Publication Cover
Stress
The International Journal on the Biology of Stress
Volume 23, 2020 - Issue 2
933
Views
11
CrossRef citations to date
0
Altmetric
Original Research Reports

Myocardial fibrosis, inflammation, and altered cardiac gene expression profiles in rats exposed to a predator-based model of posttraumatic stress disorder

, , , , , , , , , , & show all
Pages 125-135 | Received 15 Apr 2019, Accepted 03 Jul 2019, Published online: 26 Jul 2019

References

  • Ahmadi, N., Hajsadeghi, F., Mirshkarlo, H.B., Budoff, M., Yehuda, R., & Ebrahimi, R. (2011). Post-traumatic stress disorder, coronary atherosclerosis, and mortality. The American Journal of Cardiology, 108, 29–33. doi:10.1016/j.amjcard.2011.02.340
  • Alao, A., Selvarajah, J., & Razi, S. (2012). The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury. International Journal of Psychiatry in Medicine, 44, 165–169. doi:10.2190/PM.44.2.g
  • Asada, K., Yoshiji, H., Noguchi, R., Ikenaka, Y., Kitade, M., Kaji, K., … Fukui, H. (2007). Crosstalk between high-molecular-weight adiponectin and t-cadherin during liver fibrosis development in rats. International Journal of Molecular Medicine, 20, 725–729. doi:10.3892/ijmm.20.5.725
  • Belkin, M.R., & Schwartz, T.L. (2015). Alpha-2 receptor agonists for the treatment of posttraumatic stress disorder. Drugs in Context, 4, 212286. doi:10.7573/dic.212286
  • Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological), 57, 289–300. doi:10.1111/j.2517-6161.1995.tb02031.x
  • Beristianos, M.H., Yaffe, K., Cohen, B., & Byers, A.L. (2016). PTSD and risk of incident cardiovascular disease in aging veterans. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 24, 192–200. doi:10.1016/j.jagp.2014.12.003
  • Berridge, B.R., Mowat, V., Nagai, H., Nyska, A., Okazaki, Y., Clements, P.J., … Wells, M.Y. (2016). Non-proliferative and proliferative lesions of the cardiovascular system of the rat and mouse. Journal of Toxicologic Pathology, 29, 1S–47S. doi:10.1293/tox.29.3S-1
  • Blanchard, D.C., Griebel, G., & Blanchard, R.J. (2003). Conditioning and residual emotionality effects of predator stimuli: Some reflections on stress and emotion. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 27, 1177–1185. doi:10.1016/j.pnpbp.2003.09.012
  • Boehnlein, J.K., & Kinzie, J.D. (2007). Pharmacologic reduction of CNS noradrenergic activity in PTSD: The case for clonidine and prazosin. Journal of Psychiatric Practice, 13, 72–78. doi:10.1097/01.pra.0000265763.79753.c1
  • Cho, J.G., Lee, A., Chang, W., Lee, MS &Kim J. (2018). Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction. Frontiers in Immunology, 9, 294. doi:10.3389/fimmu.2018.00294
  • Cho, J.H., Lee, I., Hammamieh, R., Wang, K., Baxter, D., Scherler, K., … Hood, L. (2014). Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America, 111, 3188–3193. doi:10.1073/pnas.1400113111
  • Dedert, E.A., Calhoun, P.S., Watkins, L.L., Sherwood, A., & Beckham, J.C. (2010). Posttraumatic stress disorder, cardiovascular, and metabolic disease: A review of the evidence. Annals of Behavioral Medicine:A Publication of the Society of Behavioral Medicine, 39, 61–78. doi:10.1007/s12160-010-9165-9
  • Dobin, A., Davis, C.A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., … Gingeras, T.R. (2013). Star: Ultrafast universal RNA-seq aligner. Bioinformatics, 29, 15–21. doi:10.1093/bioinformatics/bts635
  • Ebenezer, P.J., Wilson, C.B., Wilson, L.D., Nair, A.R., & Francis, J. (2016). The anti-inflammatory effects of blueberries in an animal model of post-traumatic stress disorder (PTSD). PLoS One, 11, e0160923. doi:10.1371/journal.pone.0160923
  • Ehlers, A., Hackmann, A., & Michael, T. (2004). Intrusive re-experiencing in post-traumatic stress disorder: Phenomenology, theory, and therapy. Memory, 12, 403–415. doi:10.1080/09658210444000025
  • Ehlers, A., Hackmann, A., Steil, R., Clohessy, S., Wenninger, K., & Winter, H. (2002). The nature of intrusive memories after trauma: The warning signal hypothesis. Behaviour Research and Therapy, 40, 995–1002. doi:10.1016/S0005-7967(01)00077-8
