The genetic association between alpha-2-macroglobulin (A 2 M) gene deletion polymorphism and low serum A 2 M concentration in overweight/obese Thais

References

• Aekplakorn W, Chaiyapong Y, Neal B, Chariyalertsak S, Kunanusont C, Phoolcharoen W, Suriyawongpaisal P. 2004. Prevalence and determinants of overweight and obesity in thai adults: Result of the second national health examination survey. J Med Assoc Thai 87:685–693.
   PubMedGoogle Scholar
• Blacker D, Wilcox MA, Laird Jr, NM, Bassett SS, McInnis MG, Albert MS, Hyman BT, Tanzi RE. 1998. Alpha-2-macroglobu- lin is genetically associated with Alzheimer’s disease. Nat Genet Lett 19:357–360.
   PubMed Web of Science ®Google Scholar
• Blenow K, Ricksten A, Prince JA, Brookes AJ, Emahazion T, Wasslavik C, Bogdanovic N, Andreasen N, Batsman S, Marcusson J, Nagga K, Wallin A, Regland B, Olofsson H, Hesse C, Davidson P, Minthon L, Jansson A, Palmqvist L, Rymo L. 2000. No association between 12- macroglobulin (A2M) deletion and Alzheimer’s disease, and no change in A2M mRNA, protein, or protein expression. J Neural Transm 107:1065–1079.
   PubMed Web of Science ®Google Scholar
• Chen L, Baum L, Ng HK, Chan LY, Sastre I, Artiga MJ, Valdivicso F, Bullido MJ, Chiu HF, Pang CP. 1999. Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer’s disease. Neurosci Lett 269:173–177.
   PubMed Web of Science ®Google Scholar
• Chen D, Zhang JW, Zhang ZX, Wu YN, Qu QM. 2004. Association of a2- macroglobulin polymorphisms and Alzheimer’s disease in Mainland Han Chinese. J Neurol Sci 217:13–15.
   PubMed Web of Science ®Google Scholar
• Dodel RC, Bales KR, Farlow MR, Gasser T, Paul SM, Du Y. 1999. Rapid detection polymorphism in the human alpha-2-macro- globulin gene. Clin Chem 2:307.
   Google Scholar
• Duan X, Ma GY. 2002. Transgenic mice model in Alzheimer’di- sease. Hong Kong J Psychiatry 12:12–18.
   Google Scholar
• Elosua R, Demissie S, Cupples AL, Meigs BJ, Wilson PWF, Schaefer JE, Corella D, Ordovas MJ. 2003. Obesity modulates the association among APOE genotype, insulin, and glucose in men. ObesRes 11:1502–1508.
   Web of Science ®Google Scholar
• Fabrizi C, Businaro R, Lauro GM, Fumagalli L. 2001. Role of 12- macroglobulin in regulating amyloid ß-protein neurotoxicity: Protective or detrimental factor? J Neurochem 78:406–412.
   PubMed Web of Science ®Google Scholar
• Gustafson D, Elisabet R, Kaj B, Bertil S, Skoog I. 2003. An 18- year follow-up of overweight and risk of Alzheimer’s disease. Arch Intern Med 163:1524–1528.
   PubMed Web of Science ®Google Scholar
• Hope C, Mettenburg J, Gonias SL, DeKosky ST, Kamboh MI, Chu CT. 2003. Functional analysis of plasma «2 macroglobulin from Alzheimer’s disease patients with the A2M intronic deletion. Neurobiol Dis 14:504–512.
   PubMed Web of Science ®Google Scholar
• Jhoo JH, Kim KW, Lee KU, Lee JH, Kim SY, Youn JY, Youn JC, Woo JI. 2000. Association of alpha-2-macroglobulin deletionpolymorphim with sporadic Alzheimer’s disease in Korean. J Neurol Sci 184:21–25.
   Web of Science ®Google Scholar
• Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. 2000. Modulation of amyloid ß-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor- related protein pathway. J Clin Invest 106:1159–1166.
