123
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Effects of ergot alkaloids on liver function of piglets can be detected by the [13C]methacetin breath test irrespective of oral or intramuscular route of tracer administration

&
Pages 558-572 | Received 04 Jan 2012, Accepted 26 Mar 2012, Published online: 21 May 2012

References

  • EFSA . 2005 . Opinion of the Scientific Panel on Contaminants in Food Chain on a Request from the Commission Related to Ergot as Undesirable Substance in Animal Feed . The EFSA Journal , 225 : 1
  • Janssen , G. B. , Beems , R. B. , Elvers , L. H. and Speijers , G. J.A. 2000 . Subacute Toxicity of α-Ergocryptine in Sprague–Dawley Rats. 2: Metabolic and Hormonal Changes . Food Chem. Toxicol. , 38 : 689
  • Janssen , G. B. , Beems , R. B. , Speijers , G. J. and van Egmond , H. P. 2000 . Subacute Toxicity of α-Ergocryptine in Sprague–Dawley Rats. 1: General Toxicological Effects . Food Chem. Toxicol. , 38 : 679
  • Peters-Volleberg , G. W. , Beems , R. B. and Speijers , G. J. 1996 . Subacute Toxicity of Ergometrine Maleate in Rats . Food Chem. Toxicol. , 34 : 951
  • Moubarak , A. S. , Rosenkrans , C. F. jr and Johnson , Z. B. 2003 . Modulation of Cytochrome P450 Metabolism by Ergonovine and Dihydroergotamine . Vet. Hum. Toxicol. , 45 : 6
  • Settivari , R. S. , Evans , T. J. , Rucker , E. , Rottinghaus , G. E. and Spiers , D. E. 2008 . Effect of Ergot Alkaloids Associated with Fescue Toxicosis on Hepatic Cytochrome P450 and Antioxidant Proteins . Toxicol. Appl. Pharmacol. , 227 : 347
  • Braden , B. , Lembcke , B. , Kuker , W. and Caspary , W. F. 2007 . 13C-Breath Tests: Current State of the Art and Future Directions . Dig. Liver Dis. , 39 : 795
  • Ilan , Y. 2007 . Review Article: The Assessment of Liver Function Using Breath Tests . Aliment. Pharmacol. Ther. , 26 : 1293
  • Klein , P. D. 2001 . 13C Breath Tests: Visions and Realities . J. Nutr. , 131 : 1637S
  • Armuzzi , A. , Candelli , M. , Zocco , M. A. , Andreoli , A. , De , L. A. , Nista , E. C. , Miele , L. , Cremonini , F. , Cazzato , I. A. , Grieco , A. , Gasbarrini , G. and Gasbarrini , A. 2002 . Review Article: Breath Testing for Human Liver Function Assessment . Aliment. Pharmacol. Ther. , 16 : 1977
  • Candelli , M. , Cazzato , I. A. , Zocco , M. A. , Nista , E. C. , Fini , L. , Armuzzi , A. , Camise , V. , Santoro , M. , Miele , L. , Grieco , A. , Gasbarrini , G. and Gasbarrini , A. 2004 . 13C-Breath Tests in the Study of Mitochondrial Liver Function . Eur. Rev. Med. Pharmacol. Sci. , 8 : 23
  • Schneider , A. R.J. , Caspary , W. F. and Stein , J. 2004 . 13C-Breath Tests for the Assessment of Liver Function . Z. Gastroenterol. , 42 : 269 (in German).
  • Mainka , S. , Dänicke , S. and Coenen , M. 2003 . On the Influence of Ergot Contaminated Feed on Health and Performance of Pigs and Chickens . Übers. z. Tierern. , 31 : 121
  • Mainka , S. , Dänicke , S. , Böhme , H. , Ueberschär , K. H. and Liebert , F. 2007 . On the Alkaloid Content of Ergot (Claviceps purpurea) . Landbauforsch. Volk. , 57 : 51
  • Mainka , S. , Dänicke , S. , Böhme , H. , Ueberschär , K.-H. and Liebert , F. 2007 . On the Composition of Ergot, Especially Alkaloids, and the Effects of Feeding Ergot from Two Different Sources on the Performance and Health of Piglets . Anim. Feed Sci. Technol. , 139 : 52
  • Mainka , S. , Dänicke , S. , Böhme , H. , Ueberschär , K.-H. , Polten , S. and Hüther , L. 2005 . The Influence of Ergot-Contaminated Feed on Growth and Slaughtering Performance, Nutrient Digestibility and Carry Over of Ergot Alkaloids in Growing-Finishing Pigs . Arch. Anim. Nutr. , 59 : 377
  • Mainka , S. , Dänicke , S. , Böhme , H. , Wolff , J. , Matthes , S. and Flachowsky , G. 2005 . Comparative Studies on the Effect of Ergot Contaminated Feed on Performance and Health of Piglets and Chickens . Arch. Anim. Nutr. , 59 : 81
  • Naumann , C. and Bassler , R. 1993 . Die chemische Untersuchung von Futtermitteln , Darmstadt : VDLUFA-Verlag .
  • Wolff , J. , Neudecker , C. , Klug , C. and Weber , R. 1988 . Chemical and Toxicologic Studies of Native Corn in Flour and Bread . Z. Ernährungswiss. , 27 : 1
