , Baghai, T.C. , Eser, D. , Zwanzger, P. , Jordan, M. , Buechs, R. , & Rupprecht, R . (2006). Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients. Psychopharmacology, 186, 601–611. doi:10.1007/s00213-006-0382-7
   PubMed Web of Science ®Google Scholar
• Simmler, L.D. , Hysek, C.M. , & Liechti, M.E . (2011). Sex differences in the effects of MDMA (ecstasy) on plasma copeptin in healthy subjects. The Journal of Clinical Endocrinology and Metabolism, 96, 2844–2850. doi:10.1210/jc.2011-1143
   PubMed Web of Science ®Google Scholar
• Sivukhina, E.V. , & Jirikowski, G.F . (2016). Magnocellular hypothalamic system and its interaction with the hypothalamo-pituitary-adrenal axis. Steroids, 111, 21–28. doi:10.1016/j.steroids.2016.01.008
   PubMed Web of Science ®Google Scholar
• Spanakis, E.K. , Wand, G.S. , Ji, N. , & Golden, S.H . (2016). Association of HPA axis hormones with copeptin after psychological stress differs by sex. Psychoneuroendocrinology, 63, 254–261. doi:10.1016/j.psyneuen.2015.10.009
   PubMed Web of Science ®Google Scholar
• Spencer, S.J. , & Tilbrook, A . (2011). The glucocorticoid contribution to obesity. Stress (Amsterdam, Netherlands), 14, 233–246. doi:10.3109/10253890.2010.534831
   PubMed Web of Science ®Google Scholar
• Then Bergh, F. , Kumpfel, T. , Trenkwalder, C. , Rupprecht, R. , & Holsboer, F . (1999). Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS. Neurology, 53, 772–777. doi:10.1212/WNL.53.4.772
   PubMed Web of Science ®Google Scholar
• Torres, G.E. , Gainetdinov, R.R. , & Caron, M.G . (2003). Plasma membrane monoamine transporters: structure, regulation and function. Nature Reviews Neuroscience, 4, 13–25. doi:10.1038/nrn1008
   PubMed Web of Science ®Google Scholar
• Ulrich-Lai, Y.M. , & Herman, J.P . (2009). Neural regulation of endocrine and autonomic stress responses. Nature Reviews Neuroscience, 10, 397–409. doi:10.1038/nrn2647
   PubMed Web of Science ®Google Scholar
• van der Valk, E.S. , Savas, M. , & van Rossum, E.F.C . (2018). Stress and obesity: Are there more susceptible individuals? Current Obesity Reports, 7, 193–203. doi:10.1007/s13679-018-0306-y
   PubMed Web of Science ®Google Scholar
• Zhou, J . (2004). Norepinephrine transporter inhibitors and their therapeutic potential. Drugs of the Future, 29, 1235–1244. doi:10.1358/dof.2004.029.12.855246
   PubMed Web of Science ®Google Scholar