  • Frismantiene, A., Pfaff, D., Frachet, A., Coen, M., Joshi, M.B., Maslova, K., … Philippova, M. (2014). Regulation of contractile signaling and matrix remodeling by t-cadherin in vascular smooth muscle cells: Constitutive and insulin-dependent effects. Cellular Signalling, 26, 1897–1908. doi:10.1016/j.cellsig.2014.05.001
  • Gallini, R., Lindblom, P., Bondjers, C., Betsholtz, C., & Andrae, J. (2016). PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice. Experimental Cell Research, 349, 282–290. doi:10.1016/j.yexcr.2016.10.022
  • Grenon, S.M., Owens, C.D., Alley, H., Perez, S., Whooley, M.A., Neylan, T.C., … Cohen, B.E. (2016). Posttraumatic stress disorder is associated with worse endothelial function among veterans. Journal of the American Heart Association, 5, e003010. doi:10.1161/JAHA.115.003010
  • Hubbard, D.T., Blanchard, D.C., Yang, M., Markham, C.M., Gervacio, A., Chun-I, L., & Blanchard, R.J. (2004). Development of defensive behavior and conditioning to cat odor in the rat. Physiology and Behavior, 80, 525–530. doi:10.1016/j.physbeh.2003.10.006
  • Khazaie, H., Saidi, M.R., Sepehry, A.A., Knight, D.C., Ahmadi, M., Najafi, F., … Tahmasian, M. (2013). Abnormal ECG patterns in chronic post-war PTSD patients: A pilot study. International Journal of Behavioral Medicine, 20, 1–6. doi:10.1007/s12529-011-9197-y
  • Kinzie, J.D., & Leung, P. (1989). Clonidine in Cambodian patients with posttraumatic stress disorder. The Journal of Nervous and Mental Disease, 177, 546–550. doi:10.1097/00005053-198909000-00005
  • Kudrjashova, E., Bashtrikov, P., Bochkov, V., Parfyonova, Y., Tkachuk, V., Antropova, J., … Resink, T.J. (2002). Expression of adhesion molecule t-cadherin is increased during neointima formation in experimental restenosis. Histochemistry and Cell Biology, 118, 281–290. doi:10.1007/s00418-002-0463-6
  • Liao, Y., Smyth, G.K., & Shi, W. (2014). Featurecounts: An efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics, 30, 923. doi:10.1093/bioinformatics/btt656
  • Lindgren, M.E., Fagundes, C.P., Alfano, C.M., Povoski, S.P., Agnese, D.M., Arnold, M.W., … Kiecolt-Glaser, J.K. (2013). Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients. Psychooncology, 22, 1889–1894. doi:10.1002/pon.3233
  • Love, M.I., Huber, W., & Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15, 550. doi:10.1186/s13059-014-0550-8
  • Lv, Y.X., Zhong, S., Tang, H., Luo, B., Chen, S.J., Chen, L., … Tang, J.M. (2018). VEGF-A and VEGF-B coordinate the arteriogenesis to repair the infarcted heart with vagus nerve stimulation. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 48, 433–449. doi:10.1159/000491775
  • Nemeroff, C.B., Bremner, J.D., Foa, E.B., Mayberg, H.S., North, C.S., & Stein, M.B. (2006). Posttraumatic stress disorder: A state-of-the-science review. Journal of Psychiatric Research, 40, 1–21. doi:10.1016/j.jpsychires.2005.07.005
  • Onder, E., Tural, U., & Aker, T. (2006). A comparative study of fluoxetine, moclobemide, and tianeptine in the treatment of posttraumatic stress disorder following an earthquake. European Psychiatry: The Journal of the Association of European Psychiatrists, 21, 174–179. doi:10.1016/j.eurpsy.2005.03.007
  • Pitman, R.K., Rasmusson, A.M., Koenen, K.C., Shin, L.M., Orr, S.P., Gilbertson, M.W., … Liberzon, I. (2012). Biological studies of post-traumatic stress disorder. Nature Reviews. Neuroscience, 13, 769–787. doi:10.1038/nrn3339
  • Reynolds, M., & Brewin, C.R. (1999). Intrusive memories in depression and posttraumatic stress disorder. Behaviour Research and Therapy, 37, 201–215. doi:10.1016/S0005-7967(98)00132-6
  • Rorabaugh, B.R., Bui, A.D., Seeley, S.L., Eisenmann, E.D., Rose, R.M., Johnson, B.L., … Zoladz, P.R. (2019). Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 89, 117–124. doi:10.1016/j.pnpbp.2018.09.003
  • Rorabaugh, B.R., Krivenko, A., Eisenmann, E.D., Bui, A.D., Seeley, S., Fry, M.E., … Zoladz, P.R. (2015). Sex-dependent effects of chronic psychosocial stress on myocardial sensitivity to ischemic injury. Stress (Amsterdam, Netherlands), 18, 645–653. doi:10.3109/10253890.2015.1087505
  • Shirai, M., Imanaka-Yoshida, K., Schneider, M.D., Schwartz, R.J., & Morisaki, T. (2009). T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. Proceedings of the National Academy of Sciences of the United States of America, 106, 18604–18609. doi:10.1073/pnas.0900635106