  • Schumann , B. , Lebzien , P. , Ueberschär , K. H. and Dänicke , S. 2009 . Effects of the Level of Feed Intake and Ergot Contaminated Concentrate on Ergot Alkaloid Metabolism and Carry Over into Milk . Mol. Nutr. Food Res. , 53 : 931
  • Baumann , U. , Hunziker , H. R. and Zimmerli , B. 1985 . Mutterkornalkaloide in schweizerischen Getreideprodukten . Mitt. Gebiete Lebensm.Hyg. , 76 : 609
  • Nürnberg , K. , Kuhn , G. , Ender , K. , Nürnberg , G. and Hartung , M. 1997 . Characteristics of Carcass Composition, Fat Metabolism and Meat Quality of Genetically Different Pigs . Lipid/Fett , 99 : 443
  • Schulte , E. and Weber , K. 1989 . Rapid Preparation of Fatty Acid Methyl Esters from Fats with Trimethylsulfoniumhydroxide or Sodium Methylate . Fat Sci. Technol. , 91 : 181
  • Ghoos , Y. F. , Maes , B. D. , Geypens , B. J. , Mys , G. , Hiele , M. I. , Rutgeerts , P. J. and Vantrappen , G. 1993 . Measurement of Gastric Emptying Rate of Solids by Means of a Carbon-Labeled Octanoic Acid Breath Test . Gastroenterology , 104 : 1640
  • Evenepoel , P. , Geypens , B. , Luypaerts , A. , Hiele , M. , Ghoos , Y. and Rutgeerts , P. 1998 . Digestibility of Cooked and Raw Egg Protein in Humans as Assessed by Stable Isotope Techniques . J. Nutr. , 128 : 1716
  • Dänicke , S. , Beineke , A. , Goyarts , T. , Valenta , H. , Beyer , M. and Humpf , H. U. 2008 . Effects of a Fusarium Toxin-Contaminated Triticale, Either Untreated or Treated with Sodium Metabisulphite ( , SBS), on Weaned Piglets with a Special Focus on Liver Function as Determined by the 13C-Methacetin Breath Test . Arch. Anim. Nutr. , 62 : 263
  • Dänicke , S. and Döll , S. 2010 . A Probiotic Feed Additive Containing Spores of Bacillus subtilis and B. licheniformis Does Not Prevent Absorption and Toxic Effects of the Fusarium toxin Deoxynivalenol in Piglets . Food Chem. Toxicol. , 48 : 152
  • StatSoft, Inc., Tulsa, OK, 1984–1995: Statistica for the WindowsTM Operating System, Version 7.1 (1995).
  • W. Kraft and U.M. Dürr, Klinische Labordiagnostik in der Tiermedizin, 6. Auflage (Schattauer, Stuttgart/New York, 2005).
  • van Milgen , J. , Noblet , J. , Dubois , S. and Bernier , J. F. 1997 . Dynamic Aspects of Oxygen Consumption and Carbon Dioxide Production in Swine . Br. J. Nutr. , 78 : 397
  • Sanaka , M. , Yamamoto , T. and Kuyama , Y. 2008 . Retention, Fixation, and Loss of the [13C] Label: A Review for the Understanding of Gastric Emptying Breath Tests . Dig.Dis. Sci. , 53 : 1747
  • Thornhill , D. P. , Steffen , C. and Netter , K. J. 1984 . A Kinetic Evaluation of in Expired Air After 14C-Methacetin Administration in Rats, Used for the In Vivo Study of the Metabolism of Drugs . Eur. J. Drug Metab. Pharmacokinet. , 9 : 161
  • Berthold , H. K. , Giesen , T. A. and Gouni-Berthold , I. 2009 . The Stable Isotope Ketoisocaproic Acid Breath Test as a Measure of Hepatic Decarboxylation Capacity: A Quantitative Analysis in Normal Subjects After Oral and Intravenous Administration . Liver Int. , 29 : 1356
  • Tugtekin , I. , Radermacher , P. , Wachter , U. , Barth , E. , Weidenbach , H. , Adler , G. , Georgieff , M. and Vogt , J. 1999 . Comparison Between the Oral and Intravenous L-[1-13C]Phenylalanine Breath Test for the Assessment of Liver Function . Isot. Environ. Health Stud. , 35 : 147
  • Krumbiegel , P. , Günther , K. , Faust , H. , Möbius , G. , Hirschberg , K. and Schneider , G. 1985 . Nuclear Medicine Liver Function Tests for Pregnant Women and Children. 1. Breath Tests With 14C-Methacetin and 13C-Methacetin . Eur. J. Nucl. Med. , 10 : 129
  • Dänicke , S. and Diers , S. 2012 . Ergot Alkaloids in Feed Affect the Liver Function of Piglets as Evaluated by the 13C-Methacetin Breath Test . Submitted ,
  • Dänicke , S. and Diers , S. 2012 . Effects of Ergot Alkaloids on Liver Function of Piglets as Evaluated by the 13C-Methacetin and 13C-α-Ketoisocaproic Acid Breath Test . Submitted ,
  • Giannini , E. G. and Testa , R. 2004 . 13C-Breath Tests and Liver Fibrosis . Eur. Rev. Med. Pharmacol. Sci. , 8 : 51

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.