A theoretical model to study the effects of cellular stiffening on the damage evolution in deep tissue injury

References

• An , SS , Laudadio , RE , Lai , J , Rogers , RA and Fredberg , JJ . 2002 . Stiffness changes in cultured airway smooth muscle cells . Am J Physiol Cell Physiol , 283 ( 3 ) : C792 – C801 .
   PubMed Web of Science ®Google Scholar
• Bagni , MA , Cecchi , G , Colombini , B and Colomo , F . 2002 . A non-cross-bridge stiffness in activated frog muscle fibers . Biophys J , 82 ( 6 ) : 3118 – 3127 .
   PubMed Web of Science ®Google Scholar
• Black , JM and Panel , NPUA . 2005 . Moving toward consensus on deep tissue injury and pressure ulcer staging . Adv Skin Wound Care , 18 ( 8 ) : 415 – 416 . 418, 420–421
   PubMedGoogle Scholar
• Bliss , M and Simini , B . 1999 . When are the seeds of postoperative pressure sores sown? Often during surgery . BMJ , 319 ( 7214 ) : 863 – 864 .
   PubMedGoogle Scholar
• Bosboom, E. 2001. Deformation as a trigger for pressure sore related muscle damage., Thesis (PhD). Universiteit Maastricht.
   Google Scholar
• Bosboom , EM , Bouten , CV , Oomens , CW , van Straaten , HW , Baaijens , FP and Kuipers , H . 2001 . Quantification and localisation of damage in rat muscles after controlled loading; a new approach to study the aetiology of pressure sores . Med Eng Phys , 23 ( 3 ) : 195 – 200 .
   PubMed Web of Science ®Google Scholar
• Breuls, R. 2003. Experimental and theoretical analyses of compression induced muscle damage: aetiological factors in pressure ulcers. Thesis (PhD). Technische Universiteit Eindhoven.
   Google Scholar
• Breuls , RGM , Sengers , BG , Oomens , CWJ , Bouten , CVC and Baaijens , FPT . 2002 . Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach . J Biomech Eng , 124 ( 2 ) : 198 – 207 .
   PubMed Web of Science ®Google Scholar
• Breuls , RG , Bouten , CV , Oomens , CW , Bader , DL and Baaijens , FP . 2003 . A theoretical analysis of damage evolution in skeletal muscle tissue with reference to pressure ulcer development . J Biomech Eng , 125 ( 6 ) : 902 – 909 .
   PubMed Web of Science ®Google Scholar
• Ceelen, K. 2008. Modeling the development of in vitro and in vivo pressure-induced muscle damage. Thesis (PhD). Technische Universiteit Eindhoven.
   Google Scholar
• Ceelen , KK , Stekelenburg , A , Loerakker , S , Strijkers , GJ , Bader , DL , Nicolay , K , Baaijens , FPT and Oomens , CWJ . 2008a . Compression-induced damage and internal tissue strains are related . J Biomech , 41 ( 16 ) : 3399 – 3404 .
   PubMed Web of Science ®Google Scholar
• Ceelen , KK , Stekelenburg , A , Mulders , JLJ , Strijkers , GJ , Baaijens , FPT , Nicolay , K Oomens , CWJ . 2008b . Validation of a numerical model of skeletal muscle compression with MR tagging: a contribution to pressure ulcer research . J Biomech Eng , 130 ( 6 ) 061015
   PubMed Web of Science ®Google Scholar
• Chen , Y , Devivo , MJ and Jackson , AB . 2005 . Pressure ulcer prevalence in people with spinal cord injury: age-period-duration effects . Arch Phys Med Rehabil , 86 ( 6 ) : 1208 – 1213 .
   PubMed Web of Science ®Google Scholar
• Cipolla , MJ , Gokina , NI and Osol , G . 2002 . Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behavior . FASEB J , 16 ( 1 ) : 72 – 76 .
   PubMed Web of Science ®Google Scholar
• Daniel , RK , Priest , DL and Wheatley , DC . 1981 . Etiologic factors in pressure sores: an experimental model . Arch Phys Med Rehabil , 103 ( 2 ) : 492 – 498 .
   Google Scholar
• Deng , L , Fairbank , NJ , Fabry , B , Smith , PG and Maksym , GN . 2004 . Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells . Am J Physiol Cell Physiol , 287 ( 2 ) : C440 – C448 .
   PubMed Web of Science ®Google Scholar
• Garber , SL and Rintala , DH . 2003 . Pressure ulcers in veterans with spinal cord injury: a retrospective study . J Rehabil Res Dev , 40 ( 5 ) : 433 – 441 .
   PubMed Web of Science ®Google Scholar
• Geers, M, Kouznetsova, V, Brekelmans, W. 2005. Computational homogenization. CISM course materials.
   Google Scholar
• Gefen , A , Gefen , N , Linder-Ganz , E and Margulies , SS . 2005 . In vivo muscle stiffening under bone compression promotes deep pressure sores . J Biomech Eng , 127 ( 3 ) : 512 – 524 .
   PubMed Web of Science ®Google Scholar
• Gefen , A , van Nierop , B , Bader , DL and Oomens , CW . 2008 . Strain-time cell-death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury . J Biomech , 41 ( 9 ) : 2003 – 2012 .
