185
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Integration of geometric separation mechanisms by implementing curved constrictions in a biochip microchannel fluidic separator

&
Pages 314-327 | Received 02 Jun 2011, Accepted 27 Aug 2011, Published online: 10 Jan 2012

References

  • Abraham , F , Behr , M and Heinkenschloss , M . 2005 . Shape optimization in steady blood flow: a numerical study of non-Newtonian effects . Comput Methods Biomech Biomed Eng , 8 ( 2 ) : 127 – 137 .
  • Abkarian , M , Faivre , M and Viallat , A . 2007 . Swinging of red blood cells under shear flow . Phys Rev Lett , 98 ( 18 ) : 188302
  • Abkarian , M and Viallat , A . 2008 . Vesicles and red blood cells in shear flow . Soft Matter , 4 : 653 – 657 .
  • Ai , Y , Joo , SW , Jiang , Y , Xuan , X and Qian , S . 2009 . Pressure-driven transport of particles through a converging-diverging microchannel . Biomicrofluidics , 3 : 022404
  • Aoki , R , Yamada , M , Yasuda , M and Seki , M . 2009 . In-channel focusing of flowing microparticles utilizing hydrodynamic filtration . Microfluid Nanofluid , 6 : 571 – 576 .
  • Bayliss , LE . 1959 . The axial drift of the red cells when blood flows in a narrow tube . J Physiol , 149 : 593 – 613 .
  • Brown , BH , Smallwood , RH , Barber , DC , Lawford , PV and Hose , DR . 1999 . Medical physics and biomedical engineering , Bristol : Institute of Physics Publishing .
  • Chesnutt , JKW and Marshall , JS . 2009 . Effect of particle collisions and aggregation on red blood cell passage through a bifurcation . Microvasc Res , 78 : 301 – 313 .
  • Di Carlo , DD , Edd , JF , Irlmla , D , Tompkins , RG and Toner , M . 2008 . Equilibrium separation and filtration of particles using differential inertial focusing . Anal Chem , 80 : 2204 – 2211 .
  • Dijsen , FJH , van de Vosse , FN and Janssen , JD . 1999 . The influence of the non-Newtonian properties of blood on the flow in large arteries: steady flow in a carotid bifurcation model . J Biomech , 32 : 601 – 608 .
  • Enden , G and Popel , AS . 1994 . A numerical study of plasma skimming in small vascular bifurcations . J Biomech Eng , 116 ( 1 ) : 79 – 88 .
  • Fahraeus , R . 1929 . The suspension stability of the blood . Physiol Rev , 9 : 241 – 274 .
  • Fahraeus , R and Lindqvist , T . 1931 . The viscosity of the blood in narrow capillary tubes . Am J Physiol , 96 : 562 – 568 .
  • Faivre , M , Abkarian , M , Bickraj , K and Stone , HA . 2006 . Geometrical focusing of cells in a microfluidic device: a route to separate blood plasma . BioRheology , 43 : 147 – 159 .
  • Ferziger , JH and Peric , M . 1999 . Computational methods for fluid dynamics , 2nd rev. ed , London : Springer .
  • Fujiwara , H , Ishikawa , T , Lima , R , Matsuki , N , Imai , Y , Kaji , H , Nishizawa , M and Yamguchi , T . 2009 . Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel . J Biomech , 42 : 838 – 843 .
  • Fung , YC . 1973 . Stochastic flow in capillary blood vessels . Microvasc Res , 5 : 34 – 48 .
  • Fung , YC . 1993 . Biomechanics- mechanical properties of living tissues , New York : Springer .
  • Gerge , G and Silberberg , A . 1961 . Radial particle displacements in Poiseuille flow of suspension . Nature , 189 : 209 – 210 .
  • Gerge , G and Silberberg , A . 1962 . Behaviour of macroscopic rigid spheres in Poiseuille flow. Part 2, Experimental results and interpretation . J Fluid Mech , 14 : 136 – 157 .
  • Hester , JP , Kellogg , RM , Mulzet , AP , Kruger , VR , McCredie , KB and Freireich , EJ . 1979 . Principles of blood separation and component extraction in a disposable continuous-flow single-stage channel . Blood , 54 : 254 – 268 .
  • Jaggi , RD , Sandoz , R and Effenhauser , CS . 2007 . Microfluidic depletion of red blood cells from whole blood in high-aspect-ratio microchannels . Microfluid Nanofluid , 3 : 47 – 53 .
  • Kersaudy-Kerhoas , M , Dhariwal , RS and Desmulliez , MPY . 2008 . Recent advances in microparticle continuous separation . IET J Nanobiotechnol , 2 : 1 – 13 .
  • Kersaudy-Kerhoas , M , Dhariwal , R , Desmulliez , MPY and Jouvet , L . 2010 . Hydrodynamic blood plasma separation in microfluidic channels . Microfluid Nanofluid , 8 : 105 – 114 .