   PubMed Web of Science ®Google Scholar
• Ki CS, Na DL, Kim HJ, Kim JW. 2001. Alpha-1-antitrypsin and alpha-2-macroglobulin gene polymorphisms are not associated with Korean late-onset Alzheimer’s disease. Neurosci Lett 302:69–72.
   PubMed Web of Science ®Google Scholar
• Kovacs DM. 2000. 12-macroglobulin in late-onset Alzheimer’s disease. Exp Gerontol 35:473–479.
   PubMed Web of Science ®Google Scholar
• Kovacs T, Cairns NJ, Lantos PL. 1999. Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer’s disease. Neurosci Lett 273:61–83.
   PubMed Web of Science ®Google Scholar
• Krimbou L, Marcil M, Davignon J, Genest Jr. 2001. Interaction of lecithin:cholesterol acyltransferase (LCAT) 12- macroglobulin complex with low density lipoprotein receptor- related protein (LRP). J Biol Chem 276:33241–33248.
   PubMed Web of Science ®Google Scholar
• Ling Y, Morgan YL, Kalsheker N. 2003. Amyloid precursor protein (APP) and the biology of proteolytic processing: Relevance to Alzheimer’s disease. Int J Biochem Cell Biol 35:1505–1535.
   PubMed Web of Science ®Google Scholar
• Poduslo SE, Yin X. 2001. Chromosome 12 and late-onset Alzheimer’s disease. Neurosci Lett 310:188–190.
   PubMed Web of Science ®Google Scholar
• Pongpaew P, Boonyakarnkul N, Schelp FP, Changbumrung S, Supawan V, Tawprasert S. 1994. Serum concentrations of Alpha-2-macroglobulin and other serum proteinase inhibitors in Thai vegetarians and omnivores. Nutr Res 14:337–345.
   Web of Science ®Google Scholar
• Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. 1996. Degradation of amyloid ß-protein by a serine protease-12- macroglobulin complex. J Biol Chem 271:8443–8451.
   PubMed Web of Science ®Google Scholar
• Rocchi A, Pellegrini S, Siciliano G, Murri L. 2003. Causative and susceptibility genes for Alzheimer’s disease. Brain Res Bull 61:1–24.
   PubMed Web of Science ®Google Scholar
• Saunders AJ, Tanzi RE. 2003. Welcome to the complex disease world alpha2-macroglobulin and Alzheimer’s disease. Exp Neurol 184:50–53.
   PubMed Web of Science ®Google Scholar
• Saunders AJ, Bertram L, Mulin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RCP, Bassett SS, Daly MJ, Tanzi RE, Blacker D. 2003. Genetic association of Alzheimer’s disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 12:2765–2776.
   PubMed Web of Science ®Google Scholar
• Tungtrongchitr R, Pongpaew P, Vudhivai N, Changbumrung S, Tungtrongchitr A, Phonrat B, Viroonudomphol D, Pooudong S, Schelp FP. 2003. Relationship between Alpha-2-macroglobulin, anthropometric parameters and lipid profiles in Thai overweight and obese in Bangkok. Nutr Res 23:1143–1152.
   Web of Science ®Google Scholar
• Vilella E, Olivecrona GB, Stigbrand T, Jensen PE. 1994. Binding of lipoprotein lipase to 12- macroglobulin. Biochem J 300: 443–448.
   PubMed Web of Science ®Google Scholar
• Whitmer RA, Gunderson EP, Barrett-Conner E, Quesenberry CP, Jr, Yaffe K. 2005. Obesity in middle age and future risk ofdementia: A 27 year longitudinal population based study. Br Med J 1:1–5.
   Google Scholar
• Yamada M, Sodeyama N, Itoh Y, Suematsu N, Otomo E, Matsushita M, Mizusawa H. 1999. A deletion polymorphism of 12-macroglobulin gene and cerebral amyloid angiopathy. Stroke 30:2277–2279.
   PubMed Web of Science ®Google Scholar