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Computer Methods in Biomechanics and Biomedical Engineering Volume 24, 2021 - Issue 10
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Research Article

Transport and deposition of ultrafine particles in the upper tracheobronchial tree: a comparative study between approximate and realistic respiratory tract models

Jingliang DongMechanical & Automotive Engineering, School of Engineering, RMIT University, Bundoora, VIC, AustraliaORCID Iconhttps://orcid.org/0000-0002-2812-6188View further author information
ORCID Icon,
Jiang LiMechanical & Automotive Engineering, School of Engineering, RMIT University, Bundoora, VIC, AustraliaView further author information
,
Lin TianMechanical & Automotive Engineering, School of Engineering, RMIT University, Bundoora, VIC, AustraliaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7779-1926View further author information
ORCID Icon &
Jiyuan TuMechanical & Automotive Engineering, School of Engineering, RMIT University, Bundoora, VIC, AustraliaView further author information
Pages 1125-1135 | Received 23 Aug 2020, Accepted 22 Dec 2020, Published online: 07 Jan 2021

References

  • Asgharian B, Price OT. 2006. Airflow distribution in the human lung and its influence on particle deposition. Inhal Toxicol. 18(10):795–801.
  • Asgharian B, Price OT. 2007. Deposition of ultrafine (nano) particles in the human lung. Inhal Toxicol. 19(13):1045–1054.
  • Balásházy I, Hofmann W, Heistracher T. 1999. Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations. J Aerosol Sci. 30(2):185–203.
  • Cheng K-H, Cheng Y-S, Yeh H, Swift D. 1995. Deposition of ultrafine aerosols in the head airways during natural breathing and during simulated breath holding using replicate human upper airway casts. Aerosol Sci Technol. 23(3):465–474.
  • Deng Q, Deng L, Miao Y, Guo X, Li Y. 2019. Particle deposition in the human lung: Health implications of particulate matter from different sources. Environ Res. 169:237–245.
  • Dong J, Shang Y, Tian L, Inthavong K, Qiu D, Tu J. 2019a. Ultrafine particle deposition in a realistic human airway at multiple inhalation scenarios. Int J Numer Meth Biomed Engng. 35(7):e3215.
  • Dong J, Tian L, Ahmadi G. 2019b. Numerical assessment of respiratory airway exposure risks to diesel exhaust particles. Exp Comput Multiph Flow. 1(1):51–59.
  • Horsfield K, Dart G, Olson DE, Filley GF, Cumming G. 1971. Models of the human bronchial tree. J Appl Physiol. 31(2):207–217.
  • ICRP 1994. Human Respiratory Tract Model for Radiological Protection. ICRP Publication 66. Ann. ICRP.
  • Inthavong K, Tian L, Tu J. 2016. Lagrangian particle modelling of spherical nanoparticle dispersion and deposition in confined flows. J Aerosol Sci. 96:56–68.
  • Johari NH, Osman K, Helmi NHN, Abdul Kadir MAR. 2015. Comparative analysis of realistic CT-scan and simplified human airway models in airflow simulation. Comput Methods Biomech Biomed Eng. 18(1):48–56.
  • Kim YH, Tong ZB, Chan HK, Yang RY. 2019. CFD modelling of air and particle flows in different airway models. J Aerosol Sci. 134:14–28.
  • Kitaoka H, Koc S, Tetsumoto S, Koumo S, Hirata H, Kijima T. 2013. 4D model generator of the human lung, "Lung4Cer. Conf Proc IEEE Eng Med Biol Soc. 2013:453–456.
  • Kozawa KH, Winer AM, Fruin SA. 2012. Ultrafine particle size distributions near freeways: Effects of differing wind directions on exposure. Atmos Environ (1994)). 63:250–260.
  • Nicolaou L, Zaki TA. 2013. Direct numerical simulations of flow in realistic mouth–throat geometries. J Aerosol Sci. 57:71–87.
  • Phalen RF, Oldham MJ, Nel AE. 2006. Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicol Sci. 92(1):126–132.
  • Schneider IL, Teixeira EC, Silva Oliveira LF, Wiegand F. 2015. Atmospheric particle number concentration and size distribution in a traffic–impacted area. Atmos Pollut Res. 6(5):877–885.
  • Shakshuki A, Agu RU. 2017. Improving the Efficiency of Respiratory Drug Delivery: A Review of Current Treatment Trends and Future Strategies for Asthma and Chronic Obstructive Pulmonary Disease. Pulm Ther. 3(2):267–281.
  • Shang Y, Dong J, Tian L, Inthavong K, Tu J. 2019. Detailed computational analysis of flow dynamics in an extended respiratory airway model. Clin Biomech. 61:105–111.
  • Smith S, Cheng Y-S, Yeh HC. 2001. Deposition of ultrafine particles in human tracheobronchial airways of adults and children. Aerosol Sci Technol. 35(3):697–709.
  • Spiegel M, Redel T, Zhang YJ, Struffert T, Hornegger J, Grossman RG, Doerfler A, Karmonik C. 2011. Tetrahedral vs. polyhedral mesh size evaluation on flow velocity and wall shear stress for cerebral hemodynamic simulation. Comput Methods Biomech Biomed Engin. 14(1):9–22.
  • Sul B, Wallqvist A, Morris MJ, Reifman J, Rakesh V. 2014. A computational study of the respiratory airflow characteristics in normal and obstructed human airways. Comput Biol Med. 52:130–143.
  • Tian L, Shang Y, Dong J, Inthavong K, Tu J. 2017. Human nasal olfactory deposition of inhaled nanoparticles at low to moderate breathing rate. J Aerosol Sci. 113:189–200.
  • Xi J, Longest PW. 2007. Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway. Ann Biomed Eng. 35(4):560–581.
  • Yin Y, Choi J, Hoffman EA, Tawhai MH, Lin C-L. 2010. Simulation of pulmonary air flow with a subject-specific boundary condition. J Biomech. 43(11):2159–2163.
  • Zhang Z, Kleinstreuer C, Donohue JF, Kim CS. 2005. Comparison of micro- and nano-size particle depositions in a human upper airway model. J Aerosol Sci. 36(2):211–233.
  • Zhang Z, Kleinstreuer C, Kim CS, Cheng YS. 2004. Vaporizing Microdroplet Inhalation, Transport, and Deposition in a Human Upper Airway Model. Aerosol Sci Technol. 38(1):36–49.

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