  • Teekakirikul, P., Eminaga, S., Toka, O., Alcalai, R., Wang, L., Wakimoto, H., … Seidman, J.G. (2010). Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β. The Journal of Clinical Investigation, 120, 3520–3529. doi:10.1172/JCI42028
  • Tian, D., Zeng, X., Wang, W., Wang, Z., Zhang, Y., & Wang, Y. (2019). Protective effect of rapamycin on endothelial-to-mesenchymal transition in HUVECs through the Notch signaling pathway. Vascular Pharmacology, 113, 20–26. doi:10.1016/j.vph.2018.10.004
  • Vaccarino, V., Goldberg, J., Rooks, C., Shah, A.J., Veledar, E., Faber, T.L., … Bremner, J.D. (2013). Post-traumatic stress disorder and incidence of coronary heart disease: A twin study. Journal of the American College of Cardiology, 62, 970–978. doi:10.1016/j.jacc.2013.04.085
  • van Putten, S., Shafieyan, Y., & Hinz, B. (2016). Mechanical control of cardiac myofibroblasts. Journal of Molecular and Cellular Cardiology, 93, 133–142. doi:10.1016/j.yjmcc.2015.11.025
  • Vaughan, L., Marley, R., Miellet, S., & Hartley, P.S. (2018). The impact of SPARC on age-related cardiac dysfunction and fibrosis in drosophila. Experimental Gerontology, 109, 59–66. doi:10.1016/j.exger.2017.10.011
  • Wang, W., Wang, Z., Tian, D., Zeng, X., Liu, Y., Fu, Q., … Wang, Y. (2018). Integrin β3 mediates the endothelial-to-mesenchymal transition via the Notch pathway. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 49, 985. doi:10.1159/000493229
  • Wilson, C.B., McLaughlin, L.D., Ebenezer, P.J., Nair, A.R., & Francis, J. (2014a). Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder. Behavioural Brain Research, 268, 72–80. doi:10.1016/j.bbr.2014.03.029
  • Wilson, C.B., McLaughlin, L.D., Nair, A., Ebenezer, P.J., Dange, R., & Francis, J. (2013). Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. PLoS One, 8, e76146. doi:10.1371/journal.pone.0076146
  • Wilson, C.B., McLaughlin, L.D., Ebenezer, P.J., Nair, A.R., Dange, R., & Harre, J.G. (2014b). Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder.  Frontiers in Behavioral Neuroscience, 8, 256. doi:10.3389/fnbeh.2014.00256
  • Yu, G., Wang, L.G., Han, Y., & He, Q.Y. (2012). Clusterprofiler: An R package for comparing biological themes among gene clusters. Omics, 16, 284–287. doi:10.1089/omi.2011.0118
  • Zeisberg, E.M., Tarnavski, O., Zeisberg, M., Dorfman, A.L., McMullen, J.R., Gustafsson, E., … Kalluri, R. (2007). Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nature Medicine, 13, 952–961. doi:10.1038/nm1613
  • Zen, A.L., Whooley, M.A., Zhao, S., & Cohen, B.E. (2012). Post-traumatic stress disorder is associated with poor health behaviors: Findings from the heart and soul study. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association, 31, 194–201. doi:10.1037/a0025989
  • Zoladz, P.R., Conrad, C.D., Fleshner, M., & Diamond, D.M. (2008). Acute episodes of predator exposure in conjunction with chronic social instability as an animal model of post-traumatic stress disorder. Stress (Amsterdam, Netherlands), 11, 259–281. doi:10.1080/10253890701768613
  • Zoladz, P.R., & Diamond, D.M. (2013). Current status on behavioral and biological markers of PTSD: A search for clarity in a conflicting literature. Neurosci Biobehav Rev, 37, 860–895. doi:10.1016/j.neubiorev.2013.03.024
  • Zoladz, P.R., Fleshner, M., & Diamond, D.M. (2012). Psychosocial animal model of PTSD produces a long-lasting traumatic memory, an increase in general anxiety and PTSD-like glucocorticoid abnormalities. Psychoneuroendocrinology, 37, 1531–1545. doi:10.1016/j.psyneuen.2012.02.007
  • Zoladz, P.R., Fleshner, M., & Diamond, D.M. (2013). Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 44, 1–16. doi:10.1016/j.pnpbp.2013.01.001
  • Zoladz, P.R., Park, C.R., Fleshner, M., & Diamond, D.M. (2015). Psychosocial predator-based animal model of PTSD produces physiological and behavioral sequelae and a traumatic memory four months following stress onset. Physiology and Behavior, 147, 183–192. doi:10.1016/j.physbeh.2015.04.032

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.