  • Layek , GC and Midya , C . 2007 . Effect of constriction height on flow separation in a two-dimensional channel . Commun Nonlinear Sci Numer Simul , 12 : 745 – 759 .
  • Leuprecht , A and Perktold , K . 2001 . Computer simulation of non-Newtonian effects on blood flow in large arteries . Comput Methods Biomech Biomed Eng , 4 : 149 – 163 .
  • Liu , WK , Liu , Y , Farrell , D , Zhang , L , Wang , XS , Fukui , Y , Patankar , N , Zhang , Y , Bajaj , C , Lee , J , Hong , J , Chen , X and Hsu , H . 2006 . Immersed finite element method and its applications to biological systems . Comput Methods Appl Mech Eng , 195 : 1722 – 1749 .
  • Mackerle , J . 2005 . Finite element modelling and simulations in cardiovascular mechanics and cardiology: a bibliography 1993–2004 . Comput Methods Biomech Biomed Eng , 8 ( 2 ) : 59 – 81 .
  • Peskin , CS . 1977 . Numerical analysis of blood flow in the heart . J Comput Phys , 25 : 220 – 252 .
  • Qiu , Y and Tarbell , JM . 2000 . Numerical simulation of pulsatile flow in a compliant curved tube model of a coronary artery . J Biomech Eng , 122 : 77 – 85 .
  • Rubinow , SI and Keller , JB . 1961 . The transverse force on spinning sphere moving in a viscous fluid . J Fluid Mech , 11 : 447 – 459 .
  • Saffman , PG . 1965 . The lift on a small sphere in a slow shear flow . J Fluid Mech , 22 : 385 – 400 .
  • Śkalak , R and Özkaya , N . 1989 . Biofluid mechanics . Ann Rev Fluid Mech , 21 : 167 – 204 .
  • Skotheim , JM and Secomb , TW . 2007 . Red blood cells and other nonspherical capsules in shear flow: oscillatory dynamics and the tank-treading-to-tumbling transition . Phys Rev Lett , 98 ( 7 ) : 078301
  • Sollier , E , Rostainga , H , Pouteaua , P , Fouillet , Y and Achard , JL . 2009 . Passive microfluidic devices for plasma extraction from whole human blood . Sens Actuators, B , 141 : 617 – 624 .
  • Svanes , K and Zweifach , BW . 1968 . Variations in small blood vessel hematocrit produced in hypothermic rats by micro-occlusion . Microvasc Res , 1 : 210 – 220 .
  • Tsutsui , H and Ho , CM . 2009 . Cell separation by non-inertial force fields in microfluidic systems . Mech Res Commun , 36 : 92 – 103 .
  • Woodcock , JP . 1976 . Physical properties of blood and their influence on blood-flow measurement . Rep Prog Phys , 39 : 65 – 127 .
  • Xi , C and Shapley , NC . 2008 . Flows of concentrated suspensions through an asymmetric bifurcation . J Rheol , 52 ( 2 ) : 625 – 647 .
  • Xuan , X , Zhu , J and Church , C . 2010 . Particle focusing in microfluidic devices . Microfluid Nanofluid , 9 : 1 – 16 .
  • Xue , X , Marson , S , Patel , MK , Bailey , C , O'Neill , W , Topham , D , Kay , RW and Desmullies , MPY . 2011a . Progress towards the design and numerical analysis of a 3D microchannel biochip separator . Int J Numer Methods Biomed Eng , In Press, DOI: 10.1002/cnm.1439
  • Xue , X , Patel , MK , Bailey , C and Desmullies , MPY . 2011b . Geometrical optimization of a biochip microchannel fluidic separator . Comput Methods Biomech Biomed Eng , In Press, DOI: 10.1080/10255842.2011.569501
  • Xue , X , Patel , MK , Kersaudy-Kerhoas , M , Bailey , C and Desmullies , MPY . 2011c . Modelling and simulation of the behaviour of a biofluid in a microchannel biochip separator . Comput Methods Biomech Biomed Eng , 14 ( 6 ) : 549 – 560 .
  • Xue , X , Patel , MK , Kersaudy-Kerhoas , M , Desmullies , MPY , Bailey , C and Topham , D . 2012 . Analysis of fluid separation in microfluidic T-channels . Appl Math Modell , 36 ( 2 ) : 743 – 755 .
  • Yan , ZY , Acrivos , A and Weinbaum , S . 1991 . A three-dimensional analysis of plasma skimming at microvascular bifurcations . Microvasc Res , 42 : 17 – 38 .
  • Yang , S , Undar , A and Zahn , JD . 2006 . A microfluidic device for continuous, real time blood plasma separation . Lab Chip , 6 : 871 – 880 .
  • Zhang , J , Johnson , PC and Popel , AS . 2009 . Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows . Microvasc Res , 77 : 265 – 272 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.