407
Views
48
CrossRef citations to date
0
Altmetric
Original Articles

Mineral heterogeneity has a minor influence on the apparent elastic properties of human cancellous bone: a SRμCT-based finite element study

, , &
Pages 1137-1144 | Received 20 Sep 2010, Accepted 12 Apr 2011, Published online: 23 Jan 2012

References

  • Arbenz , P , van Lenthe , G , Mennel , U , Mueller , R and Sala , M . 2008 . A scalable multi-level preconditioner for matrix-free micro-finite element analysis of human bone structures . Int J Numer Methods Eng , 73 ( 7 ) : 927 – 947 .
  • Baruchel , J , Bleuet , P , Bohic , S , Bravin , A , Coan , P , David , C , Elleaume , H , Esteve , F , Peyrin , F Pfeiffer , F . 2008 . State of the art and perspectives of biomedical imaging at the ESRF . Synchrotron Radiat News , 21 ( 4 ) : 30 – 41 .
  • Bourne , B and Van der Meulen , M . 2004 . Finite element models predict cancellous apparent modulus when tissue modulus is scaled from specimen CT-attenuation . J Biomech , 37 ( 5 ) : 613 – 621 .
  • Chevalier , Y , Pahr , D , Allmer , H , Charlebois , M and Zysset , P . 2007 . Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation . J Biomech , 40 ( 15 ) : 3333 – 3340 .
  • Cowin , S , ed. 2001 . Bone mechanics handbook , 2nd ed. , Boca Raton, FL : CRC Press LLC .
  • Currey , J . 1988 . The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone . J Biomech , 21 ( 2 ) : 131 – 139 .
  • Currey , J . 1999 . What determines the bending strength of compact bone? . J Exp Biol , 202 ( 18 ) : 2495 – 2503 .
  • Eriksen , E , Axelrod , D and Melsen , F . 1994 . Bone histomorphometry , New York, NY : Raven Press .
  • Guldberg , R , Hollister , S and Charras , G . 1998 . ASME; the accuracy of digital image-based finite element models . J Biomech Eng , 120 ( 2 ) : 289 – 295 .
  • Harrison , N , McDonnell , P , O'Mahoney , D , Kennedy , O , O'Brien , F and McHugh , P . 2008 . Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties . J Biomech , 41 ( 11 ) : 2589 – 2596 .
  • Hernandez , C , Beaupre , G , Keller , T and Carter , D . 2001 . The influence of bone volume fraction and ash fraction on bone strength and modulus . Bone , 29 ( 1 ) : 74 – 78 .
  • Jaasma , M , Bayraktar , H , Niebur , G and Keaveny , T . 2002 . Biomechanical effects of intraspecimen variations in tissue modulus for trabecular bone . J Biomech , 35 ( 2 ) : 237 – 246 .
  • Kazakia , G , Burghardt , A , Cheung , S and Majumdar , S . 2008 . Assessment of bone tissue mineralization by conventional X-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements . Med Phys , 35 ( 7 ) : 3170 – 3179 .
  • Keaveny , T , Morgan , E , Niebur , G and Yeh , O . 2001 . Biomechanics of trabecular bone . Ann Rev Biomed Eng , 3 : 307 – 333 .
  • Matsuura , M , Eckstein , F , Lochmueller , EM and Zysset , P . 2008 . The role of fabric in the quasi-static compressive mechanical properties of human trabecular bone from various anatomical locations . Biomech Model Mechanobiol , 7 ( 1 ) : 27 – 42 .
  • Niebur , G , Feldstein , M , Yuen , J , Chen , T and Keaveny , T . 2000 . High-resolution finite element models with tissue strength asymmetry accurately predict failure of trabecular bone . J Biomech , 33 ( 12 ) : 1575 – 1583 .
  • Nuzzo , S , Peyrin , F , Cloetens , P , Baruchel , J and Boivin , G . 2002 . Quantification of the degree of mineralization of bone in three dimensions using synchrotron radiation microtomography . Med Phys , 29 ( 11 ) : 2672 – 2681 .
  • Pahr , D and Zysset , P . 2008 . Influence of boundary conditions on computed apparent elastic properties of cancellous bone . Biomech Model Mechanobiol , 7 ( 6 ) : 463 – 476 .
  • Renders , G , Mulder , L , Langenbach , G , van Ruijven , L and van Eijden , T . 2008 . Biomechanical effect of mineral heterogeneity in trabecular bone . J Biomech , 41 ( 13 ) : 2793 – 2798 .
  • Rincon-Kohli , L and Zysset , P . 2009 . Multi-axial mechanical properties of human trabecular bone . Biomech Model Mechanobiol , 8 ( 3 ) : 195 – 208 .
  • Roschger , P , Fratzl , P , Eschberger , J and Klaushofer , K . 1998 . Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies . Bone , 23 ( 4 ) : 319 – 326 .
  • Roschger , P , Gupta , H , Berzlanovich , A , Ittner , G , Dempster , D , Fratzl , P , Cosman , F , Parisien , M , Lindsay , R Nieves , J . 2003 . Constant mineralization density distribution in cancellous human bone . Bone , 32 ( 3 ) : 316 – 323 .
  • Roschger , P , Paschalis , E , Fratzl , P and Klaushofer , K . 2008 . Bone mineralization density distribution in health and disease . Bone , 42 ( 3 ) : 456 – 466 .
  • Ruegsegger , P , Koller , B and Muller , R . 1996 . A microtomographic system for the nondestructive evaluation of bone architecture . Calcif Tissue Int , 58 ( 1 ) : 24 – 29 .
  • Van der Linden , J , Birkenhaeger-Frenkel , D , Verhaar , J and Weinans , H . 2001 . Trabecular bone's mechanical properties are affected by its non-uniform mineral distribution . J Biomech , 34 ( 12 ) : 1573 – 1580 .
  • Van Rietbergen , B , Odgaard , A , Kabel , J and Huiskes , R . 1996 . Direct mechanics assessment of elastic symmetries and properties of trabecular bone architecture . J Biomech , 29 ( 12 ) : 1653 – 1657 .
  • Van Rietbergen , B , Weinans , H , Huiskes , R and Odgaard , A . 1995 . A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models . J Biomech , 28 ( 1 ) : 69 – 81 .
  • Van Ruijven , L , Mulder , L and van Eijden , T . 2007 . Variations in mineralization affect the stress and strain distributions in cortical and trabecular bone . J Biomech , 40 ( 6 ) : 1211 – 1218 .
  • Wolfram , U , Wilke , H and Zysset , P . 2010 . Valid finite element models of vertebral trabecular bone can be obtained using tissue properties measured with nanoindentation under wet conditions . J Biomech , 43 ( 9 ) : 1731 – 1737 .
  • Zysset , P . 2009 . Indentation of bone tissue: a short review . Osteoporosis Int , 20 ( 6 ) : 1049 – 1055 .
  • Zysset , P , Edward Guo , X , Edward Hoffler , C , Moore , K and Goldstein , S . 1999 . Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur . J Biomech , 32 ( 10 ) : 1005 – 1012 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.