400
Views
11
CrossRef citations to date
0
Altmetric
Articles

Mathematical models of α-synuclein transport in axons

&
Pages 515-526 | Received 19 Feb 2015, Accepted 19 Apr 2015, Published online: 24 Jul 2015

References

  • Bennett MC, Bishop JF, Leng Y, Chock PB, Chase TN, Mouradian MM. 1999. Degradation of alpha-synuclein by proteasome. J Biol Chem. 274(48):33855–33858. doi:10.1074/jbc.274.48.33855.
  • Brown A. 2000. Slow axonal transport: stop and go traffic in the axon. Nat Rev Mol Cell Biol. 1(2):153–156. doi:10.1038/35040102.
  • Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH. 2012. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain. 135(7):2058–2073. doi:10.1093/brain/aws133.
  • Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH. 2004. Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci. 24(30):6715–6723. doi:10.1523/JNEUROSCI.1594-04.2004.
  • George JL, Mok S, Moses D, Wilkins S, Bush AI, Cherny RA, Finkelstein DI. 2009. Targeting the progression of Parkinson's disease. Curr Neuropharmacol. 7(1):9–36. doi:10.2174/157015909787602814.
  • George S, Rey NL, Reichenbach N, Steiner JA, Brundin P. 2013. Alpha-synuclein: the long distance runner. Brain Pathol. 23(3):350–357. doi:10.1111/bpa.12046.
  • Goldstein LSB, Yang ZH. 2000. Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Ann Rev Neurosci. 23(1):39–71. doi:10.1146/annurev.neuro.23.1.39.
  • Jensen P, Li J, Dahlstrom A, Dotti C. 1999. Axonal transport of synucleins is mediated by all rate components. Eur J Neurosci. 11(10):3369–3376. doi:10.1046/j.1460-9568.1999.00754.x.
  • Jung P, Brown A. 2009. Modeling the slowing of neurofilament transport along the mouse sciatic nerve. Phys Biol. 6(4):046002. doi:10.1088/1478-3975/6/4/046002.
  • Kim C, Lee S. 2008. Controlling the mass action of alpha-synuclein in Parkinson's disease. J Neurochem. 107(2):303–316. doi:10.1111/j.1471-4159.2008.05612.x.
  • Konzack S, Thies E, Marx A, Mandelkow EM, Mandelkow E. 2007. Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci. 27(37):9916–9927. doi:10.1523/JNEUROSCI.0927-07.2007.
  • Kuznetsov IA, Kuznetsov AV. Forthcoming 2015a. Can numerical modeling help understand the fate of tau protein in the axon terminal? Comput Methods Biomech Biomed Eng. 10.1080/10255842.2014.994119.
  • Kuznetsov IA, Kuznetsov AV. Forthcoming 2015b. What mechanisms of tau protein transport could be responsible for the inverted tau concentration gradient in degenerating axons? Math Med Biol.
  • Li JY, Jensen PH, Dahlström A. 2002. Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS. Neuroscience. 113(2):463–478. doi:10.1016/S0306-4522(02)00143-4.
  • Li WX, Hoffman PN, Stirling W, Price DL, Lee MK. 2004. Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations. J Neurochem. 88(2):401–410. doi:10.1046/j.1471-4159.2003.02166.x.
  • Li Y, Brown A, Jung P. 2014. Deciphering the axonal transport kinetics of neurofilaments using the fluorescence photoactivation pulse-escape method. Phys Biol. 11(2):026001. doi:10.1088/1478-3975/11/2/026001.
  • Li Y, Jung P, Brown A. 2012. Axonal transport of neurofilaments: a single population of intermittently moving polymers. J Neurosci. 32(2):746–758. doi:10.1523/JNEUROSCI.4926-11.2012.
  • Millecamps S, Julien J. 2013. Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci. 14(3):161–176. doi:10.1038/nrn3380.
  • Morfini G, Pigino G, Mizuno N, Kikkawa M, Brady ST. 2007. Tau binding to microtubules does not directly affect microtubule-based vesicle motility. J Neurosci Res. 85(12):2620–2630. doi:10.1002/jnr.21154.
  • Nath S, Meuvis J, Hendrix J, Carl SA, Engelborghs Y. 2010. Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change. Biophys J. 98(7):1302–1311. doi:10.1016/j.bpj.2009.12.4290.
  • Rosenberg T, Gal-Ben-Ari S, Dieterich DC, Kreutz MR, Ziv NE, Gundelfinger ED, Rosenblum K. 2014. The roles of protein expression in synaptic plasticity and memory consolidation. Front Mol Neurosci. 7:86. doi:10.3389/fnmol.2014.00086.
  • Roy S. 2009. The paradoxical cell biology of alpha-synuclein. Cell Biol Axon. 48:159–172.
  • Roy S, Coffee P, Smith G, Liem RKH, Brady ST, Black MM. 2000. Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport. J Neurosci. 20:6849–6861.
  • Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VMY. 2007. Rapid and intermittent cotransport of slow component-b proteins. J Neurosci. 27(12):3131–3138. doi:10.1523/JNEUROSCI.4999-06.2007.
  • Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VMY. 2008. Cytoskeletal requirements in axonal transport of slow component-b. J Neurosci. 28(20):5248–5256. doi:10.1523/JNEUROSCI.0309-08.2008.
  • Saha A, Hill J, Utton M, Asuni A, Ackerley S, Grierson A, Miller C, Davies A, Buchman V, Anderton B, Hanger D. 2004. Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons. J Cell Sci. 117(7):1017–1024. doi:10.1242/jcs.00967.
  • Schapira AHV, Lang AET, Fahn S, editors. 2010. Movement disorders 4: blue books of neurology series. 35. Philadelphia (PA): Saunders.
  • Smith DA, Simmons RM. 2001. Models of motor-assisted transport of intracellular particles. Biophys J. 80(1):45–68. doi:10.1016/S0006-3495(01)75994-2.
  • Spinelli KJ, Taylor JK, Osterberg VR, Churchill MJ, Pollock E, Moore C, Meshul CK, Unni VK. 2014. Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease. J Neurosci. 34(6):2037–2050. doi:10.1523/JNEUROSCI.2581-13.2014.
  • Surguchov A. 2008. Molecular and cellular biology of synucleins. Int Rev Cell Mol Biol. 270:225–317.
  • Tang Y, Das U, Scott DA, Roy S. 2012. The slow axonal transport of alpha-synuclein-mechanistic commonalities amongst diverse cytosolic cargoes. Cytoskeleton. 69(7):506–513. doi:10.1002/cm.21019.
  • Tuszynski JA, Kurzynski M. 2003. Introduction to molecular biophysics. CRC Press: Boca Raton (FL).
  • Utton M, Noble W, Hill J, Anderton B, Hanger D. 2005. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci. 118(20):4645–4654. doi:10.1242/jcs.02558.
  • Yang M, Hasadsri L, Woods WS, George JM. 2010. Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons. Mol Neurodegener. 5(1):9. doi:10.1186/1750-1326-5-9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.