   PubMed Web of Science ®Google Scholar
• Glogauer , M , Arora , P , Yao , G , Sokholov , I , Ferrier , J and McCulloch , CA . 1997 . Calcium ions and tyrosine phosphorylation interact coordinately with actin to regulate cytoprotective responses to stretching . J Cell Sci , 110 ( 1 ) : 11 – 21 .
   PubMedGoogle Scholar
• Lam , WA , Rosenbluth , MJ and Fletcher , DA . 2007 . Chemotherapy exposure increases leukemia cell stiffness . Blood , 109 ( 8 ) : 3505 – 3508 .
   PubMed Web of Science ®Google Scholar
• Linder-Ganz , E and Gefen , A . 2003 . “ Stiffening of muscle tissue under bone compression is a key factor in formation of pressure sores ” . In Engineering in medicine and biology society. Proceedings of the 25th annual international conference of the IEEE Vol. 2 , 1839 – 1842 .
   Google Scholar
• Linder-Ganz , E and Gefen , A . 2004 . Mechanical compression-induced pressure sores in rat hindlimb: muscle stiffness, histology, and computational models . J Appl Physiol , 96 ( 6 ) : 2034 – 2049 .
   PubMed Web of Science ®Google Scholar
• Linder-Ganz , E and Gefen , A . 2007 . The effects of pressure and shear on capillary closure in the microstructure of skeletal muscles . Ann Biomed Eng , 35 ( 12 ) : 2095 – 2107 .
   PubMed Web of Science ®Google Scholar
• Linder-Ganz , E and Gefen , A . 2009 . Stress analyses coupled with damage laws to determine biomechanical risk factors for deep tissue injury during sitting . J Biomech Eng , 131 ( 1 ) 011003
   PubMed Web of Science ®Google Scholar
• Linder-Ganz , E , Engelberg , S , Scheinowitz , M and Gefen , A . 2006 . Pressure-time cell death threshold for albino rat skeletal muscles as related to pressure sore biomechanics . J Biomech , 39 ( 14 ) : 2725 – 2732 .
   PubMed Web of Science ®Google Scholar
• Linder-Ganz , E , Shabshin , N , Itzchak , Y and Gefen , A . 2007 . Assessment of mechanical conditions in sub-dermal tissues during sitting: a combined experimental-MRI and finite element approach . J Biomech , 40 ( 7 ) : 1443 – 1454 .
   PubMed Web of Science ®Google Scholar
• Linder-Ganz , E , Shabshin , N , Itzchak , Y , Yizhar , Z , Siev-Ner , I and Gefen , A . 2008 . Strains and stresses in sub-dermal tissues of the buttocks are greater in paraplegics than in healthy during sitting . J Biomech , 41 ( 3 ) : 567 – 580 .
   PubMed Web of Science ®Google Scholar
• Makhsous , M , Lim , D , Hendrix , R , Bankard , J , Rymer , WZ and Lin , F . 2007 . Finite element analysis for evaluation of pressure ulcer on the buttock: development and validation . IEEE Trans Neural Syst Rehabil Eng , 15 ( 4 ) : 517 – 525 .
   PubMed Web of Science ®Google Scholar
• Rodriguez , GP and Garber , SL . 1994 . Prospective study of pressure ulcer risk in spinal cord injury patients . Paraplegia , 32 ( 3 ) : 150 – 158 .
   PubMedGoogle Scholar
• Shahin , ESM , Dassen , T and Halfens , RJG . 2008 . Pressure ulcer prevalence in intensive care patients: a cross-sectional study . J Eval Clin Pract , 14 ( 4 ) : 563 – 568 .
   PubMed Web of Science ®Google Scholar
• Smit , RJM , Brekelmans , WAM and Meijer , HEH . 1998 . Prediction of the mechanical behavior of nonlinear heterogeneous systems by multi-level finite element modeling . Comput Methods Appl Mech Eng , 155 ( 12 ) : 181 – 192 .
   Google Scholar
• Stekelenburg A. 2005. Mechanisms associated with deep tissue injury induced by sustained compressive loading. Thesis (PhD). Technische Universiteit Eindhoven.
   Google Scholar
• Stekelenburg , A , Oomens , CWJ , Strijkers , GJ , de Graaf , L , Bader , DL and Nicolay , K . 2006a . A new MR-compatible loading device to study in vivo muscle damage development in rats due to compressive loading . Med Eng Phys , 28 ( 4 ) : 331 – 338 .
   PubMed Web of Science ®Google Scholar
• Stekelenburg , A , Oomens , CWJ , Strijkers , GJ , Nicolay , K and Bader , DL . 2006b . Compression-induced deep tissue injury examined with magnetic resonance imaging and histology . J Appl Physiol , 100 ( 6 ) : 1946 – 1954 .
   PubMed Web of Science ®Google Scholar
• Stekelenburg , A , Strijkers , GJ , Parusel , H , Bader , DL , Nicolay , K and Oomens , CW . 2007 . Role of ischemia and deformation in the onset of compression-induced deep tissue injury: MRI-based studies in a rat model . J Appl Physiol , 102 ( 5 ) : 2002 – 2011 .
   PubMed Web of Science ®Google Scholar
• Todd , BA and Thacker , JG . 1994 . Three-dimensional computer model of the human buttocks, in vivo . J Rehabil Res Dev , 31 ( 2 ) : 111 – 119 .
   PubMed Web of Science ®Google Scholar
• US National Pressure Ulcer Advisory Panel. 2007. Website http://www.npuap.org/ Upgraded staging system.
   Google Scholar